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Bullying, minority stress and revenge impulse among autistic college students: group differences by sexual and gender minority status. 孤独症大学生的欺凌、少数群体压力与报复冲动:性别和性别少数群体的群体差异
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1727508
Wang Qian, Chunming Chen, Baojian Wei

This study examines how bullying experiences are associated with retaliatory impulses among autistic university students, highlighting minority stress as a key mediating mechanism and sexual and gender minority (SGM) status as a moderating condition within an intersectional framework. Guided by Minority Stress Theory and Social Information Processing Theory, we surveyed 280 autistic undergraduates; 35% identified as SGM. Participants completed validated measures of bullying, minority stress, retaliatory impulse, and related psychosocial factors. Structural equation modeling and multi-group analyses were conducted to evaluate the proposed mediation and moderation patterns while adjusting for gender, grade level, social support, autistic traits, and internet use. The measurement model showed good reliability and convergent validity (Cronbach's α = 0.84-0.89; AVE = 0.62-0.69). Bullying was positively associated with minority stress, which was in turn associated with retaliatory impulses, supporting partial mediation [indirect effect = 0.42, 95% CI (0.36, 0.50)]. Multi-group results indicated stronger path coefficients in the SGM group (bullying → stress β = 0.72; stress → retaliation β = 0.66) than among non-SGM (heterosexual and cisgender) peers, consistent with the possibility that compounded stigma heightens emotional reactivity and defensive processing. Minority stress remained the strongest correlate of retaliatory impulses after covariate adjustment, whereas social support showed a protective association. Taken together, the findings suggest that retaliatory impulses among autistic students are better understood in relation to sustained identity-based exclusion and structural stressors rather than as simple dispositional aggression. The results also imply that effective prevention may require institutional and relational strategies-alongside individual support-such as inclusive curricula, peer sensitization, and policies that strengthen belonging and psychological safety in higher education.

本研究探讨了欺凌经历与自闭症大学生报复冲动之间的关系,并在交叉框架内强调了少数群体压力是一个关键的中介机制,而性和性别少数群体(SGM)地位是一个调节条件。以少数民族应激理论和社会信息加工理论为指导,对280名自闭症大学生进行问卷调查;35%被认定为SGM。参与者完成了欺凌、少数民族压力、报复冲动和相关心理社会因素的有效测量。在调整性别、年级、社会支持、自闭症特征和互联网使用等因素的基础上,采用结构方程模型和多组分析对所提出的中介和调节模式进行了评估。测量模型具有良好的信度和收敛效度(Cronbach's α = 0.84-0.89;AVE = 0.62-0.69)。欺凌与少数民族压力呈正相关,而少数民族压力又与报复冲动相关,支持部分中介作用[间接效应 = 0.42,95% CI(0.36, 0.50)]。多组研究结果显示,受欺负群体的路径系数(欺凌→压力β = 0.72;压力→报复β = 0.66)高于非受欺负群体(异性恋和顺性),这与复合污名化加剧情绪反应和防御加工的可能性一致。协变量调整后,少数民族压力与报复冲动的相关性最强,而社会支持与报复冲动的相关性最强。综上所述,这些发现表明自闭症学生的报复冲动与持续的基于身份的排斥和结构性压力源有关,而不是简单的性格攻击。研究结果还表明,有效的预防可能需要机构和关系策略,以及个人支持,如包容性课程、同伴敏感化和加强高等教育归属感和心理安全的政策。
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引用次数: 0
Strengthening tobacco control policy: using plain packaging to reduce product appeal and enhance public awareness. 加强烟草控制政策:使用平装包装降低产品吸引力,提高公众意识。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1781256
Ho Cheung William Li, Wei Xia, Hong Chen, Xinyi Xu, Laurie Long Kwan Ho, Hoi Yan Cora Mok, Oi Kwan Joyce Chung

Background: Tobacco use remains a leading cause of preventable morbidity and mortality worldwide. While smoking prevalence has recently declined in Hong Kong, progress has slowed. Plain packaging may reduce product appeal and enhance the impact of pictorial health warnings (PHWs), supporting reduced tobacco use.

Methods: A cross-sectional study was conducted from August to November 2023 among 1,256 adult smokers in Hong Kong. Participants were recruited at outdoor public smoking hotspots and shown branded and plain cigarette packs with 85% PHWs. Perceptions of pack attractiveness, noticeability of PHWs, smoking-related harm, behavioural intentions, and support for plain packaging were assessed through structured interviews. Quantitative data were weighted by age and sex, and qualitative responses were analysed thematically.

Results: Most participants perceived plain packs as less attractive (79.8%) and PHWs on plain packs were more noticeable (57.5%) than branded packs. About 45.1% perceived plain packs as disgusting, and 28.0% agreed they better conveyed severe smoking harms than branded packs. While only 17.3% reported plain packs may reduce their intention to smoke, 33.1% reported that it could deter youth from smoking. Support for plain packaging was moderate, with 35.7% in favour and 34.5% neutral. The qualitative findings reinforced these perceptions.

