Hypouricemia is a condition which refers to hyper-uric acid clearance due to a defect in renal tubular transport. It is considered as a hereditary renal problem. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury and reduced kidney function. Although avoiding exercise is considered as the best preventive measure, there are many kinds of jobs that require occupational exercise. A 32-year-old male physical trainer suffered from stage 3 Acute Kidney Injury after performing a 18-m multistage shuttle run test. His father had previously been diagnosed as having renal hypouricemia at another facility. The patient had reported having hypouricemia during a health check, but his serum uric acid concentration was within the normal range at our hospital. After treatment, he recovered from exercise-induced acute kidney injury and exhibited low serum uric acid and hyper-uric acid clearance. Since the patient desired to continue his career requiring strenuous exercise, it was difficult to propose a preventive plan against the recurrence of exercise-induced acute kidney injury. Patients suffering with hereditary renal hypouricemia are at higher risk of developing Acute Kidney Injury when undergo strenuous occupational anaerobic exercise than other workers. Hence the risks of exercise-induced acute kidney injury among patients with hypouricemia should be considered when undergoing physical occupational training.
{"title":"A Case Study on Exercise-Induced Acute Kidney Injury - Test","authors":"B. Archana","doi":"10.26452/fjphs.v2i1.137","DOIUrl":"https://doi.org/10.26452/fjphs.v2i1.137","url":null,"abstract":"Hypouricemia is a condition which refers to hyper-uric acid clearance due to a defect in renal tubular transport. It is considered as a hereditary renal problem. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury and reduced kidney function. Although avoiding exercise is considered as the best preventive measure, there are many kinds of jobs that require occupational exercise. A 32-year-old male physical trainer suffered from stage 3 Acute Kidney Injury after performing a 18-m multistage shuttle run test. His father had previously been diagnosed as having renal hypouricemia at another facility. The patient had reported having hypouricemia during a health check, but his serum uric acid concentration was within the normal range at our hospital. After treatment, he recovered from exercise-induced acute kidney injury and exhibited low serum uric acid and hyper-uric acid clearance. Since the patient desired to continue his career requiring strenuous exercise, it was difficult to propose a preventive plan against the recurrence of exercise-induced acute kidney injury. Patients suffering with hereditary renal hypouricemia are at higher risk of developing Acute Kidney Injury when undergo strenuous occupational anaerobic exercise than other workers. Hence the risks of exercise-induced acute kidney injury among patients with hypouricemia should be considered when undergoing physical occupational training. ","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77850965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Original Test title","authors":"Gnana Prakash","doi":"10.26452/fjphs.v2i1.163","DOIUrl":"https://doi.org/10.26452/fjphs.v2i1.163","url":null,"abstract":"Test abstract","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90674747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2","authors":"G. Prakash","doi":"10.26452/fjphs.v1i4.205","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.205","url":null,"abstract":"<jats:p>q</jats:p>","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73419278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 21 years old male with complaints of erythematous erosive lesions, itchy and burning sensation all over the body for 5 days and multiple erythematous maculopapular lesions on palms and soles, erosive mucosal lesions in oral mucosa, erosive erythematous lesions on the scrotum, discharge from the eye, blurring of vision and redness in both the eyes. The patient was evaluated by three local doctors but not fully diagnosed. The lesions started after taking antidepressant selective serotonin reuptake inhibitor (SSRI’S) which was Lamotrigine, along with this Aripiprazole-Atypical antidepressant and Desfenlafaxine-a serotonin and norepinephrine reuptake inhibitor (SNRI’S) was taken, it was prescribed by a psychologist who thought the patient is depressed, but the patient was inactive due to anemia. The initial dose of Lamotrigine is 25mg per day which can be managed further based on symptoms, but the patient was directly started with 100mg half tablet for 8days along with one 200mg of lamotrigine at night. The patient was not made aware of drug-related information like it’s side effects, improper drug usage and what if dose is missed. After taking patient history and examination the diagnosis was made to be Lamotrigine induced Steven Johnson syndrome (SJS). The patient was not depressed and he was not active as he was anemic. After correct diagnosis, the management was done with a corticosteroid, antihistamines, Pantoprazole, and antibiotic along with mouthwash and eye drops. The recovery period was of 40 days.
