{"title":"Translational applicability of human blood-brain barrier spheroid models for the development of brain-penetrant therapeutic antibodies.","authors":"Seiya Ohki, Tomoki Fukatsu, Hideto Morimoto, Masafumi Kinoshita, Atsushi Imakiire, Ryuji Yamamoto, Hanae Morio, Hiroyuki Sonoda, Tomomi Furihata","doi":"10.1186/s12987-025-00752-8","DOIUrl":"10.1186/s12987-025-00752-8","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"30"},"PeriodicalIF":6.2,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12911383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1186/s12987-026-00765-x
Jade Admiraal, Promise O Emeh, Marleen Bokkers, Sander P M de Ruiter, Thomas Olivier, Karla Queiroz, Todd P Burton, Nienke R Wevers
{"title":"Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow.","authors":"Jade Admiraal, Promise O Emeh, Marleen Bokkers, Sander P M de Ruiter, Thomas Olivier, Karla Queiroz, Todd P Burton, Nienke R Wevers","doi":"10.1186/s12987-026-00765-x","DOIUrl":"10.1186/s12987-026-00765-x","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"29"},"PeriodicalIF":6.2,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1186/s12987-025-00753-7
Carla Hartmann, Undine Haferkamp, Antje Appelt-Menzel, Janica Barenberg, Andreas Brachner, Toni Ehrhard, Julia Feldhaus, Anna Gerhartl, Thomas Hollemann, Linda Anna Michelle Kulka, Selin Leckzik, Jennifer Leu, Marcel Seungsu Woo, Manuel Alexander Friese, Alzheimer's Disease Neuroimaging Initiative, Marco Metzger, Winfried Neuhaus, Sabrina Oerter, Heidi Olzscha, Andreas Pich, Dagmar Riemann, Ole Pless, Dan Rujescu, Matthias Jung
{"title":"Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease.","authors":"Carla Hartmann, Undine Haferkamp, Antje Appelt-Menzel, Janica Barenberg, Andreas Brachner, Toni Ehrhard, Julia Feldhaus, Anna Gerhartl, Thomas Hollemann, Linda Anna Michelle Kulka, Selin Leckzik, Jennifer Leu, Marcel Seungsu Woo, Manuel Alexander Friese, Alzheimer's Disease Neuroimaging Initiative, Marco Metzger, Winfried Neuhaus, Sabrina Oerter, Heidi Olzscha, Andreas Pich, Dagmar Riemann, Ole Pless, Dan Rujescu, Matthias Jung","doi":"10.1186/s12987-025-00753-7","DOIUrl":"10.1186/s12987-025-00753-7","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"11"},"PeriodicalIF":6.2,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1186/s12987-026-00763-z
Mariana Melo, Ana Fortuna, João Laranjinha, Joana Bicker
{"title":"Histone and non-histone (de)acetylation impact on the blood-brain barrier.","authors":"Mariana Melo, Ana Fortuna, João Laranjinha, Joana Bicker","doi":"10.1186/s12987-026-00763-z","DOIUrl":"10.1186/s12987-026-00763-z","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"13"},"PeriodicalIF":6.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1186/s12987-026-00759-9
Annalisa Marzi, Sara Maestrini, Cristina Schenone, Lucia Pellegrino, Davide Del Chiaro, Federica Collino, Mehrnaz Hamedani, Filippo Cotellessa, Paolo Missori, Antonio Currà, Giuseppe Ribizzi, Marta Ponzano, Stefano Caneva, Matteo Pardini, Paolo Merciadri, Pietro Fiaschi, Gianluigi Zona, Carlo Trompetto, Laura Mori
{"title":"Assessment of patients affected by INPH after external lumbar drainage: what is the better timing?","authors":"Annalisa Marzi, Sara Maestrini, Cristina Schenone, Lucia Pellegrino, Davide Del Chiaro, Federica Collino, Mehrnaz Hamedani, Filippo Cotellessa, Paolo Missori, Antonio Currà, Giuseppe Ribizzi, Marta Ponzano, Stefano Caneva, Matteo Pardini, Paolo Merciadri, Pietro Fiaschi, Gianluigi Zona, Carlo Trompetto, Laura Mori","doi":"10.1186/s12987-026-00759-9","DOIUrl":"10.1186/s12987-026-00759-9","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"28"},"PeriodicalIF":6.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1186/s12987-026-00762-0
María José Oviedo, Eder Ramírez, Isabelle De Lima, Jesús Mateo Grondona, Manuel Cifuentes, Fernando Martínez, María José Barahona, Francisco Nualart, Katterine Salazar
{"title":"IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells.","authors":"María José Oviedo, Eder Ramírez, Isabelle De Lima, Jesús Mateo Grondona, Manuel Cifuentes, Fernando Martínez, María José Barahona, Francisco Nualart, Katterine Salazar","doi":"10.1186/s12987-026-00762-0","DOIUrl":"10.1186/s12987-026-00762-0","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"12"},"PeriodicalIF":6.2,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12829218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1186/s12987-025-00754-6
Sarah M Boutom, Luke D Walsh, Maxwell M Herman, Yunfeng Ding, Fatemeh Yaghoobi Hashjin, Benjamin K August, Eric V Shusta, Sean P Palecek
{"title":"Notch signaling activation reduces vesicular endocytosis in human pluripotent stem cell-derived CNS-like endothelial cells.","authors":"Sarah M Boutom, Luke D Walsh, Maxwell M Herman, Yunfeng Ding, Fatemeh Yaghoobi Hashjin, Benjamin K August, Eric V Shusta, Sean P Palecek","doi":"10.1186/s12987-025-00754-6","DOIUrl":"10.1186/s12987-025-00754-6","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"22"},"PeriodicalIF":6.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain.","authors":"Yuran Zhu, Junqing Zhu, Chenxin Ni, Anbang Chen, Longshun Li, Yue Gao, Andrew J Shoffstall, Xin Yu","doi":"10.1186/s12987-026-00758-w","DOIUrl":"10.1186/s12987-026-00758-w","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":"23"},"PeriodicalIF":6.2,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12892818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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