Conclusion: Smokers perceived plain packaging as less attractive, the PHWs on it as more noticeable, and potentially useful in preventing smoking initiation in youth. These findings support the integration of plain packaging into Hong Kong's tobacco control strategy and offer valuable insights for jurisdictions considering similar legislation.

背景:烟草使用仍然是世界范围内可预防的发病和死亡的主要原因。虽然香港的吸烟率最近有所下降,但进展缓慢。平装包装可降低产品吸引力,增强图片健康警语的影响,有助于减少烟草使用。方法:于2023年8月至11月对香港1256名成年吸烟者进行横断面研究。参与者在室外公共吸烟热点被招募,并展示了85% phw的品牌和普通香烟包装。通过结构化访谈评估了对包装吸引力、phw的可见性、吸烟相关危害、行为意图和对平装的支持的看法。定量数据按年龄和性别加权,定性回答按主题进行分析。结果:大多数参与者认为普通包装不那么吸引人(79.8%),普通包装上的phw比品牌包装更明显(57.5%)。约45.1%的人认为普通包装令人作呕,28.0%的人认为普通包装比品牌包装更能传达严重的吸烟危害。虽然只有17.3%的人认为普通包装香烟可能会降低他们吸烟的意愿,但33.1%的人认为它可以阻止青少年吸烟。对普通包装的支持是温和的,35.7%的人赞成,34.5%的人中立。定性研究结果强化了这些看法。结论:吸烟者认为普通包装不那么吸引人,其上的phw更明显,并且在防止青少年吸烟方面可能有用。这些研究结果支持将无装饰包装纳入香港的控烟策略,并为考虑类似立法的司法管辖区提供宝贵的见解。
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引用次数: 0
Beyond coverage: why Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana struggles to deliver healthcare in Jammu and Kashmir. 超越覆盖:为什么Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana在查谟和克什米尔努力提供医疗保健。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1783458
Esarul Ayub, Olusiji Adebola Lasekan, Blessy Sarah Mathew, Margot Teresa Godoy Pena, Abdul Wahid Bhat

Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana (PM-JAY), the biggest publicly financed health insurance program in the world, has substantial use issues, especially in places like Jammu and Kashmir that are affected by conflict. Despite the program's goal of ensuring equal and cashless access to healthcare, the existing literature does not offer region-specific insights into the actual obstacles preventing its adoption. This study intends to identify and measure the physical, administrative, financial, and informational hurdles experiences by the beneficiaries in the urban and semi-rural areas of Jammu and Kashmir face when utilizing PM-JAY. Primary data was gathered through structured interviews with 320 randomly chosen PM-JAY recipients using a cross-sectional approach. To evaluate the relative effects of various obstacles on scheme use, the study used binary logistic regression, chi-square tests, Pearson correlation, and descriptive statistics. Despite being enrolled, only 48.4% of enrollees reported accessing PM-JAY services. The most significant positive predictors of usage were health literacy and awareness gaps, notably knowledge of empanelled hospital lists (OR = 1.245, p < 0.05) and awareness of scheme entitlement (OR = 1.253, p < 0.05). A statistically significant negative factor was inadequate road infrastructure (OR = 0.761, p < 0.05). Despite being often mentioned, administrative and financial obstacles were surprisingly not significant in the regression model. There were no discernible variations in use between the two districts, indicating problems with systemic access. Increasing PM-JAY use in disadvantaged areas requires more than just financial incentives; it also requires better physical infrastructure and informational availability. To convert coverage into useful access, policymakers should concentrate on region-specific IEC initiatives, transportation connectivity, and health system navigation support mechanisms. These interventions are essential for translating PM-JAY's theoretical coverage into meaningful, equitable healthcare access, particularly in underserved and fragile regions like Jammu and Kashmir.

世界上最大的公共资助医疗保险项目Ayushman bharatpradhan Mantri Jan Arogya Yojana (PM-JAY)在使用方面存在大量问题,特别是在查谟和克什米尔等受冲突影响的地区。尽管该计划的目标是确保平等和无现金获得医疗保健,但现有文献并没有提供具体区域的见解,以了解阻碍其采用的实际障碍。本研究旨在确定和衡量查谟和克什米尔城市和半农村地区的受益人在使用PM-JAY时面临的物质、行政、财务和信息障碍。采用横断面方法对随机选择的320名PM-JAY接受者进行结构化访谈,收集主要数据。为了评估各种障碍对方案使用的相对影响,研究使用了二元逻辑回归、卡方检验、Pearson相关和描述性统计。尽管注册了,但只有48.4%的注册者报告使用PM-JAY服务。使用率最显著的正向预测因子是健康素养和意识差距,特别是对入选医院名单的了解(OR = 1.245,p p p)
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引用次数: 0
Exploring the multidimensional factors associated with the incidence of bacillary dysentery in China based on a panel data model. 基于面板数据模型探讨中国细菌性痢疾发病率相关的多维因素。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1701162
Yanbin Hao, Dinglin Yu

Objective: Bacillary dysentery (BD) remains a public health concern in China, with its incidence influenced by multidimensional and interconnected factors. This study aimed to quantify the correlations between meteorological conditions, socioeconomic status, health resources, forest coverage, and BD incidence-an integrated analysis lacking in previous research. The results provide a comprehensive evidence base for formulating targeted BD prevention strategies.

