The use of antipsychotics in schizophrenic patients often causes side effects in the form of Extra Pyramidal Syndrome (EPS), namely the presence of uncontrolled muscle movement disorders such as seizures, shaking and so on. The incidence of EPS is more common with the use of typical antipsychotics than atypicals. This study aims to see the incidence of EPS in inpatients with schizophrenia at the Aceh Mental Hospital located in Banda Aceh in 2020. The population in this study were all inpatients who were given typical antipsychotics. While the research sample was 399 samples collected from medical record data of inpatients in 2020, so the study was retrospective with a cross sectional approach. Data collected in the form of patient identity (gender, age), drug therapy (typical antipsychotics) and the incidence of EPS. The results showed that schizophrenic patients who received typical antipsychotic therapy who were hospitalized at the Aceh mental hospital in 2020, were 324 men (81.2%) and 75 women (18.8%), with the highest age range being at 36-45 years amounting to 202 people (50.6%). Typical antipsychotic therapy used in the form of combination of typical-typical and typical-atypical drugs, namely clozapine-trifluperazine (40.6%), chlorpromazine-risperidone (20.3%), haloperidol-chlorpromazine-trifluperazine (16%), haloperidolchlorpromazine (7%), and haloperidol-trifluperazine (5%). The incidence of EPS that occurred was 113 people (28.3%), with the highest number of EPS occurring from the administration of haloperidol-chlorpromazine-trifluperazine combination antipsychotic therapy, which was 61 people (15.3%).
{"title":"GAMBARAN KEJADIAN EKSTRAPIRAMIDAL SINDROM PADA PASIEN TERAPI ANTIPSIKOTIK TIPIKAL DI RUMAH SAKIT JIWA ACEH","authors":"Vivi Asfianti, Alfi Syahfitri, Zuhairiah Nst","doi":"10.51771/fj.v2i2.367","DOIUrl":"https://doi.org/10.51771/fj.v2i2.367","url":null,"abstract":"The use of antipsychotics in schizophrenic patients often causes side effects in the form of Extra Pyramidal Syndrome (EPS), namely the presence of uncontrolled muscle movement disorders such as seizures, shaking and so on. The incidence of EPS is more common with the use of typical antipsychotics than atypicals. This study aims to see the incidence of EPS in inpatients with schizophrenia at the Aceh Mental Hospital located in Banda Aceh in 2020. The population in this study were all inpatients who were given typical antipsychotics. While the research sample was 399 samples collected from medical record data of inpatients in 2020, so the study was retrospective with a cross sectional approach. Data collected in the form of patient identity (gender, age), drug therapy (typical antipsychotics) and the incidence of EPS. The results showed that schizophrenic patients who received typical antipsychotic therapy who were hospitalized at the Aceh mental hospital in 2020, were 324 men (81.2%) and 75 women (18.8%), with the highest age range being at 36-45 years amounting to 202 people (50.6%). Typical antipsychotic therapy used in the form of combination of typical-typical and typical-atypical drugs, namely clozapine-trifluperazine (40.6%), chlorpromazine-risperidone (20.3%), haloperidol-chlorpromazine-trifluperazine (16%), haloperidolchlorpromazine (7%), and haloperidol-trifluperazine (5%). The incidence of EPS that occurred was 113 people (28.3%), with the highest number of EPS occurring from the administration of haloperidol-chlorpromazine-trifluperazine combination antipsychotic therapy, which was 61 people (15.3%).","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83907946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The modified formulation provides a fairly effective way to overcome the problem of bioavailability and results in increasing drug reactions and minimizing fluctuations in blood levels during release. The crosslinker in this study is sodium tripolyphosphate (Na-TPP) which is considered the best binding agent and can produce prolonged drug release. The purpose of this study was to determine the profile of theophylline release from the capsule shell of the alginate-chitosan matrix combination using the crosslink method. The capsule shell was made with the ratio of the percentage of alginate ; chitosan; The TPP are F1 (2%; 2%; 4%) and F2 (4%; 2%; 4%). The difference in percentage is intended to determine the ratio of the most optimal levels of releasing theophylline. The results obtained showed that theophylline capsules from formulas F1 and F2 could release the drug slowly and for a long time to the artificial intestinal fluid pH 7.4 for 8 hours for formula F1 and for 12 hours for formula F2 with a cumulative percentage of release of 99.75%.
