Hormones and Behavior最新文献_第6页

Within-litter variation in maternal care is a key contributor to individual differences in offspring behavior and monoamine neurochemistry in female Long–Evans rats 母性照顾的窝内差异是雌性Long-Evans大鼠后代行为和单胺神经化学个体差异的关键因素

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-25 DOI: 10.1016/j.yhbeh.2025.105821

Quintin A. Whitman , Amirreza Mirzaei , Samantha C. Lauby , Diptendu Chatterjee , Alison Fleming , Patrick O. McGowan

The care that a mother rat provides is essential for the ability of her pups to survive and thrive. Maternal care naturally varies between litters, including among animals with close genetic relatedness. There are also significant differences in behavior even among offspring reared together. Our lab and others have documented stable, naturally occurring individual differences in maternal care received by individual pups within the litter that persist throughout at least the first ten days of postnatal life. In this study, we hypothesized that within-litter variation in maternal care received constitutes a significant source of variation in offspring behavior and neurochemistry in Long-Evans rats. We analyzed measures related to maternal care behavior, offspring anxiety-like and social behaviors, and neurotransmitter levels in specific brain regions after the offspring became mothers themselves. For statistical modeling, we used the coefficient of variation (CV) to standardize and directly compare between- and within-litter variation across a range of behavioral and neurophysiological outcomes. Several variables analyzed showed greater within-litter CVs than between-litter CVs, especially for offspring behavior and levels of the monoamines dopamine, serotonin, and their primary metabolites DOPAC (3,4-dihydroxyphenylacetic acid) and 5-HIAA (5-hydroxyindoleacetic acid) in the nucleus accumbens, ventral tegmental area, medial preoptic area, hippocampus, and prefrontal cortex. Our findings suggest that within-litter variation in maternal care plays a prominent role in behavioral and physiological outcomes. This study provides a methodological advance by demonstrating that within-litter variability often exceeds between-litter variability across maternal, behavioral, and neurochemical domains, challenging a key assumption in experimental designs using littermate controls.

母鼠提供的照顾对幼鼠的生存和茁壮成长至关重要。母性照顾在不同胎仔之间自然是不同的，包括在遗传亲缘关系密切的动物之间。即使在共同抚养的后代中，行为也存在显著差异。我们的实验室和其他实验室已经记录了稳定的、自然发生的个体差异，这些差异至少在出生后的头十天内持续存在。在本研究中，我们假设，在龙伊文斯大鼠的后代行为和神经化学变异中，母性照顾的窝内变化是一个重要的来源。我们分析了与母亲照顾行为、后代焦虑和社交行为以及后代成为母亲后特定大脑区域的神经递质水平相关的测量。对于统计建模，我们使用变异系数（CV）来标准化和直接比较一系列行为和神经生理结果的凋落物之间和凋落物内的变异。分析的几个变量表明，窝内CVs大于窝间CVs，特别是后代行为和单胺类多巴胺、血清素及其主要代谢物DOPAC（3,4-二羟基苯基乙酸）和5-HIAA（5-羟基吲哚乙酸）在伏隔核、腹侧被盖区、内侧视前区、海马和前额皮质中的水平。我们的研究结果表明，产妇护理的窝内变化在行为和生理结果中起着重要作用。本研究提供了一个方法上的进步，通过证明在母系、行为和神经化学领域，窝内变异性往往超过窝间变异性，挑战了使用窝友控制的实验设计中的一个关键假设。

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引用次数: 0

Hormonal contraceptives modulate resilience to psychiatric and neurodegenerative disease 激素避孕药调节对精神和神经退行性疾病的恢复力

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-22 DOI: 10.1016/j.yhbeh.2025.105823

Kristen M. Schuh, Leah M. Conrad, Natalie C. Tronson

Hormonal contraceptives (HCs) are one of the most widely used classes of drug worldwide and are a critical part of women's health. Beyond their primary use for birth control, HCs exert many health benefits, including treatment of menstrual-related symptoms and reduced risk of certain types of cancers. Here, we focus on the role of HCs in promoting resilience to depression and Alzheimer's disease. Although risks for depression with HC use have been widely stated, HCs only increase risk for up to 10 % of users, and conversely improve mood and protect against depression for many others. Emerging evidence also suggests that HC use protects against age-related cognitive decline and Alzheimer's disease, even decades after HC use. We propose that these effects are due to modulatory effects of HCs on stress-related signaling and neuroimmune function. In this paper, we discuss how HCs interact with stress responsivity, neuroimmune signaling, and other individual differences to promote resilience or susceptibility to psychiatric and neurological disorders.

