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Alzheimer’s disease after a major surgery: are we prepared? 大手术后的阿尔茨海默病:我们准备好了吗?
Pub Date : 2022-06-02 DOI: 10.53986/ibjm.2022.0023
Kaushik Bhattacharya, N. Bhattacharya
Historia del artículo: Recibido 29 Abril 2022 Recibido en forma revisada 28 Mayo 2022 Aceptado 02 Junio 2022 Palabras clave: Alzheimer Cognición Delirio © 2022 Los Autores. Publicado por Iberoamerican Journal of Medicine. Éste es un artículo en acceso abierto bajo licencia CC BY (http://creativecommons. org/licenses/by/4.0/). HOW TO CITE THIS ARTICLE: Bhattacharya K, Bhattacharya N. Alzheimer’s disease after a major surgery: are we prepared? Iberoam J Med. 2022;4(3):131-132. doi: 10.53986/ibjm.2022.0023.
文章历史:收到2022年4月29日修订形式收到2022年5月28日接受2022年6月02日关键词:阿尔茨海默病认知谵妄©2022作者。发表于《伊比利亚美洲医学杂志》。这是一篇在CC BY许可下开放获取的文章(http://creativecommons)。org/licenses/by/4.0/)。如何引用这篇文章:Bhattacharya K, Bhattacharya N.阿尔茨海默病在大手术后:我们准备好了吗?4(3):131-132。doi: 10.53986 / ibjm.2022.0023。
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引用次数: 0
Research activity during the residency program. Are we in the good way? 实习期间的研究活动。我们在好的方向上吗?
Pub Date : 2022-04-27 DOI: 10.53986/ibjm.2022.0021
E. Esteban-Zubero, C. García-Muro
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引用次数: 0
Rising incidence of carbapenem resistant isolates: an Argentinian hospital’s experience. More trouble in the aftermath of the COVID-19 pandemic 碳青霉烯耐药分离株发病率上升:阿根廷一家医院的经验。2019冠状病毒病大流行带来更多麻烦
Pub Date : 2022-04-12 DOI: 10.53986/ibjm.2022.0020
Maximiliano Gabriel Castro, L. Ubiergo, Macarena Vicino, G. Cuevas, F. Argarañá
Introduction: During COVID-19 outbreaks, disproportionate use of antibiotics, high Intensive Care Units burden and longer in-hospital stays may have aggravated the emergency posed by carbapenem-resistant isolates. Therefore, we set out to determine whether the incidence of carbapenem-resistant isolates rose in a tertiary care center in Santa Fe, Argentina during the period with active cases of COVID-19. Material and methods: In this retrospectively designed analytic epidemiologic study, two periods were defined: Period 1 (without active cases of COVID-19) from September 2019 to August 2020 and Period 2 (starting at the onset of the first wave of COVID-19 in this Institution) from September 2020 to June 2021. All clinically relevant microbiological samples taken during these periods in the Internal Medicine, Surgical and Intensive Care Unit wards were included. The primary analysis of interest was the differential incidence between the two periods, overall and in the Intensive Care Units wards in particular. Results: 9,135 hospitalizations, 50,145 patient-days of analysis. 7,285 clinical samples were taken, with an overall positivity for carbapenem-resistant isolates of 12.1% (n=883). Overall carbapenem-resistant isolates incidence during Period 2 was 2.5 times higher than in Period 1 (2.52 vs 0.955/100 patient-days, p<0.001). Intensive Care Units’ carbapenem-resistant isolates incidence raised from 6.78 to 8.69/100 patient-days in Period 2 (p=0.006). Conclusions: We found alarming rates of carbapenem-resistant isolates in our center, 2.5 times higher in the period following the first wave of COVID-19. This rise was due to a higher amount of clinically relevant microbiological samples taken and to a higher carbapenem resistance among Enterobacteria and non-fermentative Gram-negative bacilli. To our knowledge, this is one of the few Latin-American reports on the effect of the COVID-19 pandemic on carbapenem-resistant isolates incidence.
