There is increasing attention on the topic of collaboration for sustainable food supply chains (SFSCs), with increasingly contributing journals and publications every year. The urgency of this topic is even more highlighted due to the COVID‐19 pandemic and the more recent energy and food crisis. Hence, the field needs to have a good portrait of the ongoing research in this area and to better understand future research directions to enable optimized future strategic plans and problem‐solving capability of effective collaboration for SFSCs. This paper reviews, analyses, and synthesizes the current state of research into collaboration for SFSCs. We examine a sample of 528 articles identified from the Scopus and Web of Science databases using bibliometric analysis methodology. We identify four research clusters: collaboration and sustainable supply chain management, emerging markets and resilience, digital technologies, and perishable food products. This paper clarifies interrelated themes and identifies a range of topic areas that still demand further investigation.
可持续食品供应链（SFSCs）合作这一主题日益受到关注，每年都有越来越多的期刊和出版物发表相关文章。由于 COVID-19 大流行以及最近的能源和粮食危机，这一主题的紧迫性更加突出。因此，该领域需要对这一领域正在进行的研究有一个很好的了解，并更好地理解未来的研究方向，以优化未来的战略计划和有效合作的 SFSCs 解决问题的能力。本文回顾、分析并综合了当前针对可持续发展社区服务中心合作的研究现状。我们采用文献计量分析方法，对 Scopus 和 Web of Science 数据库中的 528 篇文章进行了抽样研究。我们确定了四个研究集群：协作与可持续供应链管理、新兴市场与复原力、数字技术和易腐食品。本文阐明了相互关联的主题，并确定了一系列仍需进一步研究的主题领域。
{"title":"Collaboration for the sustainable food supply chain: A bibliometric analysis","authors":"Linh Nguyen Khanh Duong, Vikas Kumar, Qile He","doi":"10.1002/bse.4051","DOIUrl":"https://doi.org/10.1002/bse.4051","url":null,"abstract":"There is increasing attention on the topic of collaboration for sustainable food supply chains (SFSCs), with increasingly contributing journals and publications every year. The urgency of this topic is even more highlighted due to the COVID‐19 pandemic and the more recent energy and food crisis. Hence, the field needs to have a good portrait of the ongoing research in this area and to better understand future research directions to enable optimized future strategic plans and problem‐solving capability of effective collaboration for SFSCs. This paper reviews, analyses, and synthesizes the current state of research into collaboration for SFSCs. We examine a sample of 528 articles identified from the Scopus and Web of Science databases using bibliometric analysis methodology. We identify four research clusters: collaboration and sustainable supply chain management, emerging markets and resilience, digital technologies, and perishable food products. This paper clarifies interrelated themes and identifies a range of topic areas that still demand further investigation.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"6 1","pages":""},"PeriodicalIF":13.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1158/0008-5472.can-24-1263
Terrance J. Haanen, Sophie Boock, Catherine G. Callahan, Irene Peris, Kaitlin P. Zawacki, Brynne Raines, Charles A. Nino, Brian Tran, Alexis Harold, Gabrielle Hodges Onishi, Matthew Hinderman, Amanda Dowdican, Wei Huang, Derek J. Taylor, Sarah E. Taylor, Mark W. Jackson, Analisa DiFeo, Caitlin M. O'Connor, Goutham Narla
Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate and metastasize. Previous work identified mutational hotspots within PPP2R1A, which encodes the Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous PPP2R1A mutations, P179R and S256F, occur exclusively within high-grade subtypes of uterine cancer and can drive tumorigenesis and metastasis. Elucidation of the mechanisms by which PP2A-Aα mutants promote tumor development and progression could help identify therapeutic opportunities. Here, we showed that expression of these mutants in USC/UCS cell-lines enhanced tumor-initiating capacity, drove a hybrid epithelial-to-mesenchymal (EM) plasticity phenotype, and elevated secretion of the tumorigenic cytokine IGFBP2. Therapeutic targeting of the IGFBP2/IGF1R signaling axis using small molecules and genetic approaches resulted in marked tumor growth inhibition. Mechanistically, PP2A regulated IGFBP2 expression through the transcription factor, NF-κB, which harbors a B56 recognition motif. Collectively, these results identify a role for PP2A in regulating paracrine cancer cell signaling that can be targeted to block the initiation and metastasis of high-grade uterine cancer.
