Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1727508
Wang Qian, Chunming Chen, Baojian Wei
This study examines how bullying experiences are associated with retaliatory impulses among autistic university students, highlighting minority stress as a key mediating mechanism and sexual and gender minority (SGM) status as a moderating condition within an intersectional framework. Guided by Minority Stress Theory and Social Information Processing Theory, we surveyed 280 autistic undergraduates; 35% identified as SGM. Participants completed validated measures of bullying, minority stress, retaliatory impulse, and related psychosocial factors. Structural equation modeling and multi-group analyses were conducted to evaluate the proposed mediation and moderation patterns while adjusting for gender, grade level, social support, autistic traits, and internet use. The measurement model showed good reliability and convergent validity (Cronbach's α = 0.84-0.89; AVE = 0.62-0.69). Bullying was positively associated with minority stress, which was in turn associated with retaliatory impulses, supporting partial mediation [indirect effect = 0.42, 95% CI (0.36, 0.50)]. Multi-group results indicated stronger path coefficients in the SGM group (bullying → stress β = 0.72; stress → retaliation β = 0.66) than among non-SGM (heterosexual and cisgender) peers, consistent with the possibility that compounded stigma heightens emotional reactivity and defensive processing. Minority stress remained the strongest correlate of retaliatory impulses after covariate adjustment, whereas social support showed a protective association. Taken together, the findings suggest that retaliatory impulses among autistic students are better understood in relation to sustained identity-based exclusion and structural stressors rather than as simple dispositional aggression. The results also imply that effective prevention may require institutional and relational strategies-alongside individual support-such as inclusive curricula, peer sensitization, and policies that strengthen belonging and psychological safety in higher education.
{"title":"Bullying, minority stress and revenge impulse among autistic college students: group differences by sexual and gender minority status.","authors":"Wang Qian, Chunming Chen, Baojian Wei","doi":"10.3389/fpubh.2026.1727508","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1727508","url":null,"abstract":"<p><p>This study examines how bullying experiences are associated with retaliatory impulses among autistic university students, highlighting minority stress as a key mediating mechanism and sexual and gender minority (SGM) status as a moderating condition within an intersectional framework. Guided by Minority Stress Theory and Social Information Processing Theory, we surveyed 280 autistic undergraduates; 35% identified as SGM. Participants completed validated measures of bullying, minority stress, retaliatory impulse, and related psychosocial factors. Structural equation modeling and multi-group analyses were conducted to evaluate the proposed mediation and moderation patterns while adjusting for gender, grade level, social support, autistic traits, and internet use. The measurement model showed good reliability and convergent validity (Cronbach's <i>α</i> = 0.84-0.89; AVE = 0.62-0.69). Bullying was positively associated with minority stress, which was in turn associated with retaliatory impulses, supporting partial mediation [indirect effect = 0.42, 95% CI (0.36, 0.50)]. Multi-group results indicated stronger path coefficients in the SGM group (bullying → stress <i>β</i> = 0.72; stress → retaliation <i>β</i> = 0.66) than among non-SGM (heterosexual and cisgender) peers, consistent with the possibility that compounded stigma heightens emotional reactivity and defensive processing. Minority stress remained the strongest correlate of retaliatory impulses after covariate adjustment, whereas social support showed a protective association. Taken together, the findings suggest that retaliatory impulses among autistic students are better understood in relation to sustained identity-based exclusion and structural stressors rather than as simple dispositional aggression. The results also imply that effective prevention may require institutional and relational strategies-alongside individual support-such as inclusive curricula, peer sensitization, and policies that strengthen belonging and psychological safety in higher education.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1727508"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1781256
Ho Cheung William Li, Wei Xia, Hong Chen, Xinyi Xu, Laurie Long Kwan Ho, Hoi Yan Cora Mok, Oi Kwan Joyce Chung
Background: Tobacco use remains a leading cause of preventable morbidity and mortality worldwide. While smoking prevalence has recently declined in Hong Kong, progress has slowed. Plain packaging may reduce product appeal and enhance the impact of pictorial health warnings (PHWs), supporting reduced tobacco use.
Methods: A cross-sectional study was conducted from August to November 2023 among 1,256 adult smokers in Hong Kong. Participants were recruited at outdoor public smoking hotspots and shown branded and plain cigarette packs with 85% PHWs. Perceptions of pack attractiveness, noticeability of PHWs, smoking-related harm, behavioural intentions, and support for plain packaging were assessed through structured interviews. Quantitative data were weighted by age and sex, and qualitative responses were analysed thematically.
Results: Most participants perceived plain packs as less attractive (79.8%) and PHWs on plain packs were more noticeable (57.5%) than branded packs. About 45.1% perceived plain packs as disgusting, and 28.0% agreed they better conveyed severe smoking harms than branded packs. While only 17.3% reported plain packs may reduce their intention to smoke, 33.1% reported that it could deter youth from smoking. Support for plain packaging was moderate, with 35.7% in favour and 34.5% neutral. The qualitative findings reinforced these perceptions.