{"title":"STUDI PELEPASAN TEOFILIN DARI CANGKANG KAPSUL ALGINAT-KITOSAN MENGGUNAKAN TRIPOLIFOSFAT SEBAGAI CROSSLINKER","authors":"Cut Intan Annisa Puteri, Rahmadani Rahmadani, Chairunnisa Anggi","doi":"10.51771/fj.v2i2.372","DOIUrl":"https://doi.org/10.51771/fj.v2i2.372","url":null,"abstract":"The modified formulation provides a fairly effective way to overcome the problem of bioavailability and results in increasing drug reactions and minimizing fluctuations in blood levels during release. The crosslinker in this study is sodium tripolyphosphate (Na-TPP) which is considered the best binding agent and can produce prolonged drug release. The purpose of this study was to determine the profile of theophylline release from the capsule shell of the alginate-chitosan matrix combination using the crosslink method. The capsule shell was made with the ratio of the percentage of alginate ; chitosan; The TPP are F1 (2%; 2%; 4%) and F2 (4%; 2%; 4%). The difference in percentage is intended to determine the ratio of the most optimal levels of releasing theophylline. The results obtained showed that theophylline capsules from formulas F1 and F2 could release the drug slowly and for a long time to the artificial intestinal fluid pH 7.4 for 8 hours for formula F1 and for 12 hours for formula F2 with a cumulative percentage of release of 99.75%.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90901924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
URTI (Upper Respiratory Tract Infection) is a major disease in children in outpatient installation. Antibiotics are the most widely used class of drugs to treat infections. Antibiotics must be used rationally. Because the bad impact that occurs is the emergence of bacterial resistance. This study aims to obtain an overview of the rationality of the use of antibiotics in URTI patients, especially in children aged 5 to 11 years. The method used is a retrospective descriptive method, using medical record cards and prescription sheets for patients diagnosed with URTI and receiving antibiotics at the Gunungsitoli District Health Center during the period January to December 2020. Sampling used the purposive sampling method. Data that met the inclusion criteria were children aged 5-11 years and receiving antibiotic therapy. Then a table is made which includes the patient's identity, diagnosis, antibiotics, and the dose used. Then presented in the form of percentages, average values and tables. The results showed that of the 64 patients who suffered the most URTI by age were patients aged 5 years (26.56%), the antibiotic group that was most often prescribed was the penicillin group, namely amoxicillin. (54.69%). Evaluation of rational use of antibiotics based on the 2011 Ministry of Health guidelines includes the right patient criteria (100%), right indication (100%), right frequency (100%), right drug (100%), right duration (98.44%), and right dose (93.75%).