Methods: Using panel data from 31 Chinese provinces (2014 ~ 2018), including BD incidence rates and 12 indicators of proxy variables at the ecological level, fixed-effects and random-effects models with Driscoll-Kraay robust standard errors were applied.

Results: The results of the random-effects model incorporating multidimensional factors showed that a 1% increase in the number of beds per 1,000 people in healthcare facilities, GDP per capita, and forest coverage was significantly associated with decreases in BD incidence rates of 2, 0.8, and 0.6%, respectively, (all p < 0.05). These findings indicate ecological associations with the incidence of BD across different provinces in China.

Conclusion: Improvements in regional investment in healthcare resources, economic development, and forest coverage were inversely associated with BD incidence, suggesting potential protective effects at the population level.

目的:细菌性痢疾(Bacillary dysentery, BD)是中国的一个公共卫生问题,其发病受多方面、相互关联的因素影响。本研究旨在量化气象条件、社会经济状况、卫生资源、森林覆盖率和BD发病率之间的相关性,这是以往研究缺乏的综合分析。研究结果为制定有针对性的BD预防策略提供了全面的证据基础。方法:利用中国31个省份(2014年 ~ 2018年)的面板数据,包括BD发病率和12个生态水平代理变量指标,应用具有Driscoll-Kraay稳健标准误差的固定效应和随机效应模型。结果:纳入多维因素的随机效应模型结果显示,每1000人医疗机构床位数、人均GDP和森林覆盖率每增加1%,BD发病率分别下降2%、0.8%和0.6%,显著相关(均p )。区域医疗资源投资、经济发展和森林覆盖率的改善与BD发病率呈负相关,表明在人口水平上具有潜在的保护作用。
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引用次数: 0
From internal echoes to sharing experiences: transformative learning with voice apps to enhance transgender care literacy in medical students. 从内部回声到分享经验:通过语音应用程序进行变革性学习,提高医学生的跨性别护理素养。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1767576
Susanne Gahbauer, Shamim Sherafat, Michaela Wagner-Menghin

Introduction: Gendered voice perception is central to gender recognition and can be a major source of distress for transgender people, yet voice and voice therapy remain marginal in medical curricula. This study examined how a digital, experiential seminar using voice-feedback applications can foster medical students' understanding of gendered voice and transgender health.

Methods: We conducted a qualitative observational study within a 135-min online seminar, "Feminize Your Resonance!", embedded in a fourth-year public health module at the Medical University of Vienna. One hundred medical students used commercially available voice apps to experiment with their own pitch and resonance and submitted app screenshots and written reflections via an online learning platform. We applied a narrative analysis, based on narrative episodes in students' accounts, using a multi-stage coding process supported by qualitative data analysis software to map learning processes in several stages.

Results: Analysis yielded three interlinked themes-implicit voice awareness, technology engagement, and sharing transgender experience-organized into a five-phase learning journey from pre-existing discomfort with one's recorded voice to social awareness with voice challenges of transgender individuals. Students moved from internal, often negative, self-evaluation to critical appraisal of app algorithms, exploration of their own vocal plasticity, and perspective-taking on the challenges of gender-affirming voice transition.

Conclusion: Technologically mediated voice exploration can catalyze transformative learning about the role of voice in gender incongruence and support the development of affective and clinical competencies in medical education. Potentially the training facilitates communicating with transgender individuals empathically, not only related to transgender-affirming care but in all healthcare settings.