Conclusion: Smokers perceived plain packaging as less attractive, the PHWs on it as more noticeable, and potentially useful in preventing smoking initiation in youth. These findings support the integration of plain packaging into Hong Kong's tobacco control strategy and offer valuable insights for jurisdictions considering similar legislation.
{"title":"Strengthening tobacco control policy: using plain packaging to reduce product appeal and enhance public awareness.","authors":"Ho Cheung William Li, Wei Xia, Hong Chen, Xinyi Xu, Laurie Long Kwan Ho, Hoi Yan Cora Mok, Oi Kwan Joyce Chung","doi":"10.3389/fpubh.2026.1781256","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1781256","url":null,"abstract":"<p><strong>Background: </strong>Tobacco use remains a leading cause of preventable morbidity and mortality worldwide. While smoking prevalence has recently declined in Hong Kong, progress has slowed. Plain packaging may reduce product appeal and enhance the impact of pictorial health warnings (PHWs), supporting reduced tobacco use.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from August to November 2023 among 1,256 adult smokers in Hong Kong. Participants were recruited at outdoor public smoking hotspots and shown branded and plain cigarette packs with 85% PHWs. Perceptions of pack attractiveness, noticeability of PHWs, smoking-related harm, behavioural intentions, and support for plain packaging were assessed through structured interviews. Quantitative data were weighted by age and sex, and qualitative responses were analysed thematically.</p><p><strong>Results: </strong>Most participants perceived plain packs as less attractive (79.8%) and PHWs on plain packs were more noticeable (57.5%) than branded packs. About 45.1% perceived plain packs as disgusting, and 28.0% agreed they better conveyed severe smoking harms than branded packs. While only 17.3% reported plain packs may reduce their intention to smoke, 33.1% reported that it could deter youth from smoking. Support for plain packaging was moderate, with 35.7% in favour and 34.5% neutral. The qualitative findings reinforced these perceptions.</p><p><strong>Conclusion: </strong>Smokers perceived plain packaging as less attractive, the PHWs on it as more noticeable, and potentially useful in preventing smoking initiation in youth. These findings support the integration of plain packaging into Hong Kong's tobacco control strategy and offer valuable insights for jurisdictions considering similar legislation.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1781256"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1783458
Esarul Ayub, Olusiji Adebola Lasekan, Blessy Sarah Mathew, Margot Teresa Godoy Pena, Abdul Wahid Bhat
Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana (PM-JAY), the biggest publicly financed health insurance program in the world, has substantial use issues, especially in places like Jammu and Kashmir that are affected by conflict. Despite the program's goal of ensuring equal and cashless access to healthcare, the existing literature does not offer region-specific insights into the actual obstacles preventing its adoption. This study intends to identify and measure the physical, administrative, financial, and informational hurdles experiences by the beneficiaries in the urban and semi-rural areas of Jammu and Kashmir face when utilizing PM-JAY. Primary data was gathered through structured interviews with 320 randomly chosen PM-JAY recipients using a cross-sectional approach. To evaluate the relative effects of various obstacles on scheme use, the study used binary logistic regression, chi-square tests, Pearson correlation, and descriptive statistics. Despite being enrolled, only 48.4% of enrollees reported accessing PM-JAY services. The most significant positive predictors of usage were health literacy and awareness gaps, notably knowledge of empanelled hospital lists (OR = 1.245, p < 0.05) and awareness of scheme entitlement (OR = 1.253, p < 0.05). A statistically significant negative factor was inadequate road infrastructure (OR = 0.761, p < 0.05). Despite being often mentioned, administrative and financial obstacles were surprisingly not significant in the regression model. There were no discernible variations in use between the two districts, indicating problems with systemic access. Increasing PM-JAY use in disadvantaged areas requires more than just financial incentives; it also requires better physical infrastructure and informational availability. To convert coverage into useful access, policymakers should concentrate on region-specific IEC initiatives, transportation connectivity, and health system navigation support mechanisms. These interventions are essential for translating PM-JAY's theoretical coverage into meaningful, equitable healthcare access, particularly in underserved and fragile regions like Jammu and Kashmir.
