Social determinants of health (SDoH) are often associated with frailty outcomes, yet the potential role of biological aging (BA) in this relationship remains unclear. This study quantified BA-mediated (PhenoAge, Klemera–Doubal method biological age [KDM-Age]) pathways linking SDoH to frailty and assessed the predictive performance of the biological aging models for risk stratification.
Materials and Methods
Data from 10 763 participants in the National Health and Nutrition Examination Survey (NHANES) were analyzed. A composite SDoH score (0–8) was constructed across eight socioeconomic domains. Associations were evaluated via multivariable logistic regression, restricted cubic splines (RCS), and mediation analyses. XGBoost was trained to assess predictive performance and feature contributions. Results: Each unit increase in SDoH score elevated frailty odds by 30%, with PhenoAge and KDM-Age mediating 1.19% and 1.25% of the association, respectively. High SDoH (> 6) synergized with accelerated BA to amplify frailty risk (RERI > 1). Age stratification showed null effects in adults > 75 years, supporting gerontological transition theories.
{"title":"Social Determinants of Health, Biological Aging, and Their Impact on Frailty Risk: Mediation and Interaction Effects Analysis","authors":"Zhaoqi Yan, Yifeng Xu, Xiufan Du","doi":"10.1111/ggi.70331","DOIUrl":"10.1111/ggi.70331","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Social determinants of health (SDoH) are often associated with frailty outcomes, yet the potential role of biological aging (BA) in this relationship remains unclear. This study quantified BA-mediated (PhenoAge, Klemera–Doubal method biological age [KDM-Age]) pathways linking SDoH to frailty and assessed the predictive performance of the biological aging models for risk stratification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Data from 10 763 participants in the National Health and Nutrition Examination Survey (NHANES) were analyzed. A composite SDoH score (0–8) was constructed across eight socioeconomic domains. Associations were evaluated via multivariable logistic regression, restricted cubic splines (RCS), and mediation analyses. XGBoost was trained to assess predictive performance and feature contributions. Results: Each unit increase in SDoH score elevated frailty odds by 30%, with PhenoAge and KDM-Age mediating 1.19% and 1.25% of the association, respectively. High SDoH (> 6) synergized with accelerated BA to amplify frailty risk (RERI > 1). Age stratification showed null effects in adults > 75 years, supporting gerontological transition theories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SDoH adversity accelerates biological aging, synergistically amplifying frailty risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"HQ8: Do Nutritional Interventions Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty","authors":"Ken Sugimoto, Hidetaka Wakabayashi, Junko Ueshima, Fumihiko Nagano, Tatsuro Inoue, Keisuke Maeda, Koichi Yamamoto, Hiromi Rakugi, Masahiro Akishita, Hidenori Arai","doi":"10.1111/ggi.70299","DOIUrl":"10.1111/ggi.70299","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ya Qin, Xiao Liang, Xia Sun, Shuai Yan, Nanyao Wang, Qiong Wang, Dan Wu
Background
Lung cancer is associated with a high risk of thromboembolism. The incidence and mortality of lung cancer increased in the population over 60 years old. Our research aimed to reveal the risk factors and prognosis of thromboembolism in elderly patients with stage IV lung cancer.
Methods
Metastatic lung cancer patients over 60 years of age at the Affiliated Jiangyin Hospital of Nantong University between 1 January 2011 and 30 June 2019 were screened. Univariable and multivariable analyses were conducted to reveal the risk factors for thromboembolism. Log-rank test and multivariate Cox regression analysis were performed to determine the prognosis of this cohort.
Results
Four hundred and fourteen-patients included in this study, 33 developed venous thromboembolism (VTE), and 39 developed arterial thromboembolism (ATE), respectively. Body mass index (BMI) and D-dimer level were independent risk factors associated with VTE. History of hypertension was an independent risk factor related to ATE. Older patients with ATE were associated with shorter overall survival (OS) of 7 months.
Conclusions
Higher levels of BMI and D-dimer were related to VTE, while hypertension was related to ATE. ATE was associated with a poorer prognosis. In clinical practice, appropriate prevention and treatment of thromboembolism should be conducted in this cohort.
