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A 410-nW efficient QRS processor for mobile ECG monitoring in 0.18-μm CMOS 用于0.18 μm CMOS的移动心电监测的410-nW高效QRS处理器
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-10-01 DOI: 10.1109/BioCAS.2016.7833713
Peng Li, Hanjun Jiang, Wendi Yang, Ming Liu, Xu Zhang, Xiaohui Hu, B. Pang, Zhaolin Yao, Hongda Chen
This paper proposes a low power and efficient QRS processor for real-time and continuous mobile ECG monitoring. The QRS detection algorithm is based on the harr wavelet transform. In order to reduce power consumption, an optimized FIR filter structure is proposed. To improve accuracy, R position modification (RPM) has been designed. Fabricated with the 0.18-μm N-well CMOS 1P6M technology, power consumption of this chip is only 410 nW in 1 V voltage supply, which is much lower than that of previous work. Validated by all 48 databases in the MIT-BIH arrhythmia database, sensitivity (Se) and positive prediction (Pr) are 99.60% and 99.77% respectively.
提出了一种低功耗、高效的QRS处理器,用于实时、连续移动心电监测。QRS检测算法是基于harr小波变换的。为了降低功耗,提出了一种优化的FIR滤波器结构。为了提高精度,设计了R位置修正(RPM)。该芯片采用0.18 μm n阱CMOS 1P6M工艺制作,在1v电压下功耗仅为410 nW,大大低于之前的工作。通过MIT-BIH心律失常数据库中48个数据库的验证,灵敏度(Se)和阳性预测(Pr)分别为99.60%和99.77%。
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引用次数: 6
Self-Powered Forward Error-Correcting Biosensor Based on Integration of Paper-Based Microfluidics and Self-Assembled Quick Response Codes. 基于纸基微流体与自组装快速响应码集成的自供电前向纠错生物传感器。
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-10-01 DOI: 10.1109/TBCAS.2016.2580156
Mingquan Yuan, Keng-ku Liu, S. Singamaneni, S. Chakrabartty
This paper extends our previous work on silver-enhancement based self-assembling structures for designing reliable, self-powered biosensors with forward error correcting (FEC) capability. At the core of the proposed approach is the integration of paper-based microfluidics with quick response (QR) codes that can be optically scanned using a smart-phone. The scanned information is first decoded to obtain the location of a web-server which further processes the self-assembled QR image to determine the concentration of target analytes. The integration substrate for the proposed FEC biosensor is polyethylene and the patterning of the QR code on the substrate has been achieved using a combination of low-cost ink-jet printing and a regular ballpoint dispensing pen. A paper-based microfluidics channel has been integrated underneath the substrate for acquiring, mixing and flowing the sample to areas on the substrate where different parts of the code can self-assemble in presence of immobilized gold nanorods. In this paper we demonstrate the proof-of-concept detection using prototypes of QR encoded FEC biosensors.
本文扩展了我们之前基于银增强的自组装结构的工作,用于设计可靠的、具有前向纠错(FEC)能力的自供电生物传感器。该方法的核心是将基于纸张的微流体与可使用智能手机进行光学扫描的快速响应(QR)码相结合。扫描的信息首先被解码以获得网络服务器的位置,该服务器进一步处理自组装的QR图像以确定目标分析物的浓度。所提出的FEC生物传感器的集成基板是聚乙烯,基板上的QR码图案已经使用低成本喷墨打印和常规圆珠笔的组合实现。在基板下方集成了一个基于纸张的微流体通道,用于获取、混合和将样品流动到基板上的区域,在这些区域中,代码的不同部分可以在固定金纳米棒的存在下自组装。在本文中,我们演示了使用QR编码FEC生物传感器原型的概念验证检测。
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引用次数: 3
In-Vivo Validation of Fully Implantable Multi-Panel Devices for Remote Monitoring of Metabolism. 用于代谢远程监测的全植入式多面板设备的体内验证。
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-10-01 DOI: 10.1109/TBCAS.2016.2584239
C. Baj-Rossi, A. Cavallini, Enver G. Kilinc, Francesca Stradolini, T. Rezzonico Jost, M. Proietti, G. De Micheli, F. Grassi, C. Dehollain, S. Carrara
This paper presents the in-vivo tests on a Fully Implantable Multi-Panel Devices for Remote Monitoring of endogenous and exogenous analytes. To investigate issues on biocompatibility, three different covers have been designed, realized and tested in mice for 30 days. ATP and neutrophil concentrations have been measured, at the implant site after the device was explanted, to assess the level of biocompatibility of the device. Finally, fully working prototypes of the device were implanted in mice and tested. The implanted devices were used to detect variations in the physiological concentrations of glucose and paracetamol. Data trends on these analytes have been successfully acquired and transmitted to the external base station. Glucose and paracetamol (also named acetaminophen) have been proposed in this research as model molecules for applications to personalized and translational medicine.
