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Statement on medication simplification in long-term care facilities by the Japanese Society of Geriatric Pharmacy: English translation of the Japanese article 日本老年药学学会关于长期护理机构药物简化的声明:日语文章的英文翻译。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-12-04 DOI: 10.1111/ggi.15009
Hiroshi Maruoka, Shota Hamada, Eriko Koujiya, Kazumi Higashihara, Hiroshi Shinonaga, Katsuaki Arai, Saiko Saotome, Takashi Okura, Fumihiro Mizokami, Jiro Okochi, Yasushi Takeya, Naomi Kurata, Masahiro Akishita, Japanese Society of Geriatric Pharmacy Working Group on Medication Simplification in Long-term Care Facilities

Many older adults who are certified for long-term care services live or stay in long-term care facilities (LTCFs), where they receive medical and nursing care. These individuals often encounter medication-related problems, such as polypharmacy and complex medication regimens, including frequent administration schedules. Although considerable attention has been paid to polypharmacy in the context of optimizing medication use in older adults, little emphasis has been placed on simplifying these regimens. Recently, the Japanese Society of Geriatric Pharmacy issued statements on medication simplification in LTCFs based on a scoping review of the literature and expert opinions. In these statements, medication simplification is defined as the process of reducing the number of medication administration times, ideally to once during lunchtime. The statements outline principles and processes to achieve medication simplification through interprofessional collaboration, including consolidating and reducing the number of medication administration times a day to minimize the risk of medication errors and ensure medical safety. Medication simplification will play a substantial role in alleviating the burden of medication intake for residents, and in reducing and equalizing the workload of medication administration for staff members throughout the day in LTCFs. These statements suggest that administering medication during lunchtime is beneficial when an adequate number of staff members are available in LTCFs. We hope that these statements will help ensure patient safety, and facilitate successful medication optimization for all medical, nursing and social care professionals working in LTCFs. Geriatr Gerontol Int 2025; 25: 14–24.

许多获得长期护理服务认证的老年人生活或住在长期护理设施中,在那里他们接受医疗和护理。这些人经常遇到与药物有关的问题,如多种药物和复杂的药物治疗方案,包括频繁的给药计划。尽管在优化老年人药物使用的背景下,已经对多种药物治疗给予了相当大的关注,但很少强调简化这些方案。最近,日本老年药学学会在文献综述和专家意见的基础上发表了关于ltcf药物简化的声明。在这些陈述中,药物简化被定义为减少药物管理次数的过程,理想情况下是在午餐时间一次。这些声明概述了通过跨专业协作实现药物简化的原则和程序,包括合并和减少每天的药物管理次数,以尽量减少药物错误的风险并确保医疗安全。简化用药将在减轻居民服药负担方面发挥重要作用,并在减少和平衡长期医疗中心工作人员全天的用药管理工作量方面发挥重要作用。这些陈述表明,如果长期中心有足够数量的工作人员,在午餐时间给药是有益的。我们希望这些声明将有助于确保患者的安全,并促进所有在长期护理中心工作的医疗、护理和社会护理专业人员成功地优化药物。Geriatr Gerontol Int 2024;••: ••-••.
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引用次数: 0
Unraveling the molecular dissociation between aging and atherosclerosis: A bioinformatics approach 揭示衰老和动脉粥样硬化之间的分子分离:生物信息学方法。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-12-04 DOI: 10.1111/ggi.15024
Takahiro Kamihara, Tomoyasu Kinoshita, Reo Kawano, Seiya Tanaka, Takuya Omura, Ken Tanaka, Akihiro Hirashiki, Manabu Kokubo, Hidenori Arai, Atsuya Shimizu

Aim

In clinical practice, cardiologists frequently note substantial differences in coronary artery health among patients of the same age bracket. This observation led to our investigation into identifying genes that are shared between atherosclerosis and aging, as well as those that are specifically amplified in atherosclerosis alone.

