Introduction: Low levels of vitamin D have been linked to raised periodontal inflammation, a higher concentration of periodontopathogens, greater periodontal destruction, and more severe periodontitis. This study aimed to assess the influence of vitamin D and calcium levels on periodontitis. Material and methods: A search for studies on vitamin D, calcium, and periodontal disease was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Scopus. For continuous outcomes, the estimates of effects of an intervention were expressed as mean differences (MD), using the inverse variance (IV) method with 95% confidence intervals. The meta-analysis was conducted using RevMan 5.4 software. Results: Thirty-one studies with 14,340 participants were included in this meta-analysis. Periodontitis patients had mean vitamin D concentrations significantly lower than controls without the disease (p<0.001). Likewise, these patients showed significantly lower serum vitamin D concentrations (p<0.001) and higher salivary vitamin D concentrations, although without reaching statistical significance (p=0.70). Regarding calcium levels, periodontitis patients had significantly higher salivary levels than controls (p<0.001). Conclusions: Low vitamin D and high calcium levels are associated with an increased periodontitis risk.
导言:低水平的维生素D与牙周炎症、较高浓度的牙周病原、更大程度的牙周破坏和更严重的牙周炎有关。本研究旨在评估维生素D和钙水平对牙周炎的影响。材料和方法:在以下数据库中搜索维生素D、钙和牙周病的研究:PubMed (MEDLINE, Cochrane Library)、Web of Science (WoS)和Scopus。对于连续结果，干预效果的估计用平均差异(MD)表示，使用95%置信区间的逆方差(IV)方法。meta分析采用RevMan 5.4软件进行。结果:本荟萃分析纳入31项研究，14340名参与者。牙周炎患者的平均维生素D浓度显著低于无牙周炎的对照组(p<0.001)。同样，这些患者血清维生素D浓度显著降低(p<0.001)，唾液维生素D浓度显著升高，尽管没有达到统计学意义(p=0.70)。关于钙水平，牙周炎患者的唾液水平明显高于对照组(p<0.001)。结论:低维生素D和高钙水平与牙周炎风险增加有关。
{"title":"Association of periodontitis with vitamin D and calcium levels: a meta-analysis","authors":"A. Rodríguez-Archilla, Nnuar Mohamed-El-Founti","doi":"10.53986/ibjm.2023.0003","DOIUrl":"https://doi.org/10.53986/ibjm.2023.0003","url":null,"abstract":"Introduction: Low levels of vitamin D have been linked to raised periodontal inflammation, a higher concentration of periodontopathogens, greater periodontal destruction, and more severe periodontitis. This study aimed to assess the influence of vitamin D and calcium levels on periodontitis. Material and methods: A search for studies on vitamin D, calcium, and periodontal disease was conducted in the following databases: PubMed (MEDLINE, Cochrane Library), Web of Science (WoS), and Scopus. For continuous outcomes, the estimates of effects of an intervention were expressed as mean differences (MD), using the inverse variance (IV) method with 95% confidence intervals. The meta-analysis was conducted using RevMan 5.4 software. Results: Thirty-one studies with 14,340 participants were included in this meta-analysis. Periodontitis patients had mean vitamin D concentrations significantly lower than controls without the disease (p<0.001). Likewise, these patients showed significantly lower serum vitamin D concentrations (p<0.001) and higher salivary vitamin D concentrations, although without reaching statistical significance (p=0.70). Regarding calcium levels, periodontitis patients had significantly higher salivary levels than controls (p<0.001). Conclusions: Low vitamin D and high calcium levels are associated with an increased periodontitis risk.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80196366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Liver cancer is one of the most common malignant tumors in the world, and patients with liver cancer are often in the middle and late stages of cancer when they are diagnosed. Copper death is a newly discovered new cell death method. It is a copper-dependent and regulated cell death method. At the same time, Long noncoding RNAs (LncRNAs) also play an important regulatory role in the pathological process of tumors such as liver cancer. Materials and methods: First, the expression levels of CuProtosis-related genes in liver cancer samples were extracted, and a CuProtosis- related LncRNA prognostic model was constructed. C-index curve and ROC curve were drawn by survival analysis, PFS analysis, and independent prognosis analysis. The model was also validated by clinical grouping and PCA principal component analysis. To ensure its accuracy, enrichment analysis, immune analysis and tumor mutational burden analysis further explored the potential function of this model, and finally discussed potential drugs targeting this model. Results: A prognostic model for predicting survival was constructed and its high predictive ability in liver cancer patients was validated. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment showed that the differential genes were mainly enriched in 5 pathways. Meanwhile, six differentially expressed immune functions were found in the high-risk and low-risk groups. The survival rate of patients in the high mutation group was significantly lower than that of the patients with liver cancer in the low mutation group. Twelve drugs with significant differences in drug sensitivity between high- and low-risk groups were explored. Conclusions: The risk-prognosis model based on CuProtosis LncRNA established in this study is expected to be used to predict the prognosis and immunotherapy response of liver cancer patients. It provides new clues and methods for predicting the survival time of liver cancer patients, and also provides new ideas for guiding individualized immunotherapy strategies for liver cancer patients in the future.
