S. Gondhowiardjo, Denny Handoyo, Mahesa Auzan, S. M. Sekarutami, N. Christina, Steven Octavianus, R. K. Priharto, -. Widyastuti
Cancer Profile in West Jakarta: A 5-year descriptive study Soehartati Gondhowiardjo*, Denny Handoyo, Mahesa Auzan, Sri Mutya Sekarutami, Nadia Christina, Steven Octavianus, R. Koesmedi Priharto**, Widyastuti** * Oncology Center Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia ¶ Radiation Oncology Department, Facuty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia ** Provincial Health Office DKI Jakarta
{"title":"Cancer Profile in West Jakarta: A 5-year descriptive study","authors":"S. Gondhowiardjo, Denny Handoyo, Mahesa Auzan, S. M. Sekarutami, N. Christina, Steven Octavianus, R. K. Priharto, -. Widyastuti","doi":"10.32532/jori.v9i2.94","DOIUrl":"https://doi.org/10.32532/jori.v9i2.94","url":null,"abstract":"Cancer Profile in West Jakarta: A 5-year descriptive study Soehartati Gondhowiardjo*, Denny Handoyo, Mahesa Auzan, Sri Mutya Sekarutami, Nadia Christina, Steven Octavianus, R. Koesmedi Priharto**, Widyastuti** * Oncology Center Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia ¶ Radiation Oncology Department, Facuty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia ** Provincial Health Office DKI Jakarta","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121599405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Gondhowiardjo, Dion Firli Bramantyo, Steven Octavianus, S. M. Sekarutami, N. Christina, R. K. Priharto, Widyastuti
Background: Cancer is the leading causes of death with a comparable number of mortality rate to coronary heart disease and stroke. The burden of cancer will continue to increase, especially in developing countries including Indonesia. This study reports the profile of cancer patients domiciled in the administrative area of North Jakarta and Kepulauan Seribu in 2008 – 2012. Materials and Methods: This was a descriptive study. Patients data were collected from cancer registries all hospitals located in administrative area of North Jakarta and Kepulauan Seribu. This data was pooled and extracted from DKI Jakarta Cancer Registry Control Center at RSCM. The primary site and histology of malignancies were verified and coded based on the International Classification of Diseases for Oncology (ICD-O). Data were analyzed using descriptive statistics in SPSS 20.0 Results: There are 2185 cases or around 14.8% of all cases of cancer patients verified in the database. Of those, 740 were male and 1445 female. The most prevalent age group was 45 - 54 years old, which was 29%. The highest distribution of cancer stage was in stage 3, which is 21.1%. The most common cancer in all sex groups were breast cancer, cervical cancer, nasopharyngeal cancer, hematopoietic system malignancy, and ovarian cancer. In men, the top five most cancers were nasopharyngeal cancer, lung cancer, hematopoietic system, lymphoma, and liver cancer. Whereas in women, most cancer sequences were breast cancer, cervical cancer, ovarian cancer, thyroid cancer, and hematopoietic system.