{"title":"Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer","authors":"Terrance J. Haanen, Sophie Boock, Catherine G. Callahan, Irene Peris, Kaitlin P. Zawacki, Brynne Raines, Charles A. Nino, Brian Tran, Alexis Harold, Gabrielle Hodges Onishi, Matthew Hinderman, Amanda Dowdican, Wei Huang, Derek J. Taylor, Sarah E. Taylor, Mark W. Jackson, Analisa DiFeo, Caitlin M. O'Connor, Goutham Narla","doi":"10.1158/0008-5472.can-24-1263","DOIUrl":"https://doi.org/10.1158/0008-5472.can-24-1263","url":null,"abstract":"Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate and metastasize. Previous work identified mutational hotspots within PPP2R1A, which encodes the Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous PPP2R1A mutations, P179R and S256F, occur exclusively within high-grade subtypes of uterine cancer and can drive tumorigenesis and metastasis. Elucidation of the mechanisms by which PP2A-Aα mutants promote tumor development and progression could help identify therapeutic opportunities. Here, we showed that expression of these mutants in USC/UCS cell-lines enhanced tumor-initiating capacity, drove a hybrid epithelial-to-mesenchymal (EM) plasticity phenotype, and elevated secretion of the tumorigenic cytokine IGFBP2. Therapeutic targeting of the IGFBP2/IGF1R signaling axis using small molecules and genetic approaches resulted in marked tumor growth inhibition. Mechanistically, PP2A regulated IGFBP2 expression through the transcription factor, NF-κB, which harbors a B56 recognition motif. Collectively, these results identify a role for PP2A in regulating paracrine cancer cell signaling that can be targeted to block the initiation and metastasis of high-grade uterine cancer.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"127 1","pages":""},"PeriodicalIF":11.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.jhazmat.2024.136489
Pooja Sharma, Palak Bakshi, Rekha Chouhan, Sumit G. Gandhi, Rupinder Kaur, Ashutosh Sharma, Renu Bhardwaj, Abdulaziz Abdullah Alsahli, Parvaiz Ahmad
Chromium (Cr) toxicity impairs essential morphological and metabolic activities in plants. The present investigation was carried out to evaluate the beneficial role of plant growth promoting rhizobacterial strains namely Pseudomonas aeruginosa (M1), Burkholderia gladioli (M2) and earthworms (Eisenia fetida) in alleviating Cr toxicity in 10 days old Brassica juncea L. The findings delineated that addition of earthworms and PGPR restored growth, boosted Cr uptake and showed upregulation of metal transporter genes (SULTR 1-4). Supplementation of rhizospheric amendments reinstated Cr induced impairment in photosynthetic attributes. Gaseous exchange attributes, the efficiency of PS II, the content of total phenols, anthocyanin and flavonoids was enhanced with application of earthworms along with PGPR. Confocal imaging of primary photosynthetic pigment (chlorophyll), accessory photosynthetic pigment (carotenoids) and total phenols showed maximum fluorescence with combined inoculation of earthworms and both microbial strains (M1M2). The gene expression analysis revealed that Phyotene synthase (PSY), Photosystem II core protein psb A, psb B were down regulated in Cr stressed seedlings which upon supplementation with earthworms and PGPR were upregulated. Further, Phenylalanine ammonialyase (PAL), chalcone synthase (CHS) were upregulated with addition of earthworms and PGPR. Increased nitric oxide content, enhanced activity and upregulation of nitrate reductase (NR) gene was observed with addition of PGPR and earthworms
铬（Cr）毒性会损害植物的基本形态和代谢活动。本研究旨在评估促进植物生长的根瘤菌株，即铜绿假单胞菌（M1）、伯克霍尔德氏菌（M2）和蚯蚓（Eisenia fetida）在减轻 10 天大的甘蓝（Brassica juncea L）的铬毒性中的有益作用。补充根瘤菌群改良剂后，铬对光合特性的影响得以恢复。在施用蚯蚓和 PGPR 的同时，气体交换属性、PS II 的效率、总酚、花青素和类黄酮的含量都得到了提高。对初级光合色素（叶绿素）、辅助光合色素（类胡萝卜素）和总酚的共焦成像显示，蚯蚓和两种微生物菌株（M1M2）联合接种后荧光最大。基因表达分析表明，Cr 胁迫下的幼苗中，叶绿素合成酶（PSY）、光系统 II 核心蛋白 psb A 和 psb B 受到下调，而在补充蚯蚓和 PGPR 后，它们受到上调。此外，加入蚯蚓和 PGPR 后，苯丙氨酸氨酰化酶（PAL）和查尔酮合成酶（CHS）也得到了上调。加入 PGPR 和蚯蚓后，一氧化氮含量增加，硝酸还原酶（NR）基因的活性增强并上调。
