Pub Date : 2025-12-18Print Date: 2025-12-01DOI: 10.1183/13993003.01610-2025
Mitja Jevnikar, Philippe Brenot, Mithum Kularatne, Alexandre Rodière, Elise Noël-Savina, Ari Chaouat, Samuel Dolidon, Athénaïs Boucly, Olivier Sitbon, Laurent Savale, David Montani, Olaf Mercier, Marc Humbert, Elie Fadel, Xavier Jaïs
{"title":"Chronic thromboembolic pulmonary hypertension associated with venous thoracic outlet syndrome: a retrospective case series.","authors":"Mitja Jevnikar, Philippe Brenot, Mithum Kularatne, Alexandre Rodière, Elise Noël-Savina, Ari Chaouat, Samuel Dolidon, Athénaïs Boucly, Olivier Sitbon, Laurent Savale, David Montani, Olaf Mercier, Marc Humbert, Elie Fadel, Xavier Jaïs","doi":"10.1183/13993003.01610-2025","DOIUrl":"10.1183/13993003.01610-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18Print Date: 2025-12-01DOI: 10.1183/13993003.00728-2025
Jessica Pohl, Matthias I Gröschel, Nino Neumann, Anett Tillmann, Stephan Waldeck, Tobias Schneider, Daniel Overhoff, Stephanie G Lange, Thomas Bucksch, Rebecca Peuker, Dominic Rauschning, Gwendolyn Scheumann, Lorenz Scheit, Maximilian Schreiner, Werner Wenzel, Kai Kehe, Inna Friesen, Viola Dreyer, Stefan Niemann, Leif-Erik Sander, Martin Witzenrath, Geraldine Nouailles, Christian M Zobel
{"title":"Active case finding for tuberculosis among Ukrainian soldiers by German armed forces.","authors":"Jessica Pohl, Matthias I Gröschel, Nino Neumann, Anett Tillmann, Stephan Waldeck, Tobias Schneider, Daniel Overhoff, Stephanie G Lange, Thomas Bucksch, Rebecca Peuker, Dominic Rauschning, Gwendolyn Scheumann, Lorenz Scheit, Maximilian Schreiner, Werner Wenzel, Kai Kehe, Inna Friesen, Viola Dreyer, Stefan Niemann, Leif-Erik Sander, Martin Witzenrath, Geraldine Nouailles, Christian M Zobel","doi":"10.1183/13993003.00728-2025","DOIUrl":"10.1183/13993003.00728-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12713385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18Print Date: 2025-12-01DOI: 10.1183/13993003.E6606-2025
{"title":"<i>ERJ</i> Podcast December 2025: Year in review.","authors":"","doi":"10.1183/13993003.E6606-2025","DOIUrl":"https://doi.org/10.1183/13993003.E6606-2025","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"66 6","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1183/13993003.52563-2024
{"title":"\"Natural disasters and respiratory health.\" I. Annesi-Maesano, H. Bayram, L. Cecchi, et al. Eur Respir J 2025; 66: 2402563.","authors":"","doi":"10.1183/13993003.52563-2024","DOIUrl":"https://doi.org/10.1183/13993003.52563-2024","url":null,"abstract":"","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"125 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1183/13993003.00070-2025
Stig Holm Ovesen,Søren Helbo Skaarup,Rasmus Aagaard,Nikolaj Raaber,Gitte Boier Tygesen,Thomas Nielsen,Charlotte Møgelvang,Jesper Wamberg,Peter Biesenbach,Christina Brandhof,Danny Yu,Jakob Grønnebæk Rhode,Christian Linde Larsen,Kas Zarandi,Christina Katrin Lehmann,Søren Majgaard Pedersen,Mads Damgaard Mørkenborg,Ronja Leth,Simon Thorgaard-Rasmussen,Philip Uhd,Bo Løfgren,Stefan Posth,Michael Dan Arvig,Bo Martin Bibby,Christian B Laursen,Hans Kirkegaard,Jesper Weile
BACKGROUNDPrevious trials have suggested that point-of-care ultrasound for emergency department (ED) patients with dyspnea increases the proportion of patients discharged within 24 h. We aimed to assess whether this effect could be confirmed.METHODSThis trial was a randomized controlled trial in ten Danish EDs. Adult patients presenting to the ED with dyspnea as the chief complaint were randomized to the addition or omission of focused lung and cardiac ultrasound. The primary outcome was the proportion of patients discharged alive within 24 h. Secondary outcomes included overall hospital length of