Pub Date : 2024-12-01DOI: 10.1016/j.gore.2024.101550
Arielle H. Katcher , Michelle P. Greenman , Sudarshana Roychoudhury , Gary L. Goldberg
The use of immunohistochemistry (IHC) and molecular pathology has been widely adopted over the past 3 decades and has aided in the precision of diagnosing gynecologic tumors. While many tumors can be diagnosed by histologic appearance on routine hematoxylin and eosin stained slides, the use of IHC has dramatically changed practice, leading to a better understanding and subtyping of gynecologic tumors. This detailed classification of tumors has aided in the implementation and development of targeted therapies. Available IHC stains and their applications continue to rapidly evolve. Our review aims to provide updated information on the use of IHC in gynecologic tumors. We will also address the rationale for preferred therapeutic regimens that are personalized based on IHC.
{"title":"Utilization of immunohistochemistry in gynecologic tumors: An expert review","authors":"Arielle H. Katcher , Michelle P. Greenman , Sudarshana Roychoudhury , Gary L. Goldberg","doi":"10.1016/j.gore.2024.101550","DOIUrl":"10.1016/j.gore.2024.101550","url":null,"abstract":"<div><div>The use of immunohistochemistry (IHC) and molecular pathology has been widely adopted over the past 3 decades and has aided in the precision of diagnosing gynecologic tumors. While many tumors can be diagnosed by histologic appearance on routine hematoxylin and eosin stained slides, the use of IHC has dramatically changed practice, leading to a better understanding and subtyping of gynecologic tumors. This detailed classification of tumors has aided in the implementation and development of targeted therapies. Available IHC stains and their applications continue to rapidly evolve. Our review aims to provide updated information on the use of IHC in gynecologic tumors. We will also address the rationale for preferred therapeutic regimens that are personalized based on IHC.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"56 ","pages":"Article 101550"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.gore.2024.101573
Kristina W. Thiel, Danielle Enserro, Talayeh Ghezelayagh, Marc Radke, Elizabeth Swisher, Krishnansu Tewari, Larry J. Copeland, Heidi Gray, Frederick Ueland, Gottfried Konecny, Premal Thaker, Andrea Wahner-Hendrickson, Heather Lankes, Michael Bookman, Michael Birrer, Barbara Norquist, Kimberly Leslie
{"title":"Abstract #22: Impact of somatic TP53 mutation type on benefit from bevacizumab in patients with ovarian cancer, a secondary analysis of NRG/GOG-0218","authors":"Kristina W. Thiel, Danielle Enserro, Talayeh Ghezelayagh, Marc Radke, Elizabeth Swisher, Krishnansu Tewari, Larry J. Copeland, Heidi Gray, Frederick Ueland, Gottfried Konecny, Premal Thaker, Andrea Wahner-Hendrickson, Heather Lankes, Michael Bookman, Michael Birrer, Barbara Norquist, Kimberly Leslie","doi":"10.1016/j.gore.2024.101573","DOIUrl":"10.1016/j.gore.2024.101573","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"57 ","pages":"Article 101573"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143204850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.gore.2024.101598
Kayla M. Sompel, Cam Nguyen, Nicole Marjon, Benjamin Bitler, Rebecca Wolsky, Christine Walsh, Kian Behbakht, Michelle Castro Arredondo
{"title":"Abstract #47: Pathologic staging discrepancies between stage I and II ovarian and tubal high grade serous carcinoma (HGSC) and impact on survival.","authors":"Kayla M. Sompel, Cam Nguyen, Nicole Marjon, Benjamin Bitler, Rebecca Wolsky, Christine Walsh, Kian Behbakht, Michelle Castro Arredondo","doi":"10.1016/j.gore.2024.101598","DOIUrl":"10.1016/j.gore.2024.101598","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"57 ","pages":"Article 101598"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143199456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.gore.2024.101563
Joe Haydamous, Jorge Cervantes, Anna M. Brown, Anna Jo Smith, Shearwood McClelland, Joseph A. Lucci, Diego Aviles, J. Alejandro Rauh-Hain, Abigail Zamorano
{"title":"Abstract #12: Evaluating Caregiver Distress: Caring for Those Who Care for Our Patients","authors":"Joe Haydamous, Jorge Cervantes, Anna M. Brown, Anna Jo Smith, Shearwood McClelland, Joseph A. Lucci, Diego Aviles, J. Alejandro Rauh-Hain, Abigail Zamorano","doi":"10.1016/j.gore.2024.101563","DOIUrl":"10.1016/j.gore.2024.101563","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"57 ","pages":"Article 101563"},"PeriodicalIF":1.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143206675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}