European Respiratory Journal最新文献

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Reply: The rationale for distinguishing RB-ILD and AMP. 答：区分RB-ILD和AMP的基本原理。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.02029-2025

Sara Piciucchi,Ayodeji Adegunsoye,William D Travis,Andrew G Nicholson,Athol U Wells,Wendy A Cooper,Yet H Khor,Marlies S Wijsenbeek,Amita Sharma,Lida P Hariri,Katerina Antoniou,Raphael Borie,Aurelie Fabre,Yoshikazu Inoue,Kerri A Johannson,Takeshi Johkoh,Leticia Kawano-Dourado,Ella Kazerooni,Toby M Maher,Philip L Molyneaux,Raymond Protti,Claudia Ravaglia,Elisabetta A Renzoni,Ryoko Saito-Koyama,Nicola Sverzellati,Simon L F Walsh,Paul J Wolters,Soo-Ryum Yang,Christopher J Ryerson

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The demise of DIP, and the way forward. DIP的消亡，以及前进的方向。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.01745-2025

Sanjay Mukhopadhyay,Irene Sansano

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Challenges in harmonising terms and patterns among interstitial pneumonias: enter idiopathic bronchiolocentric interstitial pneumonia. 协调间质性肺炎术语和模式的挑战：进入特发性细支气管中心性间质性肺炎。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.01773-2025

Evans R Fernández Pérez

引用次数: 0

Novel pathomechanisms of ventilator-induced neonatal lung injury: new targets to overcome ongoing challenges. 呼吸机诱导新生儿肺损伤的新病理机制：克服持续挑战的新目标。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.01672-2025

Harald Ehrhardt,Birte Staude,Steven H Abman

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Classification of interstitial pneumonias: ready for the future or stuck in the past? 间质性肺炎的分类：为未来做好准备还是停留在过去？

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.01845-2025

Martin Kolb,Vincent Cottin,Bruno Crestani

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Cooling the flames, clearing the airways: systemic inflammation in the era of elexacaftor/tezacaftor/ivacaftor. 清火，清气道：脱脂油时代的全身性炎症。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.01805-2025

Chanhee Seo,Christina S Thornton

引用次数: 0

Substituting bronchiolocentric interstitial pneumonia for hypersensitivity pneumonitis: a word of caution. 用细支气管中心性间质性肺炎代替过敏性肺炎：一个警告。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.01604-2025

Ganesh Raghu,Martine Remy-Jardin,David A Lynch,Jeffrey L Myers

引用次数: 0

Reply: Bronchiolocentric interstitial pneumonia is a morphological term used for lung biopsy and chest imaging pattern and is not a substitute for hypersensitivity pneumonitis. 回答：细支气管中心性间质性肺炎是用于肺活检和胸部影像学的形态学术语，不能替代过敏性肺炎。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 DOI: 10.1183/13993003.02009-2025

Christopher J Ryerson,Ayodeji Adegunsoye,Sara Piciucchi,Lida P Hariri,Yet H Khor,Marlies S Wijsenbeek,Athol U Wells,Amita Sharma,Wendy A Cooper,Katerina Antoniou,Raphael Borie,Aurelie Fabre,Yoshikazu Inoue,Kerri A Johannson,Takeshi Johkoh,Leticia Kawano-Dourado,Ella Kazerooni,Toby M Maher,Philip L Molyneaux,Raymond Protti,Claudia Ravaglia,Elisabetta A Renzoni,Ryoko Saito-Koyama,Nicola Sverzellati,Simon L F Walsh,Paul J Wolters,Soo-Ryum Yang,William D Travis,Andrew G Nicholson

引用次数: 0

Characterising research trends in bronchiectasis through AI-powered analytics. 通过人工智能分析描述支气管扩张的研究趋势。

IF 21 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-12-04 Print Date: 2025-12-01 DOI: 10.1183/13993003.00894-2025

Jayanth Kumar Narayana, Yolanda Koo Wei Ling, Micheál Mac Aogáin, Sanjay H Chotirmall

Background: Interest in bronchiectasis is increasing and no prior study has used artificial intelligence (AI) to interrogate its rich, multidimensional literature to characterise research trends, themes and knowledge gaps.

Methods: We reviewed original bronchiectasis research between 1949 and 2024 (a 75-year period) to identify, characterise and assess research trends and trajectories using two AI-powered approaches: 1) Atlas, an AI topic-modelling tool; and 2) a custom model, leveraging ChatGPT embedding and text generation models.

Results: AI-powered analytics revealed a nine-fold increase in bronchiectasis research speed since 2000, typified by enhanced richness with four new research topics emerging every 5 years. Publication trends mirror clinical and technological advances, exemplified by significant rises in computed tomography, microbiome and clinical studies following the adoption of high-resolution computed tomography (1970s), next-generation sequencing (2005) and the first clinical guidelines (2008-2010), respectively. Topics with sustained growth (i.e. popular topics) include bronchiectasis-COPD overlap, microbiome infection, cardiovascular health and exacerbations. Those with sudden, short-term increased interest (i.e. trending topics) have focused on microbial pathogens and primary ciliary dyskinesia genetics. Mortality represents a nascent topic, demonstrating the highest year-on-year interest. Growth of research within the "vicious vortex" demonstrates thematic imbalance, with few studies overlapping with non-vortex components. Evolving research focus towards inflammation is evident, with increased work on comorbidities and quality of life demonstrating a shift from disease-centric to patient-centric research.

Conclusion: AI captures bronchiectasis as a dynamic and interdisciplinary field in continuing growth. Emerging research topics extend beyond the vicious vortex framework, indicating a transition from disease-centric to patient-centric approaches to optimise clinical care.