stay, chest imaging utilization, and 72 h alive and revisit-free.RESULTSAmong 674 patients who were randomized between January 25, 2023, and August 23, 2024, 663 were included in the analysis. The primary outcome occurred in 141 (42.6%) of 331 patients in the intervention group versus 151 (45.5%) of 332 in the control group (risk difference: -2.9; 95% confidence interval: -10.4-4.7; p=0.45). The overall incidence rate of hospital discharges per person-days at risk was 0.28 in the intervention group versus 0.32 in the control group (hazard ratio: 0.93; 95% confidence interval: 0.79-1.08; p=0.35).CONCLUSIONSIn adult ED patients with dyspnea as chief complaint, a point-of-care ultrasound-driven diagnostic pathway did not alter the proportion of patients discharged alive within 24 h or the overall hospital length of stay compared with standard care.
{"title":"A Point-of-Care Ultrasound-Driven Diagnostic Pathway for Emergency Department Patients with Dyspnea: A Randomized Controlled Trial.","authors":"Stig Holm Ovesen,Søren Helbo Skaarup,Rasmus Aagaard,Nikolaj Raaber,Gitte Boier Tygesen,Thomas Nielsen,Charlotte Møgelvang,Jesper Wamberg,Peter Biesenbach,Christina Brandhof,Danny Yu,Jakob Grønnebæk Rhode,Christian Linde Larsen,Kas Zarandi,Christina Katrin Lehmann,Søren Majgaard Pedersen,Mads Damgaard Mørkenborg,Ronja Leth,Simon Thorgaard-Rasmussen,Philip Uhd,Bo Løfgren,Stefan Posth,Michael Dan Arvig,Bo Martin Bibby,Christian B Laursen,Hans Kirkegaard,Jesper Weile","doi":"10.1183/13993003.00070-2025","DOIUrl":"https://doi.org/10.1183/13993003.00070-2025","url":null,"abstract":"BACKGROUNDPrevious trials have suggested that point-of-care ultrasound for emergency department (ED) patients with dyspnea increases the proportion of patients discharged within 24 h. We aimed to assess whether this effect could be confirmed.METHODSThis trial was a randomized controlled trial in ten Danish EDs. Adult patients presenting to the ED with dyspnea as the chief complaint were randomized to the addition or omission of focused lung and cardiac ultrasound. The primary outcome was the proportion of patients discharged alive within 24 h. Secondary outcomes included overall hospital length of stay, chest imaging utilization, and 72 h alive and revisit-free.RESULTSAmong 674 patients who were randomized between January 25, 2023, and August 23, 2024, 663 were included in the analysis. The primary outcome occurred in 141 (42.6%) of 331 patients in the intervention group versus 151 (45.5%) of 332 in the control group (risk difference: -2.9; 95% confidence interval: -10.4-4.7; p=0.45). The overall incidence rate of hospital discharges per person-days at risk was 0.28 in the intervention group versus 0.32 in the control group (hazard ratio: 0.93; 95% confidence interval: 0.79-1.08; p=0.35).CONCLUSIONSIn adult ED patients with dyspnea as chief complaint, a point-of-care ultrasound-driven diagnostic pathway did not alter the proportion of patients discharged alive within 24 h or the overall hospital length of stay compared with standard care.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"82 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDNoonan syndrome (NS) is a RASopathy inherited in an autosomal dominant manner, mainly caused by gain-of-function variants activating the RAS/MAPK signalling pathway. Pulmonary hypertension (PH) may occur in NS, but its mechanisms, clinical characteristics, and outcomes remain poorly defined.METHODSWe analysed data from the French PH Network to characterize the phenotype of NS patients who develop PH, and conducted a systematic analysis of the literature.RESULTSSeven patients were identified from the French PH Network (male/female ratio: 1.1), with a median age at PH diagnosis of 9 years (range 5-21). Genetic analysis