Methods

Our study leveraged existing gene expression datasets from the Gene Expression Omnibus (GEO), avoiding the need for new experimental research involving human or animal subjects. We focused on analyzing two specific datasets: one comprising artery samples from individuals with and without atherosclerosis, and the other featuring samples from people in middle age versus those in older age groups. To identify significant genes, we applied a technique known as the weighted average difference (WAD).

Results

Our analysis identified 14 genes that were upregulated in both aging and atherosclerosis, hinting at the involvement of the type I interferon response in both conditions. Conversely, 408 genes that exhibited heightened activity within atherosclerotic lesions indicated an augmentation in lysosome-related processes. While aging might create a groundwork that predisposes individuals to atherosclerosis, the progression of atherosclerosis also involves distinct factors such as type I interferon response and an increase in lysosomal activity.

Conclusions

Aging encompasses more than just the senescence of vascular cells; it is significantly affected by extracellular factors such as type I interferon. The onset of atherosclerosis, therefore, cannot be attributed solely to aging. Instead, it likely involves enhanced mechanisms such as phagocytosis and heighted lysosomal activity. Geriatr Gerontol Int 2025; 25: 108–115.

目的:在临床实践中,心脏病专家经常注意到同一年龄段患者冠状动脉健康状况的实质性差异。这一观察结果导致我们对动脉粥样硬化和衰老之间共有的基因以及在动脉粥样硬化中特异性扩增的基因进行了研究。方法:我们的研究利用基因表达Omnibus (GEO)现有的基因表达数据集,避免了涉及人类或动物受试者的新实验研究的需要。我们重点分析了两个特定的数据集:一个包括有动脉粥样硬化和没有动脉粥样硬化的个体的动脉样本,另一个包括中年人群和老年人群的样本。为了识别重要基因,我们采用了加权平均差(WAD)技术。结果:我们的分析确定了14个基因在衰老和动脉粥样硬化中均上调,暗示在这两种情况下都参与了I型干扰素反应。相反,在动脉粥样硬化病变中表现出高活性的408个基因表明溶酶体相关过程的增强。虽然衰老可能为个体易患动脉粥样硬化奠定了基础,但动脉粥样硬化的进展也涉及不同的因素,如I型干扰素反应和溶酶体活性的增加。结论:衰老不仅仅包括血管细胞的衰老;它受到细胞外因子如I型干扰素的显著影响。因此,动脉粥样硬化的发生不能仅仅归因于衰老。相反,它可能涉及增强的机制,如吞噬作用和高溶酶体活性。Geriatr Gerontol Int 2024;••: ••-••.
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引用次数: 0
Limited impact of weekend admissions on hip fracture outcomes in elderly patients: A study from a Japanese nationwide medical claims database 周末入院对老年患者髋部骨折结局影响有限:一项来自日本全国医疗索赔数据库的研究。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-12-04 DOI: 10.1111/ggi.15041
Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

Aim

The effectiveness of early surgery in preventing complications in elderly Japanese hip fracture patients and the impact of weekend hospitalization need further investigation. The purpose of this study was to determine whether weekend hospitalization affects the incidence of various sequelae and death during hospitalization in elderly hip fracture patients using a comprehensive Japanese hip fracture case database.

Methods

We retrospectively analyzed the Japanese National Administrative DPC (Diagnosis Procedure Combination) database from April 2016 to March 2022. During this period, approximately 1100 DPC-affiliated hospitals consistently provided medical records with consent for the study. The study focused on weekend hospitalizations and investigated the associations with postoperative pneumonia, pulmonary embolism, myocardial infarction, urinary tract infection, acute renal dysfunction, dementia, and in-hospital mortality after propensity score matching. Owing to the large population size of the study, significance levels were strictly enforced, and a P-value < 0.001 was considered statistically significant.