在2019冠状病毒病暴发期间,过度使用抗生素、重症监护病房负担沉重和住院时间较长可能加剧了碳青霉烯耐药分离株造成的紧急情况。因此,我们着手确定在COVID-19活跃病例期间,阿根廷圣达菲一家三级保健中心的碳青霉烯类耐药分离株的发病率是否上升。材料和方法:在这项回顾性设计的分析流行病学研究中,定义了两个时期:第1期(2019年9月至2020年8月无COVID-19活动性病例)和第2期(从该机构第一波COVID-19开始),从2020年9月至2021年6月。在此期间,在内科、外科和重症监护病房采集的所有临床相关微生物样本都被包括在内。主要分析的兴趣是两个时期之间的发病率差异,总体而言,特别是在重症监护病房。结果:9135例住院,50145例患者日分析。共采集临床样本7285份,碳青霉烯类耐药菌株总体阳性12.1% (n=883)。第2期耐碳青霉烯类分离株的总发生率是第1期的2.5倍(2.52 vs 0.955/100患者-天,p<0.001)。重症监护病房碳青霉烯耐药分离株的发病率在第二阶段从6.78 /100患者-天上升到8.69/100患者-天(p=0.006)。结论:我们发现本中心碳青霉烯类耐药分离株的发生率令人担忧,在第一波COVID-19之后的时期高出2.5倍。这一上升是由于临床相关微生物样本的数量增加,以及肠杆菌和非发酵革兰氏阴性杆菌对碳青霉烯的耐药性增加。据我们所知,这是关于COVID-19大流行对碳青霉烯耐药分离株发病率影响的少数拉丁美洲报告之一。
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引用次数: 3
Sympathovagal equilibrium analysis in patients with COVID-19 COVID-19患者交感迷走神经平衡分析
Pub Date : 2022-04-07 DOI: 10.53986/ibjm.2022.0019
H. Musacchio, Florencia Cogliano, Hugo J Miño, G. Romagnoli, Florencia Debona, Delfina Godano, F. Barbone
Introduction: With the increase of COVID-19 cases, an unusual manifestation for this type of virus began to appear anosmia and dysgeusia, which could indicate a neurologic alteration. In this context, it seems likely that subclinical manifestations of baroreflex involvement occur. The vegetative nervous system carries out the regulation of the baroreflex through the balance between sympathetic and parasympathetic activity. The objective of this study is to verify whether patients with COVID-19 present alteration of this equilibrium. Material and methods: Patients included had a confirmed diagnosis of COVID-19 admitted to the Internal Medicine Department of JB Iturraspe Hospital. A Holter recording was performed at rest for 5 minutes, determining the variables in the frequency domain using Fourier transform analysis. We excluded patients with diabetes, medicated with drugs that modify heart rate or with a history of irradiation to the neck. Results: 68 patients were studied. The mean age was 49±13 years. The median systolic blood pressure was 120 mmHg and the diastolic blood pressure 80 mmHg. The heart rate was 76±13 beats per minute and the median respiratory rate was 24 (16 to 40). Anosmia was observed in 22% and dysgeusia in 19% The variables in the frequency domain were: Low-frequency power (LF) 135.8ms2 (13.7-2861.7); High-frequency power (HF), 89.04ms2 (4.1-5234.4), LFnu 57.5±22.3, HFnu 43.1±22.6. LF:HF 2.1±2. 41.2% of the patients had a high LF:HF. Conclusions: LF and HF components can be obtained through frequency analysis. The relationship between these two elements would thus represent the sympathovagal balance and is expressed as the LF/HF ratio. We observed that 41.2% of the studied patients showed elevated LF/HF ratio. The 41.2% of the patients presented an increased LF:HF ratio, which could be interpreted as an alteration in autonomic function.