{"title":"Clinical Characteristics and Prognosis of Thromboembolism in Elderly Patients With Stage IV Lung Cancer","authors":"Ya Qin, Xiao Liang, Xia Sun, Shuai Yan, Nanyao Wang, Qiong Wang, Dan Wu","doi":"10.1111/ggi.70325","DOIUrl":"10.1111/ggi.70325","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lung cancer is associated with a high risk of thromboembolism. The incidence and mortality of lung cancer increased in the population over 60 years old. Our research aimed to reveal the risk factors and prognosis of thromboembolism in elderly patients with stage IV lung cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Metastatic lung cancer patients over 60 years of age at the Affiliated Jiangyin Hospital of Nantong University between 1 January 2011 and 30 June 2019 were screened. Univariable and multivariable analyses were conducted to reveal the risk factors for thromboembolism. Log-rank test and multivariate Cox regression analysis were performed to determine the prognosis of this cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four hundred and fourteen-patients included in this study, 33 developed venous thromboembolism (VTE), and 39 developed arterial thromboembolism (ATE), respectively. Body mass index (BMI) and D-dimer level were independent risk factors associated with VTE. History of hypertension was an independent risk factor related to ATE. Older patients with ATE were associated with shorter overall survival (OS) of 7 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Higher levels of BMI and D-dimer were related to VTE, while hypertension was related to ATE. ATE was associated with a poorer prognosis. In clinical practice, appropriate prevention and treatment of thromboembolism should be conducted in this cohort.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ggi.70325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilyas Akkar, Mustafa Hakan Dogan, Zeynep Iclal Turgut, Ayse Dikmeer, Merve Yilmaz Kars, Muhammet Cemal Kizilarslanoglu
Background/Aim
This study aimed to investigate the general characteristics of the oldest patients followed up in a geriatrics ward after surviving the intensive care unit (ICU) and their hospital and long-term clinical outcomes.
Materials and Methods
The study was designed as a retrospective and observational cohort. It included patients aged ≥ 85 who were followed up in the geriatrics ward of our hospital between August 20, 2020, and August 20, 2023, transferred to the geriatrics ward from an ICU (ICU survivors), and met the inclusion criteria. The ICU and ward follow-ups of all patients were examined in detail using the electronic hospital record files, and their final status (discharged or alive) from the hospital was learned by phone interview.
Results
Of the patients included in the study (n = 101), 64.4% were female, and the median age was 88 (85–98) years (median follow-up period 114 [11–822] days). At the end of the follow-up period, 79.20% of the patients had died. After long-term follow-up from ICU hospitalization, the median survival time was 114 days (95% CI: 68–160). When the independent factors associated with death during the follow-up period were examined, ICU Length of Stay (ICU-LOS) (Hazard Ratio (HR): 1.258, p = 0.022), Nutrition Risk Screening-2002 (NRS-2002) score (HR: 2.953, p = 0.004), mobilization status (HR: 5.257, p = 0.027), malignancy (HR: 23.770, p = 0.015), and urinary catheterization (HR: 5.199, p = 0.048) were found to be independent related parameters.
Conclusion
This study has shown that critically ill patients of advanced age who survived ICU admission face a high mortality rate and a limited median survival time. Additionally, ICU-LOS, mobilization status, malnutrition risk, malignancy, and urinary catheterization were identified as potential independent predictors of long-term mortality in this population.