激素避孕药是世界上使用最广泛的药物之一，是妇女健康的重要组成部分。除了主要用于节育之外，hc还具有许多健康益处，包括治疗月经相关症状和降低某些类型癌症的风险。在这里，我们关注hc在促进抑郁症和阿尔茨海默病的恢复能力中的作用。虽然使用大麻有抑郁症的风险已经被广泛指出，但大麻只增加了高达10%的使用者的风险，相反，对许多其他人来说，大麻可以改善情绪，防止抑郁。新出现的证据还表明，使用HC可以防止与年龄相关的认知能力下降和阿尔茨海默病，即使在使用HC几十年后也是如此。我们认为这些影响是由于hc对应激相关信号和神经免疫功能的调节作用。在本文中，我们讨论了hc如何与应激反应、神经免疫信号和其他个体差异相互作用，以促进对精神和神经疾病的恢复力或易感性。

引用次数: 0

Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking 中枢甲状腺激素受体- β：对酒精的敏感性和调节饮酒的作用。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-18 DOI: 10.1016/j.yhbeh.2025.105822

Michael C. Johnson , Michelle A. Nipper , Kelly M. Abshire , Jessica E. Rehmann , Jonathan A. Zweig , Theresa N. Vu , Mandee A. Bell , Tapasree Banerji , Thomas S. Scanlan , Andrey E. Ryabinin , Deena M. Walker

Clinical and preclinical evidence indicate that both peripheral and central elements of the hypothalamic-pituitary-thyroid (HPT) axis are dysregulated in alcohol use disorder, and that thyroid hormone system dysregulation is associated alcohol craving and co-morbid mood and depression-related disorders. Yet, no study has investigated if central nervous system (CNS) thyroid hormone receptors, primary targets of thyroid hormone and major regulators of the HPT axis are involved in alcohol consumption. We utilized a 24-h access two-bottle choice (2BC) voluntary ethanol (EtOH) drinking paradigm to assess if the expression of CNS thyroid hormone receptors is sensitive to voluntary alcohol consumption in C57BL/6 J mice. We found that thyroid hormone receptor-beta (Thrb/THRβ) mRNA expression was significantly reduced in the paraventricular nucleus of the hypothalamus of EtOH drinking mice compared to water controls. In addition, EtOH drinking mice exhibited peripheral elevation of serum triiodothyronine. Next, we utilized the CNS selective THRβ agonist, Sob-AM2, to determine if central activation of THRβ would influence voluntary alcohol drinking in mice in the same EtOH 2BC drinking paradigm. We found that repeated treatment with Sob-AM2 significantly reduced daily EtOH intake and preference, while in conjunction increasing water intake. In summary, we found that hypothalamic Thrb expression is sensitive to voluntary alcohol drinking, and that CNS THRβ activity regulates alcohol consumption in mice. Taken together, our results highlight an important role of central thyroid hormone receptor signalling in alcohol drinking and indicate therapeutic potential of CNS selective thyromimetics in treatment of alcohol use disorder.

临床和临床前证据表明，下丘脑-垂体-甲状腺（HPT）轴的外周和中枢元素在酒精使用障碍中都是失调的，甲状腺激素系统失调与酒精渴望和共病的情绪和抑郁相关障碍有关。然而，没有研究调查中枢神经系统（CNS）甲状腺激素受体、甲状腺激素的主要靶点和HPT轴的主要调节因子是否与饮酒有关。我们利用24小时进入两瓶选择（2BC）自愿饮酒（EtOH）范式来评估C57BL/6 J小鼠CNS甲状腺激素受体的表达是否对自愿饮酒敏感。我们发现，与水对照组相比，饮用EtOH小鼠下丘脑室旁核中甲状腺激素受体- β (Thrb/THRβ) mRNA表达显著降低。此外，饮用EtOH小鼠外周血血清三碘甲状腺原氨酸升高。接下来，我们利用中枢神经系统选择性THRβ激动剂Sob-AM2来确定在相同的EtOH 2BC饮酒模式下，中枢激活THRβ是否会影响小鼠的自愿饮酒。我们发现反复使用Sob-AM2显著降低每日EtOH摄入量和偏好，同时增加水摄入量。总之，我们发现下丘脑Thrb表达对自愿饮酒敏感，中枢神经系统THRβ活性调节小鼠的酒精消耗。综上所述，我们的研究结果强调了中枢甲状腺激素受体信号在饮酒中的重要作用，并表明中枢神经系统选择性拟甲状腺药物治疗酒精使用障碍的治疗潜力。

