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TINGKAT PENGETAHUAN SISWA KELAS XI TERHADAP PENGGUNAAN ANTASIDA DI SMAN 2 BANGUNTAPAN BANTUL 在SMAN 2班的大二学生对杀虫剂的了解水平
Pub Date : 2023-02-17 DOI: 10.51771/fj.v3i1.397
Mexsi Mutia Rissa, Arinta Nur Rahayuning Putri
Gastritis atau yang biasa dikenal dengan maag adalah penyakit inflamasi akut atau kronis pada mukosa lambung dengan ciri-ciri rasa tidak nyaman pada epigastrium, mual, muntah dan sendawa. Kejadian gastritis di beberapa wilayah Indonesia cukup tinggi dengan prevalensi 274.396 kasus dari 238.452.952 penduduk. Beberapa survei menunjukkan bahwa gastritis paling sering menyerang usia produktif, yaitu pelajar.Tujuan dari penelitian ini untuk mengetahui tingkat pengetahuan penggunaan antasida pada siswa SMAN 2 Banguntapan Bantul bulan februari 2022. Jenis penelitian ini adalah kuantitatif observasional dengan pendekatan secara crossectional dan pengambilan data dengan memberikan kuesioner kepada responden. Penelitian ini menggunakan metode survei deskriptif yaitu menghitung jumlah jawaban yang benar kemudian dihitung persentase tingkat pengetahuan dan di ketegorikan berdasarkan baik, cukup baik, kurang baik. Berdasarkan hasil yang diperoleh bahwa tingkat pengetahuan siswa di SMAN 2 Banguntapan Bantul yang berpengetahuan baik sebanyak 52 responden (72%) dan yang berpengetahuan cukup sebanyak 10 responden (14%) dan yang berpengetahuan kurang sebanyak 10 responden (14%). Kesimpulan dari penelitian ini yaitu tingkat pengetahuan siswa terhadap penggunaan antasida mayoritas baik.
胃炎或俗称胃溃疡是胃粘膜的急性炎症或慢性疾病,表皮、恶心、呕吐和打嗝具有不舒服的特征。印度尼西亚一些地区的胃炎发病率很高,238,452952名居民中有274,396例发病率。一些调查表明,胃炎最容易影响学生的工作年龄。本研究的目的是了解到2022年2月SMAN 2班的学生使用抗除草剂的知识水平。这类研究是一种量化观察方法,通过向受访者提交问卷进行分析和数据检索。本研究采用描述性调查的方法,即计算正确答案的数量,然后计算知识水平的百分比,并根据井、相当好、较差来对其进行分类。根据结果,斯曼2号的学生知识水平良好,共有52名受访者(72%),知识渊博的学生有10人(14%),知识渊博的学生有10人(14%)。这项研究的结论是,学生在使用杀虫剂方面的知识水平充其量是好的。
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引用次数: 0
KEJADIAN EFEK SAMPING KAPTOPRIL DI SALAH SATU APOTEK DI KOTA MEDAN PADA BULAN JUNI-JULI TAHUN 2022 2022年6月至7月,棉兰市的一家药店发生了KAPTOPRIL副作用
Pub Date : 2023-02-17 DOI: 10.51771/fj.v3i1.398
U. Manik, Rahmadani Rahmadani
Kejadian efek samping obat merupakan suatu reaksi obat yang merugikan dan tidak diinginkan pada dosis lazim yang digunakan manusia untuk pencegahan, diagnosis atau terapi penyakit. Kaptopril merupakan obat antihipertensi yang bekerja menghambat Angiotensin Converting Enzym (ACE).  Kaptopril merupakan salah satu obat yang dapat menyebabkan efek samping . Pelaporan efek samping obat  di apotek sangat terbatas. Oleh karena itu, penelitian ini dilakukan bertujuan mengetahui kejadian efek samping obat di Apotek UMI FARMA. Penelitian ini merupakan penelitian observasional deskriptif dengan data prospektif yang dilakukan di APOTEK UMI FARMA. Periode penelitian Juni-Juli 2022.Populasi yang digunakan adalah seluruh pasien yang mendapatkan resep kaptopril di Apotek UMI FARMA periode Juni-Juli 2022. Hasil penelitian ini menunjukkan bahwa dari 59 pasien terdapat 54 pasien mengalami