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Medical Tourism: The Critical Role between Taiwan and Mainland China. 医疗旅游:台湾与大陆之间的关键角色。
Pub Date : 2020-07-24 DOI: 10.31829/2641-7456/ahs2020-4(1)-128
Recent evidence showed that the International Medical Tourism conference held in Shanghai reported there are 12million outbound medical tourists each year in the whole world, which increased about 15% to 25% per year. Databases were systematically searched between 2010 and 2012 and 60 papers were selected for review. (Fig.1, Fig.2). About 50-60 thousand Chinese go oversea for medical treatment not including the health examination and plastic surgery. Moreover, the target Asia countries are India and Thailand because they provide more cheaper medical services. There are lots of Chinese individuals came to Taiwan searching medical evaluation and therapy about that time. However, due to the political policy changed that the Chinese people are prohibited to come to Taiwan individually, therefore, the medical tourism were marked reduced. In the meantime, China tries to develop inbound and outbound medical tourism themselves and providing more cheaper and quality medical treatment and health examination.
最近的证据显示,在上海举行的国际医疗旅游会议报告称,全球每年有1200万出境医疗游客,每年增长约15%至25%。系统检索2010 - 2012年间的数据库,选取60篇论文进行综述。(图1,图2)。约有5 -6万中国人出国就医,不包括健康检查和整形手术。此外,目标亚洲国家是印度和泰国,因为它们提供更便宜的医疗服务。当时有很多中国人来台湾寻求医疗评估和治疗。然而,由于政治政策的改变,禁止中国人来台湾个人,因此,医疗旅游明显减少。与此同时,中国自身也在努力发展入境和出境医疗旅游,提供更便宜、更优质的医疗和健康检查。
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引用次数: 0
Bence-Jones Protein, Rat IGG, H.R.P, Alkaline Phosphatase, Bovine Serum Albumine used as Antigens in the Immune Response of the Sea Star. Bence-Jones蛋白、大鼠IGG、H.R.P、碱性磷酸酶、牛血清白蛋白作为海星免疫应答抗原的研究。
Pub Date : 2020-07-20 DOI: 10.31829/2641-7456/ahs2020-4(1)-127
Immunocompetent cells were described in the sea star Asterina gibbosa: they recognize specifically various antigens. In the present work, Asterina gibbosa were immunized with Bence-Jones protein, other ones with Rat IGG, at last certain with H.RP (Horse-radish Peroxydase) and the last ones with Alkaline Phosphatase: a crossed immune reaction occurs between Rat IGG and B.J protein, but not between B.J and H.R.P not between Rat IGG and H.R.P and not between Alkaline Phosphatase and B.J, not between Alkaline Phosphatase and Rat IGG, used as antigens.
在海星Asterina gibbosa中描述了免疫活性细胞:它们特异性地识别各种抗原。本研究分别用Bence-Jones蛋白和大鼠IGG免疫长毛象,最后用马萝卜过氧酶(H.RP)免疫,最后用碱性磷酸酶免疫:大鼠IGG和b - j蛋白之间发生交叉免疫反应,b - j和h -r - p之间不发生交叉免疫反应,大鼠IGG和h -r - p之间不发生交叉免疫反应,碱性磷酸酶和b - j之间不发生交叉免疫反应,碱性磷酸酶和g - g之间不发生交叉免疫反应。
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引用次数: 0
SARS-CoV-2, the Tiny Creature which Scared the Globe. SARS-CoV-2,吓坏全球的小生物。
Pub Date : 2020-07-13 DOI: 10.31829/2641-7456/ahs2020-4(1)-126
The 7th of January 2020, the novel Coronavirus was identified as the causative agent of COVID19, a potentially deadly disease. The first cases were reported in Wuhan, Hubei province in China, but since the 11th of March 2020, a novel Coronavirus outbreak has been considered as a pandemic. Belonging to Coronavirus family, SARS-CoV-2 is believed to be originated in bat then transmitted to humans by an intermediate animal host. Inhalation or touching infected droplets are the major ways to transmit the disease from human-to-human. Most of the patients are mild or asymptomatic. Symptomatic ones present mainly fever, sore throat, dyspnea, but in certain cases, it can lead to pneumonia, acute respiratory distress syndrome, or even multi-organ dysfunction. Molecular detection methods are at high importance mainly rtqPCR. High-throughput sequencing of the whole genome can also be used, but it is very expensive. CRISPR Cas 12 has just got the initial validation as a detection tool of SARS-CoV-2. Serological tests and CT chest scan are also involved in the diagnosis. Treatment is symptomatic and supportive including isolation of patients. However, many drugs and vaccine candidates are under clinical experimentation. In this review, we prepared a quick summary of SARS-CoV-2 origin, transmission, clinical manifestations and management by highlighting the variable diagnostic methods and potential therapeutic agents, which may prevent the disease or fight the virus. It also provides a bird's eye view about the current outbreak status in Syrian Arab Republic in the Middle East.
