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Refining the Interpretation of Cognitive Domain-Specific Neuropsychiatric Symptoms in Alzheimer's Disease 细化阿尔茨海默病认知领域特异性神经精神症状的解释。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-06 DOI: 10.1111/ggi.70392
Siru Wang, Hao Liu
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引用次数: 0
Association of Physical Frailty With Serum Growth Differentiation Factor-15 and Cognitive Decline: A Cross-Sectional Study 体质虚弱与血清生长分化因子-15和认知能力下降的关系:一项横断面研究。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1111/ggi.70377
Kazuhiro Yoshiura, Yosuke Osuka, Kaori Kinoshita, Noriko Hori, Jiaqi Li, Georg von Fingerhut, Tohru Hosoyama, Daichi Shigemizu, Marie Takemura, Yasumoto Matsui, Shosuke Satake

Aim

Growth differentiation factor-15 (GDF-15) is a biomarker reflecting aging and cellular stress, associated with physical frailty and cognitive decline. We cross-sectionally examined whether physical frailty is involved in the association between GDF-15 and cognitive decline. Understanding this association may help to consider frailty-related cognitive decline and potential preventive approaches.

Methods

This cross-sectional study included 134 participants aged 65 years or older, excluding those with severe renal dysfunction, immune-related diseases, and those with dementia or suspected dementia (Mini-Mental State Examination [MMSE] score ≤ 23). Serum GDF-15 levels were measured, and cognitive decline was assessed using the MMSE with a cutoff score of 27 or lower. Physical frailty was evaluated using the revised Japanese Cardiovascular Health Study criteria comprising five components: shrinking, exhaustion, weakness, slowness, and low activity.

Results

A mediation analysis adjusted for age, sex, and education showed a significant indirect effect of GDF-15 on cognitive decline through physical frailty (β = 0.921, 95% confidence interval [CI]: 0.279–1.560). The total effect was also significant (β = 1.020, 95% CI: 0.030–2.010), whereas the direct effect was not significant (β = 0.100, 95% CI: −0.991 to 1.190).

Conclusions

This study suggests a potential involvement of physical frailty in the relationship between serum GDF-15 levels and cognitive decline. Serum GDF-15 levels may have potential as a clinical indicator for frailty-related cognitive decline in the future. Further longitudinal studies are needed to explore this relationship and clarify the role of GDF-15.

目的:生长分化因子-15 (Growth differentiation factor-15, GDF-15)是反映衰老和细胞应激的生物标志物,与身体虚弱和认知能力下降有关。我们横断面研究了身体虚弱是否与GDF-15和认知能力下降之间的关系有关。了解这种关联可能有助于考虑与虚弱相关的认知能力下降和潜在的预防方法。方法:本横断面研究纳入了134名年龄在65岁及以上的参与者,排除了严重肾功能不全、免疫相关疾病、痴呆或疑似痴呆(MMSE评分≤23)的患者。测量血清GDF-15水平,并使用MMSE评估认知能力下降,临界值为27或更低。使用修订后的日本心血管健康研究标准对身体虚弱进行评估,该标准包括五个组成部分:萎缩、疲惫、虚弱、行动迟缓和低活动量。结果:经年龄、性别和受教育程度调整的中介分析显示,GDF-15通过身体虚弱对认知能力下降有显著的间接影响(β = 0.921, 95%可信区间[CI]: 0.279-1.560)。总效应也显著(β = 1.020, 95% CI: 0.030 ~ 2.010),而直接效应不显著(β = 0.100, 95% CI: -0.991 ~ 1.190)。结论:本研究表明,血清GDF-15水平与认知能力下降之间的关系可能与身体虚弱有关。血清GDF-15水平可能有潜力作为未来虚弱相关认知能力下降的临床指标。需要进一步的纵向研究来探索这种关系并阐明GDF-15的作用。
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引用次数: 0
Domain-Specific Physical Activity and Its Association With Frailty Syndrome: Evidence From NHANES Using Phenotype and Index-Based Models 领域特异性体力活动及其与虚弱综合征的关联:来自NHANES的证据,使用表型和基于指数的模型。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-04 DOI: 10.1111/ggi.70384
Fujue Ji, Jiao Liu, Jiaxuan Chen, Hyeonseung Rheem, Haesung Lee, Jong-Hee Kim

Background

Frailty syndrome is a common age-related condition associated with increased risks of disability, hospitalization, and mortality. Although physical activity (PA) is a modifiable lifestyle factor, limited research has explored how specific PA domains relate to frailty using validated multidimensional models. This study aimed to examine the associations between 4 PA domains—total PA, occupational PA (OPA), transport-related PA (TPA), and leisure-time PA (LTPA)—and frailty syndrome, as assessed by both the frailty phenotype (FP) and frailty index (FI) models in a nationally representative U.S. sample.

Methods

We analyzed data from 59 842 adults who participated in 6 cycles of the National Health and Nutrition Examination Survey (NHANES, 2007–2018). PA levels were self-reported and categorized by weekly duration based on guideline adherence (≥ 150 min/week) and distribution quartiles. Frailty was independently assessed using FP and FI models. Multivariable linear regression, subgroup, sensitivity analysis, and dose–response analyses were conducted.