kejadian efek samping obat dan yang tidak mengalami sebanyak  5 pasien, karakteristik subjek dapat dilihat lebih banyak berusia antara 20 sampai 60 tahun yaitu sebanyak 52 responden (88,16%), disusul dengan responden yang berusia diatas 60 tahun sebanyak 7 responden (11,86%), sedangkan tidak ditemukan responden yang berusia dibawah 20 tahun. Berdasarkan jenis kelamin, responden hipertensi di Apotek UMI FARMA  pada saat dilakukan penelitian lebih banyak berjenis kelamin perempuan yaitu sebanyak 36 responden (61,01%), sedangkan laki-laki sebanyak 23 responden (38,89%). Berdasarkan kategori efek samping, pasien hipertensi yang mengonsumsi kaptopril di Apotek UMI FARMA, mayoritas mengalami efek samping dengan persentase 91,5%, sedangkan yang tidak mengalami efek samping 8,5 %. Gejala efek samping yang dialami subjek menunjukkan bahwa jenis efek samping dari penggunaan kaptopril yang paling sering terjadi yaitu batuk kering (83,33%), batuk kering disertai pusing  (1,85%), batuk kering disertai mulut kering (1,85%), batuk kering disertai konstipasi (12,9%).
药物副作用事件是一种对人类用于预防、诊断或治疗疾病的常规剂量的有害和不受欢迎的药物反应。Kaptopril是一种抑制血管紧张素转换酶的抗高血压药物。Kaptopril是唯一能引起副作用的药物。报告说,药房的药物副作用非常有限。因此,这项研究的目的是确定药物在UMI FARMA药房的副作用。本研究是一种观察性描述性研究,与UMI FARMA药剂师的前瞻性数据进行。研究期为2022年7月。使用的人群是6月至2022年7月UMI FARMA药店获得kaptopril处方的所有患者。这项研究结果表明,从59个病人有54的经历了一些药物的副作用而不经历了多达5个病人,但主体特征可以看到更多的20至60岁受访者多达52(88,16%),其次是超过60岁的受访者多达7的受访者(11,86%),而没有发现零下20岁的受访者。根据性别,UMI FARMA药房的高血压受访者在对女性进行更多的研究时,是36名受访者(6101%),而男性是23名受访者(38.89%)。根据副作用类别,在UMI FARMA药房服用kaptopril的高血压患者中,大多数都有91.5%的副作用,而没有80%的副作用。受试者所经历的副作用症状表明这种kaptopril最频繁使用的副作用就是干咳(83,33%)(1,85%),咳嗽,干咳伴有头晕伴有口干(1,85%)干,干咳伴有便秘(12,9%)。
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引用次数: 0
FORMULASI KRIM EKSTRAK DAUN KEMANGI (Ocimum basilicum L.) DENGAN VARIASI KONSENTRASI TRIETANOLAMIN DAN ASAM STEARAT 罗勒叶提取物(Ocimum basilicum L)配方。它的浓度有三他胺和草酸的变体
Pub Date : 2023-02-17 DOI: 10.51771/fj.v3i1.420
Nur Cholis Endriyatno, Fitrotul Aida
Indonesia merupakan negara yang beriklim tropis, dimana banyak sekali penyakit kulit yang dialami oleh masyarakat. Penyakit kulit salah satunya disebabkan oleh bakteri Staphylococcus aureus. Tanaman kemangi (Ocimum basilicum L.) dapat digunakan sebagai antibakteri terhadap Staphylococcus aureus dengan konsentrasi 1,5%. Kandungan senyawa tanaman kemangi (Ocimum basilicum L.) yang berperan sebagai antibakteri yaitu flavonoid, tanin, dan minyak atsiri. Ekstrak diperoleh dengan cara maserasi menggunakan penyari etanol 96%. Ekstrak diformulasi dalam sediaan krim dengan variasi konsentrasi asam stearat dan trietanolamin, untuk mengetahui kualitas sediaan dapat diketahui dari sifat fisik sediaan yang meliputi uji organoleptis, pH, homogenitas, daya sebar, daya lekat, tipe krim, dan viskositas. Hasil penelitian menunjukkan bahwa dengan variasi konsentrasi asam stearat dan trietanolamin pada krim ekstrak daun kemangi menghasilkan kualitas krim yang baik serta memenuhi sifat fisik sediaan meliputi uji organoleptis, homogenitas, pH, daya sebar, daya lekat, viskositas dan tipe krim.
