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GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.suppl-4
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引用次数: 0
尿酸は肺動脈の内皮依存性弛緩反応を阻害し肺動脈性肺高血圧症モデルラットの病態を増悪させる 尿酸抑制肺动脉的内皮依赖性松弛反应，使肺动脉性肺高血压病模型鼠的病情恶化。
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.90
M. Tanaka, Kotaro Abe, Hiroyuki Tsutsui
{"title":"尿酸は肺動脈の内皮依存性弛緩反応を阻害し肺動脈性肺高血圧症モデルラットの病態を増悪させる","authors":"M. Tanaka, Kotaro Abe, Hiroyuki Tsutsui","doi":"10.6032/gnam.42.90","DOIUrl":"https://doi.org/10.6032/gnam.42.90","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87600991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
新規選択的XDH/XO阻害薬Topiroxostatがラット虚血心臓における急性虚血再灌流障害に及ぼす影響 新型选择性XDH/XO抑制剂Topiroxostat对大鼠缺血心脏急性缺血再灌注障碍的影响
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.117
S. Tanno, Kenshiro Yamamoto, Maya Adachi, J. Miake, Kazuhide Ogino, Y. Shirayoshi, Kazuhiro Yamamoto, Ichiro Hisatome
{"title":"新規選択的XDH/XO阻害薬Topiroxostatがラット虚血心臓における急性虚血再灌流障害に及ぼす影響","authors":"S. Tanno, Kenshiro Yamamoto, Maya Adachi, J. Miake, Kazuhide Ogino, Y. Shirayoshi, Kazuhiro Yamamoto, Ichiro Hisatome","doi":"10.6032/gnam.42.117","DOIUrl":"https://doi.org/10.6032/gnam.42.117","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73034924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
通常量の補液でも痛風発作を引き起こした1例 正常量的补液也引起痛风发作的1例
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.121
Shinichiro Asakawa, Y. Tsubokawa, Chikayuki Morimoto, Yoshikazu Nemoto, Sawako Kobayashi, Michito Nagura, Yoshifuru Tamura, Shigeru Shibata, Y. Fujigaki, S. Uchida
{"title":"通常量の補液でも痛風発作を引き起こした1例","authors":"Shinichiro Asakawa, Y. Tsubokawa, Chikayuki Morimoto, Yoshikazu Nemoto, Sawako Kobayashi, Michito Nagura, Yoshifuru Tamura, Shigeru Shibata, Y. Fujigaki, S. Uchida","doi":"10.6032/gnam.42.121","DOIUrl":"https://doi.org/10.6032/gnam.42.121","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74690056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
理事長あいさつ 理事长致词
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.suppl-i
Takanori Ueda
{"title":"理事長あいさつ","authors":"Takanori Ueda","doi":"10.6032/gnam.42.suppl-i","DOIUrl":"https://doi.org/10.6032/gnam.42.suppl-i","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74734610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
非プリンキサンチンオキシダーゼ阻害薬による組織保護効果機構 非嘌呤产素氧化酶抑制剂的组织保护效果机制
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.100
K. Okamoto, Takashi Tani
{"title":"非プリンキサンチンオキシダーゼ阻害薬による組織保護効果機構","authors":"K. Okamoto, Takashi Tani","doi":"10.6032/gnam.42.100","DOIUrl":"https://doi.org/10.6032/gnam.42.100","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79492694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