世界上最大的公共资助医疗保险项目Ayushman bharatpradhan Mantri Jan Arogya Yojana (PM-JAY)在使用方面存在大量问题,特别是在查谟和克什米尔等受冲突影响的地区。尽管该计划的目标是确保平等和无现金获得医疗保健,但现有文献并没有提供具体区域的见解,以了解阻碍其采用的实际障碍。本研究旨在确定和衡量查谟和克什米尔城市和半农村地区的受益人在使用PM-JAY时面临的物质、行政、财务和信息障碍。采用横断面方法对随机选择的320名PM-JAY接受者进行结构化访谈,收集主要数据。为了评估各种障碍对方案使用的相对影响,研究使用了二元逻辑回归、卡方检验、Pearson相关和描述性统计。尽管注册了,但只有48.4%的注册者报告使用PM-JAY服务。使用率最显著的正向预测因子是健康素养和意识差距,特别是对入选医院名单的了解(OR = 1.245,p p p)
{"title":"Beyond coverage: why Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana struggles to deliver healthcare in Jammu and Kashmir.","authors":"Esarul Ayub, Olusiji Adebola Lasekan, Blessy Sarah Mathew, Margot Teresa Godoy Pena, Abdul Wahid Bhat","doi":"10.3389/fpubh.2026.1783458","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1783458","url":null,"abstract":"<p><p>Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana (PM-JAY), the biggest publicly financed health insurance program in the world, has substantial use issues, especially in places like Jammu and Kashmir that are affected by conflict. Despite the program's goal of ensuring equal and cashless access to healthcare, the existing literature does not offer region-specific insights into the actual obstacles preventing its adoption. This study intends to identify and measure the physical, administrative, financial, and informational hurdles experiences by the beneficiaries in the urban and semi-rural areas of Jammu and Kashmir face when utilizing PM-JAY. Primary data was gathered through structured interviews with 320 randomly chosen PM-JAY recipients using a cross-sectional approach. To evaluate the relative effects of various obstacles on scheme use, the study used binary logistic regression, chi-square tests, Pearson correlation, and descriptive statistics. Despite being enrolled, only 48.4% of enrollees reported accessing PM-JAY services. The most significant positive predictors of usage were health literacy and awareness gaps, notably knowledge of empanelled hospital lists (OR = 1.245, <i>p</i> < 0.05) and awareness of scheme entitlement (OR = 1.253, <i>p</i> < 0.05). A statistically significant negative factor was inadequate road infrastructure (OR = 0.761, <i>p</i> < 0.05). Despite being often mentioned, administrative and financial obstacles were surprisingly not significant in the regression model. There were no discernible variations in use between the two districts, indicating problems with systemic access. Increasing PM-JAY use in disadvantaged areas requires more than just financial incentives; it also requires better physical infrastructure and informational availability. To convert coverage into useful access, policymakers should concentrate on region-specific IEC initiatives, transportation connectivity, and health system navigation support mechanisms. These interventions are essential for translating PM-JAY's theoretical coverage into meaningful, equitable healthcare access, particularly in underserved and fragile regions like Jammu and Kashmir.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1783458"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1701162
Yanbin Hao, Dinglin Yu
Objective: Bacillary dysentery (BD) remains a public health concern in China, with its incidence influenced by multidimensional and interconnected factors. This study aimed to quantify the correlations between meteorological conditions, socioeconomic status, health resources, forest coverage, and BD incidence-an integrated analysis lacking in previous research. The results provide a comprehensive evidence base for formulating targeted BD prevention strategies.
Methods: Using panel data from 31 Chinese provinces (2014 ~ 2018), including BD incidence rates and 12 indicators of proxy variables at the ecological level, fixed-effects and random-effects models with Driscoll-Kraay robust standard errors were applied.
Results: The results of the random-effects model incorporating multidimensional factors showed that a 1% increase in the number of beds per 1,000 people in healthcare facilities, GDP per capita, and forest coverage was significantly associated with decreases in BD incidence rates of 2, 0.8, and 0.6%, respectively, (all p < 0.05). These findings indicate ecological associations with the incidence of BD across different provinces in China.
Conclusion: Improvements in regional investment in healthcare resources, economic development, and forest coverage were inversely associated with BD incidence, suggesting potential protective effects at the population level.
{"title":"Exploring the multidimensional factors associated with the incidence of bacillary dysentery in China based on a panel data model.","authors":"Yanbin Hao, Dinglin Yu","doi":"10.3389/fpubh.2026.1701162","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1701162","url":null,"abstract":"<p><strong>Objective: </strong>Bacillary dysentery (BD) remains a public health concern in China, with its incidence influenced by multidimensional and interconnected factors. This study aimed to quantify the correlations between meteorological conditions, socioeconomic status, health resources, forest coverage, and BD incidence-an integrated analysis lacking in previous research. The results provide a comprehensive evidence base for formulating targeted BD prevention strategies.</p><p><strong>Methods: </strong>Using panel data from 31 Chinese provinces (2014 ~ 2018), including BD incidence rates and 12 indicators of proxy variables at the ecological level, fixed-effects and random-effects models with Driscoll-Kraay robust standard errors were applied.</p><p><strong>Results: </strong>The results of the random-effects model incorporating multidimensional factors showed that a 1% increase in the number of beds per 1,000 people in healthcare facilities, GDP per capita, and forest coverage was significantly associated with decreases in BD incidence rates of 2, 0.8, and 0.6%, respectively, (all <i>p</i> < 0.05). These findings indicate ecological associations with the incidence of BD across different provinces in China.</p><p><strong>Conclusion: </strong>Improvements in regional investment in healthcare resources, economic development, and forest coverage were inversely associated with BD incidence, suggesting potential protective effects at the population level.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1701162"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Gendered voice perception is central to gender recognition and can be a major source of distress for transgender people, yet voice and voice therapy remain marginal in medical curricula. This study examined how a digital, experiential seminar using voice-feedback applications can foster medical students' understanding of gendered voice and transgender health.