印度尼西亚是一个热带国家,那里有大量的皮肤病。一种皮肤病是由葡萄球菌引起的。罗勒属植物(Ocimum basilicum L)的浓度为1。罗勒(Ocimum basilicum L)是一种抗菌物质,包括类黄酮、单宁和挥性油。提取液使用乙醇96%的溶液提取。溶液中提取的提取物具有不同程度的聚氨酯和三乙胺的浓度,可以揭示剂型的物理性质,其中包括有机污染物检测、pH值、同质性、舒适性、粘性、粘性、粘性和粘性。研究结果表明,罗勒提取物中苯甲酸和三乙胺的浓度的变化产生了良好的奶油质量,并满足了意愿的生理性质,包括有机淀粉检测、同质、pH、胶结、粘性、粘性和奶油类型。
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引用次数: 1
FORMULASI DAN EVALUASI SEDIAAN HAIR TONIC EKSTRAK BUAH PARE (Momordica charantia L.) PADA PERTUMBUHAN RAMBUT KELINCI 配方和评估PARE果食提取物(Momordica charantia L)。关于兔子头发的生长
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.389
Reza Farhan, Muḥammad Khātamī, Hafiz Hafiz
This study aims to determine the content of flavonoid and saponin compounds in bitter melon which is very good as a hair stimulant. The research was conducted experimentally. Hair tonic preparations were made by adding bitter melon extract with various concentrations, namely 5g (F1), 10g (F2), 15g (F3) and as blank (F0). Tests on hair tonic preparations include organoleptic test, homogeneity test, pH test, irritation test and hair growth activity test. The hair tonic preparation is stable in storage and homogeneity, the pH of the preparation is (5.7-6.4) and there is no redness or swelling of the skin when using the preparation. The results of hair growth are 5.0mm (F1), 5.6mm (F2), 6.7mm (F3) and 4.3mm (F0). The results showed that the higher the concentration, the higher the level of hair growth activity and hair tonic with the addition of bitter melon fruit extract (Momordica charantia L.) with a concentration of 15% (F3) had the best activity in rabbit hair growth.
本研究旨在测定具有促发作用的苦瓜中黄酮类化合物和皂苷类化合物的含量。这项研究是通过实验进行的。通过添加不同浓度的苦瓜提取物,分别为5g (F1)、10g (F2)、15g (F3)和空白(F0),制成护发制剂。对护发制剂的测试包括感官测试、均匀性测试、pH值测试、刺激测试和毛发生长活性测试。本品贮存均匀稳定,pH值为(5.7-6.4),使用时皮肤无红肿现象。毛发生长结果分别为5.0mm (F1)、5.6mm (F2)、6.7mm (F3)和4.3mm (F0)。结果表明,浓度越高,毛发生长活性越高,以添加浓度为15% (F3)的苦瓜果提取物(Momordica charantia L.)对兔毛生长的活性最好。
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引用次数: 0
POLA PENGOBATAN INFEKSI SALURAN PERNAFASAN AKUT (ISPA) PEDIATRIK RAWAT INAP DI PUSKESMAS SAWANG KABUPATEN ACEH UTARA
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.351
Eva Diansari Marbun, Modesta Harmoni Br. Tarigan, Erlita Utari
Acute Respiratory Infection (ARI) is a disease that is often experienced by toddlers with symptoms such as cough, runny nose and fever for the last 2 weeks. ARI can be caused by one of the factors, namely internal/environmental factors. The purpose of this study was to determine whether the treatment therapy for Pediatric ARI at the Sawang Health Center had met WHO standards or not. This study is a descriptive observational research method that aims to describe research problems that occur based on the characteristics of patients with pediatric ARI. This research was conducted from July-September 2020, while correspondent medical record data was taken in April-June 2020. while respondents who met the inclusion criteria were as many as 50 respondents. The results showed that of the 50 respondents who had ARI patients, the most experienced ARI based on gender were male (54%), and pediatric 4-7 years (56%). The class of antibiotics most often used in ARI therapy is the penicillin group (Amoxicilin) ​​(32%) compared to other groups, while additional symptomatic drugs to relieve symptoms caused by ARI that are often used are analgesic drugs (paracetamol) (100%). The results of the study based on statistical analysis tests obtained sig 0.005 results, it can be concluded that there is a significant relationship between all criteria (age, gender, use of antibiotic therapy drugs and use of symptomatic therapy drugs) and the pattern of ARI treatment at the Sawang Health Center, North Aceh Regency.