本文介绍了一种用于内源性和外源性分析物远程监测的全植入式多面板设备的体内测试。为了探讨其生物相容性问题,设计、实现了三种不同的盖层,并在小鼠体内进行了30天的试验。在装置外植后,在植入部位测量ATP和中性粒细胞浓度,以评估装置的生物相容性水平。最后,该装置的完整工作原型被植入老鼠体内并进行测试。植入的装置被用来检测葡萄糖和扑热息痛生理浓度的变化。这些分析物的数据趋势已被成功地获取并传送到外部基站。葡萄糖和扑热息痛(也被称为对乙酰氨基酚)在这项研究中被提出作为模型分子应用于个性化和转化医学。
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引用次数: 3
A 155-dB Dynamic Range Current Measurement Front End for Electrochemical Biosensing 用于电化学生物传感的155 db动态范围电流测量前端
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-10-01 DOI: 10.1109/TBCAS.2016.2612581
Shanshan Dai, Rukshan T. Perera, Zi Yang, J. Rosenstein
An integrated current measurement system with ultra wide dynamic range is presented and fabricated in a 180-nm CMOS technology. Its dual-mode design provides concurrent voltage and frequency outputs, without requiring an external clock source. An integrator-differentiator core provides a voltage output √ with a noise floor of 11.6 fA/ (Hz) and a -3 dB cutoff frequency of 1.4 MHz. It is merged with an asynchronous current-to-frequency converter, which generates an output frequency linearly proportional to the input current. Together, the voltage and frequency outputs yield a current measurement range of 155 dB, spanning from 204 fA (100 Hz) or 1.25 pA (10 kHz) to 11.6 μA. The proposed architecture's low noise, wide bandwidth, and wide dynamic range make it ideal for measurements of highly nonlinear electrochemical and electrophysiological systems.
提出并制作了一种采用180nm CMOS工艺的超宽动态范围集成电流测量系统。它的双模设计提供并发电压和频率输出,而不需要外部时钟源。积分器核心提供电压输出√,本底噪声为11.6 fA/ (Hz),截止频率为-3 dB,为1.4 MHz。它与异步电流-频率转换器合并,产生与输入电流成线性比例的输出频率。电压和频率输出产生155 dB的电流测量范围,从204 fA (100 Hz)或1.25 pA (10 kHz)到11.6 μA。该架构的低噪声、宽带宽和宽动态范围使其成为高度非线性电化学和电生理系统测量的理想选择。
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引用次数: 30
A Multi-Technique Reconfigurable Electrochemical Biosensor: Enabling Personal Health Monitoring in Mobile Devices 多技术可重构电化学生物传感器:在移动设备中实现个人健康监测
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-10-01 DOI: 10.1109/TBCAS.2016.2586504
Alexander Sun, A. Venkatesh, D. Hall
This paper describes the design and characterization of a reconfigurable, multi-technique electrochemical biosensor designed for direct integration into smartphone and wearable technologies to enable remote and accurate personal health monitoring. By repurposing components from one mode to the next, the biosensor's potentiostat is able reconfigure itself into three different measurements modes to perform amperometric, potentiometric, and impedance spectroscopic tests all with minimal redundant devices. A 3.9 × 1.65 cm2 PCB prototype of the module was developed with discrete components and tested using Google's Project Ara modular smartphone. The amperometric mode has a ±1 nA to ±200 μA measurement range. When used to detect pH, the potentiometric mode achieves a resolution of <; 0.08 pH units. In impedance measurement mode, the device can measure 50 Ω-10 MΩ and has been shown to have <; 6° of phase error. This prototype was used to perform several point-of-care health tracking assays suitable for use with mobile devices: 1) Blood glucose tests were conducted and shown to cover the diagnostic range for Diabetic patients (~200 mg/dL). 2) Lactoferrin, a biomarker for urinary tract infections, was detected with a limit of detection of approximately 1 ng/mL. 3) pH tests of sweat were conducted to track dehydration during exercise. 4) EIS was used to determine the concentration of NeutrAvidin via a label-free assay.
