Pub Date : 2024-03-15DOI: 10.31146/1682-8658-ecg-218-10-114-119
T. A. Samgina, L. V. Kochetova
The aim of the study: to determine the influence of genetic predisposition and diet on the risk of severe acute pancreatitis (АР). Materials and methods. The results of diagnostics and treatment of 547 patients with acute pancreatitis were analyzed, 97 of them had a severe АР. Patients' blood DNA samples were used as research material. Detailed questionnaire on nutrition was carried out, the qualitative and quantitative composition of the food consumed was assessed. Genomic DNA was isolated using the standard PCE method. Genotyping was performed on a MALDI-TOF MassARRAY-4 analyzer. The role of the following polymorphic variants was studied: SPINK1 C>T (rs6580502), PRSS1 C>T (rs10273639), CFTR A>G (rs213950), TNF -308 G>A (rs1800629), IL1B A>G (rs16944), IL5 A>G (rs2069812), IL6 G>C (rs1800795), IL10 T>C (rs1800896), CETP G>A (rs708272) and LPL T>G (rs320). Statistical analysis was performed using SNPStats and Statistica 10.0 software. Results. In our study, we found that carriers of A/A rs2069812 IL5, G/G-G/C rs1800795 IL6 and T/T rs320 LPL genotypes increased the risk of severe acute pancreatitis. Alcohol abuse increases the risk of severe disease in carriers of T/T SPINK1 (rs6580502) and A/A CFTR (rs213950) genotypes. Constant exposure to alimentary risk factor manifested by increased consumption of fatty foods increases the risk in carriers of G/A-A/A rs 16944 IL1B, reduced protein and carbohydrate intake with food - in carriers of G/A-A/A rs2069812 IL5, carbohydrate - in carriers of G/A-A/A rs708272 CETP. Conclusion. Predictive diagnostics plays an important role in the prevention of severe acute pancreatitis, eliminating the effects of risk factors in carriers of genotypes associated with a severe course of the disease will make it possible to achieve positive success in the prevention of AP, to reduce the frequency of complications and the development of its severe course, to reduce mortality.
{"title":"The risk of severe acute pancreatitis depending on the genetic predisposition and diet","authors":"T. A. Samgina, L. V. Kochetova","doi":"10.31146/1682-8658-ecg-218-10-114-119","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-218-10-114-119","url":null,"abstract":"The aim of the study: to determine the influence of genetic predisposition and diet on the risk of severe acute pancreatitis (АР). Materials and methods. The results of diagnostics and treatment of 547 patients with acute pancreatitis were analyzed, 97 of them had a severe АР. Patients' blood DNA samples were used as research material. Detailed questionnaire on nutrition was carried out, the qualitative and quantitative composition of the food consumed was assessed. Genomic DNA was isolated using the standard PCE method. Genotyping was performed on a MALDI-TOF MassARRAY-4 analyzer. The role of the following polymorphic variants was studied: SPINK1 C>T (rs6580502), PRSS1 C>T (rs10273639), CFTR A>G (rs213950), TNF -308 G>A (rs1800629), IL1B A>G (rs16944), IL5 A>G (rs2069812), IL6 G>C (rs1800795), IL10 T>C (rs1800896), CETP G>A (rs708272) and LPL T>G (rs320). Statistical analysis was performed using SNPStats and Statistica 10.0 software. Results. In our study, we found that carriers of A/A rs2069812 IL5, G/G-G/C rs1800795 IL6 and T/T rs320 LPL genotypes increased the risk of severe acute pancreatitis. Alcohol abuse increases the risk of severe disease in carriers of T/T SPINK1 (rs6580502) and A/A CFTR (rs213950) genotypes. Constant exposure to alimentary risk factor manifested by increased consumption of fatty foods increases the risk in carriers of G/A-A/A rs 16944 IL1B, reduced protein and carbohydrate intake with food - in carriers of G/A-A/A rs2069812 IL5, carbohydrate - in carriers of G/A-A/A rs708272 CETP. Conclusion. Predictive diagnostics plays an important role in the prevention of severe acute pancreatitis, eliminating the effects of risk factors in carriers of genotypes associated with a severe course of the disease will make it possible to achieve positive success in the prevention of AP, to reduce the frequency of complications and the development of its severe course, to reduce mortality.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"52 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.31146/1682-8658-ecg-218-10-77-87
