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Effect of COVID-19 on the characteristics and outcome of patients who have otitis media with effusion: a case-control study. COVID-19 对中耳炎伴流脓患者特征和预后的影响:一项病例对照研究。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-10 DOI: 10.1186/s13005-024-00429-x
Yue Fan, Wei Liu, Yinan Liang, Xin Xia, Fangxu Yan, Xingming Chen

Background: Few studies have examined the otologic symptoms of Coronavirus disease 2019 (COVID-19). The objective of this study was to identify the effect of COVID-19 on the characteristics and outcomes of patients who have otitis media with effusion (OME).

Methods: This case-control study compared the characteristics and outcomes of OME patients who did or did not have COVID-19. A total of 65 patients with previous COVID-19 and 40 patients who did not have COVID-19 (controls) were enrolled from October 1, 2022 to January 31, 2023 at a single institution in China. Demographics, medical histories, morbidities, hearing test results, treatments, and outcomes of the two groups were compared.

Results: The COVID-19 group had significantly better outcomes from OME than the control group, with higher rates of complete resolution (64.6% vs. 30%) and improvement (30.8% vs. 17.5%), and a lower rate of persistent OME (4.6% vs. 52.5%). Previous COVID-19 was independently associated with a more favorable OME outcome in three multivariate logistic regression models. The COVID-19 group also had a greater improvement in hearing threshold based on air-bone gap measurements.

Conclusion: The outcomes of OME patients who had previous COVID-19 were generally good, in that most patients responded well to treatment and achieved complete resolution or improvement within one month.

背景:很少有研究对2019年冠状病毒病(COVID-19)的耳科症状进行研究。本研究旨在确定 COVID-19 对中耳炎伴流脓(OME)患者的特征和预后的影响:这项病例对照研究比较了接受或未接受 COVID-19 治疗的 OME 患者的特征和预后。从 2022 年 10 月 1 日至 2023 年 1 月 31 日,中国一家医疗机构共招募了 65 名曾感染 COVID-19 的患者和 40 名未感染 COVID-19 的患者(对照组)。对两组患者的人口统计学、病史、发病情况、听力测试结果、治疗方法和疗效进行了比较:结果:COVID-19治疗组的OME疗效明显优于对照组,完全缓解率(64.6%对30%)和改善率(30.8%对17.5%)均高于对照组,OME持续率(4.6%对52.5%)也低于对照组。在三个多变量逻辑回归模型中,既往接受过COVID-19治疗与更有利的OME治疗结果独立相关。根据气骨间隙测量结果,COVID-19组患者的听阈改善幅度也更大:曾接受过COVID-19治疗的OME患者的疗效普遍良好,因为大多数患者对治疗反应良好,并在一个月内达到完全缓解或改善。
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引用次数: 0
Third molar eruption in dental panoramic radiographs as a feature for forensic age assessment - new reference data from a German population. 作为法医年龄评估特征的牙齿全景照片中的第三磨牙萌出--来自德国人口的新参考数据。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-05-10 DOI: 10.1186/s13005-024-00431-3
Maximilian Timme, Jan Viktorov, Laurin Steffens, Adam Streeter, André Karch, Andreas Schmeling

Forensic age assessment in the living can provide legal certainty when an individual's chronological age is unknown or when age-related information is questionable. An established method involves assessing the eruption of mandibular third molars through dental panoramic radiographs (PAN). In age assessment procedures, the respective findings are compared to reference data. The objective of this study was to generate new reference data in line with the required standards for mandibular third molar eruption within a German population. For this purpose, 605 PANs from 302 females and 303 males aged 15.04 to 25.99 years were examined. The PANs were acquired between 2013 and 2020, and the development of the mandibular third molars was rated independently by two experienced examiners using the Olze et al. staging scale from 2012. In case of disagreement in the assigned ratings, a consensus was reached through arbitration. While the mean, median and minimum ages were observed to increase with each stage of mandibular third molar eruption according to the Olze method, there was considerable overlap in the distribution of age between the stages. The minimum age for stage D, which corresponds to complete tooth eruption, was 16.1 years for females and 17.1 years for males. Thus, the completion of mandibular third molar eruption was found in both sexes before reaching the age of 18. In all individuals who had at least one tooth with completed eruption and who were younger than 17.4 years of age (n = 10), mineralization of the teeth in question was not complete. Based on our findings, the feature of assessing mandibular third molar eruption in PAN cannot be relied upon for determining age of majority.