{"title":"EVALUASI RASIONALITAS PENGGUNAAN ANTIBIOTIK ISPA PADA PASIEN RAWAT JALAN DI PUSKESMAS KECAMATAN GUNUNG SITOLI","authors":"Artha Yuliana Sianipar, Grace Anastasia Ginting, Yosefin Hellen","doi":"10.51771/fj.v2i2.352","DOIUrl":"https://doi.org/10.51771/fj.v2i2.352","url":null,"abstract":"URTI (Upper Respiratory Tract Infection) is a major disease in children in outpatient installation. Antibiotics are the most widely used class of drugs to treat infections. Antibiotics must be used rationally. Because the bad impact that occurs is the emergence of bacterial resistance. This study aims to obtain an overview of the rationality of the use of antibiotics in URTI patients, especially in children aged 5 to 11 years. The method used is a retrospective descriptive method, using medical record cards and prescription sheets for patients diagnosed with URTI and receiving antibiotics at the Gunungsitoli District Health Center during the period January to December 2020. Sampling used the purposive sampling method. Data that met the inclusion criteria were children aged 5-11 years and receiving antibiotic therapy. Then a table is made which includes the patient's identity, diagnosis, antibiotics, and the dose used. Then presented in the form of percentages, average values and tables. The results showed that of the 64 patients who suffered the most URTI by age were patients aged 5 years (26.56%), the antibiotic group that was most often prescribed was the penicillin group, namely amoxicillin. (54.69%). Evaluation of rational use of antibiotics based on the 2011 Ministry of Health guidelines includes the right patient criteria (100%), right indication (100%), right frequency (100%), right drug (100%), right duration (98.44%), and right dose (93.75%).","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83605075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grace Anastasia Br. Ginting, Eva Diansari Marbun, Andre Prayoga, Rosmeri Br Karo
Pulmonary tuberculosis is an infectious disease, so non-adherence to treatment will result in treatment failure, risk of death, and cause more patients to become resistant. This study aims to determine the relationship between the characteristics of pulmonary tuberculosis outpatients on the level of medication adherence in Sawit Seberang Public Health Center. This research was conducted with a cross sectional survey research method. The instrument used in this study was a validated questionnaire containing 8 questions about patient compliance and pill count data by calculating the patient's remaining medication. A total of 45 patients were used as respondents who had pulmonary tuberculosis. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) version 18 program. The results showed that the level of compliance of pulmonary tuberculosis patients in Sawit Seberang Public Health Center based on the questionnaire was high, namely 62.2%, and the compliance level of pulmonary tuberculosis patients in Sawit Seberang Public Health Center based on the Pill Count was perfect, namely 93.3%. Patient characteristics (gender, age, education, and occupation) did not affect the level of compliance of patients taking pulmonary tuberculosis drugs with p values of 0.462, 0.527, 0.260, 0.482 respectively. This study proves that the level of compliance of pulmonary tuberculosis patients in Sawit Seberang Public Health Center based on the questionnaire is high and based on the Pill Count is perfect. Patient characteristics (gender, age, education, and occupation) did not affect the patient's level of compliance to taking pulmonary tuberculosis drugs.
{"title":"HUBUNGAN KARAKTERISTIK PASIEN RAWAT JALAN TUBERKULOSIS PARU TERHADAP TINGKAT KEPATUHAN MINUM OBAT DI PUSKESMAS SAWIT SEBERANG","authors":"Grace Anastasia Br. Ginting, Eva Diansari Marbun, Andre Prayoga, Rosmeri Br Karo","doi":"10.51771/fj.v2i2.348","DOIUrl":"https://doi.org/10.51771/fj.v2i2.348","url":null,"abstract":"Pulmonary tuberculosis is an infectious disease, so non-adherence to treatment will result in treatment failure, risk of death, and cause more patients to become resistant. This study aims to determine the relationship between the characteristics of pulmonary tuberculosis outpatients on the level of medication adherence in Sawit Seberang Public Health Center. This research was conducted with a cross sectional survey research method. The instrument used in this study was a validated questionnaire containing 8 questions about patient compliance and pill count data by calculating the patient's remaining medication. A total of 45 patients were used as respondents who had pulmonary tuberculosis. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) version 18 program. The results showed that the level of compliance of pulmonary tuberculosis patients in Sawit Seberang Public Health Center based on the questionnaire was high, namely 62.2%, and the compliance level of pulmonary tuberculosis patients in Sawit Seberang Public Health Center based on the Pill Count was perfect, namely 93.3%. Patient characteristics (gender, age, education, and occupation) did not affect the level of compliance of patients taking pulmonary tuberculosis drugs with p values of 0.462, 0.527, 0.260, 0.482 respectively. This study proves that the level of compliance of pulmonary tuberculosis patients in Sawit Seberang Public Health Center based on the questionnaire is high and based on the Pill Count is perfect. Patient characteristics (gender, age, education, and occupation) did not affect the patient's level of compliance to taking pulmonary tuberculosis drugs.