I. Druk, E. Usacheva, E. Nadey, S. S. Safronova, N. A. Usachev
Gastroesophageal reflux disease (GERD) continues to be one of the most common diseases in primary health care. In recent years, the presence of several diseases in the same patient at the same time has been widely discussed. An increase in persons suffering from several chronic diseases is associated with a deterioration in the quality of life, a high risk of hospitalization and mortality, and taking into account the presence of co/poly/multimorbidity is necessary for decision-making when developing a patient management strategy in primary health care. Studies on GERD, obesity and bronchial asthma have shown that there are common and bidirectional mechanisms in the development of these diseases. And, there are many gaps in understanding these relationships, it is important to identify concomitant diseases, since they can be the cause of resistance to therapy, to form an unfavorable prognosis of their course.
{"title":"Gastroesophageal reflux disease, obesity, bronchial asthma: simple combination or complex interaction","authors":"I. Druk, E. Usacheva, E. Nadey, S. S. Safronova, N. A. Usachev","doi":"10.31146/1682-8658-ecg-218-10-77-87","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-218-10-77-87","url":null,"abstract":"Gastroesophageal reflux disease (GERD) continues to be one of the most common diseases in primary health care. In recent years, the presence of several diseases in the same patient at the same time has been widely discussed. An increase in persons suffering from several chronic diseases is associated with a deterioration in the quality of life, a high risk of hospitalization and mortality, and taking into account the presence of co/poly/multimorbidity is necessary for decision-making when developing a patient management strategy in primary health care. Studies on GERD, obesity and bronchial asthma have shown that there are common and bidirectional mechanisms in the development of these diseases. And, there are many gaps in understanding these relationships, it is important to identify concomitant diseases, since they can be the cause of resistance to therapy, to form an unfavorable prognosis of their course.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.31146/1682-8658-ecg-218-10-63-76
E. Ermolenko, G. G. Alyokhina, V. Kashchenko, A. Zakharenko, O. Ten, A. S. Morozova, A. Tsapieva, A. S. Ilyina, T. S. Ovchinnikov, O. E. Punchenko, N. Gladyshev, A. V. Dmitriev, A. Suvorov
Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of the study was to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and E. hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. The use of autoprobiotics did not cause side effects and led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The features of the intestinal microbiome in patients with CRC were revealed, which are fundamentally different from those of other authors by an increase in alpha- biodiversity, lactobacilli, bifidobacteria, Bacteroides thetaiotaomicron and its additional differences associated with the absence of non-pathogenic enterococci: a greater amount of Parvimonas micra, a smaller amount of Akkermansia spp., an increase in the content of Klebsiella sp., Fusobacterium nucleatum and Clostridium perfringens. The use of autoprobiotics led to the elimination of P. micra, a decrease in C. perfringens, which led to the normalization of the microbiota in most patients. The effectiveness of autoprobiotics in the treatment of CRC has been proven, which, apparently, is associated with a change in the composition of intestinal microbiocenosis.