当一个人的法定年龄不详或与年龄有关的信息存在疑问时,活人的法医年龄评估可以提供法律上的确定性。一种成熟的方法是通过牙科全景X光片(PAN)评估下颌第三磨牙的萌出情况。在年龄评估过程中,会将相应的评估结果与参考数据进行比较。本研究的目的是根据德国人口下颌第三磨牙萌出的规定标准生成新的参考数据。为此,研究人员检查了来自 302 名女性和 303 名男性的 605 个 PANs,年龄在 15.04 岁至 25.99 岁之间。这些 PANs 是在 2013 年至 2020 年期间获得的,下颌第三磨牙的发育情况由两名经验丰富的检查员使用 2012 年的 Olze 等人分期量表进行独立评分。如果分配的评分出现分歧,则通过仲裁达成共识。根据Olze方法,下颌第三磨牙萌出的平均年龄、中位数和最小年龄随着每个阶段的增加而增加,但各阶段之间的年龄分布有相当大的重叠。D 阶段相当于牙齿完全萌出,女性的最小年龄为 16.1 岁,男性为 17.1 岁。因此,男女均在 18 岁之前完成下颌第三磨牙的萌出。在至少有一颗牙齿萌出完成且年龄小于 17.4 岁的所有个体中(n = 10),相关牙齿的矿化尚未完成。根据我们的研究结果,评估潘氏下颌第三磨牙萌出的特征不能作为确定成年年龄的依据。
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引用次数: 0
Magnetic resonance imaging for jawbone assessment: a systematic review 用于颌骨评估的磁共振成像:系统性综述
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-19 DOI: 10.1186/s13005-024-00424-2
Hian Parize, Sofya Sadilina, Ricardo Armini Caldas, João Victor Cunha Cordeiro, Johannes Kleinheinz, Dalva Cruz Laganá, Newton Sesma, Lauren Bohner
To evaluate the accuracy of magnetic resonance imaging (MRI) for jawbone assessment compared to reference-standard measurements in the literature. An electronic database search was conducted in PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library in June 2022, and updated in August 2023. Studies evaluating the accuracy of MRI for jawbone assessment compared with reference-standard measurements (histology, physical measurements, or computed tomography) were included. The outcome measures included bone histomorphometry and linear measurements. The risk of bias was assessed by the Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2). The review was registered in the PROSPERO database (CRD42022342697). From 63 studies selected for full-text analysis, nine manuscripts were considered eligible for this review. The studies included assessments of 54 participants, 35 cadavers, and one phantom. A linear measurement error ranging from 0.03 to 3.11 mm was shown. The accuracy of bone histomorphometry varies among studies. Limitations of the evidence included heterogeneity of MRI protocols and the methodology of the included studies. Few studies have suggested the feasibility of MRI for jawbone assessment, as MRI provides comparable results to those of standard reference tests. However, further advancements and optimizations are needed to increase the applicability, validate the efficacy, and establish clinical utility of these methods.
评估磁共振成像(MRI)与文献中的参考标准测量值相比,在颌骨评估方面的准确性。于 2022 年 6 月在 PubMed、EMBASE、Scopus、Web of Science 和 Cochrane Library 中进行了电子数据库检索,并于 2023 年 8 月进行了更新。纳入的研究评估了磁共振成像与参考标准测量(组织学、物理测量或计算机断层扫描)相比在颌骨评估方面的准确性。结果测量包括骨组织形态测量和线性测量。偏倚风险通过诊断准确性研究质量评估工具(QUADAS-2)进行评估。该综述已在 PROSPERO 数据库(CRD42022342697)中注册。从 63 篇被选中进行全文分析的研究中,有 9 篇手稿被认为符合本综述的要求。这些研究包括对 54 名参与者、35 具尸体和一个模型的评估。结果显示,线性测量误差从 0.03 毫米到 3.11 毫米不等。不同研究中骨组织形态测量的准确性各不相同。证据的局限性包括核磁共振成像方案和所纳入研究的方法的异质性。很少有研究表明核磁共振成像用于颌骨评估是可行的,因为核磁共振成像可提供与标准参考测试相当的结果。然而,要提高这些方法的适用性、验证其有效性并确定其临床实用性,还需要进一步的改进和优化。
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引用次数: 0
Assessment of a novel electrochemically deposited smart bioactive trabecular coating (SBTC®): a randomized controlled clinical trial 新型电化学沉积智能生物活性小梁涂层 (SBTC®) 的评估:随机对照临床试验
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-16 DOI: 10.1186/s13005-024-00426-0
Mark Adam Antal, Ramóna Kiscsatári, Gábor Braunitzer, József Piffkó, Endre Varga, Noam Eliaz
A randomized controlled clinical trial of dental implants was conducted to compare the clinical properties of a novel electrochemically deposited calcium phosphate coating to those of a common marketed surface treatment. Forty implants of the same brand and type were placed in 20 fully edentulous participants requiring mandibular implantation. The two study groups were defined by the surface treatment of the implants. 20 implants in the control group were coated via a commercial electrochemical surface treatment that forms a mixture of brushite and hydroxyapatite, while the remaining 20 in the test group were coated with a novel electrochemical Smart Bioactive Trabecular Coating (SBTC®). A split-mouth design was employed, with each participants receiving one control implant in one mandibular side and a test implant in the other. To mitigate potential operator-handedness bias, control and test implants were randomly assigned to mandibular sides. All cases underwent digital planning, implant placement with a static surgical guide, and participants received locator-anchored full-arch dentures. The primary outcome was implant stability (measured using Osstell ISQ) assessed at insertion, loading, and then 3 months, 9 months, and 2 years post-insertion. The secondary outcome was bone level change (in millimeters) over the 2-year observation period. Oral health-related quality of life (OHRQL) was monitored using the OHIP-14 questionnaire. Complications and adverse events were recorded. Successful osseointegration and implant stability were achieved in all cases, allowing loading. ISQ values steadily increased throughout the observation period. While no significant differences were observed between the SBTC® and control coatings, the test group exhibited a higher ISQ gain. Bone resorption was somewhat lower in the SBTC® but not significantly so. Patients' OHRQL significantly improved after denture delivery and remained stable throughout the follow-up. No complications or adverse events were observed. Based on the study results, we conclude that the new surface treatment is a safe alternative to the widely used control surface, demonstrating similar osseointegrative properties and time-dependent bone level changes. Further research may explore the broader implications of these findings. The study is registered on clinicaltrials.gov under the identifier ID: NCT06034171.
