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A decision tree model to help treatment decision-making for severe spontaneous intracerebral hemorrhage: Erratum 帮助严重自发性脑出血治疗决策的决策树模型:勘误
IF 15.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 DOI: 10.1097/js9.0000000000001761
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引用次数: 0
A multicenter case–controlled study on laparoscopic hepatectomy versus microwave ablation as first-line therapy for 3–5 cm hepatocellular carcinoma in patients aged 60 and older: Erratum 一项关于腹腔镜肝切除术与微波消融术的多中心病例对照研究,作为60岁及以上患者治疗3-5厘米肝细胞癌的一线疗法:勘误
IF 15.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 DOI: 10.1097/js9.0000000000001760
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引用次数: 0
Successful robotic kidney transplantation for surgeons with no experience in minimally invasive surgery: a single institution experience: Erratum 没有微创手术经验的外科医生也能成功进行机器人肾移植手术:一家医疗机构的经验:勘误
IF 15.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 DOI: 10.1097/js9.0000000000001759
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引用次数: 0
Book Review: Cosmetic procedures in skin of color 书评:有色人种皮肤的美容程序
IF 13.8 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-06-01 DOI: 10.1016/j.jaad.2024.05.069
D. Elston
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引用次数: 0
Recent advances in stem cells therapy: efficacy, ethics, safety concerns and future directions focusing on neurodegenerative disorders- a review 干细胞疗法的最新进展:以神经退行性疾病为重点的疗效、伦理、安全问题和未来方向--综述
IF 15.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-15 DOI: 10.1097/js9.0000000000001609
Rekha Khandia, Pankaj Gurjar, Priyanka, Victoria Romashchenko, Sami A. Al-HUSSAIN, Magdi E. A. Zaki
Neurodegeneration refers to the gradual loss of neurons and extensive changes occur in glial cells like tau inclusions in astrocytes and oligodendrocytes, α-synuclein inclusions in oligodendrocytes and SOD1 aggregates in astrocytes along with deterioration in the motor, cognition, learning, and behaviour. Common neurodegenerative disorders are Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Amyotrophic Lateral Sclerosis (ALS), Huntington’s disease (HD), Spinocerebellar Ataxia (SCAs), and Supranuclear palsy are some common one. There is a lack of effective treatment for neurodegenerative diseases, and scientists are putting their efforts into developing therapies against them. Stem cell therapy has emerged as a hope for neurodegenerative disorders since it is not only the damaged neurons that might be replaced, but other neuromodulators and neuroprotectors are secreted. Stem cell terminal differentiation before implantation ensures the implantation of correct cells and molecular markers like carbonic anhydrase II, CNPase (2′,3′-cyclic nucleotide 3′-phosphohydrolase), myelin basic protein (MBP), and myelin oligodendrocyte glycoprotein ​(MOG) elucidate the differentiation. Secretion of various growth factors like epidermal growth factor (EGF), keratinocyte growth factor (KGF), vascular endothelial growth factor-α (VEGF-α), transforming growth factor (TGF) and macrophage inflammatory protein (MIP) supports cell survival, cell proliferation, blood vessel formation, axon regeneration, and neuroglial functional connection formation at the site of degeneration. Adverse effects of stem cell therapy, like teratogenicity and differentiation in different cells other than the desired one under the influence of microenvironment, are a few key concerns. Post-transplantation improved synaptic plasticity, apoptosis inhibition, and reduction in tau-phosphorylation and Amyloid beta (Aβ) production has been observed in Alzheimer’s patients.A large number of experimental, preclinical, and clinical studies have been conducted, and encouraging results have been obtained. The present review exhaustively discusses various kinds of stem cells, their usage in treating neurodegenerative disorders, limitations and challenges, and ethical issues related to stem cell therapy.
