Objective: To explore the psychological status and influencing factors of the public during the COVID-19 outbreak in 2019, and to provide a basis for psychological health interventions. Method: A cross-sectional survey was conducted using online questionnaires from January 31 to February 2, 2020. A survey was conducted on adults affected by the epidemic in various parts of China. The questionnaire included demographic data, anxiety, psychological resilience, and a self-designed stressor scale, and was conducted using χ Perform statistical analysis using 2-test and logistic regression analysis. A total of 4827 valid questionnaires were obtained, with an average age of (32.3 ± 10.0) years. Women accounted for 67.7%, only 7.9% had a history of exposure to Hubei, and 14.8% had suspected or confirmed cases in the community. The average score of GAD-7 is 6.29 ± 5.48, and the incidence of moderate to severe anxiety is 22.6%. Using moderate to severe anxiety as the dependent variable, logistic regression analysis found that there is a moderate to high understanding of COVID-19 (OR: 2.74-7.97, P). Conclusion: Overattention to COVID-19 information and perception of transmission risk during the outbreak of the epidemic will increase the risk of anxiety. The public generally experiences anxiety, and psychological intervention should be strengthened to increase social support and improve psychological resilience.
{"title":"Public anxiety and its influencing factors in the initial outbreak of COVID-19","authors":"陈苏虹, Chen Su-hong, 戴俊明, Dai Jun-ming, 胡俏, H. Qiao, 陈浩, Chen Hao, 王一, Wang Yi, 高俊岭, Gao Junling, 郑频频, Zheng Pin-pin, 傅华, Fu Hua","doi":"10.3969/J.ISSN.1672-8467.2020.03.012","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2020.03.012","url":null,"abstract":"目的探索2019冠状病毒病（COVID-19）暴发疫情下公众的心理状况及影响因素，为心理健康干预提供依据。 方法自2020年1月31日至2月2日采用线上问卷开展横断面调查。以中国各地受疫情影响的成年人为调查对象，问卷包括人口学资料、焦虑情况、心理弹性与自拟压力源量表，并采用χ2检验与Logistic回归分析进行统计分析。 结果共获得4 827份有效问卷，平均年龄（32.3±10.0）岁，女性占67.7%，有湖北暴露史者仅占7.9%，而小区有疑似或确诊病例者占14.8%。GAD-7平均得分为6.29±5.48，中重度焦虑现患率为22.6%。以中重度焦虑为因变量，Logistic回归分析发现对COVID-19有中、高等了解（OR：2.74~7.97，P 结论疫情暴发下对COVID-19信息的过度关注和对传播风险的感知会增加焦虑风险。公众普遍出现焦虑，应当加强心理干预，增加社会支持并提高心理弹性。","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48031399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To understand the level of public media exposure and mental health status in sudden public health events, and to provide a basis for optimizing the channels of health communication and the content and direction of health education. Method: A cross-sectional study was used to design and distribute a structured self filled electronic questionnaire. Information on public media exposure, health behavior cognition, and mental health status of Chinese citizens aged ≥ 18 years old was collected online from January 31 to February 2, 2020. apply χ 2 tests and logistic regression were used for statistical analysis. A total of 4827 valid questionnaires were collected, with males accounting for 32.3% and those currently residing in Hubei accounting for 2.7%. The age range was 18-85 years old, with an average of (32.32 ± 9.98) years old. 38.4% and 22.7% of the media exposed to epidemic information for more than 3 hours and less than 1 hour per day, respectively. The proportion of anxiety is 53.3%, the proportion of severe anxiety is 9.6%, and the proportion of depression is 48.3%. The higher the media exposure, the more comprehensive the preventive measures are（ ρ= 0.091, P Conclusion: Media exposure can affect the public's mental health, increase the risk of anxiety and depression. While preventing and controlling the epidemic, attention should be paid to counseling the public's mental health.