我们对牙科植入物进行了一项随机对照临床试验,以比较新型电化学沉积磷酸钙涂层的临床特性与市场上常见的表面处理方法的临床特性。40 个相同品牌和类型的种植体被植入 20 名需要进行下颌种植的完全无牙患者体内。根据种植体表面处理的不同分为两个研究组。对照组的 20 个种植体采用商业电化学表面处理方法进行涂层,形成刷状石和羟基磷灰石的混合物,而试验组的其余 20 个种植体则采用新型电化学智能生物活性小梁涂层 (SBTC®)。测试组采用分口设计,每位参与者的下颌一侧植入对照组种植体,另一侧植入测试组种植体。为减少潜在的操作者手感偏差,对照种植体和测试种植体被随机分配到下颌一侧。所有病例都进行了数字化规划,并使用静态手术导板植入种植体,参与者还接受了定位器固定的全口义齿。主要结果是种植体的稳定性(使用 Osstell ISQ 测量),评估包括植入、加载以及植入后 3 个月、9 个月和 2 年。次要结果是两年观察期内骨水平的变化(以毫米为单位)。口腔健康相关生活质量(OHRQL)使用 OHIP-14 问卷进行监测。并对并发症和不良事件进行记录。所有病例都成功实现了骨结合和种植体稳定性,可以进行加载。在整个观察期间,ISQ 值稳步上升。虽然 SBTC® 涂层和对照涂层之间没有明显差异,但试验组的 ISQ 增量更高。SBTC® 的骨吸收率略低,但并不明显。义齿安装后,患者的 OHRQL 明显改善,并在整个随访期间保持稳定。没有发现并发症或不良事件。根据研究结果,我们得出结论:新的表面处理方法与广泛使用的对照表面相比是一种安全的替代方法,具有类似的骨结合特性和随时间变化的骨水平变化。进一步的研究可能会探索这些发现的更广泛意义。该研究已在 clinicaltrials.gov 上注册,标识符 ID:NCT06034171:NCT06034171。
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引用次数: 0
Clinical efficacy of intraoral ultrasonography versus transgingival probing for measurement of gingival thickness in different gingival biotypes: a clinical trial 口内超声波与经龈探针测量不同牙龈生物类型的牙龈厚度的临床疗效:一项临床试验
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-02 DOI: 10.1186/s13005-024-00422-4
Maryam Alizad-Rahvar, Yaser Safi, Mahdi Kadkhodazadeh, Mohammad Parham Ghomashi
Transgingival probing is conventionally used for gingival thickness (GT) measurement. However, invasiveness is a major drawback of transgingival probing. Thus, researchers have been in search of alternative methods for measurement of GT. This study compared the clinical efficacy of intraoral ultrasonography and transgingival probing for measurement of GT in different biotypes. This clinical trial was conducted on 34 patients requiring crown lengthening surgery. GT was measured at 40 points with 2- and 4-mm distances from the free gingival margin (FGM) of anterior and premolar teeth of both jaws in each patient by an intraoral ultrasound probe. For measurement of GT by the transgingival probing method, infiltration anesthesia was induced, and a #25 finger spreader (25 mm) was vertically inserted into the soft tissue until contacting bone. The inserted length was measured by a digital caliper with 0.01 mm accuracy. All measurements were made by an operator with high reliability under the supervision of a radiologist. Data were analyzed by t-test, Power and Effect Size formula, and intraclass correlation coefficient (ICC). The two methods were significantly different in measurement of GT in both thick and thin biotypes at 2- and 4-mm distances (P < 0.001). The two methods had a significant difference in both the mandible (P < 0.001) and maxilla (P < 0.001) and in both the anterior (P < 0.003) and premolar (P < 0.003) regions. Although the difference was statistically significant in t-tests, the power and effect formula proved it to be clinically insignificant. Also, the ICC of the two methods revealed excellent agreement. The results showed optimal agreement of ultrasound and transgingival probing for measurement of GT. The study was approved by the ethics committee of Shahid Beheshti University of Medical Sciences on 2021-12-28 (IR.SBMU.DRC.REC.1400.138) and registered in the Iranian Registry of Clinical Trials on 2022-03-14 (IRCT20211229053566N1).
经龈探针是测量牙龈厚度(GT)的传统方法。然而,侵入性是经龈探针的一个主要缺点。因此,研究人员一直在寻找测量牙龈厚度的替代方法。这项研究比较了口内超声波检查和经龈探针测量不同生物类型牙龈厚度的临床疗效。这项临床试验针对 34 名需要进行牙冠延长手术的患者。使用口内超声探针测量了每位患者两颌前磨牙和前臼齿游离龈缘(FGM)上距离 2 毫米和 4 毫米的 40 个点的 GT 值。采用经龈探针法测量 GT 时,先进行浸润麻醉,然后将 25 号手指扩张器(25 毫米)垂直插入软组织,直至接触牙槽骨。插入长度由数字卡尺测量,精确度为 0.01 毫米。所有测量均在放射科医生的监督下由一名可靠性极高的操作员完成。数据分析采用 t 检验、功率和效应大小公式以及类内相关系数 (ICC)。在 2 毫米和 4 毫米的距离上,两种方法在测量厚生物型和薄生物型的 GT 方面有明显差异(P < 0.001)。两种方法在下颌骨(P < 0.001)和上颌骨(P < 0.001)以及前磨牙(P < 0.003)和前臼齿(P < 0.003)区域均有显著差异。虽然这种差异在 t 检验中具有统计学意义,但功率和效应公式证明这种差异在临床上并不显著。此外,两种方法的 ICC 显示出极好的一致性。结果表明,超声和经龈探针测量 GT 的一致性最佳。该研究于 2021-12-28 获得沙希德-贝赫什提医科大学伦理委员会批准(IR.SBMU.DRC.REC.1400.138),并于 2022-03-14 在伊朗临床试验注册中心注册(IRCT20211229053566N1)。
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引用次数: 0
Long-term surgical outcome and impact on daily life activities of strabismus surgery in thyroid-associated ophthalmopathy with and without previous orbital decompression. 既往接受过眼眶减压术和未接受过眼眶减压术的甲状腺相关性眼病患者接受斜视手术的长期手术效果及其对日常生活活动的影响。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-04-01 DOI: 10.1186/s13005-024-00423-3
Matilde Roda, Nicola Valsecchi, Natalie di Geronimo, Andrea Repaci, Valentina Vicennati, Uberto Pagotto, Michela Fresina, Luigi Fontana, Costantino Schiavi