{"title":"Combined application of earthworms and plant growth promoting rhizobacteria improve metal uptake, photosynthetic efficiency and modulate secondary metabolites levels under chromium metal toxicity in Brassica juncea L","authors":"Pooja Sharma, Palak Bakshi, Rekha Chouhan, Sumit G. Gandhi, Rupinder Kaur, Ashutosh Sharma, Renu Bhardwaj, Abdulaziz Abdullah Alsahli, Parvaiz Ahmad","doi":"10.1016/j.jhazmat.2024.136489","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136489","url":null,"abstract":"Chromium (Cr) toxicity impairs essential morphological and metabolic activities in plants. The present investigation was carried out to evaluate the beneficial role of plant growth promoting rhizobacterial strains namely <em>Pseudomonas aeruginosa</em> (M1), <em>Burkholderia gladioli</em> (M2) and earthworms (<em>Eisenia fetida</em>) in alleviating Cr toxicity in 10 days old <em>Brassica juncea</em> L. The findings delineated that addition of earthworms and PGPR restored growth, boosted Cr uptake and showed upregulation of metal transporter genes (<em>SULTR 1-4).</em> Supplementation of rhizospheric amendments reinstated Cr induced impairment in photosynthetic attributes. Gaseous exchange attributes, the efficiency of PS II, the content of total phenols, anthocyanin and flavonoids was enhanced with application of earthworms along with PGPR. Confocal imaging of primary photosynthetic pigment (chlorophyll), accessory photosynthetic pigment (carotenoids) and total phenols showed maximum fluorescence with combined inoculation of earthworms and both microbial strains (M1M2). The gene expression analysis revealed that <em>Phyotene synthase (PSY),</em> Photosystem II core protein <em>psb A</em>, <em>psb B</em> were down regulated in Cr stressed seedlings which upon supplementation with earthworms and PGPR were upregulated. Further, <em>Phenylalanine ammonialyase (PAL), chalcone synthase (CHS)</em> were upregulated with addition of earthworms and PGPR. Increased nitric oxide content, enhanced activity and upregulation of nitrate reductase (<em>NR</em>) gene was observed with addition of PGPR and earthworms","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"9 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sewage systems are a major source for microplastics in riverine exports to oceans. Urban areas are generally considered hotspots for microplastic discharge, whereas emissions from rural areas remain largely understudied. Hence, this study investigated the abundance, characteristics, and polymer types of microplastics in rural wastewater treatment plants (WWTPs) in Guiyang and estimated the annual microplastic emissions of China based on sewage discharge. The influent abundance of microplastics was 3.8-8.2 items/L, the effluent abundance was 3.1-5.9 items/L, with a lower removal rate of 14.4%-54.6%, which might be influenced by lower operating loads and influent concentrations. Raman spectroscopy analysis revealed that polyvinyl alcohol (PVA) was the predominant polymer type. Rural WWTPs were more effective at removing large-sized particles (> 0.1 mm) and films, resulting in higher removal effectiveness by weight (49.1%) compared to urban WWTPs (30.8%). Based on the abundance of microplastics in WWTPs within the study area and China's annual sewage discharge, this study estimated the microplastic emissions released through sewage in China in 2022. The annual microplastic emissions through sewage in China were estimated to be 2995.7 tons, with rural and urban areas contributing 25.1% and 74.9%, respectively. Approximately 724.8 tons and 1001.6 tons of microplastics were removed from rural and urban WWTPs, respectively. This work indicates the unignorable emissions of microplastics from rural sewage and highlights the crucial role of rural WWTPs in reducing microplastic pollution.