{"title":"Investigation of General Characteristics, Short and Long-Term Clinical Outcomes of Oldest Old (≥ 85 Years) Intensive Care Unit Survivors Transferred to a Geriatrics Ward","authors":"Ilyas Akkar, Mustafa Hakan Dogan, Zeynep Iclal Turgut, Ayse Dikmeer, Merve Yilmaz Kars, Muhammet Cemal Kizilarslanoglu","doi":"10.1111/ggi.70313","DOIUrl":"10.1111/ggi.70313","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background/Aim</h3>\u0000 \u0000 <p>This study aimed to investigate the general characteristics of the oldest patients followed up in a geriatrics ward after surviving the intensive care unit (ICU) and their hospital and long-term clinical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study was designed as a retrospective and observational cohort. It included patients aged ≥ 85 who were followed up in the geriatrics ward of our hospital between August 20, 2020, and August 20, 2023, transferred to the geriatrics ward from an ICU (ICU survivors), and met the inclusion criteria. The ICU and ward follow-ups of all patients were examined in detail using the electronic hospital record files, and their final status (discharged or alive) from the hospital was learned by phone interview.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the patients included in the study (<i>n</i> = 101), 64.4% were female, and the median age was 88 (85–98) years (median follow-up period 114 [11–822] days). At the end of the follow-up period, 79.20% of the patients had died. After long-term follow-up from ICU hospitalization, the median survival time was 114 days (95% CI: 68–160). When the independent factors associated with death during the follow-up period were examined, ICU Length of Stay (ICU-LOS) (Hazard Ratio (HR): 1.258, <i>p</i> = 0.022), Nutrition Risk Screening-2002 (NRS-2002) score (HR: 2.953, <i>p</i> = 0.004), mobilization status (HR: 5.257, <i>p</i> = 0.027), malignancy (HR: 23.770, <i>p</i> = 0.015), and urinary catheterization (HR: 5.199, <i>p</i> = 0.048) were found to be independent related parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study has shown that critically ill patients of advanced age who survived ICU admission face a high mortality rate and a limited median survival time. Additionally, ICU-LOS, mobilization status, malnutrition risk, malignancy, and urinary catheterization were identified as potential independent predictors of long-term mortality in this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the impact of endurance exercise training on kidney function in senescence-accelerated mouse prone 8 (SAMP8) mice.
Methods
Thirty-week-old male SAMP8 mice were divided into two groups: one group underwent treadmill exercise for 10 weeks (Old-Ex group, n = 12), while the other group remained sedentary (Old-Cont group, n = 12). Additionally, a group of 8- to 10-week-old SAMP8 mice served as a young control (Young-Cont group, n = 22).
Results
Although renal function was similar in the three groups, the renal mRNA expression of monocyte chemoattractant protein-1, macrophage infiltration, and collagen-type III-positive area in the interstitium was significantly higher in the Old-Cont group than in the Young-Cont group. However, these factors were significantly suppressed in the Old-Ex group. Renal protein expression of hypoxia-inducible factor-1α was significantly upregulated in the Old-Cont group compared to the Young-Cont group but was significantly suppressed in the Old-Ex group. In terms of proteins related to mitochondrial function, renal protein expressions of peroxisome proliferator-activated receptor gamma coactivator 1α and medium-chain acyl-CoA dehydrogenase were comparable between the Old-Cont and Young-Cont groups but were significantly upregulated in the Old-Ex group compared to the Old-Cont group. Renal protein expression of cytochrome c oxidase subunit 5B was significantly downregulated in the Old-Cont group compared to the Young-Cont group, and this downregulation was significantly restored by exercise.
Conclusion
This study suggests that endurance exercise training may suppress renal interstitial inflammation and fibrosis in the kidneys of aged SAMP8 mice by preventing renal hypoxia and preserving mitochondrial function.
{"title":"Effect of Endurance Exercise Training on the Kidneys of the Senescence-Accelerated Mouse Prone 8 Model","authors":"Kazuho Inoue, Seiko Hoshino, Kimie Katayama, Junko Asano, Takayuki Akagi, Keiichi Ohata, Takeshi Sugaya, Shiika Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori","doi":"10.1111/ggi.70321","DOIUrl":"10.1111/ggi.70321","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate the impact of endurance exercise training on kidney function in senescence-accelerated mouse prone 8 (SAMP8) mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-week-old male SAMP8 mice were divided into two groups: one group underwent treadmill exercise for 10 weeks (Old-Ex group, <i>n</i> = 12), while the other group remained sedentary (Old-Cont group, <i>n</i> = 12). Additionally, a group of 8- to 10-week-old SAMP8 mice served as a young control (Young-Cont group, <i>n</i> = 22).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Although renal function was similar in the three groups, the renal mRNA expression of <i>monocyte chemoattractant protein-1</i>, macrophage infiltration, and collagen-type III-positive area in the interstitium was significantly higher in the Old-Cont group than in the Young-Cont group. However, these factors were significantly suppressed in the Old-Ex group. Renal protein expression of hypoxia-inducible factor-1α was significantly upregulated in the Old-Cont group compared to the Young-Cont group but was significantly suppressed in the Old-Ex group. In terms of proteins related to mitochondrial function, renal protein expressions of peroxisome proliferator-activated receptor gamma coactivator 1α and medium-chain acyl-CoA dehydrogenase were comparable between the Old-Cont and Young-Cont groups but were significantly upregulated in the Old-Ex group compared to the Old-Cont group. Renal protein expression of cytochrome c oxidase subunit 5B was significantly downregulated in the Old-Cont group compared to the Young-Cont group, and this downregulation was significantly restored by exercise.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that endurance exercise training may suppress renal interstitial inflammation and fibrosis in the kidneys of aged SAMP8 mice by preventing renal hypoxia and preserving mitochondrial function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Visual Correction of Balance Useful for Care Planning of Fall Prevention of Dementia?","authors":"Rhuhei Nakai, Koichi Kozaki, Masahiro Akishita, Kenji Toba","doi":"10.1111/ggi.70322","DOIUrl":"10.1111/ggi.70322","url":null,"abstract":"","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The primary objective was to examine the association between unplanned physician-led home visits and patient complexity, as measured by the Minnesota Complexity Assessment Method (MCAM), and between mortality and patient complexity. The secondary objective was to investigate the relationship between patient complexity and patients' wishes to die at home, families' acceptance of the patients' deaths at home, and the location of death.