revealed five pathogenic variants in PTPN11 and one in SOS1. Associated features included facial dysmorphism, growth retardation, atrial septal defect and pulmonary valve stenosis. Hemodynamics showed severe precapillary PH without acute vasodilator response: mean pulmonary artery pressure 55 mmHg (40-78), cardiac output 3.95 L.min-1 (3.12-4.95) and pulmonary vascular resistance 13 WU (10-15.3). Computed tomography of the chest identified perivascular ground-glass opacities, mediastinal infiltration, dilated bronchial arteries, distal pulmonary vascular tortuosity and possible arteriovenous shunts. Five patients were treated with drugs approved for PAH. Three patients died and one underwent lung transplantation. Explanted lungs revealed plexiform lesions associated with diffuse lymphangiectasia. Twelve additional cases from the literature included seven with precapillary PH, four with postcapillary PH due to cardiomyopathy, and one without RHC.CONCLUSIONPrecapillary and postcapillary PH may complicate the course of NS, potentially in association with congenital heart defects and multisystem manifestations. Further studies are needed to better delineate the phenotype of PH in patients with NS.
{"title":"Pulmonary hypertension in patients with Noonan syndrome.","authors":"Julien Grynblat,Mathieu Farges,Pascal Magro,Laurent Savale,Maria-Rosa Ghigna,Julia Tagmouti,Xavier Jais,Athénaïs Boucly,Marilyne Levy,Fabrice Antigny,Olivier Meyrignac,Stanislas Lyonnet,Helene Cavé,Romain Nicolle,Sylvain Marchand-Adam,Olivier Sitbon,Florence Coulet,Marc Humbert,Damien Bonnet,David Montani","doi":"10.1183/13993003.01796-2025","DOIUrl":"https://doi.org/10.1183/13993003.01796-2025","url":null,"abstract":"BACKGROUNDNoonan syndrome (NS) is a RASopathy inherited in an autosomal dominant manner, mainly caused by gain-of-function variants activating the RAS/MAPK signalling pathway. Pulmonary hypertension (PH) may occur in NS, but its mechanisms, clinical characteristics, and outcomes remain poorly defined.METHODSWe analysed data from the French PH Network to characterize the phenotype of NS patients who develop PH, and conducted a systematic analysis of the literature.RESULTSSeven patients were identified from the French PH Network (male/female ratio: 1.1), with a median age at PH diagnosis of 9 years (range 5-21). Genetic analysis revealed five pathogenic variants in PTPN11 and one in SOS1. Associated features included facial dysmorphism, growth retardation, atrial septal defect and pulmonary valve stenosis. Hemodynamics showed severe precapillary PH without acute vasodilator response: mean pulmonary artery pressure 55 mmHg (40-78), cardiac output 3.95 L.min-1 (3.12-4.95) and pulmonary vascular resistance 13 WU (10-15.3). Computed tomography of the chest identified perivascular ground-glass opacities, mediastinal infiltration, dilated bronchial arteries, distal pulmonary vascular tortuosity and possible arteriovenous shunts. Five patients were treated with drugs approved for PAH. Three patients died and one underwent lung transplantation. Explanted lungs revealed plexiform lesions associated with diffuse lymphangiectasia. Twelve additional cases from the literature included seven with precapillary PH, four with postcapillary PH due to cardiomyopathy, and one without RHC.CONCLUSIONPrecapillary and postcapillary PH may complicate the course of NS, potentially in association with congenital heart defects and multisystem manifestations. Further studies are needed to better delineate the phenotype of PH in patients with NS.","PeriodicalId":12265,"journal":{"name":"European Respiratory Journal","volume":"116 1","pages":""},"PeriodicalIF":24.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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