Gastroenterology最新文献

{"title":"Reply.","authors":"Roupen Djinbachian, Douglas K Rex, Daniel Von Renteln","doi":"10.1053/j.gastro.2024.08.023","DOIUrl":"10.1053/j.gastro.2024.08.023","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1496-1497"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Implementation of a Clinical Decision Support Tool to Improve Adherence to Colonoscopy Follow-Up Guidelines.","authors":"Brian A Sullivan, Hochong Gilles, Lyndsey Knauf, Steve S Choi, Jill Moore, Jason A Dominitz","doi":"10.1053/j.gastro.2024.08.004","DOIUrl":"10.1053/j.gastro.2024.08.004","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1446-1448.e4"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Anna-Klara Wiklund, Giola Santoni, Jesper Lagergren","doi":"10.1053/j.gastro.2024.09.018","DOIUrl":"10.1053/j.gastro.2024.09.018","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1508-1509"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Cancer-Induced Metabolic Dysregulation Syndrome: Clinical Profile, Proposed Mechanisms, and Unanswered Questions.","authors":"LaNisha Patterson, Frederico G S Toledo, Anirban Maitra, Suresh T Chari","doi":"10.1053/j.gastro.2024.08.029","DOIUrl":"10.1053/j.gastro.2024.08.029","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1251-1255"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Research on Helicobacter pylori Eradication and Esophageal Adenocarcinoma Risk: A Call for Broader Studies and Methodological Rigor.","authors":"Xiaolong Guo, Yongfeng Wang, Hui Cai","doi":"10.1053/j.gastro.2024.08.042","DOIUrl":"10.1053/j.gastro.2024.08.042","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1506-1507"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions for Improving Quality of Colonoscopy.","authors":"Qing-Hua Wang, Min Zhang, Hua Chen, Wei Han","doi":"10.1053/j.gastro.2024.05.040","DOIUrl":"10.1053/j.gastro.2024.05.040","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1509-1510"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cause of Hepatic Mass With High Metabolic Activity and Jaundice.","authors":"Tao Zeng, Jing Xiong, Xinhua Li","doi":"10.1053/j.gastro.2024.06.020","DOIUrl":"10.1053/j.gastro.2024.06.020","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1274-1277"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With a Blood Test That Meets the Centers for Medicare & Medicaid Services Coverage Decision\".","authors":"Amar K Das, Craig Eagle, AmirAli Talasaz","doi":"10.1053/j.gastro.2024.05.038","DOIUrl":"10.1053/j.gastro.2024.05.038","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1502-1503"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Enterotype-Dependent Stability of the Gut Microbiome on Postgastrectomy Malnutrition in Gastric Cancer Patients.","authors":"Han Na Oh, Woo Jun Sul, Sang-Yong Son, Sang-Uk Han, Hoon Hur, Sun Gyo Lim","doi":"10.1053/j.gastro.2024.08.006","DOIUrl":"10.1053/j.gastro.2024.08.006","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1449-1452.e3"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases.","authors":"Joseph J Zhao, Chin-Ann Johnny Ong, Supriya Srivastava, Daryl Kai Ann Chia, Haoran Ma, Kiekyon Huang, Taotao Sheng, Kalpana Ramnarayanan, Xuewen Ong, Su Ting Tay, Takeshi Hagihara, Angie Lay Keng Tan, Melissa Ching Ching Teo, Qiu Xuan Tan, Gillian Ng, Joey Wee-Shan Tan, Matthew Chau Hsien Ng, Yong Xiang Gwee, Robert Walsh, Jia Hao Law, Asim Shabbir, Guowei Kim, Yvonne Tay, Zhisheng Her, Giuseppe Leoncini, Bin Tean Teh, Jing Han Hong, Ryan Yong Kiat Tay, Chong Boon Teo, Mark P G Dings, Maarten Bijlsma, Jeffrey Huey Yew Lum, Sachin Mathur, Filippo Pietrantonio, Steven M Blum, Hanneke van Laarhoven, Samuel J Klempner, Wei Peng Yong, Jimmy Bok Yan So, Qingfeng Chen, Patrick Tan, Raghav Sundar","doi":"10.1053/j.gastro.2024.08.007","DOIUrl":"10.1053/j.gastro.2024.08.007","url":null,"abstract":"<p><strong>Background & aims: </strong>Peritoneal metastasis (PM) in gastric cancer (GC) is associated with poor prognosis and significant morbidity. We sought to understand the genomic, transcriptomic, and tumor microenvironment (TME) features that contribute to peritoneal organotropism in GC.</p><p><strong>Methods: </strong>We conducted a comprehensive multi-omic analysis of 548 samples from 326 patients, including primary tumors, matched normal tissues; peritoneal metastases, and adjacent-normal peritoneal tissues. We used whole exome sequencing, whole transcriptome sequencing, and digital spatial profiling to investigate molecular alterations, gene expression patterns, and TME characteristics associated with PM.</p><p><strong>Results: </strong>Our analysis identified specific genomic alterations in primary tumors, including mutations in ELF3, CDH1, and PIGR, and TME signatures, such as stromal infiltration and M2 macrophage enrichment, associated with increased risk of PM. We observed distinct transcriptional programs and immune compositions in GCPM compared with liver metastases, highlighting the importance of the TME in transcoelomic metastasis. We found differential expression of therapeutic targets between primary tumors and PM, with lower CLDN18.2 and FGFR2b expression in PM. We unravel the roles of the TME in niche reprogramming within the peritoneum, and provide evidence of pre-metastatic niche conditioning even in early GC without clinical PM. These findings were further validated using a humanized mouse model, which demonstrated niche remodeling in the peritoneum during transcoelomic metastasis.</p><p><strong>Conclusion: </strong>Our study provides a comprehensive molecular characterization of GCPM and unveils key biological principles underlying transcoelomic metastasis. The identified predictive markers, therapeutic targets, and TME alterations offer potential avenues for targeted interventions and improved patient outcomes.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1384-1398.e4"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}