{"title":"A Case Report: Lamotrigine Induced Steven Johnson Syndrome","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.202","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.202","url":null,"abstract":"A 21 years old male with complaints of erythematous erosive lesions, itchy and burning sensation all over the body for 5 days and multiple erythematous maculopapular lesions on palms and soles, erosive mucosal lesions in oral mucosa, erosive erythematous lesions on the scrotum, discharge from the eye, blurring of vision and redness in both the eyes. The patient was evaluated by three local doctors but not fully diagnosed. The lesions started after taking antidepressant selective serotonin reuptake inhibitor (SSRI’S) which was Lamotrigine, along with this Aripiprazole-Atypical antidepressant and Desfenlafaxine-a serotonin and norepinephrine reuptake inhibitor (SNRI’S) was taken, it was prescribed by a psychologist who thought the patient is depressed, but the patient was inactive due to anemia. The initial dose of Lamotrigine is 25mg per day which can be managed further based on symptoms, but the patient was directly started with 100mg half tablet for 8days along with one 200mg of lamotrigine at night. The patient was not made aware of drug-related information like it’s side effects, improper drug usage and what if dose is missed. After taking patient history and examination the diagnosis was made to be Lamotrigine induced Steven Johnson syndrome (SJS). The patient was not depressed and he was not active as he was anemic. After correct diagnosis, the management was done with a corticosteroid, antihistamines, Pantoprazole, and antibiotic along with mouthwash and eye drops. The recovery period was of 40 days.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74351388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study mucoadhesive buccal tablets of Olmesartan can be used to bypass the extensive hepatic first-pass metabolism and improve the bioavailability. The mucoadhesive Buccal tablets of Olmesartan are a drug of choice in the treatment of high blood pressure, heart failure, and diabetic kidneys. The FTIR results revealed that there was no interaction between drugs and other excipients. All the post-compression parameter was within acceptable limits. The in vitro drug release was in the range of 85.35% to 99.65% after 8 hrs the very best regression integrity (r) the best fit role model for F1 to F8 used to be zero-order and for F9 it was Higuchi matrix.
{"title":"Formulation Design and Evaluation of Olmesartan Mucoadhesive Buccal Tablets","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.184","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.184","url":null,"abstract":"The present study mucoadhesive buccal tablets of Olmesartan can be used to bypass the extensive hepatic first-pass metabolism and improve the bioavailability. The mucoadhesive Buccal tablets of Olmesartan are a drug of choice in the treatment of high blood pressure, heart failure, and diabetic kidneys. The FTIR results revealed that there was no interaction between drugs and other excipients. All the post-compression parameter was within acceptable limits. The in vitro drug release was in the range of 85.35% to 99.65% after 8 hrs the very best regression integrity (r) the best fit role model for F1 to F8 used to be zero-order and for F9 it was Higuchi matrix.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84885201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hand-washing is significant in agriculture, housekeeping, and in addition vital in houses and daycare plans. The artificial handwash formulations an effort antiquated entice formulate a polyherbal hand wash victimization extract of Sida cardifolia, Azadirachta indica, aloe vera gel, and lemon juice. The pH of hand wash was ranging from 6.36 to 6.88. The handwash formulations were ranges from 56 cp to 62 cp. The formulation planned out along with lemon juice displayed the best antimicrobial utilization than the formulation while not lemon juice. The stableness reports no change in pH & Viscosity referred to in the formulations. The effects of the present work support the internalization as well as utilization of herbs in the formulation to help give better results.