高尿酸血症を有する血液透析患者におけるフェブキソスタットの薬物動態および有効性・忍容性の検討 非布基索司他对高尿酸血症血液透析患者的药代动力学及有效性和耐受性的研究
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.78
Michito Nagura, Shinichiro Asakawa, Yosuke Kawamorita, Daigo Toyoki, Yoshifuru Tamura, Takanori Kumagai, S. Shibata, Y. Fujigaki, S. Uchida
{"title":"高尿酸血症を有する血液透析患者におけるフェブキソスタットの薬物動態および有効性・忍容性の検討","authors":"Michito Nagura, Shinichiro Asakawa, Yosuke Kawamorita, Daigo Toyoki, Yoshifuru Tamura, Takanori Kumagai, S. Shibata, Y. Fujigaki, S. Uchida","doi":"10.6032/gnam.42.78","DOIUrl":"https://doi.org/10.6032/gnam.42.78","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78704682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
高尿酸血症・痛風患者への看護指導について 高尿酸血症、痛风患者的护理指导
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.124
Y. Toya, Hiroshi Ooyama, Mieko Yokozeki, H. Moromizato, K. Ooyama, Shin Fujimori
{"title":"高尿酸血症・痛風患者への看護指導について","authors":"Y. Toya, Hiroshi Ooyama, Mieko Yokozeki, H. Moromizato, K. Ooyama, Shin Fujimori","doi":"10.6032/gnam.42.124","DOIUrl":"https://doi.org/10.6032/gnam.42.124","url":null,"abstract":"","PeriodicalId":12746,"journal":{"name":"GOUT AND NUCLEIC ACID METABOLISM","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86758549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ガイドラインの策定方法 指南的制定方法
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/gnam.42.suppl-13
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引用次数: 0
The use survey of antihyperuricemic in clinicians 临床医生抗高尿酸血症药的使用情况调查
GOUT AND NUCLEIC ACID METABOLISM
Pub Date : 2018-07-25 DOI: 10.6032/GNAM.42.23
T. Hosoya, N. Kamatani, A. Taniguchi
高尿酸血症・痛風の治療ガイドラインも2011年に 第2版の追補がされ約6年が経過した(第1版2002 年,第2版2010年発行).その間,尿酸生成抑制薬 であるフェブキソスタット(2011年5月販売開始) とトピロキソスタット(2013年9月販売開始)が, 開発・上市された.アロプリノール以来約40年 新規開発のなかった尿酸生成抑制薬が本邦で 開発され,従来の尿酸生成抑制薬に加え薬剤選択 の幅が広がったことから,臨床医の尿酸降下薬 の使用実態についてアンケート調査を実施した. アンケート配布数665名のうち186名の有効回答 を得られた.使用している尿酸降下薬としては, フェブキソスタット183名,アロプリノール161名, ベンズブロマロン153名,トピロキソスタット86名 (いずれも累計)と,大多数の医師が複数の薬剤 を使い分けていた.尿酸降下薬の使用基準とし ては,合併症がない場合で8または9mg/dL以上 が 85.5%,合併症がある場合で 7または 9mg /dL 以上が 91.4%を占めた.また,尿酸降下療法の 目標とした血清尿酸値の達成度は, 「ほぼすべての 患者で達成(100%)」および「大体の患者で達成 (75%)」を併せて,85.5%がほぼ目標を達成して いた.今回の結果から,高尿酸血症・痛風の治療 ガイドラインに基づく尿酸降下薬の使用開始が 浸透していることが示された.
高尿酸血症和痛风的治疗指南也在2011年追加了第2版，大约过了6年(第1版2002年，第2版2010年发行).在此期间，尿酸生成抑制药favkeyasstat(2011年5月开始销售)和topirokeyasstat(2013年9月开始销售)自异丙醇以来约40年没有新开发的尿酸生成抑制药在本国成功开发成功，在原有的尿酸生成抑制药的基础上拓宽了药物选择范围，成为临床医生的降尿酸药物。的使用情况进行了问卷调查，在665份问卷中得到了186份有效回答。正在使用的降尿酸药有非布基索司他183名、异丙醇161名、大多数医生分别使用了多种药物，其中苯斯布罗马隆153名，托匹罗基索司他86名(均为累计)。作为降尿酸药的使用标准，在没有并发症的情况下超过8或9mg/dL的占85.5%，在有并发症的情况下超过7或9mg/dL的占91.4%。在目标血清尿酸值实现度方面，包括“几乎所有患者均实现(100%)”和“大部分患者均实现(75%)”在内，有85.5%的患者基本实现了目标。此次结果表明，基于高尿酸血症和痛风治疗指南的降尿酸药物的使用已逐渐普及。
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引用次数: 3
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