{"title":"Significant effects of Rural Wastewater Treatment Plants in Reducing Microplastic Pollution: A Perspective from China's Southwest Area","authors":"Shilin Gao, Qixin Wu, Borui Zhang, Meixue Peng, Jie Zeng, Liang Zhu","doi":"10.1016/j.jhazmat.2024.136488","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136488","url":null,"abstract":"Sewage systems are a major source for microplastics in riverine exports to oceans. Urban areas are generally considered hotspots for microplastic discharge, whereas emissions from rural areas remain largely understudied. Hence, this study investigated the abundance, characteristics, and polymer types of microplastics in rural wastewater treatment plants (WWTPs) in Guiyang and estimated the annual microplastic emissions of China based on sewage discharge. The influent abundance of microplastics was 3.8-8.2 items/L, the effluent abundance was 3.1-5.9 items/L, with a lower removal rate of 14.4%-54.6%, which might be influenced by lower operating loads and influent concentrations. Raman spectroscopy analysis revealed that polyvinyl alcohol (PVA) was the predominant polymer type. Rural WWTPs were more effective at removing large-sized particles (> 0.1<!-- --> <!-- -->mm) and films, resulting in higher removal effectiveness by weight (49.1%) compared to urban WWTPs (30.8%). Based on the abundance of microplastics in WWTPs within the study area and China's annual sewage discharge, this study estimated the microplastic emissions released through sewage in China in 2022. The annual microplastic emissions through sewage in China were estimated to be 2995.7 tons, with rural and urban areas contributing 25.1% and 74.9%, respectively. Approximately 724.8 tons and 1001.6 tons of microplastics were removed from rural and urban WWTPs, respectively. This work indicates the unignorable emissions of microplastics from rural sewage and highlights the crucial role of rural WWTPs in reducing microplastic pollution.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"35 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1097/hep.0000000000001166
Cynthia Levy, Christopher L. Bowlus
Primary biliary cholangitis (PBC) is an enigmatic, autoimmune disease targeting the small intralobular bile ducts resulting in cholestasis and potentially progression to biliary cirrhosis. Primarily affecting middle-aged women, the diagnosis of PBC is typically straightforward with most patients presenting with cholestatic liver tests and the highly specific anti-mitochondrial antibody. For decades, the foundational treatment of PBC has been ursodeoxycholic acid (UDCA) which delays disease progression in most patients but has no impact on PBC symptoms. Large cohort studies of patients with PBC have established the benefit of maximizing the reduction in serum alkaline phosphatase with UDCA and the need to add second-line agents in patients who do not achieve an adequate response. Advances in the understanding of bile acid physiology have led to the development of new agents that improve cholestasis in patients with PBC and are predicted to reduce the risk of disease progression. Obeticholic acid, the first second-line therapy to be approved for PBC, significantly improves liver biochemistries and has been associated with improved long term clinical outcomes but is limited by its propensity to induce pruritus. Elafibranor and seladelpar are peroxisome proliferator-activated receptor agonists recently approved for use in patient with PBC, whereas bezafibrate and fenofibrate are available as off-label therapies. They also have shown biochemical improvements among patients with an inadequate response to UDCA, but may improve symptoms of pruritus. Herein, we review the patient features to consider when deciding whether a second-line agent is indicated and which agent to consider for a truly personalized approach to PBC patient care.