性别声音感知是性别认知的核心,可能是跨性别者痛苦的主要来源,但声音和声音治疗在医学课程中仍然处于边缘地位。本研究考察了使用语音反馈应用程序的数字化体验研讨会如何促进医学生对性别声音和跨性别健康的理解。方法:我们在一个135分钟的在线研讨会“女性化你的共鸣!”中进行了定性观察研究,该研讨会嵌入了维也纳医科大学四年级公共卫生模块。100名医学生使用商业上可获得的语音应用程序来试验自己的音高和共振,并通过在线学习平台提交应用程序截图和书面反思。我们采用了叙事分析,基于学生叙述中的叙事情节,使用定性数据分析软件支持的多阶段编码过程来映射几个阶段的学习过程。结果:分析产生了三个相互关联的主题——隐性声音意识、技术参与和跨性别经验分享——组织成五个阶段的学习之旅,从预先存在的对录制声音的不适到跨性别个体对声音挑战的社会意识。学生们从内部(通常是消极的)自我评价转向对应用程序算法的批判性评价,探索自己的声音可塑性,以及对性别肯定声音转变的挑战的看法。结论:技术介导的语音探索可以促进语音在性别不一致中的作用的变革性学习,并支持医学教育中情感和临床能力的发展。培训可能会促进与跨性别者的共情交流,不仅与跨性别确认护理有关,而且与所有医疗保健环境有关。
{"title":"From internal echoes to sharing experiences: transformative learning with voice apps to enhance transgender care literacy in medical students.","authors":"Susanne Gahbauer, Shamim Sherafat, Michaela Wagner-Menghin","doi":"10.3389/fpubh.2026.1767576","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1767576","url":null,"abstract":"<p><strong>Introduction: </strong>Gendered voice perception is central to gender recognition and can be a major source of distress for transgender people, yet voice and voice therapy remain marginal in medical curricula. This study examined how a digital, experiential seminar using voice-feedback applications can foster medical students' understanding of gendered voice and transgender health.</p><p><strong>Methods: </strong>We conducted a qualitative observational study within a 135-min online seminar, \"Feminize Your Resonance!\", embedded in a fourth-year public health module at the Medical University of Vienna. One hundred medical students used commercially available voice apps to experiment with their own pitch and resonance and submitted app screenshots and written reflections via an online learning platform. We applied a narrative analysis, based on narrative episodes in students' accounts, using a multi-stage coding process supported by qualitative data analysis software to map learning processes in several stages.</p><p><strong>Results: </strong>Analysis yielded three interlinked themes-implicit voice awareness, technology engagement, and sharing transgender experience-organized into a five-phase learning journey from pre-existing discomfort with one's recorded voice to social awareness with voice challenges of transgender individuals. Students moved from internal, often negative, self-evaluation to critical appraisal of app algorithms, exploration of their own vocal plasticity, and perspective-taking on the challenges of gender-affirming voice transition.</p><p><strong>Conclusion: </strong>Technologically mediated voice exploration can catalyze transformative learning about the role of voice in gender incongruence and support the development of affective and clinical competencies in medical education. Potentially the training facilitates communicating with transgender individuals empathically, not only related to transgender-affirming care but in all healthcare settings.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1767576"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Instant messaging-based digital health interventions for diabetes management: a domain-structured systematic review and meta-analysis of randomized controlled trials. 基于即时通讯的糖尿病管理数字健康干预:随机对照试验的领域结构系统回顾和荟萃分析。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1780625
Shan Chen, Emma Mirza Wati Mohamad, Arina Anis Azlan, Xixi Zhao
<p><strong>Background: </strong>Instant messaging delivered through social platforms is increasingly used to support diabetes self-management. However, evidence remains difficult to interpret because trials vary widely in platform choice, intervention design, outcome constructs, and measurement instruments.</p><p><strong>Objective: </strong>To synthesize the effects of instant-messaging interventions for diabetes across pre-specified outcome domains, and to explore whether platform type, follow-up duration, and study size help explain variation in effect estimates.</p><p><strong>Methods: </strong>We searched seven databases (2010-2025) for randomized controlled trials in which diabetes interventions were primarily delivered via instant-messaging/social platforms. Outcomes were organized a priori into six domains: health behaviors, diabetes knowledge, attitudes/self-efficacy, glycemic outcomes, other clinical outcomes, and diabetes-related complications. Continuous outcomes were pooled as standardized mean differences (SMDs) and binary outcomes as risk ratios (RRs) using random-effects models (REML). To improve interpretability, we prioritized domain-level synthesis and performed platform-stratified pooling only when at least three effect sizes were available within a given domain. Heterogeneity was summarized using τ<sup>2</sup> and I<sup>2</sup>. Robustness was assessed using leave-one-out analyses; small-study effects were evaluated using funnel plots and Egger's test when ≥10 studies contributed to an analysis. Exploratory meta-regression examined follow-up duration and ln(sample size).</p><p><strong>Results: </strong>Twenty-three trials contributed 236 effect estimates. Overall pooled effects across all continuous and binary outcomes were close to null and statistically non-significant, with substantial heterogeneity. Domain-specific synthesis showed clearer patterns: diabetes knowledge demonstrated the largest pooled improvement (SMD = 1.065, 95% CI 0.185-1.944), glycemic outcomes improved on continuous measures (SMD = -0.519, 95% CI -0.719 to -0.319), and behavioral outcomes showed a small but significant benefit (SMD = 0.359, 95% CI 0.010-0.709). Attitudes/self-efficacy and other clinical outcomes were more heterogeneous and did not show clear pooled benefits. For complications (binary outcomes), the pooled estimate suggested a potential reduction in risk (RR = 0.67, 95% CI 0.44-1.00) based on three studies and should be interpreted cautiously. Platform-overview pooling of continuous outcomes suggested variability across platforms, with more consistently positive pooled effects for Facebook Messenger-based interventions than for WhatsApp or WeChat; however, platform-by-domain pooling was often not estimable because many platform-domain combinations contributed fewer than three effect sizes. Meta-regression did not identify a clear linear association of follow-up duration or ln(sample size) with effect size, and explained little heterogenei
背景:通过社交平台提供的即时通讯越来越多地用于支持糖尿病的自我管理。然而,证据仍然难以解释,因为试验在平台选择、干预设计、结果结构和测量工具方面存在很大差异。目的:综合即时通讯干预对糖尿病预先指定结果域的影响,并探讨平台类型、随访时间和研究规模是否有助于解释效果估计的差异。方法:我们检索了7个数据库(2010-2025),其中糖尿病干预主要通过即时通讯/社交平台提供的随机对照试验。结果被先验地分为六个领域:健康行为、糖尿病知识、态度/自我效能、血糖结果、其他临床结果和糖尿病相关并发症。使用随机效应模型(REML)将连续结果合并为标准化平均差异(SMDs),将二元结果合并为风险比(rr)。为了提高可解释性,我们优先考虑领域级综合,并仅在给定领域内至少有三个效应量可用时才进行平台分层池化。用τ2和I2总结异质性。鲁棒性评估采用留一分析;当≥10项研究参与分析时,使用漏斗图和Egger检验评估小研究效应。探索性meta回归检验了随访时间和ln(样本量)。结果:23项试验贡献了236个效应估计。所有连续和二元结果的总体合并效应接近于零,在统计上不显著,具有很大的异质性。特定领域综合显示出更清晰的模式:糖尿病知识显示出最大的综合改善(SMD = 1.065, 95% CI 0.185-1.944),血糖结果在连续测量中得到改善(SMD = -0.519, 95% CI -0.719至-0.319),行为结果显示出虽小但显著的改善(SMD = 0.359, 95% CI 0.010-0.709)。态度/自我效能感和其他临床结果的异质性更大,没有显示出明确的综合效益。对于并发症(二元结果),汇总估计表明基于三项研究的潜在风险降低(RR = 0.67, 95% CI 0.44-1.00),应谨慎解释。连续结果的平台总体汇总表明,平台之间存在差异,基于Facebook messenger的干预措施比基于WhatsApp或微信的干预措施具有更一致的积极汇总效应;然而,平台-领域池化通常无法估计,因为许多平台-领域组合贡献的效应量少于3个。meta回归没有发现随访时间或ln(样本量)与效应大小有明确的线性关联,并且解释了很少的异质性。结论:即时通讯对糖尿病的干预并没有产生明显有利的总体效果,但它们在行为结果和选定的临床终点上显示出可靠的益处。效果的变化似乎与干预设计和实施的差异更一致,而不仅仅是平台标签。未来的试验应该更详细地报告干预组件和维护策略,并评估交互式、护理集成的消息传递模型。系统评价注册:https://www.crd.york.ac.uk/PROSPERO/view/CRD420251079157,标识符:CRD420251079157。
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引用次数: 0
Early mortality risk prediction in severe fever with thrombocytopenia syndrome using an interpretable machine learning model based on routine clinical parameters. 基于常规临床参数的可解释机器学习模型预测发热伴血小板减少综合征的早期死亡风险。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1776344
Qian Dai, Ji Guo, Liangfei Xu, Qiong Lu, He Chen, Yuanyuan Hu, Ying Wang, Tong Tong