Results

After performing propensity score matching based on age, sex, and comorbidities, 111 035 patient pairs were identified, comparing those admitted on weekends versus weekdays. The analysis showed no heightened risk of sequelae for those admitted during the weekend compared with weekdays. Additionally, there was a slight trend toward higher mortality risk during weekend hospital stays; however, the increase was insignificant, with a hazard ratio of 1.071 (95% confidence interval: 1.005–1.140, P = 0.03).

Conclusion

The results of this study indicate that weekend hospitalization for elderly patients with hip fractures is not definitively associated with an increase in various sequelae or in-hospital mortality and that the importance of early surgery for elderly patients with hip fractures may be recognized and promoted in Japan. Geriatr Gerontol Int 2025; 25: 75–81.

目的:日本老年髋部骨折患者早期手术预防并发症的效果及周末住院治疗的影响有待进一步探讨。本研究的目的是利用日本髋部骨折病例综合数据库,确定周末住院是否影响老年髋部骨折患者住院期间各种后遗症和死亡的发生率。方法:回顾性分析2016年4月至2022年3月日本国家行政DPC(诊断程序组合)数据库。在此期间,约有1100家dpc附属医院在同意的情况下一直为研究提供医疗记录。该研究的重点是周末住院治疗,并调查了倾向评分匹配后与术后肺炎、肺栓塞、心肌梗死、尿路感染、急性肾功能障碍、痴呆和住院死亡率的关系。由于该研究的人口规模较大,因此严格执行显著性水平,p值结果:在基于年龄、性别和合并症进行倾向评分匹配后,确定了111,035对患者,并将周末和工作日入院的患者进行了比较。分析显示,与平日相比,周末入院的患者的后遗症风险并没有增加。此外,周末住院期间的死亡风险略有上升趋势;然而,增加不显著,风险比为1.071(95%置信区间:1.005-1.140,P = 0.03)。结论:本研究结果表明,老年髋部骨折患者的周末住院治疗与各种后遗症或住院死亡率的增加并没有明确的联系,日本可以认识和推广老年髋部骨折患者早期手术的重要性。Geriatr Gerontol Int 2024;••: ••-••.
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引用次数: 0
Shorter duration until death is associated with lower hope among patients receiving home medical care: A cohort study 在接受家庭医疗护理的患者中,离死亡时间较短与希望较低有关:一项队列研究。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-12-01 DOI: 10.1111/ggi.15029
Yukio Tsugihashi, Masakazu Yasunaka, Shinu Hayashi, Hidekazu Iida, Yutaka Shirahige, Noriaki Kurita, The ZEVIOUS group
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引用次数: 0
Prolonged subcutaneous swelling after head trauma: A rare but serious case of angiosarcoma of the scalp that should be known by dermatologists as well as by elderly-healthcare professionals 头部外伤后的长期皮下肿胀:这是一个罕见但严重的头皮血管肉瘤病例,皮肤科医生和老年保健专业人员都应了解。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-27 DOI: 10.1111/ggi.15038
Emika Murasawa, Mai Noto, Takahiro Otani, Michihiro Kono, Naoko Mori
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引用次数: 0
Comment on: Association of oral hypofunction with aspiration pneumonia, fractures and mortality in older Japanese adults 评论日本老年人口腔功能低下与吸入性肺炎、骨折和死亡率的关系。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-26 DOI: 10.1111/ggi.15028
Merve Yilmaz Kars, Muhammet Orhan Tuncez, Mustafa Hakan Dogan, Ilyas Akkar, Zeynep Iclal Turgut, Orhan Cicek, Muhammet Cemal Kizilarslanoglu
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引用次数: 0
Is oral frailty a cause or a consequence? 口腔虚弱是原因还是结果?
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-26 DOI: 10.1111/ggi.15023
Ryota Sakurai, Hiroyuki Suzuki
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引用次数: 0
Chronic low back pain and decreased physical activity are associated with social frailty incidence among community-dwelling older adults 在社区居住的老年人中,慢性腰背痛和体力活动减少与社会脆弱性发生率有关。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-25 DOI: 10.1111/ggi.15021
Soichiro Matsuda, Takehiko Doi, Osamu Katayama, Fumio Sakimoto, Keitaro Makino, Motoki Sudo, Yukari Yamashiro, Naoto Takayanagi, Hiroyuki Shimada

Aim

Nearly half of older adults with frailty experience chronic pain. Chronic pain contributes to activity restrictions. Decreased physical activity with chronic pain is associated not only with physical dysfunction but also with reduced engagement in social activities. We aimed to verify the hypothesis that chronic pain and decreased physical activity are associated with social frailty incidence.