2020年1月7日,新型冠状病毒被确定为covid - 19的病原体,这是一种潜在的致命疾病。第一批病例是在中国湖北省武汉市报告的,但自2020年3月11日以来,一场新型冠状病毒爆发被认为是一场大流行。SARS-CoV-2属于冠状病毒科,据信起源于蝙蝠,然后通过中间动物宿主传播给人类。吸入或接触受感染的飞沫是人际传播疾病的主要途径。大多数患者症状轻微或无症状。有症状的主要表现为发热、喉咙痛、呼吸困难,但在某些情况下,可导致肺炎、急性呼吸窘迫综合征,甚至多器官功能障碍。分子检测方法主要是rtqPCR。全基因组的高通量测序也可以使用,但它非常昂贵。CRISPR cas12作为SARS-CoV-2的检测工具刚刚获得初步验证。血清学检查和胸部CT扫描也可用于诊断。治疗是对症和支持性的,包括隔离患者。然而,许多药物和候选疫苗正处于临床试验阶段。本文就SARS-CoV-2的来源、传播途径、临床表现和治疗进行综述,重点介绍不同的诊断方法和可能预防或对抗该病毒的潜在治疗药物。它还提供了关于中东阿拉伯叙利亚共和国当前疫情状况的鸟瞰图。
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引用次数: 1
Three Categories of Mood Stabilizers which are used in Clinical Practice. 临床实践中使用的三种情绪稳定剂。
Pub Date : 2020-07-09 DOI: 10.31829/2641-7456/ahs2020-4(1)-125
In the patients with bipolar disorder, mood stabilizers would be used to diminish swings of the mood. Antipsychotics, lithium and anticonvulsants are used as mood stabilizers. The exact mechanisms of these drugs in controlling the mood swings are not clear specifically with regard to antipsychotics. These drugs have effects on dopamine receptors in the pathways related to motivation and emotion, in some parts of the brain like nucleus accumbens, amygdala and hippocampus. The mechanism of action of lithium is different from antipsychotics. Lithium protects neurons from insults and inhibits cellular apoptosis process by glycogen synthase kinase-3b inhibition or increasing anti-apoptotic protein BCL-2 production. Inhibiting the inositol-1-phosphatase by lithium, cause it to have effects on inositol phosphate second messengers production. Dentate gyrus new neurons growth, will be promoted by lithium either. Lithium also decreases the suicide risk in the patients.
在双相情感障碍患者中,使用情绪稳定剂来减少情绪波动。抗精神病药、锂和抗惊厥药被用作情绪稳定剂。这些药物在控制情绪波动方面的确切机制还不清楚,特别是抗精神病药物。这些药物对大脑某些部位,如伏隔核、杏仁核和海马体中与动机和情绪相关的通路中的多巴胺受体有影响。锂的作用机制不同于抗精神病药物。锂通过抑制糖原合成酶激酶3b或增加抗凋亡蛋白BCL-2的产生,保护神经元免受损伤,抑制细胞凋亡过程。锂对肌醇-1-磷酸酶的抑制作用,使其对肌醇磷酸第二信使的产生产生影响。锂离子也会促进齿状回新神经元的生长。锂也能降低病人的自杀风险。
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引用次数: 0
Epidemiological Survey on the Utilization of Insecticide Treated Mosquito Nets in Malaria Control among Gyadi-Gyadi Communities in Kano, Nigeria. 尼日利亚卡诺市Gyadi-Gyadi社区使用驱虫蚊帐控制疟疾的流行病学调查
Pub Date : 2020-07-04 DOI: 10.31829/2641-7456/ahs2020-4(1)-124
Background: Malaria causes an overwhelmingly large number of cases and deaths round the globe every year. Insecticide treated mosquito nets (ITNs) have raised a renewed interest to serve as tools for malaria control in Africa. This survey was, therefore, designed to provide information about the knowledge, attitude and experience of the community about malaria as a disease and its preventive methods, particularly acceptability, affordability and compliance to the use of insecticide treated mosquito nets, and factors influencing its possession and utilization of ITNs among Gyadi-Gyadi communities in Kano, Nigeria. Methods: A community based cross-sectional study was conducted in Gyadi-Gyadi from January, 2020 to February, 2020. Data was collected using a pretested structured questionnaire. Descriptive analysis was performed to obtain the frequency distribution of the variables. Results: The result shows that 341 participants responded to the questionnaire. 64.5% of the respondents had heard about the mosquito net. 45% of the respondents in the survey reported the presence of at least one mosquito net in their households. 69.2% of the participants perceived fever, headache and chilling of the body as the main symptoms of malaria. Conclusion: The utilization of mosquito nets at the time of the study was very low. However, acceptability and willingness to use ITNs for malaria prevention was very high. It is recommended that communities should be strongly sensitized on the importance of ITNs for malaria control and the availability and affordability should be insured.