随着COVID-19病例的增加,这种类型的病毒的一种不寻常的表现开始出现嗅觉缺失和语言障碍,这可能表明神经系统的改变。在这种情况下,似乎有可能出现压反射受累的亚临床表现。植物神经系统通过交感神经和副交感神经活动的平衡来调节压力反射。本研究的目的是验证COVID-19患者是否存在这种平衡的改变。材料和方法:纳入的患者在JB Iturraspe医院内科确诊为COVID-19。在静止状态下进行5分钟的动态心电图记录,利用傅里叶变换分析确定频域中的变量。我们排除了糖尿病患者、正在服用改变心率药物的患者或有颈部照射史的患者。结果:68例患者。平均年龄49±13岁。收缩压中位数为120 mmHg,舒张压中位数为80 mmHg。心率为76±13次/分,呼吸频率中位数为24(16 ~ 40)。频域变量为:低频功率(LF) 135.8ms2 (13.7-2861.7);高频功率(HF) 89.04ms2 (4.1-5234.4), LFnu 57.5±22.3,HFnu 43.1±22.6。低频:高频2.1±2。41.2%的患者有较高的LF:HF。结论:通过频率分析可以得到低频和高频成分。因此,这两个因素之间的关系代表了交感迷走神经平衡,并以LF/HF比值表示。我们观察到41.2%的研究患者出现LF/HF比值升高。41.2%的患者出现LF:HF比值升高,可解释为自主神经功能的改变。
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引用次数: 0
A case of Aluminum Phosphide poisoning managed successfully in Nepal: A Case Report 尼泊尔成功处理的一例磷化铝中毒:一例报告
Pub Date : 2022-04-02 DOI: 10.53986/ibjm.2022.0018
S. Jha, Angela Basnet, Sabin Chaulagain, S. Ojha
Aluminum phosphide (ALP) is a highly toxic compound most commonly available as Celphos in Nepal. Suicidal ingestion is common in developing countries like Nepal as it is easily available and has a high mortality rate. Farmers to protect crops from rodents and pests use it. Here we present a case of a 24-year-old female with suicidal ingestion of one and a half-tablet of ALP presented with abdominal pain and vomiting. The patient developed metabolic acidosis, hyperkalemia, acute respiratory distress, and hypotension during the Intensive Care Unit stay. Supportive treatment with gastric lavage (coconut oil), intravenous magnesium sulfate, sodium-bicarbonate infusion, adequate vasopressor and close monitoring of hemodynamic parameters helped in the survival of the patient.
磷化铝(ALP)是一种剧毒化合物,在尼泊尔最常见的是Celphos。自杀式摄入在尼泊尔等发展中国家很常见,因为它很容易获得,而且死亡率很高。农民用它来保护庄稼免受啮齿动物和害虫的侵害。在这里,我们提出一个病例24岁的女性自杀摄入一片剂半ALP表现为腹痛和呕吐。患者在重症监护室期间出现代谢性酸中毒、高钾血症、急性呼吸窘迫和低血压。支持治疗包括洗胃(椰子油)、静脉注射硫酸镁、碳酸氢钠输注、充足的血管加压剂和密切监测血流动力学参数,有助于患者的生存。
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引用次数: 1
Corynebacterium endocarditis in a patient with a cardiac implantable electronic device 心脏植入式电子装置患者的棒状杆菌心内膜炎
Pub Date : 2022-04-02 DOI: 10.53986/ibjm.2022.0017
S. Alkan, U. Küçük, S. Şahin, T. Önder
Cardiac implantable electronic device (CIED) infections have been rising around the world. Many microorganisms can lead to this disease. Corynebacterium species are catalase-positive Gram-positive bacilli, also known as "diphtheroids" or "coryneform" bacteria, were once almost universally dismissed as contamination when recovered from patients, but they are now increasingly being linked to serious infections and have the ability to form biofilms and rarely cause CIED infections and this can be complicated as infective endocarditis. Corynebacterium spp. are frequently overlooked as contaminants in blood cultures, yet they can cause a serious infective endocarditis (IE). Antibiotic resistance is increasing among Corynebacterium spp., and this makes treatment more challenging. There are few reports of IE caused by Corynebacterium spp., and more research is needed. Here, we report a case of 55- year old man with Corynebacterium spp. cardiac device-related infective endocarditis.