Methods

The study included 1198 community-dwelling older adults (aged 70.2 ± 6.3 years) without social frailty at baseline. Chronic pain, physical activity and basic information were assessed at baseline. The participants were divided into two groups based on the presence (yes, n = 167) or absence (no, n = 1031) of chronic low back pain. The incidence of social frailty was investigated during the follow-up examination after 2.5 years.

Results

Binomial logistic regression analysis showed that older adults with chronic low back pain and low step counts had a higher odds ratio for the development of incident social frailty than older adults without chronic low back pain and high step counts (odds ratio 1.89, 95% confidence interval 1.03–3.46).

Conclusion

Our results suggest that a combination of chronic low back pain and low step counts is associated with the incidence of social frailty. Further research is required to establish intervention methods for pain and decreased physical activity to prevent social frailty. Geriatr Gerontol Int 2025; 25: 25–30.

目的:近一半的体弱老年人会有慢性疼痛。慢性疼痛会导致活动受限。慢性疼痛导致的体力活动减少不仅与身体功能障碍有关,还与社交活动减少有关。我们旨在验证慢性疼痛和体力活动减少与社会虚弱发生率相关的假设:研究纳入了 1198 名社区居住的老年人(年龄为 70.2 ± 6.3 岁),他们在基线时均无社交虚弱。基线时对慢性疼痛、体力活动和基本信息进行了评估。根据有无慢性腰背痛(有,167 人;无,1031 人)将参与者分为两组。在 2.5 年后的随访检查中,对社会脆弱性的发生率进行了调查:二项式逻辑回归分析表明,与无慢性腰背痛且步数较多的老年人相比,患有慢性腰背痛且步数较少的老年人发生社会脆弱性的几率更高(几率比1.89,95%置信区间1.03-3.46):我们的研究结果表明,慢性腰背痛和低步数与社会脆弱性的发生率有关。我们需要进一步研究,以确定针对疼痛和体力活动减少的干预方法,从而预防社会性虚弱。Geriatr Gerontol Int 2024; --:-----.
{"title":"Chronic low back pain and decreased physical activity are associated with social frailty incidence among community-dwelling older adults","authors":"Soichiro Matsuda,&nbsp;Takehiko Doi,&nbsp;Osamu Katayama,&nbsp;Fumio Sakimoto,&nbsp;Keitaro Makino,&nbsp;Motoki Sudo,&nbsp;Yukari Yamashiro,&nbsp;Naoto Takayanagi,&nbsp;Hiroyuki Shimada","doi":"10.1111/ggi.15021","DOIUrl":"10.1111/ggi.15021","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Nearly half of older adults with frailty experience chronic pain. Chronic pain contributes to activity restrictions. Decreased physical activity with chronic pain is associated not only with physical dysfunction but also with reduced engagement in social activities. We aimed to verify the hypothesis that chronic pain and decreased physical activity are associated with social frailty incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 1198 community-dwelling older adults (aged 70.2 ± 6.3 years) without social frailty at baseline. Chronic pain, physical activity and basic information were assessed at baseline. The participants were divided into two groups based on the presence (yes, <i>n</i> = 167) or absence (no, <i>n</i> = 1031) of chronic low back pain. The incidence of social frailty was investigated during the follow-up examination after 2.5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Binomial logistic regression analysis showed that older adults with chronic low back pain and low step counts had a higher odds ratio for the development of incident social frailty than older adults without chronic low back pain and high step counts (odds ratio 1.89, 95% confidence interval 1.03–3.46).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results suggest that a combination of chronic low back pain and low step counts is associated with the incidence of social frailty. Further research is required to establish intervention methods for pain and decreased physical activity to prevent social frailty. <b>Geriatr Gerontol Int 2025; 25: 25–30</b>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"25 1","pages":"25-30"},"PeriodicalIF":2.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible negative impact of polypharmacy on surgical outcomes in older patients with lumbar spinal stenosis 多种药物对老年腰椎管狭窄症患者手术效果的可能负面影响。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-25 DOI: 10.1111/ggi.15026
Soya Kawabata, Takehiro Michikawa, Sota Nagai, Yuki Akaike, Takaya Imai, Kei Ito, Hiroki Takeda, Daiki Ikeda, Shinjiro Kaneko, Nobuyuki Fujita