背景:疟疾每年在全球造成大量病例和死亡。经杀虫剂处理的蚊帐(ITNs)重新引起了人们对作为非洲疟疾控制工具的兴趣。因此,这项调查的目的是提供有关社区对疟疾作为一种疾病及其预防方法的知识、态度和经验的信息,特别是关于使用驱虫蚊帐的可接受性、可负担性和依从性,以及影响尼日利亚卡诺Gyadi-Gyadi社区拥有和使用驱虫蚊帐的因素。方法:于2020年1月至2020年2月在嘉地-嘉地进行基于社区的横断面研究。使用预先测试的结构化问卷收集数据。进行描述性分析以获得变量的频率分布。结果:共有341人参与问卷调查。64.5%的受访者听说过蚊帐。调查中45%的答复者报告家中至少有一顶蚊帐。69.2%的参与者认为发烧、头痛和身体发冷是疟疾的主要症状。结论:调查时蚊帐使用率很低。然而,使用ITNs预防疟疾的可接受性和意愿非常高。建议应使社区强烈认识到驱虫蚊帐对疟疾控制的重要性,并确保其可得性和可负担性。
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引用次数: 0
Rapid Eye Movement Sleep Behavior Disorder (RBD) 快速眼动睡眠行为障碍(RBD)
Pub Date : 2020-06-26 DOI: 10.31829/2641-7456/ahs2020-4(1)-122
Normal skeletal muscle atonia's intermittent absence, which results in acting out patient's dreams, is the characteristic of the Rapid eye movement Behavior Disorder or RBD. The occurrence of RBD is in the last third part of the night. In this part, the REM sleep is much more common. The dreams during RBD would be vivid and patient's violent and aggressive behavior and movements can be dangerous for the patient and his/her bed partner. RBD is most common in older men. Its etiology is not clear but RBD is associated with some neurodegenerative diseases like multiple system atrophy, parkinson's disease and lewy body dementia. This association specifically with parkinson's disease is high, since about 50 percent of the patients with RBD develop parkinson's disease during years. In the association between RBD and neurodegenerative diseases, RBD's occurrence would usually be preceded such neurodegenerative diseases by several years.