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引用次数: 0

A systematic review and experimental study of micro/nanoplastic-induced endocrine disruption in rodents: Potential links to autism spectrum disorder 微/纳米塑料诱导的啮齿动物内分泌干扰的系统综述和实验研究：与自闭症谱系障碍的潜在联系

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-15 DOI: 10.1016/j.yhbeh.2025.105818

Lucas F. Fowler , T. Nadine Burry , Alexandre S. Maekawa , Lindsay S. Cahill

Recent research shows that microplastic (diameter < 5 mm) and nanoplastic (diameter < 1 μm) exposures can have endocrine-disrupting effects and lead to autism spectrum disorder (ASD)-like behaviours in rodent models. We combine both a (i) systematic literature review and (ii) experimental study to synthesize the potential mechanisms underlying the link between micro−/nanoplastic (MNP) exposure and ASD, focusing on endocrine disruption and articles utilizing rodent models. First, we identify and discuss trends in the literature, outline research gaps, and suggest future directions. Most articles measured gonadal hormones in male adult rodents and consistently reported decreased testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with MNP exposure. Females were understudied, with no trends emerging in exposure-induced hormone disruption. Second, we present experimental data demonstrating direct effects of maternal polystyrene NP exposure on neuroendocrine systems and inflammatory markers in the fetal brain. Cytokines, interleukin-2 (IL-2) and interleukin-6 (IL-6), and triiodothyronine (T3) were significantly altered in the fetal brain following prenatal exposure to NPs, and thyroxine (T4) and T were significantly suppressed in female NP-exposed fetuses but not in males. Together, these findings demonstrate that MNP exposure during adulthood and early development affect multiple endocrine systems, including those implicated in autism spectrum disorder, in a sex-dependent manner. We synthesize how such results are important to motivate exposure studies in animals and humans and future regulatory guidelines on MNPs.

最近的研究表明，在啮齿动物模型中，微塑料（直径5毫米）和纳米塑料（直径1 μm）暴露会产生内分泌干扰效应，并导致自闭症谱系障碍（ASD）样行为。我们结合了(i)系统的文献综述和（ii）实验研究，综合了微/纳米塑料（MNP）暴露与ASD之间联系的潜在机制，重点是内分泌干扰和利用啮齿动物模型的文章。首先，我们识别和讨论文献中的趋势，概述研究差距，并建议未来的方向。大多数文章测量了雄性成年啮齿动物的性腺激素，并一致报告了MNP暴露后睾酮(T)、黄体生成素（LH）和卵泡刺激素（FSH）的下降。对女性进行了充分的研究，没有发现暴露引起的激素紊乱的趋势。其次，我们提供的实验数据表明母体聚苯乙烯NP暴露对胎儿大脑神经内分泌系统和炎症标志物的直接影响。产前暴露于np后，胎儿脑内细胞因子、白细胞介素-2 （IL-2）、白细胞介素-6 （IL-6）和三碘甲状腺原氨酸（T3）显著改变，女性暴露于np的胎儿甲状腺素（T4）和T显著抑制，而男性暴露于np的胎儿则无显著抑制。总之，这些发现表明，在成年期和发育早期接触MNP会以性别依赖的方式影响多种内分泌系统，包括与自闭症谱系障碍有关的内分泌系统。我们综合了这些结果对激励动物和人类暴露研究以及未来MNPs监管指南的重要性。

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引用次数: 0

Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans 人际感觉运动同步中的催产素动力学：人类对照实验

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-13 DOI: 10.1016/j.yhbeh.2025.105817

Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina

Interpersonal sensorimotor synchronisation is the coordination of movement between individuals that underlies successful interpersonal communication. Previous research has indicated the potential involvement of oxytocin (OXT) in the process of synchronisation.