{"title":"Construction of a model for predicting the prognosis of liver cancer patients based on CuProtosis-related LncRNA","authors":"Yiyang Chen, Wanbang Zhou, Yiju Gong, Xinde Ou","doi":"10.53986/ibjm.2023.0001","DOIUrl":"https://doi.org/10.53986/ibjm.2023.0001","url":null,"abstract":"Introduction: Liver cancer is one of the most common malignant tumors in the world, and patients with liver cancer are often in the middle and late stages of cancer when they are diagnosed. Copper death is a newly discovered new cell death method. It is a copper-dependent and regulated cell death method. At the same time, Long noncoding RNAs (LncRNAs) also play an important regulatory role in the pathological process of tumors such as liver cancer. Materials and methods: First, the expression levels of CuProtosis-related genes in liver cancer samples were extracted, and a CuProtosis- related LncRNA prognostic model was constructed. C-index curve and ROC curve were drawn by survival analysis, PFS analysis, and independent prognosis analysis. The model was also validated by clinical grouping and PCA principal component analysis. To ensure its accuracy, enrichment analysis, immune analysis and tumor mutational burden analysis further explored the potential function of this model, and finally discussed potential drugs targeting this model. Results: A prognostic model for predicting survival was constructed and its high predictive ability in liver cancer patients was validated. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment showed that the differential genes were mainly enriched in 5 pathways. Meanwhile, six differentially expressed immune functions were found in the high-risk and low-risk groups. The survival rate of patients in the high mutation group was significantly lower than that of the patients with liver cancer in the low mutation group. Twelve drugs with significant differences in drug sensitivity between high- and low-risk groups were explored. Conclusions: The risk-prognosis model based on CuProtosis LncRNA established in this study is expected to be used to predict the prognosis and immunotherapy response of liver cancer patients. It provides new clues and methods for predicting the survival time of liver cancer patients, and also provides new ideas for guiding individualized immunotherapy strategies for liver cancer patients in the future.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86350965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Rivera, Maria Catalina Ferreria, Laura Libreros-Peña, M. Shah, J. Aristizábal, E. Muñoz, Catalina Gomez-Duarte, Beatriz Eugenia Ossa-Lopez, Gabriel Burbano-Montenegro, Ankur Seth
Introduction: Glaucoma is a leading cause of irreversible blindness worldwide; several risk factors have been identified as major underlying causes for developing this condition. Optic disc hemorrhage has been identified as a risk factor for the development and progression of primary open-angle glaucoma, as well it has been related to playing an important role in normal-tension glaucoma. Material and methods: A cross-sectional study was conducted in Colombia among hypertensive and diabetic patients. This study included 2,067 subjects older than 50 years who were attended by a group of ophthalmologists in six cities in Colombia who conducted a complete medical and ophthalmological examination and applied standardized questionnaires and interviews aiming to evaluate participant’s health conditions and lifestyles. Results: We found a prevalence of Optic disc hemorrhage (ODH) of 0.4%. ODH presented an OR: 8.82 (95% CI 1.60 - 48.52) for the presence of Glaucoma. Patients diagnosed with systemic hypertension had an OR: 0.02 (95% CI 0.00 - 0.96); Patients with Retinal Nerve Fiber Layer Defect (RNFL) presented an OR: 509.40 (95% CI 8.60 - 30152.97) for the presence of ODH and 50% of patients with ODH did not have a diagnosis of glaucoma. Conclusions: Despite the low prevalence of ODH in our study (0.4%), its presence is a High-risk factor for the presence of Glaucoma. RNFL defect is also highly related to ODH and the presence of Glaucoma.