正常骨骼肌肌张力障碍的间歇性缺失,导致患者的梦被表演出来,是快速眼动行为障碍(RBD)的特征。RBD发生在夜晚的最后三分之一。在这部分,快速眼动睡眠更为常见。RBD期间的梦是生动的,患者的暴力和攻击性行为和动作对患者和他/她的床伴可能是危险的。RBD最常见于老年男性。其病因尚不清楚,但RBD与多系统萎缩、帕金森病、路易体痴呆等神经退行性疾病有关。特别是与帕金森病的相关性很高,因为大约50%的RBD患者会在数年内患上帕金森病。在RBD与神经退行性疾病的关系中,RBD的发生通常比神经退行性疾病早几年。
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引用次数: 0
Metformin and Exercise; the Effects of Metformin in the Body Building to Minimize the Effects of the Use of Anabolics: Case Report for a Randomized Controlled Trial 二甲双胍与运动;二甲双胍在健身中的作用,以尽量减少使用合成代谢的影响:一项随机对照试验的病例报告
Pub Date : 2020-06-03 DOI: 10.31829/2641-7456/ahs2020-4(1)-118
Metformin is an oral antidiabetic used in the treatment of type 2 diabetes mellitus. More precisely, it belongs to the class of biguanides, Metformin is used in the treatment of type 2 diabetes mellitus both as monotherapy and in combination therapy with other oral antidiabetic agents or with insulin, when dietary interventions and exercise are not sufficient to control the disease. When used in overweight diabetic patients, metformin also causes a decrease in the complications of diabetes and its use has been associated with stabilization and, albeit modest, loss of body weight.In type 2 diabetes mellitus (called also DM2 and in the past 'adult diabetes' or 'food') the insulin produced by the pancreas is unable to fully exert its action so that the body even produces it in excess, with the result on the one hand of making increasing weight and on the other hand progressively depleting the pancreas, is unable to meet the body's needs. It is as if the body were resisting the action of insulin. Metformin reduces insulin resistance. It is taken by mouth and is the only drug useful in all stages of type 2 diabetes. It also helps improve the balance of fats and, to a limited extent, blood pressure. Metformin alone has important effects on blood sugar. Accompanied by physical exercise, weight loss and possibly other medications, it is often an effective therapy. It does not cause hypoglycemia, helps not to gain weight or even reduces it. The main feature of Metformin is to interact strongly with AMPK by regulating its expression. In fact, its down regulation leads to consuming ATP, synthesizing cholesterol and fatty acids and consuming glucose: a situation in which insulin levels are quite high (therefore energy abundance).On the contrary, its up regulation leads to the creation of ATP, consuming more fatty acids for energy purposes and it is a metabolic situation similar to caloric restriction in which insulin levels are kept low (therefore energy scarcity). Metformin by upregulating AMPK has therefore shown to have a somewhat transversal therapeutic use in the treatment of metabolic dysfunctions.
二甲双胍是一种用于治疗2型糖尿病的口服降糖药。更确切地说,它属于双胍类药物,当饮食干预和运动不足以控制疾病时,二甲双胍用于治疗2型糖尿病,既可以单独治疗,也可以与其他口服抗糖尿病药物或胰岛素联合治疗。在超重的糖尿病患者中使用二甲双胍也能减少糖尿病的并发症,并且它的使用与体重的稳定和(尽管是适度的)减轻有关。在2型糖尿病(也称为DM2,过去称为“成人糖尿病”或“食物”)中,胰腺产生的胰岛素不能充分发挥其作用,以至于身体甚至产生过量的胰岛素,其结果是一方面使体重增加,另一方面逐渐耗尽胰腺,无法满足身体的需要。这就好像身体在抵抗胰岛素的作用。二甲双胍可以降低胰岛素抵抗。它是口服的,是唯一一种对2型糖尿病所有阶段都有效的药物。它还有助于改善脂肪平衡,并在一定程度上改善血压。二甲双胍单独对血糖有重要影响。伴随着体育锻炼,减肥和可能的其他药物,它通常是一个有效的治疗方法。它不会引起低血糖,有助于不增加体重,甚至减少体重。二甲双胍的主要特点是通过调节AMPK的表达与AMPK强相互作用。事实上,它的下调会导致消耗ATP,合成胆固醇和脂肪酸,消耗葡萄糖:在这种情况下,胰岛素水平相当高(因此能量丰富)。相反,它的向上调节导致ATP的产生,消耗更多的脂肪酸用于能量目的,这是一种类似于热量限制的代谢情况,胰岛素水平保持在低水平(因此能量短缺)。因此,二甲双胍通过上调AMPK显示出在治疗代谢功能障碍方面具有一定的横向治疗用途。
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引用次数: 0
Role of Co-Infection in the Immunopathology of COVID-19 in pregnancy 合并感染在妊娠期COVID-19免疫病理中的作用
Pub Date : 2020-05-29 DOI: 10.31829/2641-7456/ahs2020-4(1)-117
“Co-infection” differs from single infection mainly in the effect of co-infection on the host health which may be harmful, beneficial or absent. This effect occurs mainly due to changes in host immune response. Co-infection is used in treatment of other diseases not just infectious ones. It’s well known that co-infection may have beneficial effects that can improve overall outcome better than single agent infection especially in case of viruses. There are many immunological mechanisms to achieve that. As co-infection has a beneficial effect that we may use it in treatment, there is harmful effect that we should avoid. In this review we tried to evaluate the effect of co-infection in pregnancy with coronavirus disease-2019 (COVID-19) and how the immune system of the pregnant women will respond to co-infection.