{"title":"Development and Pre-Clinical Evaluation of Polyherbal Hand Wash","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.176","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.176","url":null,"abstract":"Hand-washing is significant in agriculture, housekeeping, and in addition vital in houses and daycare plans. The artificial handwash formulations an effort antiquated entice formulate a polyherbal hand wash victimization extract of Sida cardifolia, Azadirachta indica, aloe vera gel, and lemon juice. The pH of hand wash was ranging from 6.36 to 6.88. The handwash formulations were ranges from 56 cp to 62 cp. The formulation planned out along with lemon juice displayed the best antimicrobial utilization than the formulation while not lemon juice. The stableness reports no change in pH & Viscosity referred to in the formulations. The effects of the present work support the internalization as well as utilization of herbs in the formulation to help give better results.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74049633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Generic medicines are identical/ clone to an innovator or product brand name. After expiration of patent terms of the innovator product, other pharmaceutical companies usually apply to the drug regulatory bodies for approval to market the generic versions of the innovator's drugs. Generic drugs in the market were sold under the non-proprietary name or brand name. Drugs and medicines form a significant portion of out of pocket (OOP) expenses in Indian households. In order to resolve this issue, Government of India launched Jan Aushadhi Scheme (JAS) to provide inexpensive generic drugs to the patients. A separate interview was conducted for the illiterate people and Google forms were forwarded through whatsapp for literates, both contain the same questions to exclude the bias. The collected data was analysed and converted to graphs/ pie charts and the collected data was documented. Our study concludes that by using the questionnaire, the total patients (n= 500) were interviewed, different ages of people were included(15 to above 50).15-30 age group 29.2%, 31-49 age group 39.8%, above 50 age group 31% were involved. Male 60.4%, Female 39.4%, literate 47.4%, illiterate 52.6%, rural 49%, urban 51% were involved. A standard survey form/data collection sheet for both rural and urban population was used. Both literates and illiterates in rural and urban population almost 49% preferred branded drugs due to brand trust, quality, efficacy, and nearly 38% purchase medications based on the availability and remaining 13% preferred generic due to various reasons like cost effectiveness, same as branded quality and effectiveness.
{"title":"Perception of rural and urban population on generic and branded drugs","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.175","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.175","url":null,"abstract":"Generic medicines are identical/ clone to an innovator or product brand name. After expiration of patent terms of the innovator product, other pharmaceutical companies usually apply to the drug regulatory bodies for approval to market the generic versions of the innovator's drugs. Generic drugs in the market were sold under the non-proprietary name or brand name. Drugs and medicines form a significant portion of out of pocket (OOP) expenses in Indian households. In order to resolve this issue, Government of India launched Jan Aushadhi Scheme (JAS) to provide inexpensive generic drugs to the patients. A separate interview was conducted for the illiterate people and Google forms were forwarded through whatsapp for literates, both contain the same questions to exclude the bias. The collected data was analysed and converted to graphs/ pie charts and the collected data was documented. Our study concludes that by using the questionnaire, the total patients (n= 500) were interviewed, different ages of people were included(15 to above 50).15-30 age group 29.2%, 31-49 age group 39.8%, above 50 age group 31% were involved. Male 60.4%, Female 39.4%, literate 47.4%, illiterate 52.6%, rural 49%, urban 51% were involved. A standard survey form/data collection sheet for both rural and urban population was used. Both literates and illiterates in rural and urban population almost 49% preferred branded drugs due to brand trust, quality, efficacy, and nearly 38% purchase medications based on the availability and remaining 13% preferred generic due to various reasons like cost effectiveness, same as branded quality and effectiveness.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80901150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this research, Anethum graveolens which is an aromatic plant that contains essential oils which have non-polar and polar components which are evaluated for their anti-oxidant property through in-vitro assays. Herbs have different chemical constituents that include the unique functions of ownership of different pharmacological activities. Extraction is the technique to extract the active constituents and phytochemical lead moiety from the crude plant. Anethum graveolens is an aromatic herb used in herbal medicine in India. An excess of flavonoids is known to have antioxidant properties in this herb. Traditionally has been used to cure and avoid illness, and the natural compounds in the plant have been used to treat other diseases. Anethum graveolens aerial parts of the plant have been extracted by using ethanol and chloroform by three separate extraction methods such as Soxhletion, Ultra-sound, and Microwave have been performed. Ultrasonic extraction was found to be the best extraction method, and ethanol was found to be the best solvent for flavonoids. Thus having a good antioxidant property.