We conducted 2 randomised controlled experiments to test the effect of synchronisation on salivary OXT concentrations. In Experiment 1, 90 volunteers (65 women) performed either synchronous or asynchronous a 5-min hand gesture task with an unfamiliar partner. In Experiment 2, 67 familiar dyads of volunteers (47 female dyads) performed the same task. Salivary OXT concentrations were measured before and after the gesture task (Experiment 1) or before, after and 10 min after the gesture task (Experiment 2). Saliva samples were analysed using the ELISA method to estimate OXT concentrations.

In Experiment 1, we found no significant differences between salivary OXT levels at baseline and after the 5-min task in either synchronous or asynchronous conditions. We also found no evidence for increased liking of a stranger after sensorimotor synchrony. In Experiment 2, the asynchronous condition led to a decrease in OXT levels over time, whereas synchronous interactions led to stable OXT levels over time. The effect of condition on OXT was not moderated by closeness or attachment style. The results are discussed in relation to research methodology used to study interpersonal synchrony.

人际感觉运动同步是个体之间运动的协调，是成功人际沟通的基础。先前的研究表明，催产素（OXT）可能参与了同步过程。我们进行了2个随机对照实验来测试同步对唾液OXT浓度的影响。在实验1中，90名志愿者（65名女性）与一个不熟悉的伙伴一起进行了5分钟的同步或非同步手势任务。在实验2中，67对熟悉的志愿者（47对女性）执行同样的任务。在手势任务之前和之后（实验1）或手势任务之前，之后和之后10分钟（实验2）测量唾液OXT浓度。使用ELISA法分析唾液样本以估计OXT浓度。在实验1中，我们发现在同步或异步条件下，基线和5分钟任务后的唾液OXT水平没有显著差异。我们也没有发现在感觉运动同步后对陌生人的好感会增加的证据。在实验2中，异步条件导致OXT水平随着时间的推移而下降，而同步交互导致OXT水平随着时间的推移而稳定。亲密程度和依恋类型不影响条件对应激反应的影响。研究结果与研究人际同步性的研究方法有关。

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引用次数: 0

Changes in steroid hormone levels based on a plastic behavioral role in two biparental cichlids, Julidochromis transcriptus and Julidochromis marlieri: A test of the Ancestral Modulation Hypothesis 基于可塑性行为作用的两种双亲本稚鱼（转录稚鱼和玛利稚鱼）类固醇激素水平变化：祖先调节假说的检验

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-10 DOI: 10.1016/j.yhbeh.2025.105820

A.P. Anderson, F. Noble, W. Cantlon, S.C.P. Renn

Cross-sexual transfer describes the situation when one sex takes on the phenotypic values of the other sex, either plastically or over evolutionary time. The underlying regulatory mechanisms of this process have been generally assumed to be related to sex-biased hormonal regulation, but explicit empirical tests have not been conducted. More recently, the Ancestral Modulation Hypothesis (AMH) has been proposed as a framework to understand the hormonal regulation that underlies cross-sexual transfer. We leverage the behavioral changes in two species of biparental cichlid, Julidochromis transcriptus and Julidochromis marlieri, to test hormonal changes when cross-sexual transfer occurs and provide an empirical test of the AMH. One species, J. transcriptus, typically forms male-larger pairs, which is generally considered to be the ancestral condition; yet females take on male behaviors when they are the larger individual in the pair. The other species, J. marlieri, typically forms female-larger pairs, a cross-sexual transfer, but can likewise shift behaviors when paired atypically. We established pairs by giving males and females of both species both larger and smaller partners and measured behavioral and hormonal changes. We found J. transcriptus females increased 11-ketotestorerone (11-KT) when becoming the larger partner and 11-KT and estradiol (E2) correlated with behaviors associated with the larger partner. We did not find any changes in hormone levels based on size or sex in J. marlieri, though behaviors did correlate with testosterone (T). These results provide qualified support for the tested prediction from the AMH framework that cross-sexual transfer can occur by coopting hormonal signaling by adjusting circulating hormones.