Methods
We applied Cox proportional hazards models to estimate cause-specific hazard ratios (HRs) for patient complexity, with unplanned home visits and deaths as dependent variables. We employed multinomial logistic regression models to evaluate relative risk ratios (RRRs) of patient complexity, with the patient's wish to die at home, the family's acceptance of the patient's death at home, and the location of death as dependent variables.
Results
A total of 712 participants were included in the analysis. The Illness domain of the MCAM was positively associated with unplanned home visits and deaths (adjusted HRs: 1.20 and 1.21, respectively). Furthermore, the Illness domain was also positively associated with patients' wishes to die at home (adjusted RRR [aRRR]: 1.24) and families' acceptance of the patients' deaths at home (aRRR: 1.19), whereas the Social domain was negatively associated with these outcomes (aRRRs: 0.81 and 0.84, respectively).
Conclusion
Patients with higher biomedical and social complexity may require closer clinical attention in physician-led home visit settings, which could help reduce unplanned visits, improve mortality-related outcomes, and enable patients and their families to choose the location of death without restrictions imposed by biopsychosocial factors.
{"title":"Association of Unplanned Home Visits, Deaths, Preference for Dying at Home, and Home Deaths With Patient Complexity in a Physician-Led Home Visit Setting: A Secondary Analysis of a Multicenter Prospective Cohort Study","authors":"Yoshifumi Sugiyama, Takamasa Watanabe, Rieko Mutai, Shunichiro Hoshimoto, Mayu Yasuda, Tetsuya Kanno, Shuhei Yoshida, Kendo Tanaka, Monami Matsumoto, Masato Matsushima","doi":"10.1111/ggi.70316","DOIUrl":"10.1111/ggi.70316","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The primary objective was to examine the association between unplanned physician-led home visits and patient complexity, as measured by the Minnesota Complexity Assessment Method (MCAM), and between mortality and patient complexity. The secondary objective was to investigate the relationship between patient complexity and patients' wishes to die at home, families' acceptance of the patients' deaths at home, and the location of death.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We applied Cox proportional hazards models to estimate cause-specific hazard ratios (HRs) for patient complexity, with unplanned home visits and deaths as dependent variables. We employed multinomial logistic regression models to evaluate relative risk ratios (RRRs) of patient complexity, with the patient's wish to die at home, the family's acceptance of the patient's death at home, and the location of death as dependent variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 712 participants were included in the analysis. The Illness domain of the MCAM was positively associated with unplanned home visits and deaths (adjusted HRs: 1.20 and 1.21, respectively). Furthermore, the Illness domain was also positively associated with patients' wishes to die at home (adjusted RRR [aRRR]: 1.24) and families' acceptance of the patients' deaths at home (aRRR: 1.19), whereas the Social domain was negatively associated with these outcomes (aRRRs: 0.81 and 0.84, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with higher biomedical and social complexity may require closer clinical attention in physician-led home visit settings, which could help reduce unplanned visits, improve mortality-related outcomes, and enable patients and their families to choose the location of death without restrictions imposed by biopsychosocial factors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12796993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are two major chronic conditions that frequently coexist, compounding clinical complications and disability. However, the global burden of COPD attributable to HF remains insufficiently characterized.