急性呼吸道感染(ARI)是一种常见于幼儿的疾病,其症状为咳嗽、流鼻涕和发烧,持续时间长达两周。ARI可由其中一种因素引起,即内部/环境因素。本研究的目的是确定Sawang卫生中心对儿童ARI的治疗是否达到了WHO的标准。本研究是一种描述性观察性研究方法,旨在描述基于小儿ARI患者特征的研究问题。本研究于2020年7月至9月进行,而相应的医疗记录数据于2020年4月至6月进行。而符合入选标准的应答者多达50人。结果显示,在50名有ARI患者的受访者中,基于性别的ARI经验最多的是男性(54%)和儿科4-7岁(56%)。与其他组相比,在ARI治疗中最常使用的抗生素类别是青霉素组(阿莫西林)(32%),而用于缓解ARI引起的症状的其他对症药物通常是镇痛药(扑热息痛)(100%)。基于统计分析测试的研究结果获得了0.005的sig结果,可以得出结论,所有标准(年龄、性别、抗生素治疗药物的使用和对症治疗药物的使用)与北亚齐省Sawang保健中心的急性呼吸道感染治疗模式之间存在显著关系。
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引用次数: 0
HUBUNGAN TINGKAT PENDIDIKAN TERHADAP PENGETAHUAN PENGGUNAAN ANALGETIK PADA MASYARAKAT DUSUN BANYUMENENG 2 GIRIHARJO PANGGANG GUNUNGKIDUL PERIODE JANUARI 2022
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.391
Dian Nur Afriyani, Dwi Hastuti
Based on the 2018 riskasdes, the prevalence of pain in Yogyakarta was 7,3%. Analgesic is one of the drugs that are often used for treatment with a percentage of 36,2-59%. Analgesic drugs can relieve pain such as menstrual pain, toothache, and headaches. Inappropriate use of analgesics in the community can cause adverse side in the long term. Sereval studies show that public knowedge is still lacking in the use of analgesics. The purpose of this study was to determine the relationship between aducation level and knowledge of analgesic use in community of Banyumeneng 2, Giriharjo, Panggang, Gunungkidul Period January 2022. The research method used is analytic observasional with a cross sectional approach. Data collection using purposive sampling technique using a knowledge questionnaire, the result abtained are processed and analyzed using SPSS 23 with Chi Square test. The number of subjects in the study were 88 respondents. This study shows that the result of the Chi-Square test obtained the Asymp value. Sig 0,000 is less than 0,05 which means Ha is accepted so it can be concluded that there is a relationship between education level and knowledge of analgesic use. The conclusion of this study is that there is a relationship between the level of education and knowledge of the use of analgesics.