跨性别转移描述了一种情况，即一种性别在可塑性或进化过程中获得了另一种性别的表型值。这一过程的潜在调节机制通常被认为与性别偏向的激素调节有关，但明确的经验检验尚未进行。最近，祖先调节假说（AMH）被提出作为一个框架来理解跨性别转移背后的激素调节。我们利用两种双亲本丽鱼（Julidochromis transcriptus）和marlieri丽鱼（Julidochromis marlieri）的行为变化来测试跨性别转移发生时激素的变化，并提供AMH的经验测试。一个物种，J. transcriptus，通常形成雄性较大的配对，这通常被认为是祖先的条件；然而，当雌性是一对中较大的个体时，它们会采取雄性的行为。另一个物种，J. marlieri，通常会形成雌性更大的配对，这是一种跨性别的转移，但当非典型配对时，也会改变行为。我们给两个物种的雄性和雌性分别提供大的和小的伴侣，并测量它们的行为和激素变化，从而建立了成对关系。我们发现雌性J. transcriptus在成为大伴侣时11-酮睾酮（11-KT）增加，11-KT和雌二醇（E2）与大伴侣的行为相关。虽然行为确实与睾酮有关，但我们没有发现任何基于体型或性别的激素水平变化。这些结果为AMH框架的预测提供了合格的支持，即通过调节循环激素来调节激素信号可以发生跨性别转移。

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引用次数: 0

The role of oxytocin in enhancing group-based guilt and promoting intergroup reconciliation in a collectivist context 在集体主义背景下，催产素在增强群体内疚和促进群体间和解中的作用

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-10 DOI: 10.1016/j.yhbeh.2025.105819

Zhiai Li , Mengsi Xu , Shiyao Huang , An Yang

Group-based guilt, arising from the awareness of harmful or immoral actions committed by fellow group members, is a powerful negative emotion. It motivates various forms of reparative behavior which mitigates the intergroup conflicts. However, the widespread expression of group-based guilt remains relatively infrequent. Therefore, how to enhance the utility of group-based guilt remains a paramount issue in the field of intergroup conflict. Oxytocin is widely recognized for its pivotal role in positively influencing social cognition and behavior. Consequently, our research aimed to investigate the potential modulation of oxytocin on group-based guilt by examining whether oxytocin enhances group-based responsibility, guilt and compensation within a collectivist cultural context. To achieve this, we conducted a double-blind, placebo-controlled experimental design: 2 (Treatment: Placebo vs. Oxytocin) × 2 (Group membership: In-group vs. Out-group). The results showed that the administration of oxytocin could enhance group-based responsibility, guilt, and compensation. In conclusion, the study of oxytocin and group-based guilt highlights the potential role of biological processes in shaping social emotions and cognition, then enhancing altruistic behavior toward the victimized group and moderating intergroup relations.

群体内疚感是一种强烈的负面情绪，它源于对群体成员有害或不道德行为的意识。它激发了各种形式的修复行为，减轻了群体间的冲突。然而，基于群体的内疚的广泛表达仍然相对较少。因此，如何提高群体内疚的效用一直是群体间冲突研究领域的一个重要课题。人们普遍认为催产素在积极影响社会认知和行为方面发挥着关键作用。因此，我们的研究旨在通过检验催产素是否在集体主义文化背景下增强群体责任、内疚和补偿来研究催产素对群体内疚的潜在调节。为了达到这个目的，我们进行了双盲、安慰剂对照的实验设计：2（治疗：安慰剂vs催产素）x2（组成员：内组vs外组）。结果表明，催产素的使用可以增强基于群体的责任、内疚和补偿。综上所述，对催产素和群体内疚的研究强调了生物过程在塑造社会情绪和认知、增强对受害群体的利他行为和调节群体间关系方面的潜在作用。

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引用次数: 0

Hormonal contraceptive use in relation to basal and reactive testosterone, DHEAS, and cortisol 激素避孕药的使用与基础和反应性睾酮，DHEAS和皮质醇的关系

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-08-29 DOI: 10.1016/j.yhbeh.2025.105806

Kathleen V. Casto , Sally Farah , Ariel Castro , Modupe Akinola , Pranjal H. Mehta

