Gastroenterology最新文献

{"title":"Treating Multiple Food Allergies With Omalizumab.","authors":"Marianna Arvanitakis","doi":"10.1053/j.gastro.2024.07.011","DOIUrl":"10.1053/j.gastro.2024.07.011","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1491-1492"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Research Strategy and Inclusion Criteria of Long-term Proton Pump Inhibitor Use.","authors":"Yanqing Niu, Xiaherezhati Aihaiti, Man Li","doi":"10.1053/j.gastro.2024.07.047","DOIUrl":"10.1053/j.gastro.2024.07.047","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1494"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Pattern Linking to Intestinal Microbial Characteristics and Colorectal Cancer Risk.","authors":"Jun Sun","doi":"10.1053/j.gastro.2024.08.012","DOIUrl":"10.1053/j.gastro.2024.08.012","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1264-1265"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acquisition of Epithelial Plasticity and the Potential Origins of Biphenotypic Cells in Chronic Liver Injury.","authors":"Stefani Tica, Brian Debosch","doi":"10.1053/j.gastro.2024.07.022","DOIUrl":"10.1053/j.gastro.2024.07.022","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1492-1493"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forging a Career in Digital Health Research.","authors":"Robert P Hirten","doi":"10.1053/j.gastro.2024.07.013","DOIUrl":"10.1053/j.gastro.2024.07.013","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1260-1263"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Search for the Ideal Weight Loss Drug: Targeting NTS-GLP1R Neurons for Satiety Without Aversion.","authors":"Lin Y Hung, Kara Gross Margolis","doi":"10.1053/j.gastro.2024.07.031","DOIUrl":"10.1053/j.gastro.2024.07.031","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1493"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Integrated Stress Response in Pancreatic Development, Tissue Homeostasis, and Cancer.","authors":"Greg Malnassy, Leah Ziolkowski, Kay F Macleod, Scott A Oakes","doi":"10.1053/j.gastro.2024.05.009","DOIUrl":"10.1053/j.gastro.2024.05.009","url":null,"abstract":"<p><p>Present in all eukaryotic cells, the integrated stress response (ISR) is a highly coordinated signaling network that controls cellular behavior, metabolism, and survival in response to diverse stresses. The ISR is initiated when any 1 of 4 stress-sensing kinases (protein kinase R-like endoplasmic reticulum kinase [PERK], general control non-derepressible 2 [GCN2], double-stranded RNA-dependent protein kinase [PKR], heme-regulated eukaryotic translation initiation factor 2α kinase [HRI]) becomes activated to phosphorylate the protein translation initiation factor eukaryotic translation initiation factor 2α (eIF2α), shifting gene expression toward a comprehensive rewiring of cellular machinery to promote adaptation. Although the ISR has been shown to play an important role in the homeostasis of multiple tissues, evidence suggests that it is particularly crucial for the development and ongoing health of the pancreas. Among the most synthetically dynamic tissues in the body, the exocrine and endocrine pancreas relies heavily on the ISR to rapidly adjust cell function to meet the metabolic demands of the organism. The hardwiring of the ISR into normal pancreatic functions and adaptation to stress may explain why it is a commonly used pro-oncogenic and therapy-resistance mechanism in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine tumors. Here, we review what is known about the key roles that the ISR plays in the development, homeostasis, and neoplasia of the pancreas.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1292-1306"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk.","authors":"Kai Wang, Chun-Han Lo, Raaj S Mehta, Long H Nguyen, Yiqing Wang, Wenjie Ma, Tomotaka Ugai, Hidetaka Kawamura, Satoko Ugai, Yasutoshi Takashima, Kosuke Mima, Kota Arima, Kazuo Okadome, Marios Giannakis, Cynthia L Sears, Jeffrey A Meyerhardt, Kimmie Ng, Nicola Segata, Jacques Izard, Eric B Rimm, Wendy S Garrett, Curtis Huttenhower, Edward L Giovannucci, Andrew T Chan, Shuji Ogino, Mingyang Song","doi":"10.1053/j.gastro.2024.07.040","DOIUrl":"10.1053/j.gastro.2024.07.040","url":null,"abstract":"<p><strong>Background & aims: </strong>Epidemiologic evidence for dietary influence on colorectal cancer (CRC) risk through the gut microbiome remains limited.</p><p><strong>Methods: </strong>Leveraging 307 men and 212 women with stool metagenomes and dietary data, we characterized and validated a sex-specific dietary pattern associated with the CRC-related gut microbial signature (CRC Microbial Dietary Score [CMDS]). We evaluated the associations of CMDS with CRC risk according to Fusobacterium nucleatum, pks⁺Escherichia coli, and enterotoxigenic Bacteroides fragilis status in tumor tissue using Cox proportional hazards regression in the Health Professionals Follow-Up Study (1986-2018), Nurses' Health Study (1984-2020), and Nurses' Health Study II (1991-2019).</p><p><strong>Results: </strong>The CMDS was characterized by high industrially processed food and low unprocessed fiber-rich food intakes. In 259,200 participants, we documented 3854 incident CRC cases over 6,467,378 person-years of follow-up. CMDS was associated with a higher risk of CRC (P_trend < .001), with a multivariable hazard ratio (HR_{Q5 vs Q1}) of 1.25 (95% CI, 1.13-1.39). The association remained after adjusting for previously established dietary patterns, for example, the Western and prudent diets. Notably, the association was stronger for tumoral F nucleatum-positive (HR_{Q5 vs Q1}, 2.51; 95% CI, 1.68-3.75; P_trend < .001; P_{heterogeneity} = .03, positivity vs negativity), pks⁺E coli-positive (HR_{Q5 vs Q1}, 1.68; 95% CI, 0.84-3.38; P_trend = .005; P_{heterogeneity} = .01, positivity vs negativity), and enterotoxigenic Bacteroides fragilis-positive CRC (HR_{Q5 vs Q1}, 2.06; 95% CI, 1.10-3.88; P_trend = .016; P_{heterogeneity} = .06, positivity vs negativity), compared with their negative counterparts.</p><p><strong>Conclusions: </strong>CMDS was associated with increased CRC risk, especially for tumors with detectable F nucleatum, pks⁺E coli, and enterotoxigenic Bacteroides fragilis in tissue. Our findings support a potential role of the gut microbiome underlying the dietary effects on CRC.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1371-1383.e4"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Hanseul Kim, Long H Nguyen","doi":"10.1053/j.gastro.2024.09.020","DOIUrl":"10.1053/j.gastro.2024.09.020","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1494-1495"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Small Bowel Crohn's Disease Strictures: To Cut, to Stretch, or to Treat Inflammation?","authors":"Cathy Lu, Brian G Feagan, Joel G Fletcher, Mark Baker, Stefan Holubar, Florian Rieder","doi":"10.1053/j.gastro.2024.08.030","DOIUrl":"10.1053/j.gastro.2024.08.030","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":"1283-1291.e1"},"PeriodicalIF":25.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}