Backgrounds: To report the long-term surgical outcomes and the impact on daily life activities of strabismus surgery in patients with Thyroid Associated Orbitopathy (TAO) with and without previous orbital decompression.

Methods: Patients who underwent strabismus surgery for TAO were retrospectively reviewed. The primary outcome was to evaluate the influence of orbital decompression on the outcomes of TAO related strabismus surgery. Surgical success was defined by the resolution of diplopia and a post-operative deviation < 10 prism diopters (PD). The secondary outcomes were the clinical features, surgical approaches, and impact on daily life activities.

Results: A total of 45 patients were included in the study. The decompression surgery group (DS) included 21 patients (46.7%), whereas the non-decompression surgery group (NDS) patients were 24 (53.3%). The mean follow-up time from the last strabismus surgery was 2,8 years (range 8-200 months). Successful surgical outcome was achieved in 57,1% of patients in the DS, and 75% of patients in the NDS (p = 0,226). DS patients required almost twice the number of surgical interventions for strabismus compared to the NDS (1,95 vs. 1,16 respectively, p = 0,006), a higher number of extraocular muscles recessed in the first surgery (2,67 vs. 1,08 respectively, p < 0.001), and a lower rate of unidirectional surgery compared to NDS (23% vs. 95%, p < 0,001). At the pre-operative assessment, 71.4% of DS patients had eso-hypotropia, while no patients had this type of strabismus in the NDS group (p < 0.001). On the other hand, the hypotropia rate was 79.2% in NDS patients and only 4.8% in DS patients (p < 0.001). Moreover, 21,8% of NDS patients used prism lenses in daily life activities, compared to 42.9% of patients that used prism lenses to reduce the impairment in their daily life activities (p = 0.016).

Conclusions: The results of our study showed that DS patients required almost twice the number of strabismus surgical procedures, a higher number of extraocular muscles recessed in the first surgery, and an increased need for prism lenses to correct the residual deviation compared to the NDS, but with similar long-term surgical outcomes.

背景:目的目的:报告既往接受过眼眶减压术和未接受过眼眶减压术的甲状腺相关眼病(TAO)患者接受斜视手术的长期手术效果及其对日常生活活动的影响:方法:对因TAO接受斜视手术的患者进行回顾性研究。主要结果是评估眼眶减压对TAO相关斜视手术结果的影响。手术成功的定义是复视和术后偏斜的消除:共有 45 名患者参与研究。减压手术组(DS)有 21 名患者(46.7%),而非减压手术组(NDS)有 24 名患者(53.3%)。从上一次斜视手术算起,平均随访时间为 2.8 年(8-200 个月)。57.1%的 DS 患者手术成功,75% 的 NDS 患者手术成功(p = 0,226)。与 NDS 相比,DS 患者需要进行斜视手术治疗的次数几乎是 NDS 的两倍(分别为 1.95 次和 1.16 次,p = 0.006),首次手术中眼外肌凹陷的次数也较多(分别为 2.67 次和 1.08 次,p 结论:我们的研究结果表明,DS 患者需要进行斜视手术治疗的次数是 NDS 的两倍(分别为 1.95 次和 1.16 次,p = 0.006):我们的研究结果表明,与 NDS 相比,DS 患者所需的斜视手术次数几乎是 NDS 的两倍,首次手术中眼外肌凹陷的次数也更多,而且需要更多的棱镜来矫正残余偏斜,但长期手术效果相似。
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引用次数: 0
Neutrophil to lymphocyte ratio in odontogenic infection: a systematic review. 牙源性感染中的中性粒细胞与淋巴细胞比率:系统综述。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-03-28 DOI: 10.1186/s13005-024-00421-5
Saeideh Ghasemi, Bardia Mortezagholi, Emad Movahed, Sahar Sanjarian, Arshin Ghaedi, Amirhossein Mallahi, Aida Bazrgar, Monireh Khanzadeh, Brandon Lucke-Wold, Shokoufeh Khanzadeh

Background: We conducted this systematic review to compile the evidence for the role of neutrophil to lymphocyte ratio (NLR) in odontogenic infection (OI) and to determine whether NLR is elevated in patients with OI. This was done to aid physicians in better understanding this condition for clinical management.