A burgeoning area of research has begun to uncover a wide range of potential neurological and psychological correlates of hormonal contraceptive (HC) use. Yet there remains a limited understanding of the underlying mechanisms for how HC use alters aspects of neurobiology and related behavioral outcomes. Uncovering these processes has the potential for new discovery in the field of behavioral neuroendocrinology, particularly in the complex interplay between steroid hormone subclasses. Although prior research has often focused on the effects of HC use on progestogen and estrogen disruption, basal and reactive androgens and cortisol may also be significantly impacted by HC use and serve critical functions throughout the brain and body. We discuss important background information on the synthesis and function of three steroid hormones – testosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol, review prior research showing how HC use is related to circulating (basal) and reactive levels, and provide sample data on salivary levels from our own research. The combined evidence shows that HC use, specifically of the OC pill, is associated with significantly reduced total, free, and salivary androgens, increased total cortisol in blood but not saliva, and a blunted salivary cortisol response to social stressors. Limited evidence provides initial indication that the specific estrogen and progestin compounds in HC formulas may differentially impact steroid hormone levels. Finally, we discuss the mechanisms by which HCs alter steroid hormone levels, the potential implications of these effects on brain and behavior outcomes, and considerations for future research.

一个新兴的研究领域已经开始揭示激素避孕药（HC）使用的广泛潜在的神经和心理相关。然而，对于HC的使用如何改变神经生物学和相关行为结果的潜在机制，人们的理解仍然有限。揭示这些过程有可能在行为神经内分泌学领域，特别是在类固醇激素亚类之间复杂的相互作用方面有新的发现。虽然先前的研究通常集中在HC使用对孕激素和雌激素破坏的影响上，但基础和反应性雄激素和皮质醇也可能受到HC使用的显著影响，并在整个大脑和身体中发挥关键作用。我们讨论了三种类固醇激素——睾酮、硫酸脱氢表雄酮（DHEAS）和皮质醇的合成和功能的重要背景信息，回顾了先前的研究，表明HC的使用如何与循环（基础）和反应水平相关，并提供了我们自己研究的唾液水平样本数据。综合证据表明，使用HC，特别是使用OC药丸，与总雄激素、游离雄激素和唾液雄激素显著降低、血液中总皮质醇增加而不是唾液中总皮质醇增加以及对社会压力源的唾液皮质醇反应减弱有关。有限的证据初步表明，HC配方中特定的雌激素和黄体酮化合物可能会对类固醇激素水平产生不同的影响。最后，我们讨论了hc改变类固醇激素水平的机制，这些影响对大脑和行为结果的潜在影响，以及对未来研究的考虑。

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引用次数: 0

Intergenerational effects of maternal androgens on vocal ontogeny and developmental plasticity in a cooperatively breeding mammal 雌性雄激素对合作繁殖哺乳动物发声个体发育和发育可塑性的代际影响

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-08-20 DOI: 10.1016/j.yhbeh.2025.105814

Britta Walkenhorst , Ines Braga Goncalves , Christine M. Drea , Marta B. Manser

Developmental plasticity, the ability to adapt one's phenotype to environmental cues, is crucial during early-life stages and can affect fitness. Despite significant androgenic variation between females of select species, the impact of maternal hormones on offspring ontogeny in wild mammals has been rarely investigated. Here, we rely on natural and experimentally induced variation in androgen action between dominant and subordinate female meerkats, Suricata suricatta, to examine plasticity of vocal development in their offspring. Meerkats are cooperatively breeding mongooses that have a rich vocal repertoire. We recorded calls produced at distinct developmental stages by offspring from dominant and subordinate control mothers that naturally differ in absolute androgen concentrations and from dominant treated mothers that had received an androgen-receptor blocker in late gestation. Using call types as indicators, we found that the offspring of dominant control mothers had a robust vocal trajectory, even under adverse environmental conditions; following full nutritional dependence, their vocal development was accelerated relative to that of other offspring. Conversely, offspring from both subordinate control and dominant antiandrogen treated mothers suffered ontogenetic delays; they showed distinct sex differences in trajectory and a greater sensitivity to socio-ecological influences. Antiandrogen-exposed offspring also showed atypical early call usage. These findings provide rare evidence of the potential for maternal androgens to mediate mammalian offspring development in accordance with demands of the socio-ecological environment.