{"title":"2019冠状病毒病（COVID-19)疫情期间公众媒体暴露及其与心理健康的关系","authors":"高俊岭 陈浩 毛一蒙 陈苏虹 戴俊明 郑频频 傅华 王一","doi":"10.3969/J.ISSN.1672-8467.2020.02.005","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2020.02.005","url":null,"abstract":"目的了解突发公共卫生事件中公众媒体暴露程度与心理健康状态，为健康传播途径和健康教育内容与方向的优化提供依据。 方法采用横断面研究，设计并发放结构化自填电子问卷，于2020年1月31日-2月2日通过网络收集≥ 18岁中国公民的公众媒体暴露、健康行为认知情况、心理健康状态等信息。使用χ2检验和Logistic回归进行统计分析。 结果共收集有效问卷4 827份，其中男性占32.3%，现居湖北者占2.7%，年龄18~85岁，平均（32.32±9.98）岁。疫情信息媒体暴露在每天3 h以上和1 h以下的分别占38.4%和22.7%。焦虑比例为53.3%，重度焦虑比例为9.6%，抑郁比例为48.3%。媒体暴露越高，预防措施越完备（ρ=0.091，P 结论媒体暴露会影响公众心理健康，增加焦虑、抑郁风险，在防控疫情的同时要注重对公众心理健康的疏导。","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"47 1","pages":"173-178"},"PeriodicalIF":0.0,"publicationDate":"2020-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44951544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-25DOI: 10.3969/J.ISSN.1672-8467.2019.01.004
Meng-han Li, Xue-mei Ding, Jian Liang
ObjectiveTo develop a method for the determination and impurity analysis of vitamin D3 soft capsules with soybean oil matrix in reverse phase high performance liquid chromatography (RP-HPLC) system. MethodsRP-HPLC system had Agilent Zorbax Eclipse XDB-C18 column (4.6 mm × 250 mm, 5 μm) with detection wavelength of 265 nm, column temperature of 25 ℃ and flow rate of 1 mL/min. Retention behaviors of vitamin D3 and its 3 isomers were studied by altering the mobile phase. Firstly, acetonitrile was mixed with different proportions of methanol, water and ethanol as the mobile phase to investigate the effects of these 4 mobile phase components on the retention behavior of vitamin D3 and its 3 main related substances (isomers) on a C18 column. Then, a suitable mobile phase was selected for content determination and impurity analysis according to the retention behavior study. ResultsThe recovery was only 80.55%-84.37% with 100% acetonitrile as the mobile phase.The addition of ethanol in acetonitrile was found to make remarkably significant improvement. Recovery rate was achieved between 98.07% and 103.23% with V (acetonitrile):V (ethanol)=90:10 as the mobile phase, while improving peak shape. The method showed good linearity [(0.52-5.2)×10-4 μmol/L, R2>0.999] and fine density (RSD < 2.32%) which can be used for determination. For impurities profile, it could be achieved using V (acetonitrile):V (water)=95:5 as the mobile phase which can obviate interference from soybean oil matrix. ConclusionsThe method established in this experiment can easily and accurately determine the content and impurity analysis of vitamin D3 soft capsules with soybean oil matrix in a RP-HPLC system.
{"title":"Reverse phase high-performance liquid chromatography (RP-HPLC) system for analysis of vitamin D3 soft capsules with soybean oil matrix","authors":"Meng-han Li, Xue-mei Ding, Jian Liang","doi":"10.3969/J.ISSN.1672-8467.2019.01.004","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2019.01.004","url":null,"abstract":"ObjectiveTo develop a method for the determination and impurity analysis of vitamin D3 soft capsules with soybean oil matrix in reverse phase high performance liquid chromatography (RP-HPLC) system.\u0000\u0000 MethodsRP-HPLC system had Agilent Zorbax Eclipse XDB-C18 column (4.6 mm × 250 mm, 5 μm) with detection wavelength of 265 nm, column temperature of 25 ℃ and flow rate of 1 mL/min. Retention behaviors of vitamin D3 and its 3 isomers were studied by altering the mobile phase. Firstly, acetonitrile was mixed with different proportions of methanol, water and ethanol as the mobile phase to investigate the effects of these 4 mobile phase components on the retention behavior of vitamin D3 and its 3 main related substances (isomers) on a C18 column. Then, a suitable mobile phase was selected for content determination and impurity analysis according to the retention behavior study.\u0000 ResultsThe recovery was only 80.55%-84.37% with 100% acetonitrile as the mobile phase.The addition of ethanol in acetonitrile was found to make remarkably significant improvement. Recovery rate was achieved between 98.07% and 103.23% with V (acetonitrile):V (ethanol)=90:10 as the mobile phase, while improving peak shape. The method showed good linearity [(0.52-5.2)×10-4 μmol/L, R2>0.999] and fine density (RSD < 2.32%) which can be used for determination. For impurities profile, it could be achieved using V (acetonitrile):V (water)=95:5 as the mobile phase which can obviate interference from soybean oil matrix.\u0000\u0000 ConclusionsThe method established in this experiment can easily and accurately determine the content and impurity analysis of vitamin D3 soft capsules with soybean oil matrix in a RP-HPLC system.","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"1 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2019-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47411789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-25DOI: 10.3969/J.ISSN.1672-8467.2017.06.013
Yi Xiao, Yizhou Jiang, Z. Shao
{"title":"Precision medicine in breast cancer research","authors":"Yi Xiao, Yizhou Jiang, Z. Shao","doi":"10.3969/J.ISSN.1672-8467.2017.06.013","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2017.06.013","url":null,"abstract":"","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"44 1","pages":"765-772"},"PeriodicalIF":0.0,"publicationDate":"2017-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47122016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-25DOI: 10.3969/J.ISSN.1672-8467.2017.06.017
Zhenguo Chen, Yan Xu
{"title":"Resolution revolution: advances and prospects of cryo-EM in structural biology","authors":"Zhenguo Chen, Yan Xu","doi":"10.3969/J.ISSN.1672-8467.2017.06.017","DOIUrl":"https://doi.org/10.3969/J.ISSN.1672-8467.2017.06.017","url":null,"abstract":"","PeriodicalId":12635,"journal":{"name":"Fudan University Journal of Medical Sciences","volume":"44 1","pages":"799-805"},"PeriodicalIF":0.0,"publicationDate":"2017-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42176356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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