Methods: The search was conducted on PubMed, Scopus, and Web of Science libraries on March 30, 2023. Two reviewers independently screened the studies using Endnote software. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies.

Results: A total of nine studies were included in the review. Among patients with OI, positive and statistically significant correlations of NLR were seen with more severe disease, a prolonged hospital stay, postoperative requirement of antibiotics, and total antibiotic dose needed. In the receiver operating characteristics (ROC) analysis, the optimum cut-off level of NLR was 5.19 (specificity: 81, sensitivity: 51). In addition, NLR was correlated with preoperative fever (p = 0.001). Among patients with Ludwig's Angina, NLR could predict disease severity and length of stay in the hospital (p = 0.032 and p = 0.033, respectively). In addition, the relationship between the NLR and mortality was statistically significant (p = 0.026, specificity of 55.5%, and sensitivity of 70.8%). Among patients with severe oral and maxillofacial space infection, a positive correlation was found between IL-6 and CRP with NLR (rs = 0.773, P = 0.005 and rs = 0.556, P = 0.020, respectively). Also, a higher NLR was considered an essential predictor of organ involvement (P = 0.027) and the number of complications (P = 0.001). However, among diabetes mellitus (DM) patients afflicted with submandibular abscesses, NLR had no association with therapeutic response.

Conclusions: Many people around the world suffer from OI, and a cheap and fast biomarker is needed for it. Interestingly, inflammation plays a role in this infection, and elevated NLR levels can be a good biomarker of inflammation and, as a result, for OI progression.

背景:我们进行了这项系统性综述,旨在汇编中性粒细胞与淋巴细胞比值(NLR)在牙源性感染(OI)中作用的证据,并确定 OI 患者的 NLR 是否升高。这样做是为了帮助医生更好地了解这种情况,以便进行临床管理:方法:2023 年 3 月 30 日在 PubMed、Scopus 和 Web of Science 图书馆进行了检索。两名审稿人使用 Endnote 软件独立筛选了这些研究。采用纽卡斯尔-渥太华量表(NOS)评估研究质量:结果:共有九项研究被纳入综述。在 OI 患者中,NLR 与病情较重、住院时间较长、术后抗生素需求量和所需抗生素总剂量呈统计学意义上的正相关。在接受者操作特征(ROC)分析中,NLR 的最佳临界值为 5.19(特异性:81,敏感性:51)。此外,NLR 与术前发热相关(p = 0.001)。在路德维希心绞痛患者中,NLR 可预测疾病严重程度和住院时间(分别为 p = 0.032 和 p = 0.033)。此外,NLR 与死亡率之间的关系具有统计学意义(p = 0.026,特异性为 55.5%,敏感性为 70.8%)。在严重口腔颌面部间隙感染患者中,IL-6 和 CRP 与 NLR 呈正相关(分别为 rs = 0.773,P = 0.005 和 rs = 0.556,P = 0.020)。此外,较高的 NLR 被认为是器官受累(P = 0.027)和并发症数量(P = 0.001)的重要预测指标。然而,在患有颌下脓肿的糖尿病(DM)患者中,NLR与治疗反应无关:全世界有许多人患有口腔颌面部脓肿,因此需要一种廉价、快速的生物标志物。有趣的是,炎症在这种感染中起着一定的作用,而 NLR 水平的升高可以作为炎症的良好生物标志物,因此也是 OI 进展的良好生物标志物。
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引用次数: 0
CT comparison of the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction. 鼻阻塞和无鼻阻塞患者蝶形孔前后鼻腔气道的 CT 对比。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-03-27 DOI: 10.1186/s13005-024-00420-6
Helen Heppt, Gerlig Widmann, Felix Riechelmann, Annette Runge, Herbert Riechelmann, Aris I Giotakis

Background: Nasal airway stenosis may lie anterior and/or posterior to the piriform aperture. We intended to compare the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction.

Methods: Segmented computed tomography cross-sectional areas of the nasal airway anterior (CT-CSAant) and posterior to the piriform aperture (at the level of the head of the inferior turbinate; CT-CSApost) were compared between patients with nasal obstruction (cases) and trauma controls. CT-CSA were approximately perpendicular to the direction of the nasal airflow. Anterior to the piriform aperture, they were tilted about 30o, 60o and 90o to the nasal floor. Posterior to the piriform aperture, they were tilted about 50o, 80o and 100o to the nasal floor. In cases, we examined the Pearson's correlation of active anterior rhinomanometry with CT-CSAant and CT-CSApost.

Results: Narrow and bilateral CT-CSApost were similarly large between 56 cases and 56 controls (all p > 0.2). On the contrary, narrow and bilateral CT-CSAant were significantly smaller in cases than in controls (all p < 0.001). The ratio of the size of CT-CSAant-30 to that of CT-CSApost-80 was significantly lower in cases (median: 0.84; lower to upper quartile: 0.55-1.13) than in controls (1.0; 0.88-1.16; Mann-Whitney U test; p = 0.006). Bilateral CT-CSAant correlated significantly with total inspiratory flow (all p < 0.026) in contrast to bilateral CT-CSApost (all p > 0.056).

Conclusions: The nasal airway anterior to the piriform aperture was smaller in patients with nasal obstruction due to skeletal nasal stenosis than that in controls. On the contrary, the nasal airway posterior to the piriform aperture was similarly large between patients with and without nasal obstruction. Furthermore, in patients with nasal obstruction, the anterior nasal airway was narrower compared to that located posterior to it. On the contrary, control patients' anterior nasal airway was as large as the posterior one.