本文描述了一种可重构的多技术电化学生物传感器的设计和特性,该传感器设计用于直接集成到智能手机和可穿戴技术中,以实现远程和准确的个人健康监测。通过将组件从一种模式转换为另一种模式,生物传感器的恒电位器能够将自身重新配置为三种不同的测量模式,以最小的冗余设备执行安培,电位和阻抗光谱测试。该模块的3.9 × 1.65 cm2的PCB原型是用分立元件开发的,并使用谷歌的Project Ara模块化智能手机进行了测试。安培模式测量范围为±1na ~±200 μA。当用于检测pH值时,电位模式的分辨率为<;0.08 pH单位。在阻抗测量模式下,该设备可以测量50 Ω-10 MΩ,并已证明具有<;6°相位误差。该原型被用于执行适合移动设备使用的几个护理点健康跟踪分析:1)进行了血糖测试,并显示其覆盖了糖尿病患者的诊断范围(~200 mg/dL)。2)乳铁蛋白是尿路感染的生物标志物,检测限约为1 ng/mL。3)通过汗液pH值测试来追踪运动过程中的脱水情况。4) EIS法无标记法测定NeutrAvidin的浓度。
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引用次数: 51
A Wirelessly-Powered Homecage With Segmented Copper Foils and Closed-Loop Power Control. 采用分段铜箔和闭环功率控制的无线供电家庭笼。
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-10-01 Epub Date: 2016-09-16 DOI: 10.1109/TBCAS.2016.2577705
S Abdollah Mirbozorgi, Yaoyao Jia, Daniel Canales, Maysam Ghovanloo

A new wireless electrophysiology data acquisition system, built around a standard homecage, is presented in this paper, which can power up and communicate with sensors and actuators/stimulators attached to or implanted in small freely behaving animal subjects, such as rodents. Key abilities of the energized homecage (EnerCage) system is enabling longitudinal experiments with minimal operator involvement or interruption, while providing test subjects with an enriched environment closer to their natural habitat, without the burden of being tethered or carrying bulky batteries. The magnetic resonant multi-coil design used in the new EnerCage-HC2 automatically localizes the transmitted electromagnetic power from a single transmitter (Tx) coil at the bottom of the cage toward the receiver coil (Rx), carried on/in the animal body, obviating the need for tracking the animal or switching the coils. In order to increase the resonators' quality factor (Q > 166) at the desired operating frequency of 13.56 MHz, while maintaining a high self-resonance frequency [Formula: see text], they are made of wide copper foils and optimally segmented based on a set of design rules that can be adopted for experimental arenas with different shapes and dimensions. The Rx rectified voltage is regulated at a user-defined window [Formula: see text] by a Tx-Rx closed-loop power control (CLPC) mechanism that creates a volume inside the homecage with 42 mW of power delivered to the load (PDL), and a homogeneous power transfer efficiency (PTE) plane of 14% on average at ∼7 cm height, plus stability against angular mis-alignments of up to 80°.

本文介绍了一种新型无线电生理学数据采集系统,该系统围绕一个标准的 "笼子"(homecage)而建,可为附着或植入啮齿动物等行为自由的小型动物实验对象体内的传感器和致动器/刺激器供电并与之通信。通电笼(EnerCage)系统的主要功能是实现纵向实验,尽量减少操作人员的参与或干扰,同时为测试对象提供更接近其自然栖息地的丰富环境,而无需拴住或携带笨重的电池。新型 EnerCage-HC2 采用磁共振多线圈设计,可自动将笼子底部的单个发射器线圈(Tx)向动物体内携带的接收器线圈(Rx)发射的电磁功率定位,无需跟踪动物或切换线圈。为了提高谐振器在 13.56 MHz 理想工作频率下的品质因数(Q > 166),同时保持较高的自谐振频率[计算公式:见正文],谐振器由宽铜箔制成,并根据一套设计规则进行了优化分段,可用于不同形状和尺寸的实验场。Rx 整流电压通过 Tx-Rx 闭环功率控制(CLPC)机制调节在用户定义的窗口[计算公式:见正文],该机制在家庭笼内创造了一个向负载(PDL)输送 42 mW 功率的容积,以及在 7 厘米高处平均 14% 的均质功率传输效率(PTE)平面,并在角度偏差达 80° 时保持稳定。
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引用次数: 0
Deep Neural Networks for Identifying Cough Sounds 识别咳嗽声音的深度神经网络
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-09-16 DOI: 10.1109/TBCAS.2016.2598794
Justice Amoh, K. Odame
In this paper, we consider two different approaches of using deep neural networks for cough detection. The cough detection task is cast as a visual recognition problem and as a sequence-to-sequence labeling problem. A convolutional neural network and a recurrent neural network are implemented to address these problems, respectively. We evaluate the performance of the two networks and compare them to other conventional approaches for identifying cough sounds. In addition, we also explore the effect of the network size parameters and the impact of long-term signal dependencies in cough classifier performance. Experimental results show both network architectures outperform traditional methods. Between the two, our convolutional network yields a higher specificity 92.7% whereas the recurrent attains a higher sensitivity of 87.7%.