根据2018年的风险表,日惹的疼痛患病率为7.3%。镇痛药是常用的治疗药物之一,占36.2 -59%。镇痛药可以缓解痛经、牙痛和头痛等疼痛。社区中不适当使用镇痛药可造成长期不良反应。几项研究表明,公众在使用镇痛药方面仍然缺乏知识。本研究的目的是确定教育水平与镇痛药使用知识之间的关系,在邦冈县吉里哈乔市Banyumeneng 2社区期间2022年1月。使用的研究方法是分析观察与横断面方法。数据收集采用有目的抽样技术,采用知识问卷,所得结果使用SPSS 23进行处理和分析,并采用卡方检验。研究对象的数量为88人。本研究表明,卡方检验的结果获得了Asymp值。Sig 000小于0.05,表明Ha被接受,因此可以得出教育水平与镇痛药使用知识之间存在关系。本研究的结论是,教育水平与镇痛药使用知识之间存在关系。
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引用次数: 0
FORMULASI KRIM MINYAK ALPUKAT (Avocado oil) DAN EFEKTIVITASNYA TERHADAP XEROSIS PADA TUMIT KAKI 鳄梨油配方(鳄梨油)和它在脚跟上对复印机的效果
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.393
F. Sari, Didi Nurhadi Illian, Ovalina Sylvia Br. Ginting
Xerosis is dry and cracked skin condition commonly in heel caused by losing of water content in stratum corneum skin lipid and natural moisturizing factor.The purpose of this study is to formulate a cream for treatment of xerosis in heel using avocado oil,consisted of avocado oil, cera alba, liquid paraffin, borax, BHT and methyl paraben. Avocado oil concentrations used were 10; 12.5; 15; 17.5 and 20%. Examination of the avocado oil creams include homogenity, measurement of pH, emulsion type, and the stability of the preparation. Stability parameters were odor, color and phase separation during storage of 12 weeks. Activity test of the preparations were performed on xerosis in heel twice a day in every day for 4 weeks. The effectiveness of the cream was tested on 21 volunteers who have xerosis on the heel for 4 weeks. The safety of cream was determined by irritation test used usage test that conducted on 10 volunteers.The results showed that avocado oil could be formulated into a cream preparation that was homogeneous and stable during 12 weeks of storage. Irritation test conducted on 10 volunteers showed that no one got irritation on the skin. Cream with avocado oil concentration of 10% had been able to restore xerosis in heel. The best skin recovery of xerosis in heel visible in avocado oil concentration of 20%. The conclusion of this study is avocado oil could be formulated in a cream. The cream didn’t induce irritation and application of the cream for 4 weeks.
干燥症是由于角质层含水量、皮肤脂质和天然保湿因子的流失而引起的干燥、皲裂的皮肤状况,常见于足跟。本研究的目的是用牛油果油、白蜡、液体石蜡、硼砂、BHT和对羟基苯甲酸甲酯配制一种治疗脚跟干枯的乳膏。使用的鳄梨油浓度为10;12.5;15;17.5%和20%。牛油果油乳膏的检查包括均质性、pH值测量、乳液类型和制剂的稳定性。贮藏12周时的稳定性参数为气味、颜色和相分离。对制剂进行足跟干枯活性试验,每天2次,连续4周。研究人员对21名志愿者进行了为期4周的测试,这些志愿者的脚后跟都有干枯症。通过对10名志愿者进行刺激试验和使用试验,确定了乳霜的安全性。结果表明,牛油果油在12周的贮存时间内可制成均匀稳定的乳膏制剂。对10名志愿者进行的刺激测试表明,没有人的皮肤受到刺激。牛油果油浓度为10%的乳膏能够恢复足跟的干燥。在牛油果油浓度为20%时,对皮肤干枯的恢复效果最好。这项研究的结论是鳄梨油可以制成奶油。膏体无刺激作用,连续使用4周。
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引用次数: 0
PENGARUH TINGKAT PENDIDIKAN TERHADAP PENGETAHUAN PENGGUNAAN ANTASIDA DI DUSUN KEPEK BANTULPERIODE JANUARI 2022
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.336
Ajeng Eka Septyaningrum, D. Hastuti
Gastritis is an inflammation of the stomach wall. Based on data from the Bantul Health Office, the incidence of gastritis in 2020 was in the third position of the 10 largest diseases in the Bantul District Health Center with a total of 25,517 cases. One treatment that can be done is to use antacids. The purpose of this study was to determine the effect of education level on knowledge of antacid use in Kepek Village, Bantul for the period January 2022. This type of research is using analytical observational method with a cross sectional approach and data collection by giving questionnaires to the respondents. The sample used was 95 respondents. The research instrument used was a questionnaire sheet. Data analysis was done inferentially. The number of correct answers is calculated then calculates the percentage level of knowledge and is categorized based on good, enough and less. The effect of education level on knowledge of antacid use was tested using SPSS with Chi-Square test. The results of data processing show that the education level of the people of Dusun Kepek consists of elementary school (12.63%), junior high school (14.74%), high school (54.73%) and undergraduate (17.89%). Validation test was carried out on 18 questions and obtained valid results totaling 13 questions. Based on the Chi-Square Test, a significance value of 0.001 <0.05 Ha was accepted, meaning that there was an influence between education level on knowledge of antacid use in Kepek Village, Bantul.