背景:鼻气道狭窄可能位于蝶形孔的前方和/或后方。我们打算比较有鼻阻塞和无鼻阻塞患者在梨状孔前后的鼻气道情况:方法:比较鼻阻塞患者(病例)和外伤对照组鼻气道前方(CT-CSAant)和蝶形孔后方(下鼻甲头水平;CT-CSApost)的分割计算机断层扫描横截面积。CT-CSA 与鼻气流方向大致垂直。在梨状孔前方,它们分别向鼻底倾斜约 30o、60o 和 90o。在蝶形孔后方,它们分别与鼻底倾斜约 50o、80o 和 100o。在病例中,我们检查了主动前鼻测量与 CT-CSAant 和 CT-CSApost 的皮尔逊相关性:结果:56 个病例和 56 个对照组的 CT-CSApost 狭窄度和双侧 CT-CSApost 相似(P 均大于 0.2)。相反,病例的窄CT-CSAant和双侧CT-CSAant明显小于对照组(所有P均反30),病例的CT-CSApost-80明显低于对照组(中位数:0.84;下四分位数到上四分位数:0.55-1.13;1.0;0.88-1.16;Mann-Whitney U检验;P = 0.006)。双侧 CT-CSAant 与总吸气流量显著相关(所有 p 后(所有 p > 0.056)):结论:与对照组相比,骨骼性鼻腔狭窄导致的鼻腔阻塞患者梨状孔前的鼻腔气道较小。相反,鼻腔阻塞患者和非鼻腔阻塞患者蝶形孔后方的鼻腔气道相似大。此外,鼻阻塞患者的前鼻气道比后鼻气道狭窄。相反,对照组患者的前鼻气道与后鼻气道一样大。
{"title":"CT comparison of the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction.","authors":"Helen Heppt, Gerlig Widmann, Felix Riechelmann, Annette Runge, Herbert Riechelmann, Aris I Giotakis","doi":"10.1186/s13005-024-00420-6","DOIUrl":"10.1186/s13005-024-00420-6","url":null,"abstract":"<p><strong>Background: </strong>Nasal airway stenosis may lie anterior and/or posterior to the piriform aperture. We intended to compare the nasal airway anterior and posterior to the piriform aperture in patients with and without nasal obstruction.</p><p><strong>Methods: </strong>Segmented computed tomography cross-sectional areas of the nasal airway anterior (CT-CSA<sub>ant</sub>) and posterior to the piriform aperture (at the level of the head of the inferior turbinate; CT-CSA<sub>post</sub>) were compared between patients with nasal obstruction (cases) and trauma controls. CT-CSA were approximately perpendicular to the direction of the nasal airflow. Anterior to the piriform aperture, they were tilted about 30<sup>o</sup>, 60<sup>o</sup> and 90<sup>o</sup> to the nasal floor. Posterior to the piriform aperture, they were tilted about 50<sup>o</sup>, 80<sup>o</sup> and 100<sup>o</sup> to the nasal floor. In cases, we examined the Pearson's correlation of active anterior rhinomanometry with CT-CSA<sub>ant</sub> and CT-CSA<sub>post</sub>.</p><p><strong>Results: </strong>Narrow and bilateral CT-CSA<sub>post</sub> were similarly large between 56 cases and 56 controls (all p > 0.2). On the contrary, narrow and bilateral CT-CSA<sub>ant</sub> were significantly smaller in cases than in controls (all p < 0.001). The ratio of the size of CT-CSA<sub>ant-30</sub> to that of CT-CSA<sub>post-80</sub> was significantly lower in cases (median: 0.84; lower to upper quartile: 0.55-1.13) than in controls (1.0; 0.88-1.16; Mann-Whitney U test; p = 0.006). Bilateral CT-CSA<sub>ant</sub> correlated significantly with total inspiratory flow (all p < 0.026) in contrast to bilateral CT-CSA<sub>post</sub> (all p > 0.056).</p><p><strong>Conclusions: </strong>The nasal airway anterior to the piriform aperture was smaller in patients with nasal obstruction due to skeletal nasal stenosis than that in controls. On the contrary, the nasal airway posterior to the piriform aperture was similarly large between patients with and without nasal obstruction. Furthermore, in patients with nasal obstruction, the anterior nasal airway was narrower compared to that located posterior to it. On the contrary, control patients' anterior nasal airway was as large as the posterior one.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"20 1","pages":"20"},"PeriodicalIF":3.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10967109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140293369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of professional, recreational and nonsinging on temporomandibular disorders - a comparative study based on a self-assessment questionnaire. 职业、娱乐和非歌唱对颞下颌关节紊乱的影响--基于自我评估问卷的比较研究。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-03-21 DOI: 10.1186/s13005-024-00419-z
Maja Wollenburg, Anne Wolowski

Background: This study investigates the relationship between professional and recreational singing on temporomandibular disorders (TMDs) in women compared to a nonsinging control group.

Methods: A total of 288 female subjects between the ages of 18 and 45 participated in the self-assessment questionnaire including demographic data, as well as questions on vocal practice and TMDs symptoms. Depending on the singing time per week, the (non)vocalists were assigned to the groups professional (n = 96), recreational (n = 96) and nonsingers (n = 96).