青光眼是世界范围内不可逆失明的主要原因;几个风险因素已被确定为发展这种情况的主要潜在原因。视盘出血是原发性开角型青光眼发生发展的危险因素，在正常眼压型青光眼中也起着重要作用。材料和方法:在哥伦比亚对高血压和糖尿病患者进行了一项横断面研究。这项研究包括2067名50岁以上的受试者，由哥伦比亚六个城市的一组眼科医生参加，他们进行了完整的医学和眼科检查，并采用标准化问卷调查和访谈，旨在评估参与者的健康状况和生活方式。结果:我们发现视盘出血(ODH)的患病率为0.4%。对于青光眼的存在，ODH的OR为8.82 (95% CI 1.60 - 48.52)。诊断为全身性高血压的患者OR为0.02 (95% CI 0.00 - 0.96);视网膜神经纤维层缺损(RNFL)患者存在ODH的OR为509.40 (95% CI 8.60 - 30152.97)， 50%的ODH患者未诊断为青光眼。结论:尽管在我们的研究中，ODH的患病率很低(0.4%)，但它的存在是青光眼存在的高危因素。RNFL缺损也与ODH和青光眼的存在高度相关。
{"title":"Relationship between Optic Disc Hemorrhage and Glaucoma among patients diagnosed with Systemic Hypertension and Diabetes Mellitus: The Colombian Glaucoma Study","authors":"C. Rivera, Maria Catalina Ferreria, Laura Libreros-Peña, M. Shah, J. Aristizábal, E. Muñoz, Catalina Gomez-Duarte, Beatriz Eugenia Ossa-Lopez, Gabriel Burbano-Montenegro, Ankur Seth","doi":"10.53986/ibjm.2022.0040","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0040","url":null,"abstract":"Introduction: Glaucoma is a leading cause of irreversible blindness worldwide; several risk factors have been identified as major underlying causes for developing this condition. Optic disc hemorrhage has been identified as a risk factor for the development and progression of primary open-angle glaucoma, as well it has been related to playing an important role in normal-tension glaucoma. Material and methods: A cross-sectional study was conducted in Colombia among hypertensive and diabetic patients. This study included 2,067 subjects older than 50 years who were attended by a group of ophthalmologists in six cities in Colombia who conducted a complete medical and ophthalmological examination and applied standardized questionnaires and interviews aiming to evaluate participant’s health conditions and lifestyles. Results: We found a prevalence of Optic disc hemorrhage (ODH) of 0.4%. ODH presented an OR: 8.82 (95% CI 1.60 - 48.52) for the presence of Glaucoma. Patients diagnosed with systemic hypertension had an OR: 0.02 (95% CI 0.00 - 0.96); Patients with Retinal Nerve Fiber Layer Defect (RNFL) presented an OR: 509.40 (95% CI 8.60 - 30152.97) for the presence of ODH and 50% of patients with ODH did not have a diagnosis of glaucoma. Conclusions: Despite the low prevalence of ODH in our study (0.4%), its presence is a High-risk factor for the presence of Glaucoma. RNFL defect is also highly related to ODH and the presence of Glaucoma.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88601194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Coronary artery ectasia (CAE) is one of the uncommon cardiovascular disorders with a clinical spectrum ranging from asymptomatic cases to myocardial infarction. Atherosclerosis plays a pivotal role in the pathogenesis of CAE. Recently, it has been determined that the atherogenic index of plasma (AIP) is a strong predictive marker for atherosclerosis. The aim of this study was to investigate whether there is a relationship between obstructive CAE and AIP in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS). Materials and methods: In this retrospective study, hospital electronic patient records were retrospectively examined. A total of 213 NSTE-ACS patients were included in the study. Patients were divided into two groups according to non-obstructive and obstructive CAE. The AIP value was compared between groups and regression analysis evaluated whether it is an indicator to predict the risk of obstructive CAE. Results: The AIP value was found to be numerically and statistically significant in the obstructive CAE group compared to the non-obstructive CAE group. The multivariate logistic regression analysis identified AIP as a predictor of obstructive CAE in NSTE-ACS patients in the receiver operating curve analysis, AIP values above 0.33 had 90% sensitivity and 68% specificity to predict obstructive CAE in NSTE-ACS patients. Conclusions: AIP values were increased in the presence of obstructive CAE in NSTE-ACS patients. Our findings suggest that AIP may be involved in the pathogenesis of obstructive CAE.