Results

Higher levels of total PA and LTPA were consistently associated with lower frailty scores in both FP and FI models. The strongest inverse associations were observed for LTPA ≥ 300 min/week. In contrast, OPA and TPA showed limited or no associations after adjustment for confounders. Subgroup and sensitivity analyses supported these findings, with particularly pronounced effects among older adults (≥ 80 years) and women.

Conclusion

LTPA demonstrated the strongest associations with lower frailty, highlighting its potential as a key target for preventive strategies and public health guidelines aimed at promoting healthy aging.

背景:虚弱综合征是一种常见的与年龄相关的疾病,与残疾、住院和死亡风险增加有关。虽然身体活动(PA)是一个可改变的生活方式因素,但有限的研究已经探索了特定的PA结构域如何使用经过验证的多维模型与脆弱性相关。本研究旨在通过脆弱表型(FP)和脆弱指数(FI)模型评估具有全国代表性的美国4个PA领域(总PA、职业PA (OPA)、运输相关PA (TPA)和休闲时间PA (LTPA))与虚弱综合征之间的关系。方法:我们分析了参加6个周期国家健康与营养检查调查(NHANES, 2007-2018)的59842名成年人的数据。PA水平是自我报告的,并根据每周持续时间(≥150分钟/周)和分布四分位数进行分类。使用FP和FI模型独立评估虚弱程度。进行多变量线性回归、亚组分析、敏感性分析和剂量-反应分析。结果:在FP和FI模型中,较高水平的总PA和LTPA始终与较低的虚弱评分相关。当LTPA≥300分钟/周时,观察到最强的负相关。相比之下,调整混杂因素后,OPA和TPA显示有限或没有关联。亚组分析和敏感性分析支持这些发现,在老年人(≥80岁)和女性中效果尤其显著。结论:LTPA显示出与较低的脆弱性最强的关联,突出了其作为旨在促进健康老龄化的预防策略和公共卫生指南的关键目标的潜力。
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引用次数: 0
Beyond Prescriptions: Addressing Stagnation in Benzodiazepine Reduction in Acute Care Geriatric Wards in Japan 超越处方:解决在日本急性护理老年病房苯二氮卓类药物减少停滞。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-03 DOI: 10.1111/ggi.70393
Takahiko Nagamine
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引用次数: 0
Letter to the Editor: Anesthesia Selection and Postoperative Outcomes in the Elderly 致编辑的信:老年人麻醉的选择和术后结果。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1111/ggi.70382
Ali İhsan Uysal
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引用次数: 0
Comment on: “Effects of Electronic Sports on Community-Dwelling Older Adults With Mild Cognitive Impairment: A Randomized Controlled Study” 评论:“电子运动对社区居住老年人轻度认知障碍的影响:一项随机对照研究”。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1111/ggi.70391
Qian Wang, Yiheng Yao, Liang Liu
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引用次数: 0
Arterial Thromboembolism in Elderly Patients With Advanced Lung Cancer 老年晚期肺癌患者动脉血栓栓塞。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1111/ggi.70389
Chieh-Kuo Lin, Chao-Chun Huang, Yi-Ching Chu
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引用次数: 0
Muscle Quality Matters More Than Quantity in Hip Fracture Recovery 髋部骨折恢复中肌肉质量比数量更重要。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1111/ggi.70388
Po-Chin Strong, Chao-Chun Huang

Unno et al. [1] recently highlighted the importance of preoperative intramuscular adipose tissue content (IMAC) in early functional recovery after hip fracture.

In daily rehabilitation practice, we frequently encounter patients who demonstrate preserved systemic stability—adequate nutritional indices and stable vital parameters—yet remain unable to initiate effective gait despite intensive therapy. The findings by Unno et al. provide a compelling physiological explanation for this clinical discrepancy: a dissociation between “systemic metabolic reserve” (reflected by PhA) [2] and “locomotor mechanical integrity” (reflected by IMAC) [1].

The authors' observation that IMAC independently predicts walking recovery, while PhA does not, raises a critical question regarding our current therapeutic strategies: Are conventional resistance-based rehabilitation paradigms sufficient for patients with high IMAC? [3] The presence of myosteatosis implies a qualitative deficit in motor unit recruitment and force transmission. Consequently, we propose that patients identified with high preoperative IMAC might require distinct interventions, such as targeted neuromuscular re-education or high-velocity power training, rather than standard strengthening protocols alone.

Finally, while the authors acknowledge the 2-week follow-up limitation, this early period is often just the beginning of the functional journey. In models like Taiwan's nationwide Post-Acute Care (PAC) program, patients undergo high-intensity rehabilitation for several weeks to months [4]. Whether IMAC retains its strong predictive value for ambulatory recovery during such prolonged, high-intensity rehabilitation remains an important and clinically actionable question that warrants further investigation.

The authors have nothing to report.

The authors have nothing to report.

The authors have nothing to report.

The authors have nothing to report.

The authors declare no conflicts of interest.