Background: Severe Fever with Thrombocytopenia Syndrome (SFTS) is characterized by high mortality and rapid progression, necessitating accurate early prognosis to optimize supportive care. However, current predictive tools often lack interpretability, require sophisticated tests unavailable in resource-limited areas, or suffer from poor generalizability. This study aimed to develop an interpretable, parsimonious, and deployable machine learning model for early mortality prediction in SFTS.

Methods: We analyzed data from 834 SFTS patients across three medical centers in Anhui, China. A LightGBM model was developed using a derivation cohort (n = 571) and validated on internal (n = 143) and two independent external cohorts (n = 80 and n = 183). Model interpretability was enhanced using SHapley Additive exPlanations (SHAP), and a web-based calculator was deployed for clinical use.

Results: The LightGBM model identified six routine clinical parameters-Age, Lactate Dehydrogenase (LDH), Activated Partial Thromboplastin Time (APTT), Uric Acid (UA), Creatinine (CRE), and Body Temperature-as the most influential predictors. Integrating these features, the model achieved robust discrimination with an Area Under the Curve (AUC) of 0.960 in the training set and 0.938 in the internal validation set. Crucially, it maintained strong performance in two independent external validation cohorts (AUC 0.871 and 0.877). SHAP analysis revealed that Age and LDH were the strongest risk factors, while Temperature exhibited a non-linear relationship with mortality risk.

Conclusion: We developed and validated a high-performance, interpretable ML model for SFTS prognosis relying on only six readily available parameters. By deploying this parsimonious model as an online calculator, we provide a practical decision-support tool to facilitate early risk stratification and timely intervention, particularly in resource-limited settings.