Methods
A comprehensive global analysis was conducted to evaluate trends in COPD prevalence and years lived with disability (YLDs) attributable to HF across 204 countries and territories. Standardized epidemiological estimates were derived through harmonized data sources and modeling frameworks. The results were stratified by sex, age group, region, and sociodemographic index (SDI). Temporal trends were quantified using the estimated annual percentage change (EAPC), and the association between national prevalence and SDI was examined using Spearman's rank correlation analysis.
Results
Globally, COPD cases attributable to HF rose from 1 504 707 to 3 613 136, and the prevalence rate increased from 28.21 to 45.79 per 100 000 population (EAPC: +1.33). YLDs grew from 134 013 to 321 753, with the rate increasing from 2.51 to 4.08 per 100 000. Males experienced slightly greater increases than females, suggesting a somewhat heavier burden. Although the EAPCs across all age groups remained relatively stable, adults aged 75 years and older exhibited the highest prevalence and YLDs. In 2021, the highest prevalence rates were observed in East Asia (104.9 per 100 000), Australasia (90.69 per 100 000), and North America (78.56 per 100 000). At the national level, Canada (115.9 per 100 000), Denmark (112.08 per 100 000), and France (98.16 per 100 000) reported the highest rates, reflecting substantial burden in high-SDI countries. A moderate positive correlation was identified between COPD prevalence and national SDI (ρ = 0.383, p < 0.001).
Conclusion
The global burden of COPD attributable to HF is increasing and exhibits marked geographic disparities, with rising trends in both low-income regions and aging, industrialized countries. These findings emphasize the need for integrated comorbidity management and region-specific health strategies.
{"title":"Declining Prevalence and Disability Burden of Chronic Obstructive Pulmonary Disease Associated With Heart Failure","authors":"Shengjie Xu, Jieqi Zhou, Xiantao Xu","doi":"10.1111/ggi.70324","DOIUrl":"10.1111/ggi.70324","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are two major chronic conditions that frequently coexist, compounding clinical complications and disability. However, the global burden of COPD attributable to HF remains insufficiently characterized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive global analysis was conducted to evaluate trends in COPD prevalence and years lived with disability (YLDs) attributable to HF across 204 countries and territories. Standardized epidemiological estimates were derived through harmonized data sources and modeling frameworks. The results were stratified by sex, age group, region, and sociodemographic index (SDI). Temporal trends were quantified using the estimated annual percentage change (EAPC), and the association between national prevalence and SDI was examined using Spearman's rank correlation analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Globally, COPD cases attributable to HF rose from 1 504 707 to 3 613 136, and the prevalence rate increased from 28.21 to 45.79 per 100 000 population (EAPC: +1.33). YLDs grew from 134 013 to 321 753, with the rate increasing from 2.51 to 4.08 per 100 000. Males experienced slightly greater increases than females, suggesting a somewhat heavier burden. Although the EAPCs across all age groups remained relatively stable, adults aged 75 years and older exhibited the highest prevalence and YLDs. In 2021, the highest prevalence rates were observed in East Asia (104.9 per 100 000), Australasia (90.69 per 100 000), and North America (78.56 per 100 000). At the national level, Canada (115.9 per 100 000), Denmark (112.08 per 100 000), and France (98.16 per 100 000) reported the highest rates, reflecting substantial burden in high-SDI countries. A moderate positive correlation was identified between COPD prevalence and national SDI (<i>ρ</i> = 0.383, <i>p</i> < 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The global burden of COPD attributable to HF is increasing and exhibits marked geographic disparities, with rising trends in both low-income regions and aging, industrialized countries. These findings emphasize the need for integrated comorbidity management and region-specific health strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Locomotive syndrome (LS) is defined as reduced mobility due to locomotor dysfunction. The sit-to-stand (STS) movement is a fundamental daily activity, and biomechanical parameters derived from STS capture quantitative aspects of mobility. However, their association with LS severity remains unclear. We aimed to examine whether STS parameters are associated with LS severity in this cross-sectional study.