{"title":"Primary Biliary Cholangitis: Personalizing Second-Line Therapies-R1","authors":"Cynthia Levy, Christopher L. Bowlus","doi":"10.1097/hep.0000000000001166","DOIUrl":"https://doi.org/10.1097/hep.0000000000001166","url":null,"abstract":"Primary biliary cholangitis (PBC) is an enigmatic, autoimmune disease targeting the small intralobular bile ducts resulting in cholestasis and potentially progression to biliary cirrhosis. Primarily affecting middle-aged women, the diagnosis of PBC is typically straightforward with most patients presenting with cholestatic liver tests and the highly specific anti-mitochondrial antibody. For decades, the foundational treatment of PBC has been ursodeoxycholic acid (UDCA) which delays disease progression in most patients but has no impact on PBC symptoms. Large cohort studies of patients with PBC have established the benefit of maximizing the reduction in serum alkaline phosphatase with UDCA and the need to add second-line agents in patients who do not achieve an adequate response. Advances in the understanding of bile acid physiology have led to the development of new agents that improve cholestasis in patients with PBC and are predicted to reduce the risk of disease progression. Obeticholic acid, the first second-line therapy to be approved for PBC, significantly improves liver biochemistries and has been associated with improved long term clinical outcomes but is limited by its propensity to induce pruritus. Elafibranor and seladelpar are peroxisome proliferator-activated receptor agonists recently approved for use in patient with PBC, whereas bezafibrate and fenofibrate are available as off-label therapies. They also have shown biochemical improvements among patients with an inadequate response to UDCA, but may improve symptoms of pruritus. Herein, we review the patient features to consider when deciding whether a second-line agent is indicated and which agent to consider for a truly personalized approach to PBC patient care.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"41 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.jhazmat.2024.136391
Selina Tisler, Nastacha Kristiansen, Jan H. Christensen
Estimating the chemical hazards of drinking water stored in reusable plastic bottles is challenging due to the numerous intentionally and unintentionally added chemicals. To address this, we developed a broad screening strategy using evaporation enrichment and liquid chromatography high-resolution mass spectrometry (LC-HRMS) to evaluate migration of non-volatile chemicals from various reusable plastic bottles. The study analyzed a wide range of materials, revealing significant variability in chemical profiles across different bottle types. Over 70% of nearly 1,000 unknown compounds were unique to specific bottles. Silicone, HDPE, LDPE, and PP bottles showed the highest migration rates, with silicone releasing the most unknowns, but also phthalates and plasticizers. PP bottles exhibited concerning migration of clarifying agents and bisphenol A derivatives. In contrast, PS, PET, PETG, and PCTG had minimal migration, indicating lower health risks. These findings highlight the need for comprehensive assessments of plastic materials to improve consumer safety.
由于可重复使用塑料瓶中有意或无意添加了大量化学物质，因此估算可重复使用塑料瓶中储存的饮用水的化学危害具有挑战性。为了解决这个问题，我们开发了一种广泛的筛选策略，利用蒸发富集和液相色谱高分辨质谱法（LC-HRMS）来评估非挥发性化学品从各种可重复使用塑料瓶中的迁移。该研究分析了多种材料，发现不同类型的瓶子在化学特征方面存在显著差异。在近 1000 种未知化合物中，70% 以上是特定瓶子所特有的。硅胶瓶、高密度聚乙烯瓶、低密度聚乙烯瓶和聚丙烯瓶的迁移率最高，其中硅胶瓶释放的未知化合物最多，但也释放邻苯二甲酸盐和增塑剂。聚丙烯瓶显示出澄清剂和双酚 A 衍生物的迁移。相比之下，PS、PET、PETG 和 PCTG 的迁移率最低，表明健康风险较低。这些发现凸显了对塑料材料进行全面评估以提高消费者安全的必要性。
{"title":"Chemical Migration from Reusable Plastic Bottles: Silicone, Polyethylene, and Polypropylene show Highest Hazard Potential in LC-HRMS Analysis","authors":"Selina Tisler, Nastacha Kristiansen, Jan H. Christensen","doi":"10.1016/j.jhazmat.2024.136391","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136391","url":null,"abstract":"Estimating the chemical hazards of drinking water stored in reusable plastic bottles is challenging due to the numerous intentionally and unintentionally added chemicals. To address this, we developed a broad screening strategy using evaporation enrichment and liquid chromatography high-resolution mass spectrometry (LC-HRMS) to evaluate migration of non-volatile chemicals from various reusable plastic bottles. The study analyzed a wide range of materials, revealing significant variability in chemical profiles across different bottle types. Over 70% of nearly 1,000 unknown compounds were unique to specific bottles. Silicone, HDPE, LDPE, and PP bottles showed the highest migration rates, with silicone releasing the most unknowns, but also phthalates and plasticizers. PP bottles exhibited concerning migration of clarifying agents and bisphenol A derivatives. In contrast, PS, PET, PETG, and PCTG had minimal migration, indicating lower health risks. These findings highlight the need for comprehensive assessments of plastic materials to improve consumer safety.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1097/hep.0000000000001164