背景:发热伴血小板减少综合征(SFTS)具有高死亡率和快速进展的特点,需要准确的早期预后来优化支持治疗。然而,目前的预测工具往往缺乏可解释性,需要在资源有限的地区无法获得的复杂测试,或者泛化能力差。本研究旨在开发一个可解释的、简洁的、可部署的机器学习模型,用于SFTS的早期死亡率预测。方法:我们分析了来自中国安徽三个医疗中心的834例SFTS患者的数据。使用衍生队列(n = 571)建立LightGBM模型,并在内部(n = 143)和两个独立的外部队列(n = 80和n = 183)上进行验证。使用SHapley加法解释(SHAP)增强了模型的可解释性,并部署了基于网络的计算器用于临床使用。结果:LightGBM模型确定了六个常规临床参数-年龄,乳酸脱氢酶(LDH),活化部分凝血活酶时间(APTT),尿酸(UA),肌酐(CRE)和体温-作为最具影响力的预测因素。综合这些特征,该模型实现了稳健的识别,训练集的曲线下面积(AUC)为0.960,内部验证集的AUC为0.938。关键是,它在两个独立的外部验证队列中保持了良好的性能(AUC分别为0.871和0.877)。SHAP分析显示,年龄和LDH是最强的危险因素,而温度与死亡风险呈非线性关系。结论:我们开发并验证了一个高性能、可解释的ML模型,该模型仅依赖于6个现成的参数来预测SFTS的预后。通过将这个简洁的模型作为在线计算器,我们提供了一个实用的决策支持工具,以促进早期风险分层和及时干预,特别是在资源有限的环境中。
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引用次数: 0
Heat and socioeconomic deprivation compound to drive coronary heart disease in Los Angeles. 高温和社会经济剥夺共同推动了洛杉矶的冠心病。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1784078
Shutong Huo, Tessa R Pulido, Reginald S Archer, Joshua B Fisher, Jason A Douglas

Background: Socioeconomic deprivation and environmental heat exposure each increase cardiovascular risk, yet evidence is limited on how these stressors co-occur and jointly shape disease burden within cities. Mapping their overlap can inform equity-oriented planning and needs-based allocation of health and social protection resources.

Methods: We conducted an ecological geospatial analysis of 2,513 census tracts in Los Angeles County. Adult coronary heart disease (CHD) prevalence was obtained from CDC Population Level Analysis and Community Estimates (2021). Socioeconomic deprivation was measured using the Social Deprivation Index (SDI), and heatwave surface heat hazard was measured using land surface temperature (LST) retrieved from the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station. We identified hot spots and overlaps using Getis-Ord Gi* statistics. Associations between SDI, LST, and CHD were estimated using z-score-standardized OLS regression with tract-level sociodemographic controls; we assessed spatial dependence and applied geographically weighted regression (GWR) with adaptive bandwidths to characterize spatial heterogeneity.

Results: CHD hot spots overlapped with high-deprivation and high-heat areas, concentrated in the south and east of Los Angeles County. In standardized OLS models (z-scored outcome and predictors), a 1-SD increase in SDI was associated with a 0.163-SD higher CHD prevalence (p < 0.001), and a 1-SD increase in LST was associated with a 0.070-SD higher CHD prevalence (p < 0.001). GWR revealed substantial geographic variation: the SDI-CHD association was strongest in central and southern tracts, whereas the LST-CHD association was strongest in central and eastern tracts, suggesting that dominant risk drivers and intervention priorities differ by neighborhood.

Conclusion: To address this, socioeconomic deprivation and urban heat indicators should be used to inform transparent resource allocation for chronic disease prevention and management. Neighborhoods with high deprivation and heat exposure should be prioritized for cooling infrastructure, home heat mitigation, and urban greening initiatives. Finally, public health, housing, and social services must work together to effectively address the structural drivers of cardiovascular disease disparities.