{"title":"A New Predictor of Obstructive Coronary Artery Ectasia in Patients with Non-ST-Elevation Acute Coronary Syndrome: The Atherogenic Index of Plasma","authors":"U. Küçük, K. Arslan","doi":"10.53986/ibjm.2022.0039","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0039","url":null,"abstract":"Introduction: Coronary artery ectasia (CAE) is one of the uncommon cardiovascular disorders with a clinical spectrum ranging from asymptomatic cases to myocardial infarction. Atherosclerosis plays a pivotal role in the pathogenesis of CAE. Recently, it has been determined that the atherogenic index of plasma (AIP) is a strong predictive marker for atherosclerosis. The aim of this study was to investigate whether there is a relationship between obstructive CAE and AIP in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS). Materials and methods: In this retrospective study, hospital electronic patient records were retrospectively examined. A total of 213 NSTE-ACS patients were included in the study. Patients were divided into two groups according to non-obstructive and obstructive CAE. The AIP value was compared between groups and regression analysis evaluated whether it is an indicator to predict the risk of obstructive CAE. Results: The AIP value was found to be numerically and statistically significant in the obstructive CAE group compared to the non-obstructive CAE group. The multivariate logistic regression analysis identified AIP as a predictor of obstructive CAE in NSTE-ACS patients in the receiver operating curve analysis, AIP values above 0.33 had 90% sensitivity and 68% specificity to predict obstructive CAE in NSTE-ACS patients. Conclusions: AIP values were increased in the presence of obstructive CAE in NSTE-ACS patients. Our findings suggest that AIP may be involved in the pathogenesis of obstructive CAE.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88114095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development of electrocardiography, one of the top scientific breakthroughs of the 20th century, occurred in the field of cardiology. The history of the ECG began long before its invention, with the advent of the study of electricity in the medical field. The idea of electrophysiology and Waller's initial recording of the ‘electrogram’ encouraged Willem Einthoven to develop new string galvanometers and turn this remarkable physiologic occurrence into a vital clinical recording tool. It has progressed from Einthoven's innovation to wearable technology. In the first part of the 20th century, a number of inventive people achieved a remarkable succession of discoveries and advancements that led to the development of the 12-lead ECG as we know it today. It went further than that. The evolution of science and technology over the years has allowed for continual development in terms of usefulness, ranging from five operators to one operator meant to record the ECG trace, and mobility, ranging from around 300 Kg to roughly around 1 Kg. Electrocardiographs in minimized form now exist thanks to the modern era of digitalization. We will go over the significant processes in the development of the ECG in this article.