神经退行性变是指神经元逐渐丧失,神经胶质细胞发生广泛变化,如星形胶质细胞和少突胶质细胞中的 tau 包涵体、少突胶质细胞中的α-突触核蛋白包涵体和星形胶质细胞中的 SOD1 聚集体,同时运动、认知、学习和行为也发生恶化。常见的神经退行性疾病有阿尔茨海默病(AD)、帕金森病(PD)、肌萎缩侧索硬化症(ALS)、亨廷顿病(HD)、脊髓小脑共济失调(SCA)和核上性麻痹等。神经退行性疾病缺乏有效的治疗方法,科学家们正在努力开发针对这些疾病的疗法。干细胞疗法已成为治疗神经退行性疾病的希望,因为它不仅可以替代受损的神经元,还能分泌其他神经调节剂和神经保护剂。干细胞植入前的终末分化可确保植入正确的细胞,而碳酸酐酶 II、CNPase(2′,3′-环核苷酸 3′-磷酸水解酶)、髓鞘碱性蛋白(MBP)和髓鞘少突胶质细胞糖蛋白(MOG)等分子标记则可阐明分化过程。表皮生长因子(EGF)、角质细胞生长因子(KGF)、血管内皮生长因子-α(VEGF-α)、转化生长因子(TGF)和巨噬细胞炎症蛋白(MIP)等各种生长因子的分泌支持细胞存活、细胞增殖、血管形成、轴突再生和变性部位神经胶质功能连接的形成。干细胞疗法的不良反应,如致畸性和在微环境影响下分化为所需细胞以外的不同细胞,是人们关注的几个关键问题。移植后,阿尔茨海默病患者的突触可塑性得到改善,细胞凋亡受到抑制,tau磷酸化和淀粉样β(Aβ)生成减少。本综述详尽讨论了各种干细胞、其在治疗神经退行性疾病中的应用、局限性和挑战,以及与干细胞疗法相关的伦理问题。
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引用次数: 0
Connie Eaves, PhD, FAACR: In Memoriam (1944–2024) 康妮-伊夫(Connie Eaves)博士,FAACR:悼念(1944-2024 年
IF 11.2 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-15 DOI: 10.1158/0008-5472.can-24-1256
M. Hirst
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引用次数: 0
Bi-directional adaptive enhanced A* algorithm for mobile robot navigation 用于移动机器人导航的双向自适应增强型 A* 算法
Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-07 DOI: 10.1108/aci-12-2023-0195
Atef Gharbi
PurposeThe present paper aims to address challenges associated with path planning and obstacle avoidance in mobile robotics. It introduces a pioneering solution called the Bi-directional Adaptive Enhanced A* (BAEA*) algorithm, which uses a new bidirectional search strategy. This approach facilitates simultaneous exploration from both the starting and target nodes and improves the efficiency and effectiveness of the algorithm in navigation environments. By using the heuristic knowledge A*, the algorithm avoids unproductive blind exploration, helps to obtain more efficient data for identifying optimal solutions. The simulation results demonstrate the superior performance of the BAEA* algorithm in achieving rapid convergence towards an optimal action strategy compared to existing methods.Design/methodology/approachThe paper adopts a careful design focusing on the development and evaluation of the BAEA* for mobile robot path planning, based on the reference [18]. The algorithm has remarkable adaptability to dynamically changing environments and ensures robust navigation in the context of environmental changes. Its scale further enhances its applicability in large and complex environments, which means it has flexibility for various practical applications. The rigorous evaluation of our proposed BAEA* algorithm with the Bidirectional adaptive A* (BAA*) algorithm [18] in five different environments demonstrates the superiority of the BAEA* algorithm. The BAEA* algorithm consistently outperforms BAA*, demonstrating its ability to plan shorter and more stable paths and achieve higher success rates in all environments.FindingsThe paper adopts a careful design focusing on the development and evaluation of the BAEA* for mobile robot path planning, based on the reference [18]. The algorithm has remarkable adaptability to dynamically changing environments and ensures robust navigation in the context of environmental changes. Its scale further enhances its applicability in large and complex environments, which means it has flexibility for various practical applications. The rigorous evaluation of our proposed BAEA* algorithm with the Bi-directional adaptive A* (BAA*) algorithm [18] in five different environments demonstrates the superiority of the BAEA* algorithm.Research limitations/implicationsThe rigorous evaluation of our proposed BAEA* algorithm with the BAA* algorithm [18] in five different environments demonstrates the superiority of the BAEA* algorithm. The BAEA* algorithm consistently outperforms BAA*, demonstrating its ability to plan shorter and more stable paths and achieve higher success rates in all environments.Originality/valueThe originality of this paper lies in the introduction of the bidirectional adaptive enhancing A* algorithm (BAEA*) as a novel solution for path planning for mobile robots. This algorithm is characterized by its unique characteristics that distinguish it from others in this field. First, BAEA* uses a unique bidirectional s