背景:社会经济剥夺和环境热暴露都会增加心血管风险,但关于这些压力因素如何共同发生并共同形成城市疾病负担的证据有限。绘制它们的重叠部分可以为面向公平的规划和基于需求的卫生和社会保护资源分配提供信息。方法:对洛杉矶县2513个人口普查区进行生态地理空间分析。成人冠心病(CHD)患病率来自CDC人口水平分析和社区估计(2021年)。利用社会剥夺指数(SDI)测量社会经济剥夺,利用空间站生态系统星载热辐射计实验获取的地表温度(LST)测量热浪地表热危害。我们使用Getis-Ord Gi*统计来确定热点和重叠。SDI、LST和CHD之间的关联使用z分数标准化OLS回归与区域水平的社会人口控制进行估计;我们评估了空间依赖性,并应用具有自适应带宽的地理加权回归(GWR)来表征空间异质性。结果:冠心病高发区与高剥夺区、高热区重叠,集中在洛杉矶县南部和东部。在标准化OLS模型(z评分结果和预测因子)中,SDI增加1个标准差与冠心病患病率升高0.163个标准差相关(p < 0.001), LST增加1个标准差与冠心病患病率升高0.070个标准差相关(p < 0.001)。GWR显示了显著的地理差异:sdi -冠心病相关性在中部和南部最强,而lst -冠心病相关性在中部和东部最强,这表明主要的风险驱动因素和干预重点因社区而异。结论:为了解决这一问题,应利用社会经济剥夺和城市热量指标为慢性病预防和管理提供透明的资源配置信息。高剥夺和热暴露的社区应优先考虑制冷基础设施,家庭热缓解和城市绿化举措。最后,公共卫生、住房和社会服务必须共同努力,有效解决心血管疾病差异的结构性驱动因素。
{"title":"Heat and socioeconomic deprivation compound to drive coronary heart disease in Los Angeles.","authors":"Shutong Huo, Tessa R Pulido, Reginald S Archer, Joshua B Fisher, Jason A Douglas","doi":"10.3389/fpubh.2026.1784078","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1784078","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic deprivation and environmental heat exposure each increase cardiovascular risk, yet evidence is limited on how these stressors co-occur and jointly shape disease burden within cities. Mapping their overlap can inform equity-oriented planning and needs-based allocation of health and social protection resources.</p><p><strong>Methods: </strong>We conducted an ecological geospatial analysis of 2,513 census tracts in Los Angeles County. Adult coronary heart disease (CHD) prevalence was obtained from CDC Population Level Analysis and Community Estimates (2021). Socioeconomic deprivation was measured using the Social Deprivation Index (SDI), and heatwave surface heat hazard was measured using land surface temperature (LST) retrieved from the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station. We identified hot spots and overlaps using Getis-Ord Gi<sup>*</sup> statistics. Associations between SDI, LST, and CHD were estimated using z-score-standardized OLS regression with tract-level sociodemographic controls; we assessed spatial dependence and applied geographically weighted regression (GWR) with adaptive bandwidths to characterize spatial heterogeneity.</p><p><strong>Results: </strong>CHD hot spots overlapped with high-deprivation and high-heat areas, concentrated in the south and east of Los Angeles County. In standardized OLS models (z-scored outcome and predictors), a 1-SD increase in SDI was associated with a 0.163-SD higher CHD prevalence (<i>p</i> < 0.001), and a 1-SD increase in LST was associated with a 0.070-SD higher CHD prevalence (<i>p</i> < 0.001). GWR revealed substantial geographic variation: the SDI-CHD association was strongest in central and southern tracts, whereas the LST-CHD association was strongest in central and eastern tracts, suggesting that dominant risk drivers and intervention priorities differ by neighborhood.</p><p><strong>Conclusion: </strong>To address this, socioeconomic deprivation and urban heat indicators should be used to inform transparent resource allocation for chronic disease prevention and management. Neighborhoods with high deprivation and heat exposure should be prioritized for cooling infrastructure, home heat mitigation, and urban greening initiatives. Finally, public health, housing, and social services must work together to effectively address the structural drivers of cardiovascular disease disparities.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1784078"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge attitude and practice of older adults rheumatoid arthritis patients regarding disease management in a cross-sectional study. 横断面研究中老年类风湿关节炎患者疾病管理的知识、态度和实践。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1763566
Yue Gou, Xuedan Shi, Ying Ouyang, Yan Wu, Rong He, Zhi Wan, Qibing Xie

Background: This study aimed to assess the knowledge, attitude, and practice (KAP) of older adults patients with rheumatoid arthritis (RA) regarding disease management.

Methods: This multicenter cross-sectional study enrolled older adults patients with RA between November and December 2024 in Sichuan Province, China. Self-administered questionnaires were utilized to collect demographic information and evaluate KAP scores.

Results: A total of 488 participants were included in the study, with 72.54% aged 60-69 years and 70.29% female. The mean KAP scores were 10.72 ± 4.68 (possible range: 0-20), 20.11 ± 2.31 (possible range: 6-30), and 25.05 ± 6.10 (possible range: 7-35), respectively. Spearman correlation analysis revealed that knowledge positively correlated with both attitude (r = 0.1293, p = 0.0042) and practice (r = 0.5037, p < 0.001), while attitude positively correlated with practice (r = 0.2066, p < 0.001). The structural equation model showed that knowledge directly affected attitude (β = -0.56, p < 0.001) and practice (β = 0.61, p < 0.001), while also indirectly affected practice through attitude mediation (β = 0.52, p < 0.001). Furthermore, attitude demonstrated a direct effect on practice (β = -0.93, p < 0.001).

Conclusion: This study found that older adults patients with RA generally exhibited insufficient knowledge and predominantly negative attitudes toward disease management, although many reported relatively proactive behaviors in managing their condition. Targeted educational interventions are necessary to improve knowledge and attitudes, which may further enhance disease management practices among older adults RA patients.