{"title":"From a laboratory to the wearables: a review on history and evolution of electrocardiogram","authors":"Rony Vincent","doi":"10.53986/ibjm.2022.0038","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0038","url":null,"abstract":"The development of electrocardiography, one of the top scientific breakthroughs of the 20th century, occurred in the field of cardiology. The history of the ECG began long before its invention, with the advent of the study of electricity in the medical field. The idea of electrophysiology and Waller's initial recording of the ‘electrogram’ encouraged Willem Einthoven to develop new string galvanometers and turn this remarkable physiologic occurrence into a vital clinical recording tool. It has progressed from Einthoven's innovation to wearable technology. In the first part of the 20th century, a number of inventive people achieved a remarkable succession of discoveries and advancements that led to the development of the 12-lead ECG as we know it today. It went further than that. The evolution of science and technology over the years has allowed for continual development in terms of usefulness, ranging from five operators to one operator meant to record the ECG trace, and mobility, ranging from around 300 Kg to roughly around 1 Kg. Electrocardiographs in minimized form now exist thanks to the modern era of digitalization. We will go over the significant processes in the development of the ECG in this article.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84260701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Usman Babar, Khwaja Muhammad Musa, Babar Ali, U. Farooq, S. Hussain, S. Réhman
Introduction: Spinal cord injury results in disability, limited participation in physical activities, and mental health problems which greatly affects the quality of life of the injured person. Engaging in physical activity is necessary for optimal recovery in individuals with spinal cord injury. Chronic spinal cord injury patients suffer from many secondary complications which become a challenge for the patient and the health care community to manage due to which recovery will be complex and difficult. The aim of this study is to find out the association of physical activity with depression among chronic spinal cord injury patients at Paraplegic Centre Peshawar. Material and methods: This study was a cross-sectional survey in which a consecutive sampling technique was used. Data was collected from n=109 spinal cord injury patients in which 85 (78.0%) were males and 24 (22.0%) were females. Physical activity was measured using the PARA-SCI scale and the CESD-R-10 questionnaire was used to assess depression. Results: The average minutes of participating in mild physical activity was 67.72 ± 17.98 minutes/week, moderate physical activity was 140.79 ± 33.47 minutes/week, heavy physical activity was 21.92 ± 9.18 minutes/week and total PA was 247.93 ± 55.76. P value= .004 for mild physical activity with depression, p value= .097 for moderate physical activity with depression, p value= .137 for heavy physical activity with depression and p value= .001 for total physical activity with depression. Conclusions: Mild and total physical activity was associated with depression. Moderate and heavy physical activity was not associated with depression.
{"title":"Level of physical activity and its association with depression among chronic spinal cord injury patients at a paraplegic centre in Peshawar","authors":"Usman Babar, Khwaja Muhammad Musa, Babar Ali, U. Farooq, S. Hussain, S. Réhman","doi":"10.53986/ibjm.2022.0037","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0037","url":null,"abstract":"Introduction: Spinal cord injury results in disability, limited participation in physical activities, and mental health problems which greatly affects the quality of life of the injured person. Engaging in physical activity is necessary for optimal recovery in individuals with spinal cord injury. Chronic spinal cord injury patients suffer from many secondary complications which become a challenge for the patient and the health care community to manage due to which recovery will be complex and difficult. The aim of this study is to find out the association of physical activity with depression among chronic spinal cord injury patients at Paraplegic Centre Peshawar. Material and methods: This study was a cross-sectional survey in which a consecutive sampling technique was used. Data was collected from n=109 spinal cord injury patients in which 85 (78.0%) were males and 24 (22.0%) were females. Physical activity was measured using the PARA-SCI scale and the CESD-R-10 questionnaire was used to assess depression. Results: The average minutes of participating in mild physical activity was 67.72 ± 17.98 minutes/week, moderate physical activity was 140.79 ± 33.47 minutes/week, heavy physical activity was 21.92 ± 9.18 minutes/week and total PA was 247.93 ± 55.76. P value= .004 for mild physical activity with depression, p value= .097 for moderate physical activity with depression, p value= .137 for heavy physical activity with depression and p value= .001 for total physical activity with depression. Conclusions: Mild and total physical activity was associated with depression. Moderate and heavy physical activity was not associated with depression.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74684136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Healthcare professionals (HCPs) play a key role in the prevention of catheter-associated urinary tract infections (CAUTI). This study aims to determine the compliance of healthcare personnel with urethral catheterisation standards and the factors affecting it. Materials and Methods: This study is a prospective survey and was conducted between February and March 2021 after ethical approval and patient consent. An internet-based, structured 39-item questionnaire was sent via email to all HCPs at Zonguldak Bulent Ecevit University Hospital, Zonguldak, Turkey. A to evaluate their knowledge and attitudes towards the prevention of CAUTI. The questionnaire was completed by 156 health professionals. For categorical parameters Fisher’s exact test, though for scale parameters student t-test, Mann–Whitney U and Kruskal–Wallis tests were used. All statistical analysis was done using SPSS 17.0. Results: The average years of experience of the HCPs who participated in the survey was 12.5 years. The level of knowledge of the doctors and the nurses about the indication of catheter insertion was similar, whereas the level of knowledge about CAUTI prevention was higher among the doctors. However, none of the participants could fully describe how to prevent CAUTI. Conclusions: The level of knowledge of CAUTI preventive measures among the participants was insufficient. To effectively preventing CAUTI, there is a need to change HCPs’ perspective on this issue, which can be achieved through training, and advantage current technologies.