Aim

Older patients with lumbar spinal stenosis (LSS) have a higher incidence of polypharmacy attributed to comorbidities and the use of pain relief medications. This study aimed to explore the effect of polypharmacy and hyperpolypharmacy on surgical outcomes in older patients with LSS based on health-related quality of life (HRQOL) and locomotive syndrome.

Methods

Consecutive patients aged ≥65 years who underwent lumbar spinal surgery for LSS were retrospectively reviewed. We assessed the preoperative and 1- and 2-year postoperative scores of three common HRQOL tools and the 25-question Geriatric Locomotive Function Scale. The patients were classified into the hyperpolypharmacy group (those taking ≥10 medications), polypharmacy group (those taking 6–9 medications) and non-polypharmacy group (those taking ≤5 medications).

Results

In total, 148 participants were evaluated. Among them, 35 were included in the non-polypharmacy group. There were no significant changes in the HRQOL and locomotive syndrome stage at baseline, even with polypharmacy progression. However, the HRQOL and locomotive syndrome stage worsened postoperatively with polypharmacy progression. When surgical efficacy was directly examined, results showed that the surgical outcomes were significantly associated with polypharmacy progression in older patients with LSS, even after adjusting for potential confounders.

Conclusions

Polypharmacy, especially hyperpolypharmacy, had a negative impact on surgical outcomes in older patients with LSS. The number of prescription drugs should be taken into consideration before surgery in this patient group. Geriatr Gerontol Int 2025; 25: 31–37.

目的:老年腰椎管狭窄症(LSS)患者由于合并症和使用止痛药物,多药治疗的发生率较高。本研究旨在根据健康相关生活质量(HRQOL)和运动综合征,探讨多药和过度多药对老年腰椎管狭窄症患者手术效果的影响:我们对年龄≥65 岁、因 LSS 而接受腰椎手术的患者进行了回顾性研究。我们评估了三种常见 HRQOL 工具和 25 个问题的老年运动功能量表的术前评分、术后 1 年和 2 年评分。患者被分为多药组(服用药物≥10种)、多药组(服用药物6-9种)和非多药组(服用药物≤5种):共有 148 名参与者接受了评估。结果:共对 148 名参与者进行了评估,其中 35 人被纳入非多药组。基线时的 HRQOL 和运动综合征阶段没有明显变化,即使是在多药治疗进展时也是如此。然而,术后随着多药治疗的进展,患者的 HRQOL 和运动综合征阶段会恶化。在直接检查手术疗效时,结果显示,即使在调整了潜在的混杂因素后,老年 LSS 患者的手术疗效仍与多重药物治疗进展有显著相关:结论:多药治疗,尤其是过度多药治疗,对老年 LSS 患者的手术效果有负面影响。在对这一患者群体进行手术前,应考虑处方药的数量。Geriatr Gerontol Int 2024; --:-----.
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引用次数: 0
Frailty as a predictor of mortality in the oldest old: A systematic review and meta-analysis 作为高龄老人死亡率预测因素的虚弱:系统回顾和荟萃分析。
IF 2.4 4区 医学 Q3 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-24 DOI: 10.1111/ggi.15025
Justina Angel Tan, Jin Hean Koh, Reshma Aziz Merchant, Li Feng Tan

Aim

Frailty is highly prevalent in old age and is associated with a high risk of mortality. Few studies have evaluated frailty as a predictor of mortality in the oldest old. This systematic review and meta-analysis aims to determine the mortality risk associated with frailty in this age group.