心脏植入式电子装置(CIED)感染在世界范围内呈上升趋势。许多微生物可导致这种疾病。棒状杆菌是过氧化氢酶阳性的革兰氏阳性杆菌,也被称为“类白喉”或“棒状”细菌,当从患者身上恢复时,它们曾经几乎被普遍认为是污染,但现在它们越来越多地与严重感染有关,并且具有形成生物膜的能力,很少引起CIED感染,这可能并发感染性心内膜炎。棒状杆菌在血液培养中作为污染物经常被忽视,但它们可以引起严重的感染性心内膜炎(IE)。棒状杆菌对抗生素的耐药性正在增加,这使得治疗更具挑战性。棒状杆菌引起的IE报道较少,有待进一步研究。在此,我们报告一例55岁男性与心脏装置相关的棒状杆菌感染性心内膜炎。
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引用次数: 0
Peripartum cardiomyopathy: A 2022 update 围产期心肌病:2022年更新
Pub Date : 2022-03-28 DOI: 10.53986/ibjm.2022.0016
D. Dash, R. Mody, Sugandhna Malan, Naveed Ahmed, Bhavya Mody
Peripartum cardiomyopathy (PPCM) is a rare but life-threatening condition defined by left ventricular dysfunction and heart failure (HF), occurring in late pregnancy or, more commonly, the early postpartum period. In African American women, women with pre-eclampsia, advanced maternal age, and numerous gestation pregnancies, there is a greater incidence. Although the pathophysiology of PPCM is still undetermined, the importance of vasculo-hormonal pathways has been suggested in research over the past decades. Sarcomere genetic polymorphisms are found in at least some women with the disorder. More than 50% of the patients recover systolic function, albeit some are left with chronic cardiomyopathy, and a small minority of patients requires mechanical support or cardiac transplantation, or both. For the diagnosis of PPCM, electrocardiographic findings of decreased myocardial function are essential. Currently, the management of PPCM is limited to standard treatments for HF with reduced ejection fraction, with attention to minimizing the potential adverse effects on the fetus in women who are still pregnant. As a result, the outcome might range from full recovery to persistent HF, arrhythmia, thromboembolic events, or death. Research on PPCM is examined in this review, as are potential future paths for further study.
围产期心肌病(PPCM)是一种罕见但危及生命的疾病,由左心室功能障碍和心力衰竭(HF)定义,发生在妊娠晚期或更常见的产后早期。在非裔美国妇女中,患有先兆子痫、高龄产妇和多次妊娠的妇女,发病率更高。虽然PPCM的病理生理机制仍未确定,但在过去几十年的研究中,血管激素通路的重要性已被提出。至少在一些患有这种疾病的女性身上发现了肉瘤基因多态性。超过50%的患者恢复了收缩功能,尽管有些患者留下了慢性心肌病,少数患者需要机械支持或心脏移植,或两者兼而有之。对于PPCM的诊断,心肌功能下降的心电图表现是必不可少的。目前,PPCM的管理仅限于对射血分数降低的心衰进行标准治疗,并注意尽量减少对仍在妊娠妇女胎儿的潜在不良影响。因此,结果可能从完全恢复到持续性心衰、心律失常、血栓栓塞事件或死亡。本文对PPCM的研究进行了综述,并对未来可能的研究方向进行了展望。
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引用次数: 0
The Impact of COVID-19 Vaccine Coverage on Deaths Outcome in Africa, Subregional Differences and the need for a Renewed Multi-level Effort COVID-19疫苗覆盖率对非洲死亡结局的影响、次区域差异以及重新开展多层次努力的必要性
Pub Date : 2022-03-17 DOI: 10.53986/ibjm.2022.0015
A. F. Setubi, Esther Nakoya, Annie-Flore K. Tchougene, X. Fopokam
Introduction: SARS-CoV-2 continues to raise health and socio-economical concerns globally. The recent discovery of the B.1.1.529 (Omicron) variant with its critical mutations has heightened the debate about the need for a better global vaccination rollout to prevent the emergence of new SARS-CoV-2 strains. Optimizing vaccine rollout in Africa is crucial for the management of the pandemic and preventing the rise of new strains. To better direct efforts and interventions it is important to know what parts of the continent necessitate more attention. Material and Methods: 30 African countries were grouped in five geographical subregions, six countries for each subregion. Data on confirmed cases, doses administered, fully vaccinated, and deaths were extracted from the Johns Hopkins Coronavirus Resource Center database. The ANOVA test evaluated differences in means for these variables classified by subregions. The correlation test and the linear regression examined the relationship between these independent variables and total deaths. Results: There was a significant regional difference in confirmed cases (P<0.0001), and in fully vaccinated (P=0.01) across the five subregions. The overall model showed that there is a significant regional difference in the three variables’ effect on total deaths (P<0.0001). The linear regression indicated an association between the total number of deaths in relation to the confirmed cases, doses administered, and fully vaccinated (P<0.0001). Discussion: This study indicates that a relation exists between total deaths and the variables confirmed cases, doses administered, and fully vaccinated. More importantly, African countries grouped in geographical subregions perform differently in terms of vaccine rollout, and that offers insights for better and oriented interventions.