{"title":"Healthcare Providers’ Compliance with Guidelines for Catheter-Associated Urinary Tract Infections in a Rural Teaching and Referral Hospital","authors":"R. Girgin, E. Horuz","doi":"10.53986/ibjm.2022.0036","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0036","url":null,"abstract":"Introduction: Healthcare professionals (HCPs) play a key role in the prevention of catheter-associated urinary tract infections (CAUTI). This study aims to determine the compliance of healthcare personnel with urethral catheterisation standards and the factors affecting it. Materials and Methods: This study is a prospective survey and was conducted between February and March 2021 after ethical approval and patient consent. An internet-based, structured 39-item questionnaire was sent via email to all HCPs at Zonguldak Bulent Ecevit University Hospital, Zonguldak, Turkey. A to evaluate their knowledge and attitudes towards the prevention of CAUTI. The questionnaire was completed by 156 health professionals. For categorical parameters Fisher’s exact test, though for scale parameters student t-test, Mann–Whitney U and Kruskal–Wallis tests were used. All statistical analysis was done using SPSS 17.0. Results: The average years of experience of the HCPs who participated in the survey was 12.5 years. The level of knowledge of the doctors and the nurses about the indication of catheter insertion was similar, whereas the level of knowledge about CAUTI prevention was higher among the doctors. However, none of the participants could fully describe how to prevent CAUTI. Conclusions: The level of knowledge of CAUTI preventive measures among the participants was insufficient. To effectively preventing CAUTI, there is a need to change HCPs’ perspective on this issue, which can be achieved through training, and advantage current technologies.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76363612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Víctor Alegre-Ituarte, Jorge Hernández-Cerdá, M. Albert-Fort
{"title":"Ocular myasthenia gravis and thymoma","authors":"Víctor Alegre-Ituarte, Jorge Hernández-Cerdá, M. Albert-Fort","doi":"10.53986/ibjm.2022.0035","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0035","url":null,"abstract":"","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81656348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The introduction of the drug-eluting (DES) stent to percutaneous coronary intervention (PCI) had a significant impact on patient management of coronary artery disease and has been called the “third revolution” in interventional cardiology after the first 2 revolutions of balloon angioplasty and bare-metal stents. The promise of adaptive remodeling, restoration of vasomotion, late luminal enlargement, and retained potential for future coronary artery bypass grafting at the site of previous PCI has been the driving force behind bioresorbable stent/scaffold (BRS) technology development. Moreover, because of the inherent risk of late and very late stent thrombosis, BRS potentially offers a solution and recent years have seen heightened interest, hype, and hope. In this current review, we are aiming to shed light on strength and weakness of various BRS including the future perspective.
