Pub Date : 2026-03-20DOI: 10.1053/j.gastro.2026.03.009
Helen Burton-Murray, Imran Aziz
No Abstract
没有抽象的
{"title":"Reply to letters on ARFID and Disorders of Gut-Brain Interaction","authors":"Helen Burton-Murray, Imran Aziz","doi":"10.1053/j.gastro.2026.03.009","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.03.009","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"13 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1053/s0016-5085(26)00163-0
No Abstract
没有抽象的
{"title":"Elsewhere in the AGA Journals (Preview Section)","authors":"","doi":"10.1053/s0016-5085(26)00163-0","DOIUrl":"https://doi.org/10.1053/s0016-5085(26)00163-0","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"9 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on “The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in Adults with Disorders of Gut-Brain Interaction”","authors":"Weiping Huang, Lidan Mao, Yunfei Chen, Yabo Wenren","doi":"10.1053/j.gastro.2025.09.054","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.09.054","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"146 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147495302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1053/j.gastro.2025.09.055
Ziyi Feng, Minhao Li, Shu Guo
No Abstract
没有抽象的
{"title":"An Appraisal of ARFID Screening and Management in Disorders of Gut-Brain Interaction","authors":"Ziyi Feng, Minhao Li, Shu Guo","doi":"10.1053/j.gastro.2025.09.055","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.09.055","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"6 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-19DOI: 10.1053/j.gastro.2025.11.029
Pankaj Jay Pasricha
No Abstract
没有抽象的
{"title":"What do our patients need: more physiological understanding or more psychological labels?","authors":"Pankaj Jay Pasricha","doi":"10.1053/j.gastro.2025.11.029","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.11.029","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"146 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-18DOI: 10.1053/j.gastro.2026.01.026
Chiara Manuli, Elisa Pose, Juan Pablo Arab, Jeffrey V Lazarus, Hugo López-Pelayo, Ramon Bataller
{"title":"Alcohol Industry Influence on Public View and Policymaking: Implications for Liver Health.","authors":"Chiara Manuli, Elisa Pose, Juan Pablo Arab, Jeffrey V Lazarus, Hugo López-Pelayo, Ramon Bataller","doi":"10.1053/j.gastro.2026.01.026","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.01.026","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1053/j.gastro.2026.03.007
Christianne J. Buskens, Willem A. Bemelman
{"title":"Interpreting a Negative Trial in Complex Perianal Crohn’s Disease: The End of Allogenic stem cell treatment for fistula patients?","authors":"Christianne J. Buskens, Willem A. Bemelman","doi":"10.1053/j.gastro.2026.03.007","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.03.007","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"20 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1053/j.gastro.2026.02.030
Sarah A. Najjar, Helene Kildegaard, Ardesheer Talati, Priscila Dib Goncalves, Andrew Del Colle, Zixing Huang, Yan Tong, Daniel Juarez, Rahi Shah, Erfaneh Barati, Taeseon Woo, Melissa Medina, Narek Israelyan, Marguerite Bernard, Ruxandra Tonea, Michelle Ovchinsky, Noa Pesner, Roey Ringel, Luisa Valdetaro, Mette Bliddal, Kara G. Margolis
Background & Aims
Adverse experiences during early life can disrupt gut-brain axis development, but the mechanisms linking early life stress (ELS) to long-term gastrointestinal (GI) dysmotility and pain remain unclear.
Methods
We used a maternal separation (MS) mouse model of ELS and assessed visceral pain sensitivity, intestinal motility, and enteric nervous system (ENS) composition. Two large human pediatric population cohorts were also analyzed for associations between early life stress and DGBI risk.
Results
MS in mice led to visceral hypersensitivity, sex-specific motility defects, and altered ENS composition, including increased serotonergic innervation and changes in subtype-specific neuronal proportions. Degarelix-mediated suppression of gonadal hormones reversed MS-induced visceral pain and motility defects, implicating sex hormones in long-term gut changes. MS led to enhanced sympathetic innervation of the ENS and chemical sympathectomy restored normal motility, suggesting sympathetic overactivity in ELS-related gut dysfunction. In humans, significant associations between maternal mental health problems and pediatric disorders of gut-brain interaction (DGBI) were observed in both cohorts, mirroring preclinical findings.
Conclusion
These results identify ELS-driven changes in enteric, sensory, and sympathetic pathways as contributors to DGBI risk and offer insight into potential therapeutic targets.