胃炎是胃壁的炎症。根据班图尔卫生办公室的数据,2020年胃炎的发病率在班图尔区卫生中心10大疾病中排名第三,共有25,517例。一种治疗方法是使用抗酸剂。本研究的目的是确定2022年1月期间班图尔Kepek村教育水平对抗酸药使用知识的影响。这种类型的研究是使用分析观察方法与横断面的方法和数据收集给受访者的问卷调查。所使用的样本是95名受访者。使用的研究工具是问卷调查表。数据分析是通过推理进行的。计算正确答案的数量,然后计算知识水平的百分比,并根据好,足够和更少进行分类。文化程度对抗酸药物使用知识的影响采用SPSS卡方检验。数据处理结果显示,都顺克佩克人的受教育程度由小学(12.63%)、初中(14.74%)、高中(54.73%)和本科(17.89%)构成。对18个问题进行验证检验,得到有效结果共计13个问题。经卡方检验,接受显著性值0.001 <0.05 Ha,说明班图尔Kepek村受教育程度对抗酸药使用知识存在影响。
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引用次数: 0
EVALUASI PEMAKAIAN VITAMIN D3 1000 IU SELAMA PANDEMI COVID-19 DI RUMAH SAKIT TK-II PUTRI HIJAU MEDAN IU女儿格林棉兰医院COVID-19大流行期间维生素D3 - 1000使用评估
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.353
Modesta Harmoni Tarigan, Christica Ilsana, Sri Multerisnawati Lubis
Large variations in COVID-19 mortality rates between countries and regions have been reported. In addition to age, comorbid diseases, and availability of health facilities; Vitamin D3 adequacy status is assumed to play a role, considering that the COVID-19 mortality rate was found to be relatively higher in countries with a high incidence of vitamin D3 deficiency, such as Italy, Spain, and France. Vitamin D3 has been shown to lower the risk of respiratory tract infections. At the same time, its effect in enhancing cellular and adaptive immunity also makes vitamin D3 worthy of consideration as a potential option for treating and preventing COVID-19. Sick Tk-II Putri Hijau Medan. This study uses a descriptive research method with a cross sectional approach with a retrospective research design, namely research by reviewing information or taking past data (Sugiyono, 2018). The data was obtained from prescriptions for the period February-April 2021. The results showed that there was an increase in the use of Vitamin D3 1000 IU, especially in moderate Covid 19 patients, as well as an increase in the use of Vitamin C 1000 mg and Vitamin C 500 mg. This is done with the aim of increasing the body's resistance when infected with Covid 19. In severe Covid 19 patients, vitamins are no longer given but rather are given anti-virus and anti-biotic treatment in the form of injections.