{"title":"Bioresorbable scaffolds: current concepts and future technology","authors":"D. Dash, Shahid Merchant","doi":"10.53986/ibjm.2022.0034","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0034","url":null,"abstract":"The introduction of the drug-eluting (DES) stent to percutaneous coronary intervention (PCI) had a significant impact on patient management of coronary artery disease and has been called the “third revolution” in interventional cardiology after the first 2 revolutions of balloon angioplasty and bare-metal stents. The promise of adaptive remodeling, restoration of vasomotion, late luminal enlargement, and retained potential for future coronary artery bypass grafting at the site of previous PCI has been the driving force behind bioresorbable stent/scaffold (BRS) technology development. Moreover, because of the inherent risk of late and very late stent thrombosis, BRS potentially offers a solution and recent years have seen heightened interest, hype, and hope. In this current review, we are aiming to shed light on strength and weakness of various BRS including the future perspective.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79196065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Çavdar, Kubilay Karaboyun, Yakup Iriagac, O. Avcı, Erdoğan, Selcuk E. Seber
Introduction: Trastuzumab emtansine (T-DM1) is one of the effective treatment options in human epidermal growth factor receptor 2 (HER2) positive breast cancer patients. In this study, we aimed to find the effect of T-DM1 on survival, its tolerability and prognostic factors of T-DM1 treatment. Material and methods: The study was designed as a single-center, retrospective study that included patients treated in the oncology department of a university hospital in Turkey. HER2-positive patients with metastatic breast cancer who had a progression response to trastuzumab and taxane treatment and received T-DM1 treatment for at least 2 months between 2016-2022 were included in the study. Adverse events were defined according to the Common Terminology Criteria for Adverse Events v5.0 (CTCAE). Kaplan-Meier methodology and Cox proportional hazard modelling were used for survival analyses. Results: The median progression-free survival (mPFS) for T-DM1 was 10.4 months and the median overall survival (mOS) was 22 months. In the created univariate cox regression model, liver metastasis, ECOG performance status, and pre-treatment serum CA 15-3 were found to be factors associated with PFS. Liver metastasis (HR=2.54, p=0.019), ECOG performance status (HR=4.66, p=0.002), and serum CA 15-3 (HR= 2.55, p=0.041) maintained their statistical significance for PFS in the established multivariate analysis. In the regression analysis for OS, only ECOG performance status (HR= 2.61, p=0.023) was found to be prognostic. While toxicity occurred in 46 (82.1%) of the patients, grade 3-4 toxicity developed in 10 (17.9%) patients. The most common side effects were anemia, thrombocytopenia, fatigue and nausea. Conclusions: T-DM1 is a safe and tolerable agent that prolongs survival. Liver metastasis, ECOG performance status, and pre-treatment serum CA 15-3 levels are independent prognostic factors for patients using T-DM1.
{"title":"Efficacy and safety of trastuzumab emtansine treatment in patients with metastatic HER-2 positive breast cancer: a single center study","authors":"E. Çavdar, Kubilay Karaboyun, Yakup Iriagac, O. Avcı, Erdoğan, Selcuk E. Seber","doi":"10.53986/ibjm.2022.0033","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0033","url":null,"abstract":"Introduction: Trastuzumab emtansine (T-DM1) is one of the effective treatment options in human epidermal growth factor receptor 2 (HER2) positive breast cancer patients. In this study, we aimed to find the effect of T-DM1 on survival, its tolerability and prognostic factors of T-DM1 treatment. Material and methods: The study was designed as a single-center, retrospective study that included patients treated in the oncology department of a university hospital in Turkey. HER2-positive patients with metastatic breast cancer who had a progression response to trastuzumab and taxane treatment and received T-DM1 treatment for at least 2 months between 2016-2022 were included in the study. Adverse events were defined according to the Common Terminology Criteria for Adverse Events v5.0 (CTCAE). Kaplan-Meier methodology and Cox proportional hazard modelling were used for survival analyses. Results: The median progression-free survival (mPFS) for T-DM1 was 10.4 months and the median overall survival (mOS) was 22 months. In the created univariate cox regression model, liver metastasis, ECOG performance status, and pre-treatment serum CA 15-3 were found to be factors associated with PFS. Liver metastasis (HR=2.54, p=0.019), ECOG performance status (HR=4.66, p=0.002), and serum CA 15-3 (HR= 2.55, p=0.041) maintained their statistical significance for PFS in the established multivariate analysis. In the regression analysis for OS, only ECOG performance status (HR= 2.61, p=0.023) was found to be prognostic. While toxicity occurred in 46 (82.1%) of the patients, grade 3-4 toxicity developed in 10 (17.9%) patients. The most common side effects were anemia, thrombocytopenia, fatigue and nausea. Conclusions: T-DM1 is a safe and tolerable agent that prolongs survival. Liver metastasis, ECOG performance status, and pre-treatment serum CA 15-3 levels are independent prognostic factors for patients using T-DM1.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80737609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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