Yuanhao Wei, Lanlan Chen, Kun Zhao
{"title":"Hematological traits in sodium-glucose cotransporter-2 efficacy: mediators or confounders ?","authors":"Yuanhao Wei, Lanlan Chen, Kun Zhao","doi":"10.1097/hep.0000000000001164","DOIUrl":"https://doi.org/10.1097/hep.0000000000001164","url":null,"abstract":"","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"22 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1097/hep.0000000000001157
Vidhu V. Thaker, Nancy Crimmins, Katherine P. Yates, Ali Mencin, Stavra Xanthakos
{"title":"Reply: Prevalence of subclinical hypothyroidism and longitudinal thyroid stimulating hormone changes in youth with metabolic dysfunction-associated steatotic liver disease: an observational study","authors":"Vidhu V. Thaker, Nancy Crimmins, Katherine P. Yates, Ali Mencin, Stavra Xanthakos","doi":"10.1097/hep.0000000000001157","DOIUrl":"https://doi.org/10.1097/hep.0000000000001157","url":null,"abstract":"","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"18 1","pages":""},"PeriodicalIF":13.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.jhazmat.2024.136468
Jian Liu, Zhanli Ren, Qiang Yu, Kai Qi, Han Wu, Zhen Wang, Guoqiang Zhang, Yang Zhang, Mingxing Jia, Peng Jia
The enrichment of fluoride in the deep geothermal water of the Lantian – Bahe Formation in parts of the Weihe Basin in China is a potential health hazard for the millions of inhabitants of this region. We conducted hydrochemical and hydrogeological analyses of water samples from 31 geothermal wells in the Weihe Basin, with the aims of determining the distribution characteristics, enrichment patterns, hydrochemical processes, and the factors influencing the geochemistry of deep geothermal fluids. We also evaluated the potential health hazards of fluoride ions in these fluids. Our results show that geothermal fluids with high fluoride content are widely distributed in the deep aquifers of the Weihe Basin. The principal hydrochemical types are: HCO3–Na and SO4⋅HCO3⋅Cl–Na. We used hydrodynamic simulation and regression analysis to show that the high proportion of HCO3– in the geothermal water facilitates the precipitation of Ca2+ and the dissolution of fluorine-bearing minerals. The high temperature, alkaline environment, cation exchange reactions, and dissolution and precipitation processes lead to Ca2+ depletion, which facilitates the release of fluoride ions from the surrounding rocks into the geothermal fluids. A human health risk assessment shows that the hazard quotient (HQ) values of geothermal water for adult males, adult females, children, and infants are: 3.96 – 14.41 (median 6.55), 3.32 – 12.08 (median 4.50), 4.63 – 16.84 (median 5.50), and 7.48 – 27.22 (median 9.00), respectively. Infants are the most susceptible to the effects of high fluoride in groundwater due to their physiological characteristics. while the potential health risks of F− for children and adult women/men are relatively low. Therefore, in the process of developing deep geothermal water, it is necessary to prevent it from mixing into shallow drinking water as much as possible. If the fluoride ion content in the shallow water exceeds the standard, it may have an impact on the local environment and residents' health. These findings provide a scientific foundation for the effective management of high fluoride groundwater in the Weihe Basin and analogous regions elsewhere.
{"title":"Hydrochemical processes and fluoride enrichment patterns in high-fluoride geothermal water in the Weihe Basin, China","authors":"Jian Liu, Zhanli Ren, Qiang Yu, Kai Qi, Han Wu, Zhen Wang, Guoqiang Zhang, Yang Zhang, Mingxing Jia, Peng Jia","doi":"10.1016/j.jhazmat.2024.136468","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136468","url":null,"abstract":"The enrichment of fluoride in the deep geothermal water of the Lantian – Bahe Formation in parts of the Weihe Basin in China is a potential health hazard for the millions of inhabitants of this region. We conducted hydrochemical and hydrogeological analyses of water samples from 31 geothermal wells in the Weihe Basin, with the aims of determining the distribution characteristics, enrichment patterns, hydrochemical processes, and the factors influencing the geochemistry of deep geothermal fluids. We also evaluated the potential health hazards of fluoride ions in these fluids. Our results show that geothermal fluids with high fluoride content are widely distributed in the deep aquifers of the Weihe Basin. The principal hydrochemical types are: HCO<sub>3</sub>–Na and SO<sub>4</sub>⋅HCO<sub>3</sub>⋅Cl–Na. We used hydrodynamic simulation and regression analysis to show that the high proportion of HCO<sub>3</sub><sup>–</sup> in the geothermal water facilitates the precipitation of Ca<sup>2+</sup> and the dissolution of fluorine-bearing minerals. The high temperature, alkaline environment, cation exchange reactions, and dissolution and precipitation processes lead to Ca<sup>2+</sup> depletion, which facilitates the release of fluoride ions from