Results: The TMDs prevalence in professional singers (42%) was higher than that in recreational singers (31%) and noticeably higher than that in nonsingers (25%). The Fisher-Freeman-Halton exact test showed that the differences between the groups were not noticeable (p = .053) but could be formulated as tendencies. The professionals suffered much more from restricted jaw movement (p = .004; OR = 2.718; 95% CI = 1.409-5.242), temporomandibular joint sounds (p < .009; OR = 2.267; 95% CI = 1.264-4.064) and temporomandibular pain (p = .010; OR = 2.333; 95% CI = 1.264-4.308) than nonsingers.

Conclusions: Singing might have an enhancing effect on the appearance of TMDs. In particular, professional singers suffered more from self-reported TMDs than recreational singers and nonsingers. In addition to the high level of physical workload if participating in professional singing, the psychosocial impact should be investigated more in further studies. No new treatment strategies resulted from this study, as the etiological significance of singing is still unclear. Knowledge about risk factors for multifactorial TMDs can help practitioners and patients prevent and treat TMDs.

背景:本研究调查了职业歌唱和娱乐歌唱对女性颞下颌关节紊乱(TMD)的影响:本研究调查了专业歌唱和娱乐歌唱与非歌唱对照组相比,对女性颞下颌关节紊乱症(TMDs)的影响关系:共有 288 名年龄在 18 岁至 45 岁之间的女性受试者参与了自我评估问卷调查,其中包括人口统计学数据以及有关声乐练习和 TMDs 症状的问题。根据每周的歌唱时间,这些(非)歌唱家被分为专业组(96 人)、娱乐组(96 人)和非歌唱家组(96 人):结果:职业歌手的 TMD 患病率(42%)高于业余歌手(31%),也明显高于非职业歌手(25%)。费舍尔-弗里曼-哈尔顿精确检验表明,组间差异并不明显(P = .053),但可被视为一种趋势。专业人员的下颌运动受限(p = .004;OR = 2.718;95% CI = 1.409-5.242)、颞下颌关节音(p 结论:专业人员的下颌运动受限更严重:唱歌可能对 TMD 的出现有促进作用。特别是,与休闲歌手和非歌手相比,专业歌手自我报告的 TMD 更严重。除了参加专业歌唱时的高强度体力劳动外,还应在进一步的研究中更多地调查其对社会心理的影响。这项研究没有提出新的治疗策略,因为歌唱的病因学意义尚不清楚。对多因素 TMD 风险因素的了解有助于从业人员和患者预防和治疗 TMD。
{"title":"Impact of professional, recreational and nonsinging on temporomandibular disorders - a comparative study based on a self-assessment questionnaire.","authors":"Maja Wollenburg, Anne Wolowski","doi":"10.1186/s13005-024-00419-z","DOIUrl":"10.1186/s13005-024-00419-z","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the relationship between professional and recreational singing on temporomandibular disorders (TMDs) in women compared to a nonsinging control group.</p><p><strong>Methods: </strong>A total of 288 female subjects between the ages of 18 and 45 participated in the self-assessment questionnaire including demographic data, as well as questions on vocal practice and TMDs symptoms. Depending on the singing time per week, the (non)vocalists were assigned to the groups professional (n = 96), recreational (n = 96) and nonsingers (n = 96).</p><p><strong>Results: </strong>The TMDs prevalence in professional singers (42%) was higher than that in recreational singers (31%) and noticeably higher than that in nonsingers (25%). The Fisher-Freeman-Halton exact test showed that the differences between the groups were not noticeable (p = .053) but could be formulated as tendencies. The professionals suffered much more from restricted jaw movement (p = .004; OR = 2.718; 95% CI = 1.409-5.242), temporomandibular joint sounds (p < .009; OR = 2.267; 95% CI = 1.264-4.064) and temporomandibular pain (p = .010; OR = 2.333; 95% CI = 1.264-4.308) than nonsingers.</p><p><strong>Conclusions: </strong>Singing might have an enhancing effect on the appearance of TMDs. In particular, professional singers suffered more from self-reported TMDs than recreational singers and nonsingers. In addition to the high level of physical workload if participating in professional singing, the psychosocial impact should be investigated more in further studies. No new treatment strategies resulted from this study, as the etiological significance of singing is still unclear. Knowledge about risk factors for multifactorial TMDs can help practitioners and patients prevent and treat TMDs.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"20 1","pages":"19"},"PeriodicalIF":3.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10956313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-stage palatal repair in non-syndromic CLP patients using anterior to posterior closure is associated with minimal need for secondary palatal surgery. 对非综合症 CLP 患者进行两阶段腭修复,采用前向后闭合,只需进行极少量的二次腭手术。
IF 3 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-03-09 DOI: 10.1186/s13005-024-00418-0
Philipp Kauffmann, Johanna Kolle, Anja Quast, Susanne Wolfer, Boris Schminke, Philipp Meyer-Marcotty, Henning Schliephake

Objective: The aim of the present study was to assess the need for secondary palatal corrective surgery in a concept of palate repair that uses a protocol of anterior to posterior closure of primary palate, hard palate and soft palate.