Methods: We conducted a qualitative observational study within a 135-min online seminar, "Feminize Your Resonance!", embedded in a fourth-year public health module at the Medical University of Vienna. One hundred medical students used commercially available voice apps to experiment with their own pitch and resonance and submitted app screenshots and written reflections via an online learning platform. We applied a narrative analysis, based on narrative episodes in students' accounts, using a multi-stage coding process supported by qualitative data analysis software to map learning processes in several stages.
Results: Analysis yielded three interlinked themes-implicit voice awareness, technology engagement, and sharing transgender experience-organized into a five-phase learning journey from pre-existing discomfort with one's recorded voice to social awareness with voice challenges of transgender individuals. Students moved from internal, often negative, self-evaluation to critical appraisal of app algorithms, exploration of their own vocal plasticity, and perspective-taking on the challenges of gender-affirming voice transition.
Conclusion: Technologically mediated voice exploration can catalyze transformative learning about the role of voice in gender incongruence and support the development of affective and clinical competencies in medical education. Potentially the training facilitates communicating with transgender individuals empathically, not only related to transgender-affirming care but in all healthcare settings.
{"title":"From internal echoes to sharing experiences: transformative learning with voice apps to enhance transgender care literacy in medical students.","authors":"Susanne Gahbauer, Shamim Sherafat, Michaela Wagner-Menghin","doi":"10.3389/fpubh.2026.1767576","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1767576","url":null,"abstract":"<p><strong>Introduction: </strong>Gendered voice perception is central to gender recognition and can be a major source of distress for transgender people, yet voice and voice therapy remain marginal in medical curricula. This study examined how a digital, experiential seminar using voice-feedback applications can foster medical students' understanding of gendered voice and transgender health.</p><p><strong>Methods: </strong>We conducted a qualitative observational study within a 135-min online seminar, \"Feminize Your Resonance!\", embedded in a fourth-year public health module at the Medical University of Vienna. One hundred medical students used commercially available voice apps to experiment with their own pitch and resonance and submitted app screenshots and written reflections via an online learning platform. We applied a narrative analysis, based on narrative episodes in students' accounts, using a multi-stage coding process supported by qualitative data analysis software to map learning processes in several stages.</p><p><strong>Results: </strong>Analysis yielded three interlinked themes-implicit voice awareness, technology engagement, and sharing transgender experience-organized into a five-phase learning journey from pre-existing discomfort with one's recorded voice to social awareness with voice challenges of transgender individuals. Students moved from internal, often negative, self-evaluation to critical appraisal of app algorithms, exploration of their own vocal plasticity, and perspective-taking on the challenges of gender-affirming voice transition.</p><p><strong>Conclusion: </strong>Technologically mediated voice exploration can catalyze transformative learning about the role of voice in gender incongruence and support the development of affective and clinical competencies in medical education. Potentially the training facilitates communicating with transgender individuals empathically, not only related to transgender-affirming care but in all healthcare settings.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1767576"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<p><strong>Background: </strong>Instant messaging delivered through social platforms is increasingly used to support diabetes self-management. However, evidence remains difficult to interpret because trials vary widely in platform choice, intervention design, outcome constructs, and measurement instruments.</p><p><strong>Objective: </strong>To synthesize the effects of instant-messaging interventions for diabetes across pre-specified outcome domains, and to explore whether platform type, follow-up duration, and study size help explain variation in effect estimates.</p><p><strong>Methods: </strong>We searched seven databases (2010-2025) for randomized controlled trials in which diabetes interventions were primarily delivered via instant-messaging/social platforms. Outcomes were organized a priori into six domains: health behaviors, diabetes knowledge, attitudes/self-efficacy, glycemic outcomes, other clinical outcomes, and diabetes-related complications. Continuous outcomes were pooled as standardized mean differences (SMDs) and binary outcomes as risk ratios (RRs) using random-effects models (REML). To improve interpretability, we prioritized domain-level synthesis and performed platform-stratified pooling only when at least three effect sizes were available within a given domain. Heterogeneity was summarized using τ<sup>2</sup> and I<sup>2</sup>. Robustness was assessed using leave-one-out analyses; small-study effects were evaluated using funnel plots and Egger's test when ≥10 studies contributed to an analysis. Exploratory meta-regression examined follow-up duration and ln(sample size).