在本文中,我们考虑了使用深度神经网络进行咳嗽检测的两种不同方法。咳嗽检测任务被视为一个视觉识别问题和一个序列到序列的标记问题。分别实现了卷积神经网络和递归神经网络来解决这些问题。我们评估了这两个网络的性能,并将它们与其他识别咳嗽声音的传统方法进行了比较。此外,我们还探讨了网络大小参数和长期信号依赖对咳嗽分类器性能的影响。实验结果表明,这两种网络结构都优于传统方法。在两者之间,我们的卷积网络产生更高的特异性92.7%,而复发达到更高的敏感性87.7%。
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引用次数: 98
Low-Radiation Cellular Inductive Powering of Rodent Wireless Brain Interfaces: Methodology and Design Guide. 啮齿动物无线脑接口的低辐射细胞感应供电:方法论和设计指南。
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-08-01 DOI: 10.1109/TBCAS.2015.2502840
N. Soltani, M. Aliroteh, M. T. Salam, J. P. Pérez Velázquez, R. Genov
This paper presents a general methodology of inductive power delivery in wireless chronic rodent electrophysiology applications. The focus is on such systems design considerations under the following key constraints: maximum power delivery under the allowable specific absorption rate (SAR), low cost and spatial scalability. The methodology includes inductive coil design considerations within a low-frequency ferrite-core-free power transfer link which includes a scalable coil-array power transmitter floor and a single-coil implanted or worn power receiver. A specific design example is presented that includes the concept of low-SAR cellular single-transmitter-coil powering through dynamic tracking of a magnet-less receiver spatial location. The transmitter coil instantaneous supply current is monitored using a small number of low-cost electronic components. A drop in its value indicates the proximity of the receiver due to the reflected impedance of the latter. Only the transmitter coil nearest to the receiver is activated. Operating at the low frequency of 1.5 MHz, the inductive powering floor delivers a maximum of 15.9 W below the IEEE C95 SAR limit, which is over three times greater than that in other recently reported designs. The power transfer efficiency of 39% and 13% at the nominal and maximum distances of 8 cm and 11 cm, respectively, is maintained.
本文介绍了在无线慢性啮齿动物电生理应用中感应供电的一般方法。重点是在以下关键约束下的系统设计考虑因素:在允许的比吸收率(SAR)下的最大功率输出,低成本和空间可扩展性。该方法包括低频铁氧体无铁芯功率传输链路中的电感线圈设计考虑,该链路包括可伸缩线圈阵列功率发送器地板和单线圈植入或磨损功率接收器。给出了一个具体的设计实例,其中包括通过动态跟踪无磁接收器空间位置来实现低sar蜂窝单发射器线圈供电的概念。利用少量低成本的电子元件监测发射器线圈的瞬时供电电流。其值的下降表明由于后者的反射阻抗而接近接收器。只有离接收器最近的发射机线圈才会被激活。在1.5 MHz的低频下工作,感应电源地板提供的最大功率为15.9 W,低于IEEE C95 SAR限制,这是最近报道的其他设计的三倍以上。在标称距离和最大距离分别为8 cm和11 cm时,功率传输效率分别保持在39%和13%。
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引用次数: 7
Wireless Fidelity Electromagnetic Field Exposure Monitoring With Wearable Body Sensor Networks 无线保真电磁场暴露监测与可穿戴身体传感器网络
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-06-01 DOI: 10.1109/TBCAS.2015.2487264
J. Lecoutere, A. Thielens, S. Agneessens, H. Rogier, W. Joseph, R. Puers
With the breakthrough of the Internet of Things and the steady increase of wireless applications in the daily environment, the assessment of radio frequency electromagnetic field (RF-EMF) exposure is key in determining possible health effects of exposure to certain levels of RF-EMF. This paper presents the first experimental validation of a novel personal exposimeter system based on a distributed measurement approach to achieve higher measurement quality and lower measurement variability than the commonly used single point measurement approach of existing exposimeters. An important feature of the system is the integration of inertial sensors in order to determine activity and posture during exposure measurements. The system is designed to assess exposure to frequencies within the 389 to 464, 779 to 928 and 2400 to 2483.5 MHz bands using only two transceivers per node. In this study, the 2400 to 2483.5 MHz band is validated. Every node provides antenna diversity for the different bands in order to achieve higher sensitivity at these frequencies. Two AAA batteries power each standalone node and as such determine the node hardware size of this proof of concept (53 mm×25 mm×15 mm), making it smaller than any other commercially available exposimeter.