目的 本文旨在解决移动机器人技术中与路径规划和避障相关的难题。它介绍了一种名为双向自适应增强 A* 算法(BAEA*)的开创性解决方案,该算法采用了一种新的双向搜索策略。这种方法有利于同时从起始节点和目标节点进行探索,提高了算法在导航环境中的效率和有效性。通过使用启发式知识 A*,该算法避免了无益的盲目探索,有助于获得更有效的数据来确定最优解。仿真结果表明,与现有方法相比,BAEA*算法在实现快速收敛以获得最佳行动策略方面表现出色。 设计/方法/途径 本文在参考文献[18]的基础上,采用精心设计的方法,重点开发和评估了用于移动机器人路径规划的 BAEA*。该算法对动态变化的环境具有显著的适应性,可确保在环境变化的情况下进行稳健导航。该算法的规模进一步增强了它在大型复杂环境中的适用性,这意味着它具有各种实际应用的灵活性。我们提出的 BAEA* 算法与双向自适应 A* 算法(BAA*)[18] 在五个不同的环境中进行了严格的评估,证明了 BAEA* 算法的优越性。BAEA*算法的性能始终优于BAA*算法,证明其有能力规划出更短、更稳定的路径,并在所有环境中实现更高的成功率。 研究结果 本文在参考文献[18]的基础上,采用精心设计,重点开发和评估了用于移动机器人路径规划的BAEA*算法。该算法对动态变化的环境具有显著的适应性,可确保在环境变化的情况下进行稳健导航。该算法的规模进一步增强了它在大型复杂环境中的适用性,这意味着它具有各种实际应用的灵活性。在五个不同的环境中,对我们提出的 BAEA* 算法和双向自适应 A* (BAA*)算法 [18] 进行了严格的评估,证明了 BAEA* 算法的优越性。BAEA* 算法的性能始终优于 BAA*,证明其有能力规划出更短、更稳定的路径,并在所有环境中实现更高的成功率。 原创性/价值本文的原创性在于引入了双向自适应增强 A* 算法 (BAEA*),作为移动机器人路径规划的新型解决方案。该算法的独特之处在于它有别于该领域的其他算法。首先,BAEA* 采用独特的双向搜索策略,允许从初始节点和目标节点探索相同的路径。这种方法通过快速收敛到最佳路径并使用 A* 启发式知识,大大提高了效率。特别是,该算法在确保更高的成功率的同时,还能快速识别更短、更稳定的路径,这对于时间敏感型应用来说是一项重要功能。此外,BAEA* 在动态变化的环境中表现出适应性和鲁棒性,不仅能避开障碍物,还能遵守各种约束条件,确保安全的路径选择。BAEA* 的规模进一步提高了其通用性,可无缝应用于广泛而复杂的环境,成为适用于各种实际应用的通用解决方案。与 BAA* 等成熟算法进行的严格评估一致表明,BAEA* 在规划较短路径方面表现出色,在不同环境中取得了更高的成功率,并巩固了其在复杂和具有挑战性的环境中的重要性。这种独创性标志着 BAEA* 具有开创性的贡献,提高了移动机器人路径规划方法的效率、适应性和适用性。
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引用次数: 0
Nanoparticle Usage in Leather Processing: Worker Safety and Health 皮革加工中的纳米粒子使用:工人安全与健康
IF 0.73 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-06 DOI: 10.1021/acs.chas.4c00006
Claudia Cirillo, Mariagrazia Iuliano, Davide Scarpa, Luca Gallucci, Claudia Florio, Gaetano Maffei, Andrea Loi, Maria Sarno
The focus on the leather market has recently been on the rise due to the global increase in demand for leather products, driven by rising disposable income levels and improving standards of living among the expanding middle-class population. To enhance the performance of the final leather product, we have employed nanoparticles (NPs) across various stages of leather manufacturing. Specifically, in the finishing process─the ultimate stage of leather production─numerous studies have underscored the significance of Ag, TiO2, and SiO2 NPs in significantly enhancing various characteristics of leather. On the other hand, the rapid growth in the application of NPs to leather finishing, and more in general in the leather industry, has occurred concomitantly with increased attention toward potential risks associated with their usage in biological systems and ecosystems. Given these considerations, the objective of this critical review is to provide a detailed and thorough analysis of the factors influencing the toxicity and cytotoxicity of nanoparticles commonly adopted in the leather finishing stage, with particular emphasis on Ag, TiO2, and SiO2 NPs, along with their effects on the safety and health of workers. Moreover, the following study aims to identify necessary precautions and safety measures that the leather industry should implement when handling nanoparticles during the finishing stage.
由于可支配收入水平不断提高,中产阶级人口不断扩大,生活水平不断改善,导致全球对皮革产品的需求增加,皮革市场的关注度近来不断上升。为了提高最终皮革产品的性能,我们在皮革制造的各个阶段都采用了纳米粒子(NPs)。具体而言,在皮革生产的最终阶段--涂饰过程中,大量研究强调了Ag、TiO2 和 SiO2 NPs 在显著提高皮革各种特性方面的重要作用。另一方面,随着氮氧化物在皮革涂饰乃至整个皮革行业应用的快速增长,人们对其在生物系统和生态系统中使用的潜在风险也越来越关注。鉴于这些考虑因素,本评论旨在对皮革涂饰阶段常用纳米粒子的毒性和细胞毒性的影响因素进行详细而透彻的分析,尤其侧重于 Ag、TiO2 和 SiO2 NPs 及其对工人安全和健康的影响。此外,以下研究旨在确定皮革行业在涂饰阶段处理纳米粒子时应采取的必要预防措施和安全措施。
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引用次数: 0
A commentary on “The value of cholinesterase inhibitors for improving neuropsychiatric and functional assessment scores in patients with alzheimer disease: a systematic review and meta-analysis of on placebo-controlled RCTs” 关于 "胆碱酯酶抑制剂对改善阿尔茨海默病患者神经精神和功能评估评分的价值:安慰剂对照研究的系统回顾和荟萃分析 "的评论文章
IF 15.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-03 DOI: 10.1097/js9.0000000000001548
Yawen He, Zhiyang Jiang, Yonghua Zhang
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引用次数: 0
A commentary on “Timing of restoration of bowel continuity after decompressing stoma, in left-sided obstructive colon cancer: a nationwide retrospective cohort” 关于 "左侧梗阻性结肠癌患者减压造口后恢复肠道连续性的时机:全国范围内的回顾性队列 "的评论文章
IF 15.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-05-03 DOI: 10.1097/js9.0000000000001520
Tingfen Han, Shuai Liu
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引用次数: 0
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ACS Chemical Health & Safety
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