Systemic Perfusion Pressure, SPP disorders cause ischemia of the affected microcirculation with critical mitochondrial damage, manifested by a hypercarbia pCO2 AV > 6 mm Hg. Thus, pCO2 has become an alarm signal, used as a marker of ischemia in terminal states with the generation of microcirculatory-mitochondrial distress syndrome, MMDS, and the installation of multiorgan organs dysfunction syndrome, MODS. Definition of SPP (~ 70 mm Hg), there is a difference between mean arterial pressure, MAP (90 mm Hg), and capillary resistance pressure, CRP (20 mm Hg) [1]. According to Maria Vasilieva's study [2,3], a tear can be a diagnostic test for various diseases. CRP in the practice of the doctor on duty can be compared with intraocular pressure, by the Kalmakov method, except for oculist glaucoma, consultation of which is essential for examining the fundus in these patients. Permissive optimization of perfusion pressure through Microcirculatory - Mitochondrial recruitment, MMR reduces the AV gap < 6 mm Hg, thus reducing MMDS. Mitochondria promote energy homeostasis by improving the functions of biosystems and pauses the expansion of MODS. Maintaining permissive SPP in critically terminal states in daily emergency clinical practice contributed to their survival [1-5]. Thus, the decisive success of Multi-organ Supportive Therapy (MOST) in Extracorporeal Life Support Organizations (ELSO) has perfusion pressure.
全身灌注压(SPP)紊乱引起微循环缺血，伴有严重的线粒体损伤，表现为高碳pCO2 AV > 6 mm Hg。因此，pCO2已成为一个报警信号，作为终末期缺血状态的标志，产生微循环-线粒体窘迫综合征(MMDS)和多器官功能障碍综合征(MODS)。定义SPP (~ 70 mm Hg)时，平均动脉压MAP (90 mm Hg)与毛细血管阻力压CRP (20 mm Hg)之间存在差异[1]。根据Maria Vasilieva的研究[2,3]，撕裂可以作为多种疾病的诊断测试。在值班医生的实践中，CRP可与眼压进行比较，通过Kalmakov方法，除了眼科青光眼，这类患者检查眼底时必须咨询。通过微循环-线粒体募集，MMR允许优化灌注压力，使房室间隙< 6 mm Hg，从而降低MMDS。线粒体通过改善生物系统的功能来促进能量稳态，并暂停MODS的扩张。在日常急诊临床实践中，在危重末期保持允许的SPP有助于患者的生存[1-5]。因此，在体外生命支持组织(ELSO)中，多器官支持治疗(MOST)成功的决定性因素是灌注压。
{"title":"Recruitment Microcirculatory - Mitochondrial through a permissive systemic perfusion pressure combats microcirculatory - mitochondrial distress syndrome. Cases report","authors":"I. Vasilieva, M. Vasilieva, I. Vasiliev","doi":"10.58676/sjmas.v1i4.24","DOIUrl":"https://doi.org/10.58676/sjmas.v1i4.24","url":null,"abstract":"Systemic Perfusion Pressure, SPP disorders cause ischemia of the affected microcirculation with critical mitochondrial damage, manifested by a hypercarbia pCO2 AV > 6 mm Hg. Thus, pCO2 has become an alarm signal, used as a marker of ischemia in terminal states with the generation of microcirculatory-mitochondrial distress syndrome, MMDS, and the installation of multiorgan organs dysfunction syndrome, MODS. Definition of SPP (~ 70 mm Hg), there is a difference between mean arterial pressure, MAP (90 mm Hg), and capillary resistance pressure, CRP (20 mm Hg) [1]. According to Maria Vasilieva's study [2,3], a tear can be a diagnostic test for various diseases. CRP in the practice of the doctor on duty can be compared with intraocular pressure, by the Kalmakov method, except for oculist glaucoma, consultation of which is essential for examining the fundus in these patients. Permissive optimization of perfusion pressure through Microcirculatory - Mitochondrial recruitment, MMR reduces the AV gap < 6 mm Hg, thus reducing MMDS. Mitochondria promote energy homeostasis by improving the functions of biosystems and pauses the expansion of MODS. Maintaining permissive SPP in critically terminal states in daily emergency clinical practice contributed to their survival [1-5]. Thus, the decisive success of Multi-organ Supportive Therapy (MOST) in Extracorporeal Life Support Organizations (ELSO) has perfusion pressure.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124855104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikolaos Tzenios, Mohamad Chahine, Mary Tazanios, Poh Omasyarifa Binti Jamal
The ketogenic (keto) diet, characterized by high fat, moderate protein, and low carbohydrate intake, has gained popularity for its potential health benefits and weight loss effects. Its impact on muscle building, however, remains a subject of interest and debate. This review aims to examine the current literature on the keto diet's role in muscle growth, recovery, and performance. We discuss how ketosis-induced changes in fat oxidation, inflammation, and hormonal balance may contribute to muscle building. The evidence suggests that, under certain conditions, the keto diet can support muscle growth and improve recovery in athletes and fitness enthusiasts.