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77923863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Distribution is an important aspect in ensuring the quality of the preparation. Medical Device Distributors must have adequate facilities and infrastructure to ensure the implementation of distribution, management, procurement, and storage. The purpose of this study was to determine Medical Device Distributors compliance with CDAKB requirements in the distribution of medical devices. This study uses the direct observation method on the research object to see the activities carried out and compare them with the CDAKB requirements listed in the Draft Technical Instructions for Supervision of Medical Device Distribution Facilities. Monitoring objects are documents, officers, facilities/infrastructure, and distribution activities. The results of the observations are the percentage of the level of fulfillment of the CDAKB requirements by dividing the total score achieved by the maximum number of scores and then multiplying by 100%. The results of the analysis of the level of CDAKB compliance show that PT. X meets 59 of 84 points (70.24%) requirements divided into 4 aspects, namely quality management system, resource management, product storage, and handling, and corrective actions, returns, and product destruction. In conclusion PT. X meets the CDAKB requirements and is in a good category.
{"title":"MONITORING DAN EVALUASI CARA DISTRIBUSI ALAT KESEHATAN YANG BAIK (CDAKB) PADA PEDAGANG ALAT KESEHATAN PT.X DI KOTA BATAM","authors":"Yan Yan, M. Asiah, Ovalina Sylvia Br. Ginting","doi":"10.51771/fj.v2i2.392","DOIUrl":"https://doi.org/10.51771/fj.v2i2.392","url":null,"abstract":"Distribution is an important aspect in ensuring the quality of the preparation. Medical Device Distributors must have adequate facilities and infrastructure to ensure the implementation of distribution, management, procurement, and storage. The purpose of this study was to determine Medical Device Distributors compliance with CDAKB requirements in the distribution of medical devices. This study uses the direct observation method on the research object to see the activities carried out and compare them with the CDAKB requirements listed in the Draft Technical Instructions for Supervision of Medical Device Distribution Facilities. Monitoring objects are documents, officers, facilities/infrastructure, and distribution activities. The results of the observations are the percentage of the level of fulfillment of the CDAKB requirements by dividing the total score achieved by the maximum number of scores and then multiplying by 100%. The results of the analysis of the level of CDAKB compliance show that PT. X meets 59 of 84 points (70.24%) requirements divided into 4 aspects, namely quality management system, resource management, product storage, and handling, and corrective actions, returns, and product destruction. In conclusion PT. X meets the CDAKB requirements and is in a good category.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87242672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aswan Pangondian Harahap, Robiatun Rambe, Ratih Paramitha, Y. Yulanda
ABSTRAK Senggani (Melastoma malabathricum L.) memiliki kandungan kimia seperti alkaloid, flavonid, tanin, saponin dan steroid . Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol dan dekok daun senggani (Melastoma malabathricum L.) serta perbandingan nilai IC50 dari ekstrak etanol dan dekok daun senggani (Melastoma malabathricum L.). Metode Ekstraksi yang digunakan dalam penelitian ini adalah maserasi dengan pelarut etanol 70% . dan dekok dengan pelarut air pada suhu 90o selama 30 menit.Pengujian aktivutas antioksidan menggunakan metode peredaman radikak bebas DPPH. Hasil ekstraksi daun senggani menggunakan pelarut etanol 70% menghasilkan ekstrak cair kemudian di kentalkan menghasilkan ekstrak kental sebanyak 110,2 gram dengan persen rendemen sebesar 22,04 %. Dekok daun senggani menggunakan pelarut air menghasilkan 49,90 gram dengan rendemen ekstraksebesar 24,95% . Dari Hasil pengukuran aktivitas antioksidan diperoleh nilai IC50 ekstrak etanol daun senggani (Melastoma malabathricum L.) sebesar 19,206 ppm, dan dekok daun senggani (Melastoma malabathricum L.) sebesar17,140 ppm. Kesimpulan bahwa Aktivitas antioksidan dari Ekstrak Etanol dan Dekok daun senggani (Melastoma malabathricum L.) diperoleh melalui metode pengujian dengan DPPH dengan nilai IC50 ekstraketanol daun senggani sebesar 19,206 ppm dan dekok daun senggani sebesar17.140 ppm dimana aktivitas antioksidan tergolong sangat kuat, kedua sempel memiliki aktivitas antioksidan yang sangat kuat tetapi Nilai IC50 Dekok daun Senggani (Melastoma malabathricum L.) lebih baik dibanding kan ekstrak Etanol Daun Senggani (Melastoma malabathricum L.). Kata Kunci : Melastoma malabathricum L, aktivitas antioksidan, metode DPPH.