{"title":"A Comparative Study on Effectiveness of Various Extraction Techniques Affecting the Anti-Oxidant Property of Anethum graveolens","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.201","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.201","url":null,"abstract":"\u0000In this research, Anethum graveolens which is an aromatic plant that contains essential oils which have non-polar and polar components which are evaluated for their anti-oxidant property through in-vitro assays. Herbs have different chemical constituents that include the unique functions of ownership of different pharmacological activities. Extraction is the technique to extract the active constituents and phytochemical lead moiety from the crude plant. Anethum graveolens is an aromatic herb used in herbal medicine in India. An excess of flavonoids is known to have antioxidant properties in this herb. Traditionally has been used to cure and avoid illness, and the natural compounds in the plant have been used to treat other diseases. Anethum graveolens aerial parts of the plant have been extracted by using ethanol and chloroform by three separate extraction methods such as Soxhletion, Ultra-sound, and Microwave have been performed. Ultrasonic extraction was found to be the best extraction method, and ethanol was found to be the best solvent for flavonoids. Thus having a good antioxidant property. \u0000","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91226546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The report planned to design plus valuate mucoadhesive buccal patches of Metoclopramide for orthopedic treatment of pain and inflammations. All eight formulation acquire numerous evaluation parameters, it used to be complete for which F1 confirmed good mucoadhesive strength, encouraging pressurized and arrant drug release, easiest In-vivo residence time, swelling index and pH shows the best formulation. The acquired in vivo effects show that the put concentration of Metoclopramide in the mouth cavity was retained above 5 pg/mE for 130 min. The effect stands for so the buccal patches of metoclopramide could be a good choice to avoid the unsatisfactory systemic unwanted effects and will be planned as a new therapeutic tool around against orthopedic diseases and disturbances.
{"title":"Formulation and In Vitro/In Vivo Evaluation of Metoclopramide Mucoadhesive Buccal Patches for Effective Pain Management","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.190","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.190","url":null,"abstract":"The report planned to design plus valuate mucoadhesive buccal patches of Metoclopramide for orthopedic treatment of pain and inflammations. All eight formulation acquire numerous evaluation parameters, it used to be complete for which F1 confirmed good mucoadhesive strength, encouraging pressurized and arrant drug release, easiest In-vivo residence time, swelling index and pH shows the best formulation. The acquired in vivo effects show that the put concentration of Metoclopramide in the mouth cavity was retained above 5 pg/mE for 130 min. The effect stands for so the buccal patches of metoclopramide could be a good choice to avoid the unsatisfactory systemic unwanted effects and will be planned as a new therapeutic tool around against orthopedic diseases and disturbances.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80744949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study aimed to formulate and evaluate clotrimazole topical gel. Clotrimazole topical gel was prepared by dispersion method by utilizing various gelling agents like Carbopol 934p, HPMC K100, and Sodium alginate in three different ratios to achieve desired drug release. Prepared six gel formulations of clotrimazole were evaluated for pH, Viscosity, Drug content, Drug diffusion studies, and Drug release kinetic studies. The Drug-polymer compatibility reports have been done by FTIR absences of extraneous interactions among excipients. CTZGF4 releases 99.53% of the drug at the end of 8 hours and was considered as the best formulation. Therefore, formulations containing Carbopol produced better results than other formulations.
{"title":"Clotrimazole Loaded Topical Gels: Formulation, Development and In-vitro Evaluation","authors":"Gnana Prakash","doi":"10.26452/fjphs.v1i4.174","DOIUrl":"https://doi.org/10.26452/fjphs.v1i4.174","url":null,"abstract":"The present study aimed to formulate and evaluate clotrimazole topical gel. Clotrimazole topical gel was prepared by dispersion method by utilizing various gelling agents like Carbopol 934p, HPMC K100, and Sodium alginate in three different ratios to achieve desired drug release. Prepared six gel formulations of clotrimazole were evaluated for pH, Viscosity, Drug content, Drug diffusion studies, and Drug release kinetic studies. The Drug-polymer compatibility reports have been done by FTIR absences of extraneous interactions among excipients. CTZGF4 releases 99.53% of the drug at the end of 8 hours and was considered as the best formulation. Therefore, formulations containing Carbopol produced better results than other formulations.","PeriodicalId":12614,"journal":{"name":"Future Journal of Pharmaceuticals and Health Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90202834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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