导言:SARS-CoV-2继续在全球引发健康和社会经济问题。最近发现的具有关键突变的B.1.1.529 (Omicron)变体加剧了关于是否需要更好地开展全球疫苗接种以防止新的SARS-CoV-2菌株出现的争论。优化在非洲的疫苗推广对于管理大流行和防止新毒株的出现至关重要。为了更好地指导努力和干预,重要的是要知道非洲大陆的哪些部分需要更多的关注。材料和方法:30个非洲国家分为5个地理分区域,每个分区域6个国家。从约翰霍普金斯大学冠状病毒资源中心的数据库中提取了确诊病例、剂量、完全接种疫苗和死亡人数的数据。方差分析(ANOVA)检验评估了按次区域分类的这些变量的均值差异。相关检验和线性回归检验了这些自变量与总死亡人数之间的关系。结果:在确诊病例(P<0.0001)和完全接种疫苗(P=0.01)方面,五个次区域存在显著的区域差异。整体模型显示,三个变量对总死亡人数的影响存在显著的区域差异(P<0.0001)。线性回归表明,死亡总人数与确诊病例、给药剂量和完全接种疫苗之间存在关联(P<0.0001)。讨论:本研究表明,总死亡人数与确诊病例、给药剂量和完全接种疫苗等变量之间存在关系。更重要的是,按地理分区域分组的非洲国家在疫苗推广方面的表现不同,这为更好和有针对性的干预措施提供了见解。
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引用次数: 0
Giant Epiphrenic Diverticulum: A Challenging Case 巨大的肾上腺憩室:一个具有挑战性的案例
Pub Date : 2022-03-10 DOI: 10.53986/ibjm.2022.0014
R. Uzdenov, Sukhrob Atakhadzhaev, M. Asim, S. Covantev
A diverticulum is a limited saccular protrusion of the esophageal wall, communicating with its lumen. Anatomically, esophageal diverticula are classified into pharyngoesophageal, median, and epiphrenic. Treatment of esophageal diverticula is based on several basic pathophysiological principles. Small and asymptomatic diverticula do not require specific treatment. Large and symptomatic diverticula require surgical intervention, consisting of diverticulectomy combined with myotomy. Operations for symptomatic epiphrenic diverticula make up no more than 2% of all operations on the esophagus. We describe a case of an epiphrenic diverticulum with the dimensions 88x60x90 mm in a 54-year-old patient. Surgical treatment of this disease was performed according to the Lewis method. The article also describes methods of dealing with concomitant postoperative complications and a brief review of the literature on epiphrenic diverticula.
憩室是食管壁有限的囊状突起,与食管壁腔相通。解剖上,食管憩室分为咽食管憩室、正中憩室和表膈憩室。食道憩室的治疗是基于几个基本的病理生理学原理。小而无症状的憩室不需要特殊治疗。大而有症状的憩室需要手术干预,包括憩室切除术和肌切开术。对症性膈憩室的手术占食道手术总数的2%。我们报告一例54岁患者的肾外憩室,尺寸为88x60x90mm。本病手术治疗按Lewis法进行。本文还介绍了处理伴随术后并发症的方法,并简要回顾了有关肾外憩室的文献。
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引用次数: 1
https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2022.0013 https://www.iberoamjmed.com/article/doi/10.53986/ibjm.2022.0013
Pub Date : 2022-02-26 DOI: 10.53986/ibjm.2022.0013
Satvinder Bakshi
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引用次数: 0
期刊
Iberoamerican Journal of Medicine
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