据报道,不同国家和地区的COVID-19死亡率存在很大差异。除了年龄、合并症和卫生设施的可用性;考虑到意大利、西班牙和法国等维生素D3缺乏症高发国家的COVID-19死亡率相对较高,维生素D3是否充足被认为发挥了作用。维生素D3已被证明可以降低呼吸道感染的风险。同时,它在增强细胞和适应性免疫方面的作用也使维生素D3值得考虑作为治疗和预防COVID-19的潜在选择。生病的Tk-II Putri Hijau Medan。本研究采用描述性研究方法,采用回顾性研究设计的横截面方法,即通过回顾信息或获取过去数据进行研究(Sugiyono, 2018)。数据来自2021年2月至4月期间的处方。结果显示,维生素D3的使用增加了1000 IU,特别是在中度Covid - 19患者中,维生素C的使用增加了1000 mg和500 mg。这样做的目的是在感染Covid - 19时增强身体的抵抗力。对于严重的Covid - 19患者,不再给予维生素,而是以注射的形式给予抗病毒和抗生素治疗。
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引用次数: 0
UJI EFEKTIVITAS ANTIINFLAMASI GEL EKSTRAK PINING BAWANG (Hornstedtia alliacea) PADA MENCIT (Mus musculus) YANG DIINDUKSI KARAGENAN 1% 测试刺山柑洋葱细味凝胶(Hornstedtia alliacea)的抗炎症作用,诱导kar草根1%
Pub Date : 2022-07-31 DOI: 10.51771/fj.v2i2.328
Muhammad Khatami, Reza Farhan, Hafiz Hafiz
The purpose of this study was to determine the concentration of onion pining extract gel which has anti-inflammatory activity in carrageenan-induced male mice. Pining onion (Horstedtia alliacea) is a member of the ginger plant (Zingiberaceae) that grows in tropical areas including Halmanera. Pining onion is usually used as an energy supplier for hunting in the forest, treating wounds and infections, the seeds are consumed by children and adults. The benefit of this research is that this research can provide scientific and truthful information to the public regarding the anti-inflammatory effects of the pining onion plant, so that it can be used as an alternative inflammatory treatment. Pining onions contain flavonoid compounds, essential oils and several other compounds that are useful as anti-inflammatory. This study made three sample formulas with the active ingredient of pining onion extract with composition 0 (negative control), formula I 5%, formula II 10%, formula III 15% and diclofenac sodium (positive control) using the maceration method, with an interval of 30 minutes. for 8 repetitions of each suspension. Inhibition of edema in the FIII group (15% pining onion extract) had the same tendency as the K+ group (Na-Diclofenac). Meanwhile, at the lowest test dose the inhibition of edema was in the FI group (5% onion pining extract). The conclusion of this study is that administration of pining onion extract gel can show anti-inflammatory activity in carrageenan-induced mice. Pining onion extract gel at a concentration of 15% is the concentration that has the best anti-inflammatory activity compared to concentrations of 10% and 5%.
本研究的目的是测定具有抗炎活性的洋葱松提取物凝胶在卡拉胶诱导的雄性小鼠体内的浓度。葱(Horstedtia alliacea)是生姜植物(姜科)的一员,生长在热带地区,包括Halmanera。洋葱通常被用作森林狩猎的能量来源,治疗伤口和感染,其种子被儿童和成人食用。本研究的好处是,本研究可以为公众提供有关葱属植物抗炎作用的科学、真实的信息,从而可以作为一种替代的炎症治疗方法。洋葱含有类黄酮化合物、精油和其他几种抗炎化合物。本研究采用浸渍法,以活性成分葱提取物0(阴性对照)、1(5%)、2(10%)、3(15%)和双氯芬酸钠(阳性对照)配制3个样品配方,浸出时间间隔为30分钟。每个悬吊重复8次。FIII组(15%洋葱提取物)对水肿的抑制趋势与K+组(na -双氯芬酸)相同。同时,在最低试验剂量下,FI组(5%洋葱松提取物)对水肿的抑制作用最大。本研究的结论是,给药葱提取物凝胶对卡拉胶诱导的小鼠具有抗炎作用。与浓度为10%和5%的洋葱提取物凝胶相比,浓度为15%的洋葱提取物凝胶具有最佳的抗炎活性。
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