{"title":"Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics","authors":"E. Ermolenko, G. G. Alyokhina, V. Kashchenko, A. Zakharenko, O. Ten, A. S. Morozova, A. Tsapieva, A. S. Ilyina, T. S. Ovchinnikov, O. E. Punchenko, N. Gladyshev, A. V. Dmitriev, A. Suvorov","doi":"10.31146/1682-8658-ecg-218-10-63-76","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-218-10-63-76","url":null,"abstract":"Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of the study was to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and E. hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. The use of autoprobiotics did not cause side effects and led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The features of the intestinal microbiome in patients with CRC were revealed, which are fundamentally different from those of other authors by an increase in alpha- biodiversity, lactobacilli, bifidobacteria, Bacteroides thetaiotaomicron and its additional differences associated with the absence of non-pathogenic enterococci: a greater amount of Parvimonas micra, a smaller amount of Akkermansia spp., an increase in the content of Klebsiella sp., Fusobacterium nucleatum and Clostridium perfringens. The use of autoprobiotics led to the elimination of P. micra, a decrease in C. perfringens, which led to the normalization of the microbiota in most patients. The effectiveness of autoprobiotics in the treatment of CRC has been proven, which, apparently, is associated with a change in the composition of intestinal microbiocenosis.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-72-75
O. Galimov, V. U. Sataev, V. O. Khanov, T. R. Ibragimov, D. Galimov, K. V. Nasyrova
The development of laparoscopic surgery, based on technological progress, and the accumulation of clinical experience makes it possible to reduce operating access, reducе the postoperative complications. Material and methods. SILS cholecystectomy were performed in 27 patients with overweight and obesity. All operations were done as planned for chronic calculousis cholecystitis. Results and discussion. We used assistive technologies for organ traction (Patent N 103722 Russian Federation) in the event of a “conflict” of instruments, which made it possible to reduce the intervention time. The mean intervention time was 55.5±6.9 minutes. In 10 patients with risk factors for the formation of trocar hernias (obesity, advanced age, functional insufficiency of the connective tissue), the access area was preventively strengthened by an implant placed over the aponeurosis. All patients were discharged in a satisfactory condition 3-4 days after surgery. Subsequently, during observation and re-examinations up to 7 years after surgery, patients did not complain about surgical intervention, felt well, and not a single case of postoperative ventral hernia was recorded. Conclusion. The advantages of cholecystectomy in overweight and obese patients using the SILS technique are obvious, associated with a reduction in the invasiveness of the operation, an excellent cosmetic result, and the achievement of a fundamentally different quality of life for patients.
{"title":"Reducing an operational access for cholecystectomy on overweight patients","authors":"O. Galimov, V. U. Sataev, V. O. Khanov, T. R. Ibragimov, D. Galimov, K. V. Nasyrova","doi":"10.31146/1682-8658-ecg-215-7-72-75","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-215-7-72-75","url":null,"abstract":"The development of laparoscopic surgery, based on technological progress, and the accumulation of clinical experience makes it possible to reduce operating access, reducе the postoperative complications. Material and methods. SILS cholecystectomy were performed in 27 patients with overweight and obesity. All operations were done as planned for chronic calculousis cholecystitis. Results and discussion. We used assistive technologies for organ traction (Patent N 103722 Russian Federation) in the event of a “conflict” of instruments, which made it possible to reduce the intervention time. The mean intervention time was 55.5±6.9 minutes. In 10 patients with risk factors for the formation of trocar hernias (obesity, advanced age, functional insufficiency of the connective tissue), the access area was preventively strengthened by an implant placed over the aponeurosis. All patients were discharged in a satisfactory condition 3-4 days after surgery. Subsequently, during observation and re-examinations up to 7 years after surgery, patients did not complain about surgical intervention, felt well, and not a single case of postoperative ventral hernia was recorded. Conclusion. The advantages of cholecystectomy in overweight and obese patients using the SILS technique are obvious, associated with a reduction in the invasiveness of the operation, an excellent cosmetic result, and the achievement of a fundamentally different quality of life for patients.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"37 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-25-33