背景:本研究旨在评估老年类风湿关节炎(RA)患者在疾病管理方面的知识、态度和实践(KAP)。方法:这项多中心横断面研究招募了2024年11月至12月在中国四川省的老年RA患者。采用自填问卷收集人口统计信息并评估KAP得分。结果:共纳入488名受试者,其中年龄60-69岁 占72.54%,女性占70.29%。平均KAP评分分别为10.72 ± 4.68(可能范围0-20)、20.11 ± 2.31(可能范围6-30)和25.05 ± 6.10(可能范围7-35)。Spearman相关分析显示,知识与态度(r = 0.1293,p = 0.0042)和实践(r = 0.5037,pr = 0.2066,p β = -0.56,p β = 0.61,p β = 0.52,p β = -0.93,p)呈正相关。结论:本研究发现,老年RA患者普遍表现出对疾病管理知识不足,态度主要为消极,尽管许多患者在病情管理方面表现出相对积极的行为。有针对性的教育干预是必要的,以提高知识和态度,这可能进一步加强老年RA患者的疾病管理实践。
{"title":"Knowledge attitude and practice of older adults rheumatoid arthritis patients regarding disease management in a cross-sectional study.","authors":"Yue Gou, Xuedan Shi, Ying Ouyang, Yan Wu, Rong He, Zhi Wan, Qibing Xie","doi":"10.3389/fpubh.2026.1763566","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1763566","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the knowledge, attitude, and practice (KAP) of older adults patients with rheumatoid arthritis (RA) regarding disease management.</p><p><strong>Methods: </strong>This multicenter cross-sectional study enrolled older adults patients with RA between November and December 2024 in Sichuan Province, China. Self-administered questionnaires were utilized to collect demographic information and evaluate KAP scores.</p><p><strong>Results: </strong>A total of 488 participants were included in the study, with 72.54% aged 60-69 years and 70.29% female. The mean KAP scores were 10.72 ± 4.68 (possible range: 0-20), 20.11 ± 2.31 (possible range: 6-30), and 25.05 ± 6.10 (possible range: 7-35), respectively. Spearman correlation analysis revealed that knowledge positively correlated with both attitude (<i>r</i> = 0.1293, <i>p</i> = 0.0042) and practice (<i>r</i> = 0.5037, <i>p</i> < 0.001), while attitude positively correlated with practice (<i>r</i> = 0.2066, <i>p</i> < 0.001). The structural equation model showed that knowledge directly affected attitude (<i>β</i> = -0.56, <i>p</i> < 0.001) and practice (<i>β</i> = 0.61, <i>p</i> < 0.001), while also indirectly affected practice through attitude mediation (<i>β</i> = 0.52, <i>p</i> < 0.001). Furthermore, attitude demonstrated a direct effect on practice (<i>β</i> = -0.93, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This study found that older adults patients with RA generally exhibited insufficient knowledge and predominantly negative attitudes toward disease management, although many reported relatively proactive behaviors in managing their condition. Targeted educational interventions are necessary to improve knowledge and attitudes, which may further enhance disease management practices among older adults RA patients.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1763566"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stigmatization related experience among mothers of children with autism. 自闭症儿童母亲的污名化相关经历。
IF 3.4 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.3389/fpubh.2026.1746420
Otilia-Rodica Butiu, Delia-Andreea Nechifor, Teodora Popescu, Rebeca-Isabela Molnar, Adriana Mihai

Introductions: This study investigates the relationship between stigmatization and stress levels among mothers of children with autism spectrum disorder (ASD).

Methods: Using items from standardized psychometric tools, the study explores how emotional burden, social strain, and coping strategies contribute to parents' perceived stigma.

Results: Findings suggest that indirect measures of stigma through psychological assessment offer a more comprehensive understanding than direct questioning, which may elicit guarded responses.

简介:本研究探讨了自闭症谱系障碍(ASD)患儿母亲的污名化与应激水平的关系。方法:采用标准化心理测量工具,探讨情绪负担、社会压力和应对策略对父母污名感的影响。结果:研究结果表明,通过心理评估对病耻感的间接测量比直接询问提供了更全面的理解,这可能会引起谨慎的反应。
{"title":"Stigmatization related experience among mothers of children with autism.","authors":"Otilia-Rodica Butiu, Delia-Andreea Nechifor, Teodora Popescu, Rebeca-Isabela Molnar, Adriana Mihai","doi":"10.3389/fpubh.2026.1746420","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1746420","url":null,"abstract":"<p><strong>Introductions: </strong>This study investigates the relationship between stigmatization and stress levels among mothers of children with autism spectrum disorder (ASD).</p><p><strong>Methods: </strong>Using items from standardized psychometric tools, the study explores how emotional burden, social strain, and coping strategies contribute to parents' perceived stigma.</p><p><strong>Results: </strong>Findings suggest that indirect measures of stigma through psychological assessment offer a more comprehensive understanding than direct questioning, which may elicit guarded responses.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1746420"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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