</p><p><strong>Results: </strong>Twenty-three trials contributed 236 effect estimates. Overall pooled effects across all continuous and binary outcomes were close to null and statistically non-significant, with substantial heterogeneity. Domain-specific synthesis showed clearer patterns: diabetes knowledge demonstrated the largest pooled improvement (SMD = 1.065, 95% CI 0.185-1.944), glycemic outcomes improved on continuous measures (SMD = -0.519, 95% CI -0.719 to -0.319), and behavioral outcomes showed a small but significant benefit (SMD = 0.359, 95% CI 0.010-0.709). Attitudes/self-efficacy and other clinical outcomes were more heterogeneous and did not show clear pooled benefits. For complications (binary outcomes), the pooled estimate suggested a potential reduction in risk (RR = 0.67, 95% CI 0.44-1.00) based on three studies and should be interpreted cautiously. Platform-overview pooling of continuous outcomes suggested variability across platforms, with more consistently positive pooled effects for Facebook Messenger-based interventions than for WhatsApp or WeChat; however, platform-by-domain pooling was often not estimable because many platform-domain combinations contributed fewer than three effect sizes. Meta-regression did not identify a clear linear association of follow-up duration or ln(sample size) with effect size, and explained little heterogenei
背景:通过社交平台提供的即时通讯越来越多地用于支持糖尿病的自我管理。然而,证据仍然难以解释,因为试验在平台选择、干预设计、结果结构和测量工具方面存在很大差异。目的:综合即时通讯干预对糖尿病预先指定结果域的影响,并探讨平台类型、随访时间和研究规模是否有助于解释效果估计的差异。方法:我们检索了7个数据库(2010-2025),其中糖尿病干预主要通过即时通讯/社交平台提供的随机对照试验。结果被先验地分为六个领域:健康行为、糖尿病知识、态度/自我效能、血糖结果、其他临床结果和糖尿病相关并发症。使用随机效应模型(REML)将连续结果合并为标准化平均差异(SMDs),将二元结果合并为风险比(rr)。为了提高可解释性,我们优先考虑领域级综合,并仅在给定领域内至少有三个效应量可用时才进行平台分层池化。用τ2和I2总结异质性。鲁棒性评估采用留一分析;当≥10项研究参与分析时,使用漏斗图和Egger检验评估小研究效应。探索性meta回归检验了随访时间和ln(样本量)。结果:23项试验贡献了236个效应估计。所有连续和二元结果的总体合并效应接近于零,在统计上不显著,具有很大的异质性。特定领域综合显示出更清晰的模式:糖尿病知识显示出最大的综合改善(SMD = 1.065, 95% CI 0.185-1.944),血糖结果在连续测量中得到改善(SMD = -0.519, 95% CI -0.719至-0.319),行为结果显示出虽小但显著的改善(SMD = 0.359, 95% CI 0.010-0.709)。态度/自我效能感和其他临床结果的异质性更大,没有显示出明确的综合效益。对于并发症(二元结果),汇总估计表明基于三项研究的潜在风险降低(RR = 0.67, 95% CI 0.44-1.00),应谨慎解释。连续结果的平台总体汇总表明,平台之间存在差异,基于Facebook messenger的干预措施比基于WhatsApp或微信的干预措施具有更一致的积极汇总效应;然而,平台-领域池化通常无法估计,因为许多平台-领域组合贡献的效应量少于3个。meta回归没有发现随访时间或ln(样本量)与效应大小有明确的线性关联,并且解释了很少的异质性。结论:即时通讯对糖尿病的干预并没有产生明显有利的总体效果,但它们在行为结果和选定的临床终点上显示出可靠的益处。效果的变化似乎与干预设计和实施的差异更一致,而不仅仅是平台标签。未来的试验应该更详细地报告干预组件和维护策略,并评估交互式、护理集成的消息传递模型。系统评价注册:https://www.crd.york.ac.uk/PROSPERO/view/CRD420251079157,标识符:CRD420251079157。
{"title":"Instant messaging-based digital health interventions for diabetes management: a domain-structured systematic review and meta-analysis of randomized controlled trials.","authors":"Shan Chen, Emma Mirza Wati Mohamad, Arina Anis Azlan, Xixi Zhao","doi":"10.3389/fpubh.2026.1780625","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1780625","url":null,"abstract":"<p><strong>Background: </strong>Instant messaging delivered through social platforms is increasingly used to support diabetes self-management. However, evidence remains difficult to interpret because trials vary widely in platform choice, intervention design, outcome constructs, and measurement instruments.</p><p><strong>Objective: </strong>To synthesize the effects of instant-messaging interventions for diabetes across pre-specified outcome domains, and to explore whether platform type, follow-up duration, and study size help explain variation in effect estimates.</p><p><strong>Methods: </strong>We searched seven databases (2010-2025) for randomized controlled trials in which diabetes interventions were primarily delivered via instant-messaging/social platforms. Outcomes were organized a priori into six domains: health behaviors, diabetes knowledge, attitudes/self-efficacy, glycemic outcomes, other clinical outcomes, and diabetes-related complications. Continuous outcomes were pooled as standardized mean differences (SMDs) and binary outcomes as risk ratios (RRs) using random-effects models (REML). To improve interpretability, we prioritized domain-level synthesis and performed platform-stratified pooling only when at least three effect sizes were available within a given domain. Heterogeneity was summarized using τ<sup>2</sup> and I<sup>2</sup>. Robustness was assessed using leave-one-out analyses; small-study effects were evaluated using funnel plots and Egger's test when ≥10 studies contributed to an analysis. Exploratory meta-regression examined follow-up duration and ln(sample size).</p><p><strong>Results: </strong>Twenty-three trials contributed 236 effect estimates. Overall pooled effects across all continuous and binary outcomes were close to null and statistically non-significant, with substantial heterogeneity. Domain-specific synthesis showed clearer patterns: diabetes knowledge demonstrated the largest pooled improvement (SMD = 1.065, 95% CI 0.185-1.944), glycemic outcomes improved on continuous measures (SMD = -0.519, 95% CI -0.719 to -0.319), and behavioral outcomes showed a small but significant benefit (SMD = 0.359, 95% CI 0.010-0.709). Attitudes/self-efficacy and other clinical outcomes were more heterogeneous and did not show clear pooled benefits. For complications (binary outcomes), the pooled estimate suggested a potential reduction in risk (RR = 0.67, 95% CI 0.44-1.00) based on three studies and should be interpreted cautiously. Platform-overview pooling of continuous outcomes suggested variability across platforms, with more consistently positive pooled effects for Facebook Messenger-based interventions than for WhatsApp or WeChat; however, platform-by-domain pooling was often not estimable because many platform-domain combinations contributed fewer than three effect sizes. Meta-regression did not identify a clear linear association of follow-up duration or ln(sample size) with effect size, and explained little heterogenei","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1780625"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1776344