Methods

An electronic systemic literature search was performed in May 2023 on three databases (Medline/PubMed, Embase, and Cochrane Library) for studies investigating the risk of mortality with frailty. A meta-analysis was done to calculate pooled mortality estimates.

Results

Frail participants had significantly lower overall survival (OS) compared with non-frail participants (hazard ratio [HR]: 1.81; 95% confidence interval [CI]: 1.32 to 2.50; P < 0.01, I2 = 100%; risk ratio [RR]: 4.15; 95% CI: 2.50 to 6.88; P < 0.01, I2 = 97%). Among participants aged 90 and above, a higher percentage of male participants was associated with poorer OS in frail participants. While the pooled association of frailty with OS remained significant across studies in participants aged less than 90 years old (HR: 2.09; 95% CI: 1.55 to 2.82; I2 = 75%), frailty was not significantly associated with OS in studies for participants aged 90 and above. The pooled association of frailty with OS was only significant for the Fried Frailty Phenotype (HR: 2.73; 95% CI: 1.05 to 7.12; I2 = 93%) and not for the Frailty Index. The pooled association also remained significant among studies that adjusted for age (HR: 1.74; 95% CI: 1.50 to 2.02; I2 = 0%) and sex (HR: 1.77; 95% CI: 1.48 to 2.11; I2 = 94%) as a covariate.

Conclusions

Frailty was significantly associated with a poorer OS in participants below the age of 90. This association was not statistically significant in those older than 90 years, with sex-differentiated effects observed. Geriatr Gerontol Int 2025; 25: 102–107.

目的:虚弱是老年人的高发病,与高死亡风险相关。很少有研究将虚弱作为预测高龄老人死亡率的指标进行评估。本系统综述和荟萃分析旨在确定该年龄组与虚弱相关的死亡率风险:方法:2023 年 5 月,我们在三个数据库(Medline/PubMed、Embase 和 Cochrane Library)中进行了电子系统文献检索,以查找与虚弱相关的死亡风险研究。通过荟萃分析,计算出了汇总的死亡率估计值:结果:与非虚弱参与者相比,虚弱参与者的总生存率(OS)明显较低(危险比 [HR]:1.81;95% 置信区间 [CI]:1.32 至 2.50;P 2 = 100%;风险比 [RR]:4.15;95% 置信区间:2.50 至 6.88;P 2 = 97%)。在90岁及以上的参与者中,男性参与者比例越高,体弱参与者的OS越差。虽然在90岁以下的参与者中,虚弱与OS的总体相关性在各项研究中仍具有显著性(HR:2.09;95% CI:1.55至2.82;I2 = 75%),但在90岁及以上的参与者中,虚弱与OS的相关性并不显著。只有弗里德虚弱表型(HR:2.73;95% CI:1.05 至 7.12;I2 = 93%)和虚弱指数(Frailty Index)的汇总结果显示,虚弱与 OS 的关系显著。在对年龄(HR:1.74;95% CI:1.50 至 2.02;I2 = 0%)和性别(HR:1.77;95% CI:1.48 至 2.11;I2 = 94%)作为协变量进行调整的研究中,汇总的关联性仍然显著:在90岁以下的参与者中,体弱与较差的OS明显相关。结论:在90岁以下的参与者中,虚弱与较差的OS有明显相关性,而在90岁以上的参与者中,这种相关性在统计学上并不显著,而且观察到了性别差异效应。Geriatr Gerontol Int 2024; --:-----.
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引用次数: 0
期刊
Geriatrics & Gerontology International
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