随着物联网的突破和日常环境中无线应用的稳步增加,射频电磁场(RF-EMF)暴露评估是确定暴露于一定水平RF-EMF可能对健康产生影响的关键。本文首次对基于分布式测量方法的新型个人暴露仪系统进行了实验验证,该系统比现有暴露仪常用的单点测量方法具有更高的测量质量和更低的测量变异性。该系统的一个重要特点是集成了惯性传感器,以便在暴露测量期间确定活动和姿态。该系统设计用于评估389至464、779至928和2400至2483.5 MHz频段内的频率暴露,每个节点仅使用两个收发器。本研究对2400 ~ 2483.5 MHz频段进行了验证。每个节点为不同的频段提供天线分集,以便在这些频率上获得更高的灵敏度。两个AAA电池为每个独立节点供电,因此确定了这个概念验证的节点硬件尺寸(53 mm×25 mm×15 mm),使其比任何其他商用曝光仪都小。
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引用次数: 10
Fully Parallel Electrical Impedance Tomography Using Code Division Multiplexing 使用码分复用的全并行电阻抗层析成像
IF 5.1 2区 医学 Q1 Engineering Pub Date : 2016-06-01 DOI: 10.1109/TBCAS.2015.2487321
M. Tsoeu, M. Inggs
Electrical Impedance Tomography (EIT) has been dominated by the use of Time Division Multiplexing (TDM) and Frequency Division Multiplexing (FDM) as methods of achieving orthogonal injection of excitation signals. Code Division Multiplexing (CDM), presented in this paper is an alternative that eliminates temporal data inconsistencies of TDM for fast changing systems. Furthermore, this approach eliminates data inconsistencies that arise in FDM when frequency bands of current injecting electrodes are chosen over frequencies that have large changes in the imaged object's impedance. To the authors knowledge no fully functional wideband system or simulation platform using simultaneous injection of Gold codes currents has been reported. In this paper, we formulate, simulate and develop a fully functional pseudo-random (Gold) code driven EIT system with 15 excitation currents and 16 separate voltage measurement electrodes. In the work we verify the use of CDM as a multiplexing modality in simultaneous injection EIT, using a prototype system with an overall bandwidth of 15 kHz, and attainable speed of 462 frames/s using codes with a period of 31 chips. Simulations and experiments are performed using the Electrical Impedance and Diffuse Optics Reconstruction Software (EIDORS). We also propose the use of image processing on reconstructed images to establish their quality quantitatively without access to raw reconstruction data. The results of this study show that CDM can be successfully used in EIT, and gives results of similar visual quality to TDM and FDM. Achieved performance shows average position error of 3.5% and size error of 6.2%.
电阻抗层析成像(EIT)一直被使用时分复用(TDM)和频分复用(FDM)作为实现激励信号正交注入的方法所主导。码分复用(Code Division Multiplexing, CDM)是一种消除时分复用(TDM)在快速变化系统中的时间数据不一致性的方法。此外,当电流注入电极的频带选择在成像对象阻抗变化较大的频率上时,这种方法消除了FDM中出现的数据不一致。据作者所知,没有使用同时注入金码电流的全功能宽带系统或仿真平台已被报道。在本文中,我们设计、仿真和开发了一个全功能的伪随机码驱动EIT系统,该系统具有15个励磁电流和16个独立的电压测量电极。在工作中,我们验证了CDM作为同时注入EIT的多路复用方式的使用,使用总带宽为15 kHz的原型系统,使用周期为31个芯片的代码可达到462帧/秒的速度。利用电阻抗和漫射光学重建软件(EIDORS)进行了仿真和实验。我们还建议在重建图像上使用图像处理来定量地确定其质量,而无需访问原始重建数据。研究结果表明,CDM可以成功地应用于EIT,并获得与TDM和FDM相似的视觉质量。实现的性能显示,平均位置误差为3.5%,尺寸误差为6.2%。
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引用次数: 10
期刊
IEEE Transactions on Biomedical Circuits and Systems
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