{"title":"Standarisasi Dan Perbandingan Uji Aktivitas Antioksidan Dari Ekstrak Etanol Dan Dekok Daun Senggani ( Melastoma malabathricum L.) Dengan Menggunakan metode DPPH","authors":"Aswan Pangondian Harahap, Robiatun Rambe, Ratih Paramitha, Y. Yulanda","doi":"10.51771/fj.v2i1.191","DOIUrl":"https://doi.org/10.51771/fj.v2i1.191","url":null,"abstract":"ABSTRAK \u0000Senggani (Melastoma malabathricum L.) memiliki kandungan kimia seperti alkaloid, flavonid, tanin, saponin dan steroid . Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol dan dekok daun senggani (Melastoma malabathricum L.) serta perbandingan nilai IC50 dari ekstrak etanol dan dekok daun senggani (Melastoma malabathricum L.). Metode Ekstraksi yang digunakan dalam penelitian ini adalah maserasi dengan pelarut etanol 70% . dan dekok dengan pelarut air pada suhu 90o selama 30 menit.Pengujian aktivutas antioksidan menggunakan metode peredaman radikak bebas DPPH. Hasil ekstraksi daun senggani menggunakan pelarut etanol 70% menghasilkan ekstrak cair kemudian di kentalkan menghasilkan ekstrak kental sebanyak 110,2 gram dengan persen rendemen sebesar 22,04 %. Dekok daun senggani menggunakan pelarut air menghasilkan 49,90 gram dengan rendemen ekstraksebesar 24,95% . Dari Hasil pengukuran aktivitas antioksidan diperoleh nilai IC50 ekstrak etanol daun senggani (Melastoma malabathricum L.) sebesar 19,206 ppm, dan dekok daun senggani (Melastoma malabathricum L.) sebesar17,140 ppm. Kesimpulan bahwa Aktivitas antioksidan dari Ekstrak Etanol dan Dekok daun senggani (Melastoma malabathricum L.) diperoleh melalui metode pengujian dengan DPPH dengan nilai IC50 ekstraketanol daun senggani sebesar 19,206 ppm dan dekok daun senggani sebesar17.140 ppm dimana aktivitas antioksidan tergolong sangat kuat, kedua sempel memiliki aktivitas antioksidan yang sangat kuat tetapi Nilai IC50 Dekok daun Senggani (Melastoma malabathricum L.) lebih baik dibanding kan ekstrak Etanol Daun Senggani (Melastoma malabathricum L.). \u0000 \u0000 \u0000Kata Kunci : Melastoma malabathricum L, aktivitas antioksidan, metode DPPH.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87093076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aims of this study were to know the partial and simultantinfluence of product image, product price and packaging to purchase decision of herbal medicine VCO. The design of this study was a case study using the primary data. The population of this study were the consumers of Matahari Pharmacy. The sample size was 69 respondents.The sample was chosen using non-probability sampling. Data was collected by interviewing and distributing questionairs. The data was analysed using multiple linear regression. The research found that the product image and product packaginghad a significant influence to the purchase decision of herbal medicine VCO, while the product price had no significant influence to the purchase decision of herbal medicine VCO. Simultaneously, product image, product price and product packaginghad significant influence to purchase decision of herbal medicine VCO.