G. Volynets, A. Nikitin, T. Skvortsova, A. Potapov, V. V. Dudurich, L. Danilov, V. Kokiashvili
Relevance. The influence of the gut microbiota on the development of various diseases is of great interest to researchers. The conducted studies showed that in patients with chronic liver diseases, the dominant taxa of the gut microbiota were Bifidobacterium longum, Bifidobacterium adolescentis, Blautia massiliensis, and in healthy children - Neisseria flavescens. There is no comparative analysis of data on the taxonomic diversity of the intestinal microbiota in autoimmune and non-autoimmune liver diseases in children. Purpose of the study. To investigate differences in the taxonomic diversity of fecal microbiota in patients with autoimmune and non-autoimmune liver diseases, as well as to evaluate potential biomarkers of 16S rRNA gene amplicons in these diseases by comparing the taxonomic composition. Scope and methods of research. A metagenomic analysis of the intestinal microbiota of 24 children with chronic liver diseases (mean age 10.3±4.7 years) was carried out with the identification of the V3-V4 region of the 16S rRNA gene. The group included 18 children with autoimmune liver diseases and 6 children with non-autoimmune liver diseases. Research results. The conducted study revealed 684 types of microorganisms in the studied samples of patients’ faeces. The analysis of the conducted studies showed that no dominant taxa were found in the faecal samples of children with autoimmune liver diseases, while Veillonella dispar, Veillonella parvula, Cloacibacillus porcorum, Prevotella histicola and Bacteroides eggerthii were the dominant taxa in patients with non-autoimmune liver diseases. Conclusion. Studies have shown differences in the composition of the gut microbiota in children with autoimmune and non-autoimmune liver diseases.
{"title":"Gut microbiota in autoimmune and non-autoimmune liver diseases in children","authors":"G. Volynets, A. Nikitin, T. Skvortsova, A. Potapov, V. V. Dudurich, L. Danilov, V. Kokiashvili","doi":"10.31146/1682-8658-ecg-215-7-25-33","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-215-7-25-33","url":null,"abstract":"Relevance. The influence of the gut microbiota on the development of various diseases is of great interest to researchers. The conducted studies showed that in patients with chronic liver diseases, the dominant taxa of the gut microbiota were Bifidobacterium longum, Bifidobacterium adolescentis, Blautia massiliensis, and in healthy children - Neisseria flavescens. There is no comparative analysis of data on the taxonomic diversity of the intestinal microbiota in autoimmune and non-autoimmune liver diseases in children. Purpose of the study. To investigate differences in the taxonomic diversity of fecal microbiota in patients with autoimmune and non-autoimmune liver diseases, as well as to evaluate potential biomarkers of 16S rRNA gene amplicons in these diseases by comparing the taxonomic composition. Scope and methods of research. A metagenomic analysis of the intestinal microbiota of 24 children with chronic liver diseases (mean age 10.3±4.7 years) was carried out with the identification of the V3-V4 region of the 16S rRNA gene. The group included 18 children with autoimmune liver diseases and 6 children with non-autoimmune liver diseases. Research results. The conducted study revealed 684 types of microorganisms in the studied samples of patients’ faeces. The analysis of the conducted studies showed that no dominant taxa were found in the faecal samples of children with autoimmune liver diseases, while Veillonella dispar, Veillonella parvula, Cloacibacillus porcorum, Prevotella histicola and Bacteroides eggerthii were the dominant taxa in patients with non-autoimmune liver diseases. Conclusion. Studies have shown differences in the composition of the gut microbiota in children with autoimmune and non-autoimmune liver diseases.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"18 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-81-85
Sh. A. Yusupov, J. O. Atakulov, A. M. Shamsiyev, J. Shamsiev
The aim of this work: to evaluate the eff ectiveness of the developed methods of perioperative treatment of Hirschsprung’s disease in children. Materials and methods. The study was conducted on the basis of the 2nd SamMI clinic in the period from 2002 to 2022. The obtained data were compared by correlation analysis with clinical and laboratory indices and with changes in solar activity by Wolf’s numbers of the period of child embryogenesis, data of Murmansk Department of HMP). Results. The results of the study of the activity of redox enzymes have established the following. When comparing the enzyme spectrum of the affected intestine and intact muscle, only a difference in the activity of SDH and LDH is revealed. Taking into account the activity of all enzymes in relation to the activity of SDH, it can be noted that alternative energy sources have a greater specific weight in the intestinal mucosa than in the muscle.