Methods
We analyzed 1047 adults (619 males, 428 females; median age 54 years) who underwent musculoskeletal health screening. LS stage was classified into non-LS, LS1, LS2, and LS3 using the stand-up test, two-step test, and the 25-question Geriatric Locomotive Function Scale. STS performance was measured with the STS force analyzer, and three parameters were derived: maximum ground reaction force normalized to body weight (F/w), rate of force development normalized to body weight (RFD/w), and stabilization time (ST). Associations between LS stage and these parameters were assessed using ordinal logistic regression adjusted for age, sex, and body mass index.
Results
Among participants, 47.0% were non-LS, 46.0% LS1, 5.8% LS2, and 1.1% LS3. Compared with non-LS, both F/w and RFD/w were significantly lower in LS1 and LS2, while ST was significantly longer in LS1. In ordinal logistic regression analysis, only RFD/w remained significantly associated with LS stage after adjustment (odds ratio: 0.84; 95% CI: 0.76–0.94; p = 0.002).
Conclusions
Our findings revealed that only lower RFD/w was independently associated with LS severity, suggesting that RFD/w could complement conventional LS risk tests.
目的：机车综合征（Locomotive syndrome， LS）被定义为由于运动功能障碍而导致的活动能力降低。坐立（STS）运动是一项基本的日常活动，从STS获得的生物力学参数捕获了活动的定量方面。然而，它们与LS严重程度的关系尚不清楚。在这项横断面研究中，我们旨在研究STS参数是否与LS严重程度相关。方法：我们分析了接受肌肉骨骼健康筛查的1047名成年人（619名男性，428名女性，中位年龄54岁）。采用站立检验、两步检验和25题老年机车功能量表将LS阶段分为非LS阶段、LS1阶段、LS2阶段和LS3阶段。使用STS力分析仪测量STS性能，并推导出三个参数：最大地面反作用力归一化到体重（F/w），力发展归一化到体重（RFD/w）和稳定时间（ST）。使用调整年龄、性别和体重指数的有序逻辑回归来评估LS阶段与这些参数之间的关系。结果：非ls患者占47.0%，LS1患者占46.0%，LS2患者占5.8%，LS3患者占1.1%。与非ls相比，LS1和LS2的F/w和RFD/w均显著降低，而LS1的ST则显著延长。在有序logistic回归分析中，只有RFD/w与调整后的LS分期仍然显著相关（优势比：0.84;95% CI: 0.76-0.94; p = 0.002）。结论：我们的研究结果显示，只有较低的RFD/w与LS严重程度独立相关，这表明RFD/w可以补充传统的LS风险测试。
{"title":"Rate of Force Development During Sit-to-Stand Movement Is Associated With Locomotive Syndrome Severity: A Cross-Sectional Study","authors":"Takashi Seya, Naoki Okubo, Shuji Nakagawa, Taisuke Kunitomo, Kanako Iinuma, Kazufumi Hisamoto, Soshi Hirata, Kenji Takahashi","doi":"10.1111/ggi.70314","DOIUrl":"10.1111/ggi.70314","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Locomotive syndrome (LS) is defined as reduced mobility due to locomotor dysfunction. The sit-to-stand (STS) movement is a fundamental daily activity, and biomechanical parameters derived from STS capture quantitative aspects of mobility. However, their association with LS severity remains unclear. We aimed to examine whether STS parameters are associated with LS severity in this cross-sectional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 1047 adults (619 males, 428 females; median age 54 years) who underwent musculoskeletal health screening. LS stage was classified into non-LS, LS1, LS2, and LS3 using the stand-up test, two-step test, and the 25-question Geriatric Locomotive Function Scale. STS performance was measured with the STS force analyzer, and three parameters were derived: maximum ground reaction force normalized to body weight (F/w), rate of force development normalized to body weight (RFD/w), and stabilization time (ST). Associations between LS stage and these parameters were assessed using ordinal logistic regression adjusted for age, sex, and body mass index.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among participants, 47.0% were non-LS, 46.0% LS1, 5.8% LS2, and 1.1% LS3. Compared with non-LS, both F/w and RFD/w were significantly lower in LS1 and LS2, while ST was significantly longer in LS1. In ordinal logistic regression analysis, only RFD/w remained significantly associated with LS stage after adjustment (odds ratio: 0.84; 95% CI: 0.76–0.94; <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings revealed that only lower RFD/w was independently associated with LS severity, suggesting that RFD/w could complement conventional LS risk tests.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":"26 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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