{"title":"ANALISIS PENGARUH CITRA PRODUK, HARGA JUAL DAN DESAIN KEMASAN TERHADAP KEPUTUSAN PEMBELIAN VCO DI APOTEK MATAHARI","authors":"Ovalina Sylvia Br. Ginting, Ahmad Arif Affandi","doi":"10.51771/fj.v2i1.206","DOIUrl":"https://doi.org/10.51771/fj.v2i1.206","url":null,"abstract":"The aims of this study were to know the partial and simultantinfluence of product image, product price and packaging to purchase decision of herbal medicine VCO. The design of this study was a case study using the primary data. The population of this study were the consumers of Matahari Pharmacy. The sample size was 69 respondents.The sample was chosen using non-probability sampling. Data was collected by interviewing and distributing questionairs. The data was analysed using multiple linear regression. \u0000The research found that the product image and product packaginghad a significant influence to the purchase decision of herbal medicine VCO, while the product price had no significant influence to the purchase decision of herbal medicine VCO. Simultaneously, product image, product price and product packaginghad significant influence to purchase decision of herbal medicine VCO.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80075664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Berenuk merupakan tanaman perdu tropis yang berkhasiat sebagai obat berbagai penyakit. Daun berenuk dalam pengobatan tradisional digunakan untuk mengobati luka baru dan menurunkan hipertensi. Pada penelitian ini dilakukan identifikasi dan isolasi pada daun berenuk (Crescentia cujete L.). Isolasi dilakukan dengan cara ekstraksi maserasi menggunakan pelarut etil asetat yang menghasilkan ekstrak kental daun berenuk. Pemisahan senyawa dari ekstrak kental etil asetat dilakukan menggunakan kromatografi kolom dan dimonitor dengan Kromatografi Lapis Tipis (KLT). Fraksi yang menunjukkan pola noda yang sama pada hasil pemisahan dengan KLT, digabungkan. Karakterisasi senyawa dilakukan dengan spektrofotometer UV-Vis dengan panjang gelombang maksimal 403 nm, spektrofotometer IR memberikan pita serapan pada bilangan gelombang 1734.82 cm-1, 1236.42 cm-1, 2983.39 cm-1, 3566.05 cm-1, dan titik leleh 194-1990C.
{"title":"ISOLASI SENYAWA EKSTRAK ETIL ASETAT DAUN TUMBUHAN BERENUK (Crescentia cujete L.)","authors":"Afdhil Arel, W. Ningsih","doi":"10.51771/fj.v2i1.250","DOIUrl":"https://doi.org/10.51771/fj.v2i1.250","url":null,"abstract":"Berenuk merupakan tanaman perdu tropis yang berkhasiat sebagai obat berbagai penyakit. Daun berenuk dalam pengobatan tradisional digunakan untuk mengobati luka baru dan menurunkan hipertensi. Pada penelitian ini dilakukan identifikasi dan isolasi pada daun berenuk (Crescentia cujete L.). Isolasi dilakukan dengan cara ekstraksi maserasi menggunakan pelarut etil asetat yang menghasilkan ekstrak kental daun berenuk. Pemisahan senyawa dari ekstrak kental etil asetat dilakukan menggunakan kromatografi kolom dan dimonitor dengan Kromatografi Lapis Tipis (KLT). Fraksi yang menunjukkan pola noda yang sama pada hasil pemisahan dengan KLT, digabungkan. Karakterisasi senyawa dilakukan dengan spektrofotometer UV-Vis dengan panjang gelombang maksimal 403 nm, spektrofotometer IR memberikan pita serapan pada bilangan gelombang 1734.82 cm-1, 1236.42 cm-1, 2983.39 cm-1, 3566.05 cm-1, dan titik leleh 194-1990C.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89689954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Diansari Marbun, Alfi Sapitri, Artha Yuliana Sianipar