Methods: A data base of patients primarily operated between 2001 and 2021 at the Craniofacial and Cleft Care Center of the University Goettingen was evaluated. Cleft lips had been repaired using Tennison Randall and Veau-Cronin procedures in conjunction with alveolar cleft repair. Cleft palate repair in CLP patients was accomplished in two steps with repair of primary palate and hard palate first using vomer flaps at the age of 10-12 months and subsequent soft palate closure using Veau/two-flap procedures 3 months later. Isolated cleft palate repair was performed in a one-stage operation using Veau/two-flap procedures. Data on age, sex, type of cleft, date and type of surgery, occurrence and location of oronasal fistulae, date and type of secondary surgery performed for correction of oronasal fistula (ONF)and / or Velophyaryngeal Insufficiency (VPI) were extracted. The rate of skeletal corrective surgery was registered as a proxy for surgery induced facial growth disturbance.

Results: In the 195 patients with non-syndromic complete CLP evaluated, a total number of 446 operations had been performed for repair of alveolar cleft and cleft palate repair (Veau I through IV). In 1 patient (0,5%), an ONF occurred requiring secondary repair. Moreover, secondary surgery for correction of VPI was required in 1 patient (0,5%) resulting in an overall rate of 1% of secondary palatal surgery. Skeletal corrective surgery was indicated in 6 patients (19,3%) with complete CLP in the age group of 15 - 22 years (n = 31).

Conclusions: The presented data have shown that two-step sequential cleft palate closure of primary palate and hard palate first followed by soft palate closure has been associated with minimal rate of secondary corrective surgery for ONF and VPI at a relatively low need for surgical skeletal correction.

研究目的本研究的目的是评估腭裂修复概念中的二次腭矫正手术的必要性,该概念采用了从前方到后方关闭原发腭、硬腭和软腭的方案:方法:对 2001 年至 2021 年期间在戈廷根大学颅颌面和唇裂治疗中心接受手术的患者进行了评估。唇裂修复采用 Tennison Randall 和 Veau-Cronin 手术,同时进行齿槽裂修复。CLP患者的腭裂修复分两步进行,首先在10-12个月大时使用穹隆瓣修复原发腭和硬腭,然后在3个月后使用Veau/双瓣手术进行软腭闭合。孤立性腭裂修复手术采用Veau/双瓣手术,分一个阶段进行。研究人员提取了患者的年龄、性别、腭裂类型、手术日期和类型、口鼻瘘的发生和位置、为矫正口鼻瘘和/或会厌咽发育不全(VPI)而进行二次手术的日期和类型等数据。骨骼矫正手术率被登记为手术引起的面部发育障碍的代表:在接受评估的 195 名非综合征完全性 CLP 患者中,共进行了 446 次牙槽骨和腭裂修复手术(Veau I 至 IV)。其中有 1 名患者(0.5%)出现腭裂,需要进行二次修复。此外,1 名患者(0.5%)需要二次手术矫正 VPI,因此腭裂二次手术的总比例为 1%。6例(19.3%)15-22岁年龄组的完全CLP患者(n = 31)需要进行骨骼矫正手术:本文提供的数据显示,先进行原发腭和硬腭的两步顺序腭裂闭合,然后再进行软腭闭合,可将ONF和VPI的二次矫正手术率降到最低,而且骨骼矫正手术的需求相对较低。
{"title":"Two-stage palatal repair in non-syndromic CLP patients using anterior to posterior closure is associated with minimal need for secondary palatal surgery.","authors":"Philipp Kauffmann, Johanna Kolle, Anja Quast, Susanne Wolfer, Boris Schminke, Philipp Meyer-Marcotty, Henning Schliephake","doi":"10.1186/s13005-024-00418-0","DOIUrl":"10.1186/s13005-024-00418-0","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study was to assess the need for secondary palatal corrective surgery in a concept of palate repair that uses a protocol of anterior to posterior closure of primary palate, hard palate and soft palate.</p><p><strong>Methods: </strong>A data base of patients primarily operated between 2001 and 2021 at the Craniofacial and Cleft Care Center of the University Goettingen was evaluated. Cleft lips had been repaired using Tennison Randall and Veau-Cronin procedures in conjunction with alveolar cleft repair. Cleft palate repair in CLP patients was accomplished in two steps with repair of primary palate and hard palate first using vomer flaps at the age of 10-12 months and subsequent soft palate closure using Veau/two-flap procedures 3 months later. Isolated cleft palate repair was performed in a one-stage operation using Veau/two-flap procedures. Data on age, sex, type of cleft, date and type of surgery, occurrence and location of oronasal fistulae, date and type of secondary surgery performed for correction of oronasal fistula (ONF)and / or Velophyaryngeal Insufficiency (VPI) were extracted. The rate of skeletal corrective surgery was registered as a proxy for surgery induced facial growth disturbance.</p><p><strong>Results: </strong>In the 195 patients with non-syndromic complete CLP evaluated, a total number of 446 operations had been performed for repair of alveolar cleft and cleft palate repair (Veau I through IV). In 1 patient (0,5%), an ONF occurred requiring secondary repair. Moreover, secondary surgery for correction of VPI was required in 1 patient (0,5%) resulting in an overall rate of 1% of secondary palatal surgery. Skeletal corrective surgery was indicated in 6 patients (19,3%) with complete CLP in the age group of 15 - 22 years (n = 31).</p><p><strong>Conclusions: </strong>The presented data have shown that two-step sequential cleft palate closure of primary palate and hard palate first followed by soft palate closure has been associated with minimal rate of secondary corrective surgery for ONF and VPI at a relatively low need for surgical skeletal correction.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"20 1","pages":"18"},"PeriodicalIF":3.0,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Head & Face Medicine
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