{"title":"Perioperative treatment of Hirschsprung’s disease in children","authors":"Sh. A. Yusupov, J. O. Atakulov, A. M. Shamsiyev, J. Shamsiev","doi":"10.31146/1682-8658-ecg-215-7-81-85","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-215-7-81-85","url":null,"abstract":"The aim of this work: to evaluate the eff ectiveness of the developed methods of perioperative treatment of Hirschsprung’s disease in children. Materials and methods. The study was conducted on the basis of the 2nd SamMI clinic in the period from 2002 to 2022. The obtained data were compared by correlation analysis with clinical and laboratory indices and with changes in solar activity by Wolf’s numbers of the period of child embryogenesis, data of Murmansk Department of HMP). Results. The results of the study of the activity of redox enzymes have established the following. When comparing the enzyme spectrum of the affected intestine and intact muscle, only a difference in the activity of SDH and LDH is revealed. Taking into account the activity of all enzymes in relation to the activity of SDH, it can be noted that alternative energy sources have a greater specific weight in the intestinal mucosa than in the muscle.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"40 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-136-142
Y. Chernenkov, I. A. Glushakov, V. D. Glushakova, O. I. Gumeniuk
The problems of nutrition of children and adolescents are currently of the greatest interest to domestic and foreign researchers. Currently, the issues of early formation of proper eating habits, taste perception and the impact of nutrition on the health of children of different ages are being actively studied. Various foreign and domestic studies of the nutrition structure and nutritional status of children and adolescents point to significant shortcomings in the organization of children’s nutrition, it is worth noting that these factors influence the formation of the health of children and adolescents of various age groups. The purpose of the review is to study the features of eating behavior, in particular, the issues of snacking and catering for children of different ages.
{"title":"Medical aspects of catering for children of different ages","authors":"Y. Chernenkov, I. A. Glushakov, V. D. Glushakova, O. I. Gumeniuk","doi":"10.31146/1682-8658-ecg-215-7-136-142","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-215-7-136-142","url":null,"abstract":"The problems of nutrition of children and adolescents are currently of the greatest interest to domestic and foreign researchers. Currently, the issues of early formation of proper eating habits, taste perception and the impact of nutrition on the health of children of different ages are being actively studied. Various foreign and domestic studies of the nutrition structure and nutritional status of children and adolescents point to significant shortcomings in the organization of children’s nutrition, it is worth noting that these factors influence the formation of the health of children and adolescents of various age groups. The purpose of the review is to study the features of eating behavior, in particular, the issues of snacking and catering for children of different ages.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"34 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-162-169
D. A. Pyhteev, T. A. Bokova, L. M. Elin, O. G. Mikhaleva
Obesity in children is often accompanied by organic and functional changes on the part of the organs of the hepatobiliary system and pancreas. The article describes a clinical case of complicated course of gastrointestinal tract and pancreatic steatosis on the background of morbid obesity in a 15-year-old child with the development of choledocholithiasis, in turn, complicated by acute pancreatitis, pancreonecrosis, peritonitis and perforation of the colon. The tactics of child management, a set of diagnostic methods of examination, methods of surgical treatment are described. The necessity of early detection of both obesity itself and timely screening of its complications and comorbid pathology to prevent potentially life-threatening conditions is shown. Ultrasound of the abdominal cavity and biochemical blood analysis are mandatory for obese children. In cases of unclear genesis of jaundice, MRI is recommended to exclude obturation and abnormalities of the biliary tract. The choice of surgical tactics for the treatment of children with GI, acute pancreatitis is determined by the combination of complications, the condition of the child and the results of laboratory-radiation research methods.