Bidara arab (Ziziphus jujuba Mill) merupakan tumbuhan semak atau pohon berduri yang digunakan sebagai obat tradisional. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri EEDBA (Ziziphus jujuba Mill) terhadap bakteri S. aureus dan S.epidermidis. Pembuatan EEDBA dilakukan dengan cara perkolasi menggunakan etanol 96%. Pengujian aktivitas antibakteri dilakukan dengan cara difusi menggunakan kertas cakram (Uji Kirby-Bauer). Hasil penelitian EEDBA sebagai antibakteri berdasarkan parameter luas zona hambat terhadap bakteri S. aureus dengan konsentrasi 2% rata-rata yaitu 11,2 mm, 3% yaitu 12,2 mm, 4% yaitu 13,4 mm, 5% yaitu 16,0 mm. Sedangkan bakteri S.epidermidis pada konsentrasi 2 % rata-rata yaitu 12,0 mm, 3% yaitu 14,6 mm, 4% yaitu 15,8 mm, 5% yaitu 16,6 mm serta diameter kontrol positif keduanya rata-rata yaitu 27,2 mm. Berdasarkan analisis statistik pada anova menunjukkan EEDBA (Ziziphus jujuba Mill) bisa menghambat pertumbuhan bakteri S. aureus dan S.epidermidis dengan sangat nyata (Fh>Ft;α=0,05).
{"title":"UJI ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA ARAB (Ziziphus jujuba Mill) TERHADAP BAKTERI S. aureus DAN S. epidermidis","authors":"Eva Diansari Marbun, Alfi Sapitri, Artha Yuliana Sianipar","doi":"10.51771/fj.v2i1.200","DOIUrl":"https://doi.org/10.51771/fj.v2i1.200","url":null,"abstract":"Bidara arab (Ziziphus jujuba Mill) merupakan tumbuhan semak atau pohon berduri yang digunakan sebagai obat tradisional. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri EEDBA (Ziziphus jujuba Mill) terhadap bakteri S. aureus dan S.epidermidis. Pembuatan EEDBA dilakukan dengan cara perkolasi menggunakan etanol 96%. Pengujian aktivitas antibakteri dilakukan dengan cara difusi menggunakan kertas cakram (Uji Kirby-Bauer). Hasil penelitian EEDBA sebagai antibakteri berdasarkan parameter luas zona hambat terhadap bakteri S. aureus dengan konsentrasi 2% rata-rata yaitu 11,2 mm, 3% yaitu 12,2 mm, 4% yaitu 13,4 mm, 5% yaitu 16,0 mm. Sedangkan bakteri S.epidermidis pada konsentrasi 2 % rata-rata yaitu 12,0 mm, 3% yaitu 14,6 mm, 4% yaitu 15,8 mm, 5% yaitu 16,6 mm serta diameter kontrol positif keduanya rata-rata yaitu 27,2 mm. Berdasarkan analisis statistik pada anova menunjukkan EEDBA (Ziziphus jujuba Mill) bisa menghambat pertumbuhan bakteri S. aureus dan S.epidermidis dengan sangat nyata (Fh>Ft;α=0,05).","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73720744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kesehatan merupakan aspek penting yang dapat mempengaruhi kehidupan setiap orang. Salah satu cara yang efektif untuk menjaga kesehatan tubuh adalah menjaga kebersihan yaitu kebersihan tangan. Tangan merupakan salah satu jalur penularan berbagai penyakit menular seperti penyakit gangguan usus dan pencernaan seperti (diare dan muntah) dan berbagai penyakit lainnya. Salah satu cara yang praktis dalam pencegahan penyakit dapat dilakukan