Folia medica最新文献

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Recent EU regulations recommend restriction of the use of medical devices in which cobalt content exceeds 0.1%. Commercially pure titanium (cpTi) and titanium alloys appear to be excellent alternatives to cobalt-based alloys in the fields of implantology and prosthodontics. The narrative review summarizes the structure and types of titanium alloys and the methods of their processing. The high biocompatibility of titanium is explained in terms of corrosion, ion release, and interaction with the biological environment. An analysis of existing studies on the mechanical properties of titanium prosthetic restorations is presented, and future perspectives are outlined.

Introduction: Psoriatic arthritis (PsA) is a chronic immune-mediated disease that extends beyond joint and skin involvement, being strongly associated with metabolic disturb ances and increased cardiovascular risk. Chronic inflammation, adipokine imbalance, and endothelial dysfunction contribute to accelerated atherosclerosis in this population.

Combined musculoskeletal traumas (MST) are complex injuries that can lead to life-threatening conditions and high mortality rates, particularly in men under 45 and women under 35. Recent increases in multiple trauma incidence highlight the need for timely intervention and effective management strategies. The concept of damage control orthopedics emphasizes the importance of stabilizing life-threatening injuries first, followed by staged surgical interventions once the patient's condition is stabilized.

Introduction: Periodontitis and apical periodontitis are multifactorial inflammatory diseases involving microbial activity and host responses that lead to tissue destruction. Biomarkers such as receptor activator of nuclear factor-kappa B (RANK), its ligand (RANKL), and the osteoprotegerin (OPG) system in gingival crevicular fluid (GCF) have been investigated for their diagnostic and prognostic roles in these conditions.

Introduction: Chronic kidney disease is characterized by the damage or dysfunction of the kidneys for a duration of at least three months, depending on its cause. End-stage kidney disease is defined by a glomerular filtration rate (GFR) of less than 15 mL/min/1.73 m2 or the need for long-term renal replacement therapy irrespective of GFR.

Pancreatic pseudocysts are considered a common complication of chronic pancreatitis. They can be infected, resulting in abscess formation; erode the wall of surrounding vascular structures, resulting in communication with them, leading to hemorrhage through the gastrointestinal tract; or rupture in the peritoneum with catastrophic consequences. Endovascular repair is a minimally invasive technique that permits exclusion of communication between pancreatic pseudocysts and vessels with low perioperative morbidity and mortality. We present a case of a symptomatic male patient with a hemorrhagic pancreatic pseudocyst due to a fistula with the superior mesenteric artery successfully managed endovascularly by deployment of a stent graft.

Introduction: Cystic fibrosis is a multi-organ genetic disorder with over 1,300 known mutations in the CFTR gene. The diversity of genetic variations leads to a wide range of clinical manifestations and disease severity.

Introduction: Incidents of foreign body ingestion and entrapment in the esophagus are a common pathology that brings patients to emergency departments. The main affected groups are children, adults over 80 years old and people with mental problems as well as patients with an anatomical predisposition to retain larger bites of food in the esophagus - conditions after surgical interventions on the esophagus, after either unintentional swallowing acids and bases or suicide attempt, growing mass causing narrowing of the esophagus in a sudden area and others.

Chronic insomnia is the most common sleep disorder, affecting up to 10% of the global population, with more than one-third of the individuals worldwide reporting insufficient sleep as a common complaint. Due to its high prevalence, insomnia frequently co-exists with various somatic and psychiatric disorders, exhibiting a bidirectional relationship in which each condition influences the other. Depression, anxiety, cardiovascular diseases, and malignancies can serve as factors triggering insomnia complaints, according to the behavioral model for insomnia development. Moreover, chronic insomnia increases the risk of these diseases through several pathogenic mechanisms, including activated stress response, altered neurotransmitter signaling, and impaired emotion regulation. This interplay creates a vicious cycle of poor sleep, deteriorated health, and impaired quality of life. Recognizing the relationship between insomnia and overall well-being is essential for adopting optimal treatment methodology, as addressing insomnia can ameliorate associated mental and physical health issues. This review explores the bidirectional association of chronic insomnia with other somatic and mental diseases, illustrating how each can aggravate the other, and emphasizes the importance of effective insomnia management in improving overall health and quality of life.