Qian Dai, Ji Guo, Liangfei Xu, Qiong Lu, He Chen, Yuanyuan Hu, Ying Wang, Tong Tong
Background: Severe Fever with Thrombocytopenia Syndrome (SFTS) is characterized by high mortality and rapid progression, necessitating accurate early prognosis to optimize supportive care. However, current predictive tools often lack interpretability, require sophisticated tests unavailable in resource-limited areas, or suffer from poor generalizability. This study aimed to develop an interpretable, parsimonious, and deployable machine learning model for early mortality prediction in SFTS.
Methods: We analyzed data from 834 SFTS patients across three medical centers in Anhui, China. A LightGBM model was developed using a derivation cohort (n = 571) and validated on internal (n = 143) and two independent external cohorts (n = 80 and n = 183). Model interpretability was enhanced using SHapley Additive exPlanations (SHAP), and a web-based calculator was deployed for clinical use.
Results: The LightGBM model identified six routine clinical parameters-Age, Lactate Dehydrogenase (LDH), Activated Partial Thromboplastin Time (APTT), Uric Acid (UA), Creatinine (CRE), and Body Temperature-as the most influential predictors. Integrating these features, the model achieved robust discrimination with an Area Under the Curve (AUC) of 0.960 in the training set and 0.938 in the internal validation set. Crucially, it maintained strong performance in two independent external validation cohorts (AUC 0.871 and 0.877). SHAP analysis revealed that Age and LDH were the strongest risk factors, while Temperature exhibited a non-linear relationship with mortality risk.
Conclusion: We developed and validated a high-performance, interpretable ML model for SFTS prognosis relying on only six readily available parameters. By deploying this parsimonious model as an online calculator, we provide a practical decision-support tool to facilitate early risk stratification and timely intervention, particularly in resource-limited settings.
{"title":"Early mortality risk prediction in severe fever with thrombocytopenia syndrome using an interpretable machine learning model based on routine clinical parameters.","authors":"Qian Dai, Ji Guo, Liangfei Xu, Qiong Lu, He Chen, Yuanyuan Hu, Ying Wang, Tong Tong","doi":"10.3389/fpubh.2026.1776344","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1776344","url":null,"abstract":"<p><strong>Background: </strong>Severe Fever with Thrombocytopenia Syndrome (SFTS) is characterized by high mortality and rapid progression, necessitating accurate early prognosis to optimize supportive care. However, current predictive tools often lack interpretability, require sophisticated tests unavailable in resource-limited areas, or suffer from poor generalizability. This study aimed to develop an interpretable, parsimonious, and deployable machine learning model for early mortality prediction in SFTS.</p><p><strong>Methods: </strong>We analyzed data from 834 SFTS patients across three medical centers in Anhui, China. A LightGBM model was developed using a derivation cohort (<i>n</i> = 571) and validated on internal (<i>n</i> = 143) and two independent external cohorts (<i>n</i> = 80 and <i>n</i> = 183). Model interpretability was enhanced using SHapley Additive exPlanations (SHAP), and a web-based calculator was deployed for clinical use.</p><p><strong>Results: </strong>The LightGBM model identified six routine clinical parameters-Age, Lactate Dehydrogenase (LDH), Activated Partial Thromboplastin Time (APTT), Uric Acid (UA), Creatinine (CRE), and Body Temperature-as the most influential predictors. Integrating these features, the model achieved robust discrimination with an Area Under the Curve (AUC) of 0.960 in the training set and 0.938 in the internal validation set. Crucially, it maintained strong performance in two independent external validation cohorts (AUC 0.871 and 0.877). SHAP analysis revealed that Age and LDH were the strongest risk factors, while Temperature exhibited a non-linear relationship with mortality risk.</p><p><strong>Conclusion: </strong>We developed and validated a high-performance, interpretable ML model for SFTS prognosis relying on only six readily available parameters. By deploying this parsimonious model as an online calculator, we provide a practical decision-support tool to facilitate early risk stratification and timely intervention, particularly in resource-limited settings.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1776344"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1784078
Shutong Huo, Tessa R Pulido, Reginald S Archer, Joshua B Fisher, Jason A Douglas
Background: Socioeconomic deprivation and environmental heat exposure each increase cardiovascular risk, yet evidence is limited on how these stressors co-occur and jointly shape disease burden within cities. Mapping their overlap can inform equity-oriented planning and needs-based allocation of health and social protection resources.