{"title":"Cancer Profile in North Jakarta and Kepulauan Seribu : A 5-year descriptive study","authors":"S. Gondhowiardjo, Dion Firli Bramantyo, Steven Octavianus, S. M. Sekarutami, N. Christina, R. K. Priharto, Widyastuti","doi":"10.32532/jori.v9i2.92","DOIUrl":"https://doi.org/10.32532/jori.v9i2.92","url":null,"abstract":"Background: Cancer is the leading causes of death with a comparable number of mortality rate to coronary heart disease and stroke. The burden of cancer will continue to increase, especially in developing countries including Indonesia. This study reports the profile of cancer patients domiciled in the administrative area of North Jakarta and Kepulauan Seribu in 2008 – 2012. Materials and Methods: This was a descriptive study. Patients data were collected from cancer registries all hospitals located in administrative area of North Jakarta and Kepulauan Seribu. This data was pooled and extracted from DKI Jakarta Cancer Registry Control Center at RSCM. The primary site and histology of malignancies were verified and coded based on the International Classification of Diseases for Oncology (ICD-O). Data were analyzed using descriptive statistics in SPSS 20.0 Results: There are 2185 cases or around 14.8% of all cases of cancer patients verified in the database. Of those, 740 were male and 1445 female. The most prevalent age group was 45 - 54 years old, which was 29%. The highest distribution of cancer stage was in stage 3, which is 21.1%. The most common cancer in all sex groups were breast cancer, cervical cancer, nasopharyngeal cancer, hematopoietic system malignancy, and ovarian cancer. In men, the top five most cancers were nasopharyngeal cancer, lung cancer, hematopoietic system, lymphoma, and liver cancer. Whereas in women, most cancer sequences were breast cancer, cervical cancer, ovarian cancer, thyroid cancer, and hematopoietic system.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132352275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
gondhow@gmail.com Rectal cancer, as a part of colorectal cancer, is one of the most common cancer in the world. In Indonesia, as reported in GLOBOCAN 2018, colorectal cancer is number eight by cancer site in term of incidence, mortality, and prevalence. It is also number five of new cases in 2018. Anatomy of rectum starts proximally at rectosigmoid junction which is as high as third sacral and extending to anorectal ring, just proximal to dentate line. In general, the upper third is located intraperitoneally and the lower two-thirds of the rectum extraperitoneally. Adenocarcinoma is the most common type of histopathology in rectal cancer. The etiology of rectal cancer is believed to be multifactorial, including both genetic and environmental factors. Hematochezia is the most common presenting symptom in rectal cancer. Diagnostic tool of rectal cancer is divided into invasive and non-invasive examinations. The simplest method to recognize is digital rectal examination that can detect around 70% of rectal cancer. TNM classification is used as a standard to evaluate the extend of tumour. Surgery alongside with radiation therapy and chemotherapy play important roles as main treatment modality of rectal cancer. The standard treatment for conventional (2-dimensional technique), consists of three 3 fields. If 3-dimensional technique preferred, 3D conformal radiotherapy (3DCRT) is more recommended than intensity-modulated radiation therapy (IMRT). For postoperative cases, the radiation treatment is conventional fractionation to a total dose of 45 Gy to the entire pelvis, followed by a boost of 5.4 Gy to the tumor bed.
{"title":"Rectal Cancer : A Mini Literature Review","authors":"I. A. Dewi, Soehartati A. Gondhowiardjo","doi":"10.32532/jori.v12i1.115","DOIUrl":"https://doi.org/10.32532/jori.v12i1.115","url":null,"abstract":"gondhow@gmail.com Rectal cancer, as a part of colorectal cancer, is one of the most common cancer in the world. In Indonesia, as reported in GLOBOCAN 2018, colorectal cancer is number eight by cancer site in term of incidence, mortality, and prevalence. It is also number five of new cases in 2018. Anatomy of rectum starts proximally at rectosigmoid junction which is as high as third sacral and extending to anorectal ring, just proximal to dentate line. In general, the upper third is located intraperitoneally and the lower two-thirds of the rectum extraperitoneally. Adenocarcinoma is the most common type of histopathology in rectal cancer. The etiology of rectal cancer is believed to be multifactorial, including both genetic and environmental factors. Hematochezia is the most common presenting symptom in rectal cancer. Diagnostic tool of rectal cancer is divided into invasive and non-invasive examinations. The simplest method to recognize is digital rectal examination that can detect around 70% of rectal cancer. TNM classification is used as a standard to evaluate the extend of tumour. Surgery alongside with radiation therapy and chemotherapy play important roles as main treatment modality of rectal cancer. The standard treatment for conventional (2-dimensional technique), consists of three 3 fields. If 3-dimensional technique preferred, 3D conformal radiotherapy (3DCRT) is more recommended than intensity-modulated radiation therapy (IMRT). For postoperative cases, the radiation treatment is conventional fractionation to a total dose of 45 Gy to the entire pelvis, followed by a boost of 5.4 Gy to the tumor bed.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131968644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
gondhow@gmail.com For humans, aging is defined as a universal biological process that manifests itself as a decrease in functional capacity and an increase in the risk of morbidity and mortality over time. Age is considered the single most significant risk factor for many chronic conditions including malignancies. The incidence of breast, lungs, prostate, colorectal, stomach, thyroid, pancreas, and ovarian cancers, as well as several types of leukemia, increase exponentially with age. Oncologists are often faced with difficulties when treating this population. Even though elderly and younger individuals seem to be able to get the same benefits to result from treatment, the elderly are at a greater risk of experiencing toxicity, serious side effects and death. A comprehensive multidisciplinary evaluation in elderly individuals with cancer can identify the risks and benefits of toxicity due to treatment plans including morbidity and mortality. Radiotherapy can be the solution in the elderly with cancer, especially in patients at high risk for systemic therapy or surgery. Radiotherapy with modern techniques and fractionation adjustments (hypofractionation) can minimize the toxicity due to therapy and can be well tolerated by elderly individuals with cancer.