{"title":"Pancreonecrosis as a complication of biliary pancreatitis in a child with morbid obesity","authors":"D. A. Pyhteev, T. A. Bokova, L. M. Elin, O. G. Mikhaleva","doi":"10.31146/1682-8658-ecg-215-7-162-169","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-215-7-162-169","url":null,"abstract":"Obesity in children is often accompanied by organic and functional changes on the part of the organs of the hepatobiliary system and pancreas. The article describes a clinical case of complicated course of gastrointestinal tract and pancreatic steatosis on the background of morbid obesity in a 15-year-old child with the development of choledocholithiasis, in turn, complicated by acute pancreatitis, pancreonecrosis, peritonitis and perforation of the colon. The tactics of child management, a set of diagnostic methods of examination, methods of surgical treatment are described. The necessity of early detection of both obesity itself and timely screening of its complications and comorbid pathology to prevent potentially life-threatening conditions is shown. Ultrasound of the abdominal cavity and biochemical blood analysis are mandatory for obese children. In cases of unclear genesis of jaundice, MRI is recommended to exclude obturation and abnormalities of the biliary tract. The choice of surgical tactics for the treatment of children with GI, acute pancreatitis is determined by the combination of complications, the condition of the child and the results of laboratory-radiation research methods.","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"36 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-46-52
Z. Mavlyanova
{"title":"Diagnosis of protein-energy deficiency in children with cerebral palsy","authors":"Z. Mavlyanova","doi":"10.31146/1682-8658-ecg-215-7-46-52","DOIUrl":"https://doi.org/10.31146/1682-8658-ecg-215-7-46-52","url":null,"abstract":"","PeriodicalId":12262,"journal":{"name":"Experimental and Clinical Gastroenterology","volume":"43 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-07DOI: 10.31146/1682-8658-ecg-215-7-102-106
I. V. Sadovnikova, A. Martusevich, E. Fedulova, A. I. Khavkin, S. A. Abramov, A. S. Kisurina
Relevance: Crystalloscopy - a method for diagnosing biological fluids (BF) allows you to evaluate the physical properties of BF crystals after dehydration, as well as indirectly determine the state of the BF proteome. Crystallography helps to identify pathological processes (inflammation, oncogenesis, trauma) in the body and further monitor the effectiveness of treatment. A defect in the HAD enzyme leads to a sharp decrease in ketogenesis, the accumulation of long-chain fatty acids, an increase in the formation of dicarboxylic acids that negatively affect the tissues of the brain, heart and liver, and inhibition of a number of enzymes (in particular, gluconeogenesis enzymes). Objective: to conduct a comparative analysis of the results of crystalloscopic examination of biological fluids in normal and metabolic pathology. Materials. Materials and methods: Crystalloscopic examination of saliva of 20 people and urine of 7 examined children without a verified diagnosis associated with metabolic pathology and a child with an established pathology of enzyme systems with liver damage. For a detailed analysis of the results of the study, the case history of child B., 10 months old, hospitalized at the Institute of Pediatrics of the University Clinic of the Volga Research Medical University in 2022, was considered. Discussion: The crystallogenic activity of the biological fluids of a patient with congenital liver enzymopathy is significantly transformed. In dried micropreparations of urine, a moderate increase in the crystal-forming ability of the biomedium was recorded, as indicated by an increase in the level of crystallization and structural index. A sharp increase in the degree of destruction of crystalline structures in the facies testified to the pathological nature of the changes. Also, pronounced shifts in the crystallogenic properties were revealed in the crystallograms of the patient’s blood serum according to the activation of dehydration structurization of the blood serum, as indicated by an increase in crystallization and structure index. Similar to urine samples, a sharp increase in the degree of facies destruction was recorded in this biological fluid compared to samples from healthy children. Conclusions: The method of crystalloscopic examination of biological fluids has the potential in the diagnosis of congenital and acquired persistent metabolic disorders due to the information content and simplicity and cost-effective study within the framework of medical examination.
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