Methods: We conducted an ecological geospatial analysis of 2,513 census tracts in Los Angeles County. Adult coronary heart disease (CHD) prevalence was obtained from CDC Population Level Analysis and Community Estimates (2021). Socioeconomic deprivation was measured using the Social Deprivation Index (SDI), and heatwave surface heat hazard was measured using land surface temperature (LST) retrieved from the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station. We identified hot spots and overlaps using Getis-Ord Gi* statistics. Associations between SDI, LST, and CHD were estimated using z-score-standardized OLS regression with tract-level sociodemographic controls; we assessed spatial dependence and applied geographically weighted regression (GWR) with adaptive bandwidths to characterize spatial heterogeneity.
Results: CHD hot spots overlapped with high-deprivation and high-heat areas, concentrated in the south and east of Los Angeles County. In standardized OLS models (z-scored outcome and predictors), a 1-SD increase in SDI was associated with a 0.163-SD higher CHD prevalence (p < 0.001), and a 1-SD increase in LST was associated with a 0.070-SD higher CHD prevalence (p < 0.001). GWR revealed substantial geographic variation: the SDI-CHD association was strongest in central and southern tracts, whereas the LST-CHD association was strongest in central and eastern tracts, suggesting that dominant risk drivers and intervention priorities differ by neighborhood.
Conclusion: To address this, socioeconomic deprivation and urban heat indicators should be used to inform transparent resource allocation for chronic disease prevention and management. Neighborhoods with high deprivation and heat exposure should be prioritized for cooling infrastructure, home heat mitigation, and urban greening initiatives. Finally, public health, housing, and social services must work together to effectively address the structural drivers of cardiovascular disease disparities.
{"title":"Heat and socioeconomic deprivation compound to drive coronary heart disease in Los Angeles.","authors":"Shutong Huo, Tessa R Pulido, Reginald S Archer, Joshua B Fisher, Jason A Douglas","doi":"10.3389/fpubh.2026.1784078","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1784078","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic deprivation and environmental heat exposure each increase cardiovascular risk, yet evidence is limited on how these stressors co-occur and jointly shape disease burden within cities. Mapping their overlap can inform equity-oriented planning and needs-based allocation of health and social protection resources.</p><p><strong>Methods: </strong>We conducted an ecological geospatial analysis of 2,513 census tracts in Los Angeles County. Adult coronary heart disease (CHD) prevalence was obtained from CDC Population Level Analysis and Community Estimates (2021). Socioeconomic deprivation was measured using the Social Deprivation Index (SDI), and heatwave surface heat hazard was measured using land surface temperature (LST) retrieved from the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station. We identified hot spots and overlaps using Getis-Ord Gi<sup>*</sup> statistics. Associations between SDI, LST, and CHD were estimated using z-score-standardized OLS regression with tract-level sociodemographic controls; we assessed spatial dependence and applied geographically weighted regression (GWR) with adaptive bandwidths to characterize spatial heterogeneity.</p><p><strong>Results: </strong>CHD hot spots overlapped with high-deprivation and high-heat areas, concentrated in the south and east of Los Angeles County. In standardized OLS models (z-scored outcome and predictors), a 1-SD increase in SDI was associated with a 0.163-SD higher CHD prevalence (<i>p</i> < 0.001), and a 1-SD increase in LST was associated with a 0.070-SD higher CHD prevalence (<i>p</i> < 0.001). GWR revealed substantial geographic variation: the SDI-CHD association was strongest in central and southern tracts, whereas the LST-CHD association was strongest in central and eastern tracts, suggesting that dominant risk drivers and intervention priorities differ by neighborhood.</p><p><strong>Conclusion: </strong>To address this, socioeconomic deprivation and urban heat indicators should be used to inform transparent resource allocation for chronic disease prevention and management. Neighborhoods with high deprivation and heat exposure should be prioritized for cooling infrastructure, home heat mitigation, and urban greening initiatives. Finally, public health, housing, and social services must work together to effectively address the structural drivers of cardiovascular disease disparities.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1784078"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1763566
Yue Gou, Xuedan Shi, Ying Ouyang, Yan Wu, Rong He, Zhi Wan, Qibing Xie
Background: This study aimed to assess the knowledge, attitude, and practice (KAP) of older adults patients with rheumatoid arthritis (RA) regarding disease management.