发育可塑性，即使一个人的表型适应环境的能力，在生命早期阶段至关重要，并可能影响健康。尽管雄性激素在某些物种的雌性之间存在显著差异，但母体激素对野生哺乳动物后代个体发育的影响很少被研究。在这里，我们依靠自然和实验诱导的雄激素作用在显性和从属雌性狐獴（Suricata suricatta）之间的变化，来研究它们后代的声音发育的可塑性。猫鼬是一种合作繁殖的猫鼬，拥有丰富的声乐曲目。在不同的发育阶段，我们记录了雄激素绝对浓度自然不同的优势对照母和在妊娠后期接受雄激素受体阻滞剂治疗的优势对照母的后代发出的叫声。使用叫声类型作为指标，我们发现优势对照母亲的后代即使在不利的环境条件下也具有稳健的声音轨迹；在完全依赖营养之后，它们的声音发育相对于其他后代加快了。相反，从属对照和显性抗雄激素治疗的母亲的后代都出现了个体发育迟缓；他们在轨迹上表现出明显的性别差异，对社会生态影响更敏感。抗雄激素暴露的后代也表现出非典型的早期呼叫使用。这些发现提供了罕见的证据，表明雌性雄激素可能根据社会生态环境的要求调节哺乳动物后代的发育。

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引用次数: 0

Hormonal intrauterine device use is related to mental rotations but not verbal memory skills 激素宫内节育器的使用与心理旋转有关，但与语言记忆能力无关

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-08-18 DOI: 10.1016/j.yhbeh.2025.105804

Ran Yan, Christel Portengen, T. Ariel Yang, Gwyneth Reece, Zoe Dunnum, Esmeralda Hidalgo-Lopez, Adriene M. Beltz

There is perennial public and scientific interest in the neuroendocrine mechanisms underlying the large gender difference in three-dimensional (3D) mental rotation skills (favoring men) and small-to-moderate difference in verbal memory (favoring women). Past research has linked androgenic progestins in oral contraceptives to enhanced spatial skills, particularly 3D mental rotations, and estradiol to enhanced verbal memory skills. Hormonal intrauterine devices (IUDs) contain an androgenic progestin (i.e., levonorgestrel) without synthetic estradiol, but there is little-to-no systematic research on the cognitive impacts of use. The current study filled this knowledge gap in a sample of 343 participants (M_age = 21.75, SD = 4.52; 57.0 % White; 84.8 % non-Latine), comparing 50 hormonal IUD users to 135 naturally cycling (NC) females who were not menstruating and to 158 males. Compared to NC females, IUD users had better 3D mental rotation performance, but similar verbal memory. Compared to males, IUD users had similar 3D mental rotations performance, but better verbal memory. Group differences were generally moderate in size, and the pattern of results persisted when both age and general cognitive ability were covaried. Findings in IUD users are consistent with hypotheses, evidencing a potential and selective impact of exogenous androgenic progestin exposure on spatial cognition, and no effects on verbal memory, as expected given the preservation of endogenous ovarian hormone function that is not suppressed as it is in other hormonal contraceptives (e.g., oral).

长期以来，公众和科学界对三维（3D）心理旋转技能（有利于男性）的巨大性别差异和言语记忆（有利于女性）的小到中等差异的神经内分泌机制感兴趣。过去的研究已经将口服避孕药中的雄激素黄体酮与增强空间技能联系起来，尤其是3D思维旋转，而雌二醇与增强语言记忆能力联系起来。激素宫内节育器（iud）含有雄激素黄体酮（即左炔诺孕酮），不含合成雌二醇，但很少或没有关于使用认知影响的系统研究。目前的研究在343名参与者的样本中填补了这一知识空白(Mage = 21.75, SD = 4.52；白人占57.0%；84.8%非拉丁裔)，将50名激素宫内节育器使用者与135名没有月经的自然周期（NC）女性和158名男性进行比较。与NC组相比，宫内节育器使用者有更好的三维心理旋转表现，但言语记忆相似。与男性相比，宫内节育器使用者有相似的3D心理旋转表现，但言语记忆更好。组间差异一般是中等大小的，当年龄和一般认知能力共变时，结果的模式仍然存在。宫内节育器使用者的研究结果与假设一致，证明外源性雄激素黄体酮暴露对空间认知有潜在和选择性的影响，而对言语记忆没有影响，正如预期的那样，由于保留了内源性卵巢激素功能，而不像其他激素避孕药（例如口服避孕药）那样受到抑制。

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