{"title":"Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings with Human Correlation","authors":"Sarah A. Najjar, Helene Kildegaard, Ardesheer Talati, Priscila Dib Goncalves, Andrew Del Colle, Zixing Huang, Yan Tong, Daniel Juarez, Rahi Shah, Erfaneh Barati, Taeseon Woo, Melissa Medina, Narek Israelyan, Marguerite Bernard, Ruxandra Tonea, Michelle Ovchinsky, Noa Pesner, Roey Ringel, Luisa Valdetaro, Mette Bliddal, Kara G. Margolis","doi":"10.1053/j.gastro.2026.02.030","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.02.030","url":null,"abstract":"<h3>Background & Aims</h3>Adverse experiences during early life can disrupt gut-brain axis development, but the mechanisms linking early life stress (ELS) to long-term gastrointestinal (GI) dysmotility and pain remain unclear.<h3>Methods</h3>We used a maternal separation (MS) mouse model of ELS and assessed visceral pain sensitivity, intestinal motility, and enteric nervous system (ENS) composition. Two large human pediatric population cohorts were also analyzed for associations between early life stress and DGBI risk.<h3>Results</h3>MS in mice led to visceral hypersensitivity, sex-specific motility defects, and altered ENS composition, including increased serotonergic innervation and changes in subtype-specific neuronal proportions. Degarelix-mediated suppression of gonadal hormones reversed MS-induced visceral pain and motility defects, implicating sex hormones in long-term gut changes. MS led to enhanced sympathetic innervation of the ENS and chemical sympathectomy restored normal motility, suggesting sympathetic overactivity in ELS-related gut dysfunction. In humans, significant associations between maternal mental health problems and pediatric disorders of gut-brain interaction (DGBI) were observed in both cohorts, mirroring preclinical findings.<h3>Conclusion</h3>These results identify ELS-driven changes in enteric, sensory, and sympathetic pathways as contributors to DGBI risk and offer insight into potential therapeutic targets.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"12 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1053/j.gastro.2026.02.035
Sare Verstockt, Julian Schwärzler, Peter Willeit, Gabriele Bislenghi, Moritz Meyer, Lisa Mayr, Kathleen Machiels, Gert De Hertogh, Matthias Lenfant, Laura Scheffauer, Felix Grabherr, Deborah Sarah Jans, Saeed Abdurahiman, Isabelle Cleynen, Almina Jukic, Luis Zundel, Patrizia Moser, Lukas Forer, Martina Witsch-Baumgartner, Marc Ferrante, João Sabino, André D’Hoore, Michael Hess, Arthur Kaser, Richard S. Blumberg, Robert Koch, Lionel Le Bourhis, Nassim Hammoudi, Dominique Cazals-Hatem, Séverine Vermeire, Herbert Tilg, Matthieu Allez, Bram Verstockt, Timon E. Adolph
Molecular phenotyping of Crohn’s disease (CD) trajectories after ileocolonic resection (ICR) enables the identification of evolving disease mechanisms and related biomarker discovery. Here, we aimed at identifying a pathogenic node with predictive value for endoscopic disease recurrence after ICR in CD.
{"title":"Identification of a druggable target that predicts postoperative Crohn’s disease recurrence","authors":"Sare Verstockt, Julian Schwärzler, Peter Willeit, Gabriele Bislenghi, Moritz Meyer, Lisa Mayr, Kathleen Machiels, Gert De Hertogh, Matthias Lenfant, Laura Scheffauer, Felix Grabherr, Deborah Sarah Jans, Saeed Abdurahiman, Isabelle Cleynen, Almina Jukic, Luis Zundel, Patrizia Moser, Lukas Forer, Martina Witsch-Baumgartner, Marc Ferrante, João Sabino, André D’Hoore, Michael Hess, Arthur Kaser, Richard S. Blumberg, Robert Koch, Lionel Le Bourhis, Nassim Hammoudi, Dominique Cazals-Hatem, Séverine Vermeire, Herbert Tilg, Matthieu Allez, Bram Verstockt, Timon E. Adolph","doi":"10.1053/j.gastro.2026.02.035","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.02.035","url":null,"abstract":"Molecular phenotyping of Crohn’s disease (CD) trajectories after ileocolonic resection (ICR) enables the identification of evolving disease mechanisms and related biomarker discovery. Here, we aimed at identifying a pathogenic node with predictive value for endoscopic disease recurrence after ICR in CD.","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"130 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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