“合并感染”与单一感染的区别主要在于合并感染对宿主健康的影响,这种影响可能有害、有益或没有。这种效应的发生主要是由于宿主免疫反应的改变。合并感染不仅用于治疗感染性疾病,还用于治疗其他疾病。众所周知,联合感染可能具有有益的效果,可以比单一药物感染更好地改善总体结果,特别是在病毒的情况下。有很多免疫机制可以做到这一点。由于合并感染有有益的影响,我们可以将其用于治疗,但也有有害的影响,我们应该避免。在本综述中,我们试图评估合并感染冠状病毒病-2019 (COVID-19)妊娠的影响,以及孕妇的免疫系统对合并感染的反应。
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引用次数: 2
Embryogenesis of an Invertebrate Lymphoid Organ: The Asterina Gibbosa Axial Organ (Asterids, Echinodermata) 无脊椎动物淋巴器官的胚胎发生:星形轴向器官(星形,棘皮目)
Pub Date : 2020-05-25 DOI: 10.31829/2641-7456/ahs2020-4(1)-116
M. Leclerc
The metamerization of the coelom leads to the axial complex genesis. Mesodermic cells appear besides the stone canal (larva 12 days old): they constitute the axial organ (AO) which develop, in the ventral side, the oral part (PO). This last part corresponds (sensu stricto) to the ancestral lymphoïd organ.
体腔的异构化导致轴向复合体的形成。中胚层细胞出现在石管(幼虫12日龄)之外:它们构成轴向器官(AO),在腹侧发育为口腔部分(PO)。最后一部分(严格意义上)与祖先的lymphoïd器官相对应。
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引用次数: 0
The Enclosed Leviathan- Pleomorphic Fibroma 封闭的利维坦——多形性纤维瘤
Pub Date : 2020-05-21 DOI: 10.31829/2641-7456/ahs2020-4(1)-115
Cutaneous pleomorphic fibroma was initially described by Kamino et al in 1989 as a dermal, pauci-cellular neoplasm with an abundant fibrous tissue stroma, atypical fibro-histiocytic cells and disseminated multinucleated giant cells(1). Pleomorphic fibroma is an exceptional, benign, polypoid ordome shaped, sparsely cellular, cutaneous fibroblastic neoplasm characteristically delineating aberrant, pleomorphic, hyperchromatic and giant multinucleated cells embedded in a collagenous stroma (2). Pleomorphic fibroma is contemplated to originate from dendrocytes, in contrast to myofibroblasts. The exceptional neoplasm can simulate adjunctive fibro-histiocytic, melanocytic or lipomatous neoplasia. Despite cellular and nuclear atypia accompanying pleomorphic, bizarre cells, the neoplasm is contemplated as architecturally and biologically benign, on account of exceptional or absent mitosis(2). Pleomorphic fibroma may be interlinked with sclerotic fibroma. Martin-Lopez defined the terminology “pleomorphic sclerotic fibroma” which posits pleomorphic fibroma, sclerotic fibroma and pleomorphic sclerotic fibroma as neoplasia representing a morphologic continuum (3).
1989年,Kamino等人最初将皮肤多形性纤维瘤描述为一种真皮、少细胞肿瘤,具有丰富的纤维组织基质、非典型纤维组织细胞和弥散性多核巨细胞(1)。多形性纤维瘤是一种罕见的、良性的、息肉样或穹窿状、细胞稀疏的皮肤成纤维细胞肿瘤,其特征是异常的、多形性的、高染色的和巨大的多核细胞包埋在胶原基质中(2)。多形性纤维瘤被认为起源于树突细胞,而不是肌成纤维细胞。特殊的肿瘤可以模拟辅助纤维组织细胞、黑素细胞或脂肪瘤样肿瘤。尽管细胞和细胞核异型性伴随着多形性、奇异的细胞,但由于异常或没有有丝分裂,肿瘤在建筑学和生物学上被认为是良性的(2)。多形性纤维瘤可能与硬化性纤维瘤相互关联。Martin-Lopez定义了“多形性硬化性纤维瘤”这一术语,将多形性纤维瘤、硬化性纤维瘤和多形性硬化性纤维瘤定义为代表形态连续体的肿瘤(3)。
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引用次数: 0
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Archives of Health Science
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