the surrounding rocks into the geothermal fluids. A human health risk assessment shows that the hazard quotient (HQ) values of geothermal water for adult males, adult females, children, and infants are: 3.96 – 14.41 (median 6.55), 3.32 – 12.08 (median 4.50), 4.63 – 16.84 (median 5.50), and 7.48 – 27.22 (median 9.00), respectively. Infants are the most susceptible to the effects of high fluoride in groundwater due to their physiological characteristics. while the potential health risks of F<sup>−</sup> for children and adult women/men are relatively low. Therefore, in the process of developing deep geothermal water, it is necessary to prevent it from mixing into shallow drinking water as much as possible. If the fluoride ion content in the shallow water exceeds the standard, it may have an impact on the local environment and residents' health. These findings provide a scientific foundation for the effective management of high fluoride groundwater in the Weihe Basin and analogous regions elsewhere.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bensulfuron-methyl (BSM), a widely used herbicide, can persist in soil and damag sensitive crops. Microbial degradation, supplemented with exogenous additives, provides an effective strategy to enhance BSM breakdown. Hansschlegelia zhihuaiae S113 has been shown to efficiently degrade this sulfonylurea herbicide. However, depending solely on a single strain for degradation proves inefficient and unlikely to achieve ideal remediation in practical applications. This study assessed the impact of various carbon sources on the degradation efficiency of S113 in BSM-polluted soil. Among these, glucose was the most effective, achieving a 98.7% degradation rate after 9 d of inoculation. In addition, seven intermediates were detected during BSM degradation in soil through the cleavage of the phenyl ring ester bond, the pyrimidine rings, and urea bridge peptide bond, among other pathways. 2-amino-4,6-dimethoxy pyrimidine (ADMP), and 2-(aminosulfonylmethyl)-methyl benzoate(MSMB) were the primary intermediates. These metabolites were less toxic to maize, sorghum, and bacteria than the BSM. Community structure analysis indicated that variations in exogenous carbon sources and environmental pollutants significantly improved the ecological functions of soil microbial communities, enhancing pollutant degradation. Addition of carbon sources notably affected soil microbial community structure, modifying metabolic activities and interaction patterns. Specifically, glucose substantially increased the richness and diversity of soil bacterial communities. These findings offer valuable insights for field remediation practices and contributed to the development of more robuste soil pollution management strategies.
{"title":"Enhanced bioremediation of bensulfuron-methyl contaminated soil by Hansschlegelia zhihuaiae S113: metabolic pathways and bacterial community structure","authors":"Hao Zhang, Houyu Yu, Yun Xiang, Hancheng Wang, Yingying Qian, Xing Huang","doi":"10.1016/j.jhazmat.2024.136471","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136471","url":null,"abstract":"Bensulfuron-methyl (BSM), a widely used herbicide, can persist in soil and damag sensitive crops. Microbial degradation, supplemented with exogenous additives, provides an effective strategy to enhance BSM breakdown. <em>Hansschlegelia zhihuaiae</em> S113 has been shown to efficiently degrade this sulfonylurea herbicide. However, depending solely on a single strain for degradation proves inefficient and unlikely to achieve ideal remediation in practical applications. This study assessed the impact of various carbon sources on the degradation efficiency of S113 in BSM-polluted soil. Among these, glucose was the most effective, achieving a 98.7% degradation rate after 9 d of inoculation. In addition, seven intermediates were detected during BSM degradation in soil through the cleavage of the phenyl ring ester bond, the pyrimidine rings, and urea bridge peptide bond, among other pathways. 2-amino-4,6-dimethoxy pyrimidine (ADMP), and 2-(aminosulfonylmethyl)-methyl benzoate(MSMB) were the primary intermediates. These metabolites were less toxic to maize, sorghum, and bacteria than the BSM. Community structure analysis indicated that variations in exogenous carbon sources and environmental pollutants significantly improved the ecological functions of soil microbial communities, enhancing pollutant degradation. Addition of carbon sources notably affected soil microbial community structure, modifying metabolic activities and interaction patterns. Specifically, glucose substantially increased the richness and diversity of soil bacterial communities. These findings offer valuable insights for field remediation practices and contributed to the development of more robuste soil pollution management strategies.","PeriodicalId":12,"journal":{"name":"ACS Chemical Health & Safety","volume":"6 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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