Methods: This multicenter cross-sectional study enrolled older adults patients with RA between November and December 2024 in Sichuan Province, China. Self-administered questionnaires were utilized to collect demographic information and evaluate KAP scores.
Results: A total of 488 participants were included in the study, with 72.54% aged 60-69 years and 70.29% female. The mean KAP scores were 10.72 ± 4.68 (possible range: 0-20), 20.11 ± 2.31 (possible range: 6-30), and 25.05 ± 6.10 (possible range: 7-35), respectively. Spearman correlation analysis revealed that knowledge positively correlated with both attitude (r = 0.1293, p = 0.0042) and practice (r = 0.5037, p < 0.001), while attitude positively correlated with practice (r = 0.2066, p < 0.001). The structural equation model showed that knowledge directly affected attitude (β = -0.56, p < 0.001) and practice (β = 0.61, p < 0.001), while also indirectly affected practice through attitude mediation (β = 0.52, p < 0.001). Furthermore, attitude demonstrated a direct effect on practice (β = -0.93, p < 0.001).
Conclusion: This study found that older adults patients with RA generally exhibited insufficient knowledge and predominantly negative attitudes toward disease management, although many reported relatively proactive behaviors in managing their condition. Targeted educational interventions are necessary to improve knowledge and attitudes, which may further enhance disease management practices among older adults RA patients.
{"title":"Knowledge attitude and practice of older adults rheumatoid arthritis patients regarding disease management in a cross-sectional study.","authors":"Yue Gou, Xuedan Shi, Ying Ouyang, Yan Wu, Rong He, Zhi Wan, Qibing Xie","doi":"10.3389/fpubh.2026.1763566","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1763566","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the knowledge, attitude, and practice (KAP) of older adults patients with rheumatoid arthritis (RA) regarding disease management.</p><p><strong>Methods: </strong>This multicenter cross-sectional study enrolled older adults patients with RA between November and December 2024 in Sichuan Province, China. Self-administered questionnaires were utilized to collect demographic information and evaluate KAP scores.</p><p><strong>Results: </strong>A total of 488 participants were included in the study, with 72.54% aged 60-69 years and 70.29% female. The mean KAP scores were 10.72 ± 4.68 (possible range: 0-20), 20.11 ± 2.31 (possible range: 6-30), and 25.05 ± 6.10 (possible range: 7-35), respectively. Spearman correlation analysis revealed that knowledge positively correlated with both attitude (<i>r</i> = 0.1293, <i>p</i> = 0.0042) and practice (<i>r</i> = 0.5037, <i>p</i> < 0.001), while attitude positively correlated with practice (<i>r</i> = 0.2066, <i>p</i> < 0.001). The structural equation model showed that knowledge directly affected attitude (<i>β</i> = -0.56, <i>p</i> < 0.001) and practice (<i>β</i> = 0.61, <i>p</i> < 0.001), while also indirectly affected practice through attitude mediation (<i>β</i> = 0.52, <i>p</i> < 0.001). Furthermore, attitude demonstrated a direct effect on practice (<i>β</i> = -0.93, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This study found that older adults patients with RA generally exhibited insufficient knowledge and predominantly negative attitudes toward disease management, although many reported relatively proactive behaviors in managing their condition. Targeted educational interventions are necessary to improve knowledge and attitudes, which may further enhance disease management practices among older adults RA patients.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1763566"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09eCollection Date: 2026-01-01DOI: 10.3389/fpubh.2026.1746420
Otilia-Rodica Butiu, Delia-Andreea Nechifor, Teodora Popescu, Rebeca-Isabela Molnar, Adriana Mihai
Introductions: This study investigates the relationship between stigmatization and stress levels among mothers of children with autism spectrum disorder (ASD).
Methods: Using items from standardized psychometric tools, the study explores how emotional burden, social strain, and coping strategies contribute to parents' perceived stigma.
Results: Findings suggest that indirect measures of stigma through psychological assessment offer a more comprehensive understanding than direct questioning, which may elicit guarded responses.
{"title":"Stigmatization related experience among mothers of children with autism.","authors":"Otilia-Rodica Butiu, Delia-Andreea Nechifor, Teodora Popescu, Rebeca-Isabela Molnar, Adriana Mihai","doi":"10.3389/fpubh.2026.1746420","DOIUrl":"https://doi.org/10.3389/fpubh.2026.1746420","url":null,"abstract":"<p><strong>Introductions: </strong>This study investigates the relationship between stigmatization and stress levels among mothers of children with autism spectrum disorder (ASD).</p><p><strong>Methods: </strong>Using items from standardized psychometric tools, the study explores how emotional burden, social strain, and coping strategies contribute to parents' perceived stigma.</p><p><strong>Results: </strong>Findings suggest that indirect measures of stigma through psychological assessment offer a more comprehensive understanding than direct questioning, which may elicit guarded responses.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"14 ","pages":"1746420"},"PeriodicalIF":3.4,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}