{"title":"Radiation Therapy Strategies in Geriatric Patients: A Literature Review","authors":"Steven Octavianus, Soehartati A. Gondhowiardjo","doi":"10.32532/jori.v12i1.133","DOIUrl":"https://doi.org/10.32532/jori.v12i1.133","url":null,"abstract":"gondhow@gmail.com For humans, aging is defined as a universal biological process that manifests itself as a decrease in functional capacity and an increase in the risk of morbidity and mortality over time. Age is considered the single most significant risk factor for many chronic conditions including malignancies. The incidence of breast, lungs, prostate, colorectal, stomach, thyroid, pancreas, and ovarian cancers, as well as several types of leukemia, increase exponentially with age. Oncologists are often faced with difficulties when treating this population. Even though elderly and younger individuals seem to be able to get the same benefits to result from treatment, the elderly are at a greater risk of experiencing toxicity, serious side effects and death. A comprehensive multidisciplinary evaluation in elderly individuals with cancer can identify the risks and benefits of toxicity due to treatment plans including morbidity and mortality. Radiotherapy can be the solution in the elderly with cancer, especially in patients at high risk for systemic therapy or surgery. Radiotherapy with modern techniques and fractionation adjustments (hypofractionation) can minimize the toxicity due to therapy and can be well tolerated by elderly individuals with cancer.","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123444011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose. The objective of this study is to review randomized clinical trials systematically that compare the outcomes of preoperative and postoperative radiotherapy in the management of rectal cancer regarding locoregional recurrance, disease free survival and overall survival.Methods. The relevant randomized clinical trials are searched via online databases such as Pubmed, Ebsco, and Proquest. RCTs publised in English between 2000 until 2020 are selected and reviewed systematically.Result. Locoregional recurrence at 5 years was statistically lower in preoperative radiotherapy group than in postoperative radiotherapy group based on two studies. Disease free survival at 5-years was statistically higher in preoprative radiotherapy group than the postoperative one based on two studies. Overall survival at 5 years was not statistically significant between two groups for each study.Conclusion. Preoperative radiotherapy is superior to postoperative radiotherapy for controlling locoregional recurrence and disease free survival, but both are equal in overall survival.
{"title":"Preoperative vs postoperative radiotherapy in the management of rectal cancer: A systematic review","authors":"M. F. Siregar","doi":"10.32532/jori.v12i1.125","DOIUrl":"https://doi.org/10.32532/jori.v12i1.125","url":null,"abstract":"Purpose. The objective of this study is to review randomized clinical trials systematically that compare the outcomes of preoperative and postoperative radiotherapy in the management of rectal cancer regarding locoregional recurrance, disease free survival and overall survival.Methods. The relevant randomized clinical trials are searched via online databases such as Pubmed, Ebsco, and Proquest. RCTs publised in English between 2000 until 2020 are selected and reviewed systematically.Result. Locoregional recurrence at 5 years was statistically lower in preoperative radiotherapy group than in postoperative radiotherapy group based on two studies. Disease free survival at 5-years was statistically higher in preoprative radiotherapy group than the postoperative one based on two studies. Overall survival at 5 years was not statistically significant between two groups for each study.Conclusion. Preoperative radiotherapy is superior to postoperative radiotherapy for controlling locoregional recurrence and disease free survival, but both are equal in overall survival. ","PeriodicalId":130312,"journal":{"name":"Radioterapi & Onkologi Indonesia","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128321208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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