背景：人们对支气管扩张的兴趣越来越大，但之前没有研究使用人工智能（AI）来询问其丰富的、多维的文献，以表征研究趋势、主题和知识差距。方法：我们回顾了1949-2024年（75年期间）支气管扩张的原始研究，以识别、表征和评估研究趋势和轨迹，使用两种人工智能支持的方法：(1)ATLAS，人工智能主题建模工具；(2)利用ChatGPT嵌入和文本生成模型的自定义模型。结果：人工智能分析显示，自2000年以来，支气管扩张的研究速度增加了9倍，其典型特征是每5年出现4个新的研究主题。出版物趋势反映了临床和技术的进步，例如计算机断层扫描（CT）、微生物组和临床研究在采用HRCT（20世纪70年代）、下一代测序（2005年）和第一个临床指南（2008-2010年）后的显著增加。持续增长（即流行）的主题包括支气管扩张-慢性阻塞性肺病重叠、微生物组感染、心血管健康和恶化，而突然、短期增加的兴趣（即趋势）集中在微生物病原体和原发性纤毛运动障碍（PCD）遗传学上。死亡率是一个新兴的话题，每年都受到最高的关注。“恶性涡”研究的增长表现出主题不平衡，很少有研究与非涡旋成分重叠。随着对合并症和生活质量的研究的增加，炎症研究的重点不断发展，这表明从以疾病为中心的研究向以患者为中心的研究转变。结论：人工智能捕捉到支气管扩张是一个不断发展的动态和跨学科领域。新兴的研究课题超越了“恶性漩涡”框架，表明从疾病到以患者为中心的方法的过渡，以优化临床护理。

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引用次数: 0

Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk. 肺液俱乐部细胞分泌蛋白减少与慢性同种异体肺移植功能障碍风险有关。

IF 24.3 1区医学 Q1 RESPIRATORY SYSTEM

European Respiratory Journal

Pub Date : 2025-11-27 DOI: 10.1183/13993003.00182-2025

Jeeyon G Rim,Jeremy M Weber,Megan L Neely,Nicholas O'Grady,Francine L Kelly,Rachel A Myers,Andrew Nagler,Patrick McArthur,Courtney W Frankel,John A Belperio,Marie Budev,Matthew G Hartwig,Tereza Martinu,John M Reynolds,Pali D Shah,Lianne G Singer,Laurie D Snyder,S Samuel Weigt,Scott M Palmer,Jamie L Todd

RATIONALELung transplant recipients with lower club cell secretory protein (CCSP) levels in the bronchoalveolar lavage fluid (BALF) early posttransplantation are at increased risk for chronic lung allograft dysfunction (CLAD). For CLAD risk stratification, we previously identified a potential risk threshold for reduced CCSP (protein-normalized CCSP <8.63 ng·µg-1). Here, we aim to validate this association in an independent patient set from a prospective observational cohort.METHODSTotal protein and CCSP were quantified in 1481 BALF samples collected over the first posttransplant year from 353 patients (validation cohort). A Cox model tested the association between time to first CCSP <8.63 ng·µg-1 and CLAD. If this threshold did not validate, we pre-specified combining the discovery and validation cohorts to rederive a reduced CCSP risk threshold considering a larger number of CLAD events. In a subset, gene expression analyses were performed on allograft biopsies to examine molecular alterations at the time of reduced CCSP.RESULTSBALF CCSP <8.63 ng·µg-1 in the first posttransplant year was not significantly associated with CLAD in the validation cohort (HR 1.41, p=0.208). However, in the combined cohort, a dense grid search, including the previously identified threshold of 8.63 ng·µg-1, revealed that the threshold of 8.63 ng·µg-1 had the largest hazard ratio for CLAD. Iterative resampling demonstrated robust reproducibility of the association between BALF CCSP <8.63 ng·µg-1 and CLAD risk across the combined cohort. Biopsies corresponding to CCSP <8.63 ng·µg-1 had a proinflammatory profile.CONCLUSIONSEarly posttransplant reductions in BALF CCSP identify lung recipients at increased CLAD risk and may associate with heightened allograft inflammation.

移植后早期支气管肺泡灌洗液（BALF）中俱乐部细胞分泌蛋白（CCSP）水平较低的肺移植受者发生慢性同种异体肺移植功能障碍（CLAD）的风险增加。对于覆层风险分层，我们之前确定了降低CCSP的潜在风险阈值（蛋白质标准化CCSP <8.63 ng·µg-1）。在这里，我们的目标是在一组独立的前瞻性观察队列患者中验证这种关联。方法对353例患者（验证队列）移植后第一年收集的1481份BALF样本进行总蛋白和CCSP定量分析。Cox模型测试了首次CCSP <8.63 ng·µg-1的时间与CLAD之间的关系。如果该阈值未被验证，我们预先指定合并发现和验证队列，以重新导出考虑到更多的CLAD事件的降低的CCSP风险阈值。在一个子集中，对同种异体移植物活检进行基因表达分析，以检查CCSP降低时的分子变化。结果在验证队列中，移植后第一年balf CCSP <8.63 ng·µg-1与CLAD无显著相关性（HR 1.41, p=0.208）。然而，在联合队列中，包括先前确定的8.63 ng·µg-1阈值在内的密集网格搜索显示，8.63 ng·µg-1阈值具有最大的CLAD风险比。反复重新采样表明，在整个联合队列中，BALF CCSP <8.63 ng·µg-1与CLAD风险之间的关联具有很强的可重复性。CCSP <8.63 ng·µg-1对应的活检具有促炎特征。结论：移植后早期BALF CCSP降低表明肺受者有增加的CLAD风险，并可能与同种异体移植物炎症加剧有关。

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