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Unno等人最近强调了术前肌内脂肪组织含量(IMAC)在髋部骨折后早期功能恢复中的重要性。在日常康复实践中,我们经常遇到这样的患者,他们表现出保持了系统的稳定性——足够的营养指标和稳定的生命参数——尽管进行了强化治疗,但仍然无法开始有效的步态。Unno等人的研究结果为这种临床差异提供了令人信服的生理学解释:“全身代谢储备”(由PhA反映)[2]与“运动机械完整性”(由IMAC反映)[1]之间的分离。作者观察到IMAC独立预测行走恢复,而PhA不能,这提出了一个关于我们当前治疗策略的关键问题:传统的基于耐药性的康复模式是否足以治疗高IMAC患者?[3]肌骨化症的存在意味着运动单位招募和力量传递的质量缺陷。因此,我们建议术前IMAC较高的患者可能需要不同的干预措施,如有针对性的神经肌肉再教育或高速力量训练,而不是单独的标准强化方案。最后,虽然作者承认2周的随访限制,但这一早期阶段通常只是功能旅程的开始。在台湾全国性的急性后护理(PAC)项目等模式中,患者需要接受几周到几个月的高强度康复治疗。在如此长时间、高强度的康复过程中,IMAC是否保持其对动态恢复的强大预测价值,仍然是一个重要的、临床可行的问题,值得进一步研究。作者没有什么可报告的。作者没有什么可报告的。作者没有什么可报告的。作者没有什么可报告的。作者声明无利益冲突。数据共享不适用于本文,因为本研究没有创建或分析新的数据。
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引用次数: 0
Tongue Pressure: A Critical Bridge Between Oral Frailty and Systemic Longevity in Older Adults 舌压:老年人口腔虚弱和全身寿命之间的关键桥梁。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1111/ggi.70383
Takahiko Nagamine

Incorporating tongue pressure as an indicator of oral frailty allows for a comprehensive approach to frailty management in older adults.

将舌压作为口腔虚弱的一个指标,可以为老年人的虚弱管理提供一个全面的方法。
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引用次数: 0
Facility-Level Factors Associated With Aspiration Pneumonia in Japanese Geriatric Health Service Settings: A Nationwide Cross-Sectional Study. 日本老年卫生服务机构与吸入性肺炎相关的设施水平因素:一项全国性的横断面研究。
IF 2.5 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-01 DOI: 10.1111/ggi.70410
Xinze Wu, Tatsuma Okazaki, Jiro Okochi, Satoru Ebihara

Background: Aspiration pneumonia (AP) is a leading cause of morbidity and mortality in older adults. Facility-level determinants of AP in long-term care settings remain poorly understood. In Japan's long-term care insurance system, geriatric health service facilities differ in their staff composition, care processes, and swallowing support systems, which may influence AP incidence.

Methods: We conducted a nationwide, facility-level cross-sectional study using data from the 2024 Survey on Eating and Swallowing Support conducted by the Japan Association of Geriatric Health Service Facilities. Of the 454 respondents, 445 facilities were included. The facilities were categorized as super-enhanced, enhanced, add-on, or basic. Facility characteristics, staffing composition, nutritional and swallowing management practices, and reimbursement-based care add-ons were compared across facility types. Multivariate logistic regression was used to identify the risk factors associated with AP occurrence.

Results: Facility type, staff composition, and care resources varied significantly. The multivariable model revealed that a history of AP (OR = 45.138, 95% CI 16.937-120.292; p < 0.001) and aspiration events (OR = 9.280, 95% CI 4.215-20.116; p < 0.001) were strongly associated with AP. Facilities lacking occupational therapists had a higher risk of AP (OR = 4.875, 95% CI 1.708-13.909; p = 0.003).

Conclusions: Facilities characterized by frequent aspiration events or a history of AP tended to have a higher incidence of AP. The absence of occupational therapists was associated with an increased facility-level risk of AP, suggesting that organizational differences in care management may influence AP in long-term care settings.

背景:吸入性肺炎(AP)是老年人发病和死亡的主要原因。在长期护理环境中,设施层面的AP决定因素仍然知之甚少。在日本的长期护理保险制度中,老年医疗服务机构在人员组成、护理流程和吞咽支持系统方面存在差异,这可能会影响AP的发病率。方法:我们使用日本老年卫生服务机构协会进行的2024年进食和吞咽支持调查的数据进行了一项全国范围内的设施级横断面研究。在454个答复者中,包括445个设施。这些设施被分为超级增强型、增强型、附加型和基本型。设施特点、人员组成、营养和吞咽管理实践以及基于报销的护理附加项目在设施类型之间进行了比较。采用多因素logistic回归来确定与AP发生相关的危险因素。结果:设施类型、人员组成、护理资源差异显著。多变量模型显示AP病史(OR = 45.138, 95% CI 16.937-120.292; p)结论:以频繁误吸事件或AP病史为特征的设施往往具有更高的AP发病率。缺乏职业治疗师与设施级别AP风险增加相关,这表明护理管理的组织差异可能会影响长期护理环境中的AP。
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引用次数: 0
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Geriatrics & Gerontology International
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