dengan menggunakan hand sanitizer sebagai pengganti cuci tangan. Metode dalam penelitian ini menggunakan eksperimental. Penelitian ini meliputi, pembuatan orientasi basis gel, menformulasikan ekstrak etanol daun sirih hijau 5%, 10%, 15%, dan 20% dalam sediaan gel hand sanitizer, uji evaluasi sediaan meliputi organoleptis, homogenitas, pH, daya sebar, uji stabilitas, dan iritasi pada kulit. Hasil penelitian menunjukkan esktrak etanol daun sirih hijau (Piper betle Linn.) dapat diformulasikan dalam bentuk sediaan gel hand sanitizer dan stabil baik fisik sediaan, homogenitas, pH, daya sebar sediaan serta tidak menimbulkan iritasi kulit. Uji organoleptik pada sediaan diperoleh pada semua F0 memiliki warna putih sedangkan pada formula 1 sampai 4 memiliki warna kuning kehijauan, pada uji homogenitas diperoleh hasil homogen untuk semua formula, pada uji pH diperoleh nilai pH berkisar antara 4-5, pada uji daya sebardiperoleh hasil pada F0 (Blanko) yaitu 6 cm, pada F1 (5%) yaitu 6,5 cm, pada F3 (15%) yaitu 6,5 cm dan pada F4 (20%) yaitu 5,5 cm, untuk uji stabilitas yaitu stabil, untuk uji iritasi yaitu tidak menyebabkan iritasi pada kulit.
{"title":"FORMULASI EKSTRAK ETANOL DAUN SIRIH HIJAU (Piper betle Linn.) Sebagai Gel Hand Sanitizer","authors":"Zulfikri Zulfikri, Cici Dianti","doi":"10.51771/fj.v2i1.209","DOIUrl":"https://doi.org/10.51771/fj.v2i1.209","url":null,"abstract":"Kesehatan merupakan aspek penting yang dapat mempengaruhi kehidupan setiap orang. Salah satu cara yang efektif untuk menjaga kesehatan tubuh adalah menjaga kebersihan yaitu kebersihan tangan. Tangan merupakan salah satu jalur penularan berbagai penyakit menular seperti penyakit gangguan usus dan pencernaan seperti (diare dan muntah) dan berbagai penyakit lainnya. Salah satu cara yang praktis dalam pencegahan penyakit dapat dilakukan dengan menggunakan hand sanitizer sebagai pengganti cuci tangan. Metode dalam penelitian ini menggunakan eksperimental. Penelitian ini meliputi, pembuatan orientasi basis gel, menformulasikan ekstrak etanol daun sirih hijau 5%, 10%, 15%, dan 20% dalam sediaan gel hand sanitizer, uji evaluasi sediaan meliputi organoleptis, homogenitas, pH, daya sebar, uji stabilitas, dan iritasi pada kulit. Hasil penelitian menunjukkan esktrak etanol daun sirih hijau (Piper betle Linn.) dapat diformulasikan dalam bentuk sediaan gel hand sanitizer dan stabil baik fisik sediaan, homogenitas, pH, daya sebar sediaan serta tidak menimbulkan iritasi kulit. Uji organoleptik pada sediaan diperoleh pada semua F0 memiliki warna putih sedangkan pada formula 1 sampai 4 memiliki warna kuning kehijauan, pada uji homogenitas diperoleh hasil homogen untuk semua formula, pada uji pH diperoleh nilai pH berkisar antara 4-5, pada uji daya sebardiperoleh hasil pada F0 (Blanko) yaitu 6 cm, pada F1 (5%) yaitu 6,5 cm, pada F3 (15%) yaitu 6,5 cm dan pada F4 (20%) yaitu 5,5 cm, untuk uji stabilitas yaitu stabil, untuk uji iritasi yaitu tidak menyebabkan iritasi pada kulit.","PeriodicalId":12464,"journal":{"name":"FORTE JOURNAL","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74379443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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