{"title":"Positive Effects of the Keto Diet on Muscle Building: A Comprehensive Overview","authors":"Nikolaos Tzenios, Mohamad Chahine, Mary Tazanios, Poh Omasyarifa Binti Jamal","doi":"10.58676/sjmas.v1i4.27","DOIUrl":"https://doi.org/10.58676/sjmas.v1i4.27","url":null,"abstract":"The ketogenic (keto) diet, characterized by high fat, moderate protein, and low carbohydrate intake, has gained popularity for its potential health benefits and weight loss effects. Its impact on muscle building, however, remains a subject of interest and debate. This review aims to examine the current literature on the keto diet's role in muscle growth, recovery, and performance. We discuss how ketosis-induced changes in fat oxidation, inflammation, and hormonal balance may contribute to muscle building. The evidence suggests that, under certain conditions, the keto diet can support muscle growth and improve recovery in athletes and fitness enthusiasts.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135792884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Tzenios, Mohamad Chahine, Poh Omasyarifa Binti Jamal, Mary E. Tazanios
The ketogenic (keto) diet, characterized by high fat, moderate protein, and low carbohydrate intake, has gained popularity for its potential health benefits and weight loss effects. Its impact on muscle building, however, remains a subject of interest and debate. This review aims to examine the current literature on the keto diet's role in muscle growth, recovery, and performance. We discuss how ketosis-induced changes in fat oxidation, inflammation, and hormonal balance may contribute to muscle building. The evidence suggests that, under certain conditions, the keto diet can support muscle growth and improve recovery in athletes and fitness enthusiasts.
{"title":"The Positive Effects of the Keto Diet on Muscle Building: A Comprehensive Overview","authors":"N. Tzenios, Mohamad Chahine, Poh Omasyarifa Binti Jamal, Mary E. Tazanios","doi":"10.58676/sjmas.v1i1.27","DOIUrl":"https://doi.org/10.58676/sjmas.v1i1.27","url":null,"abstract":"The ketogenic (keto) diet, characterized by high fat, moderate protein, and low carbohydrate intake, has gained popularity for its potential health benefits and weight loss effects. Its impact on muscle building, however, remains a subject of interest and debate. This review aims to examine the current literature on the keto diet's role in muscle growth, recovery, and performance. We discuss how ketosis-induced changes in fat oxidation, inflammation, and hormonal balance may contribute to muscle building. The evidence suggests that, under certain conditions, the keto diet can support muscle growth and improve recovery in athletes and fitness enthusiasts.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121876630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Identifying the most highly educated person in the world is challenging due to the diverse educational systems and degrees offered worldwide. This article discusses the difficulties in evaluating academic excellence and proposes potential metrics to assess the most highly educated person. It acknowledges the limitations of traditional ranking systems and explores alternative approaches to measuring educational quality. Despite these challenges, the article highlights Professor Nikolaos Tzenios' outstanding academic achievements, making him a leading contender for the title of the most highly educated person. The Official World Records (OWR) recognized Professor Nikolaos Tzenios as the "Most Highly Educated Person in the World".
{"title":"Who is the Most Educated Person in the World","authors":"Ghassan Salibi","doi":"10.58676/sjmas.v1i4.26","DOIUrl":"https://doi.org/10.58676/sjmas.v1i4.26","url":null,"abstract":"Identifying the most highly educated person in the world is challenging due to the diverse educational systems and degrees offered worldwide. This article discusses the difficulties in evaluating academic excellence and proposes potential metrics to assess the most highly educated person. It acknowledges the limitations of traditional ranking systems and explores alternative approaches to measuring educational quality. Despite these challenges, the article highlights Professor Nikolaos Tzenios' outstanding academic achievements, making him a leading contender for the title of the most highly educated person. The Official World Records (OWR) recognized Professor Nikolaos Tzenios as the \"Most Highly Educated Person in the World\".","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"289 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124167699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Tzenios, Mary E. Tazanios, Mohamad Chahine, Poh Omasyarifa Binti Jamal
Background: The role of fat consumption in human health has been the subject of much debate and research. While the association between fat intake and cardiovascular health has been well-established, the relationship between fat consumption and mood remains relatively underexplored. This review aims to provide a comprehensive overview of the literature examining the link between dietary fat intake and mood enhancement. Methods: A systematic review of the literature was conducted, focusing on studies that investigated the effects of different types of dietary fat on mood states. Studies were included if they were published between January 2000 and September 2021, and reported on the relationship between fat consumption and mood outcomes in humans. Results: The review identified a number of studies suggesting a positive association between dietary fat intake and mood enhancement. The consumption of omega-3 fatty acids, in particular, was found to have a strong association with improved mood, reduced depression, and enhanced cognitive function. The evidence for saturated fat and mood outcomes was less consistent, with some studies indicating potential detrimental effects on mood. Conclusion: The available evidence suggests that fat consumption, particularly omega-3 fatty acids, may play a role in mood enhancement. However, further research is needed to establish causality and the potential implications for public health and nutrition recommendations.
{"title":"The Relationship between Fat Consumption and Mood Enhancement: A Comprehensive Review","authors":"N. Tzenios, Mary E. Tazanios, Mohamad Chahine, Poh Omasyarifa Binti Jamal","doi":"10.58676/sjmas.v1i3.23","DOIUrl":"https://doi.org/10.58676/sjmas.v1i3.23","url":null,"abstract":"Background: The role of fat consumption in human health has been the subject of much debate and research. While the association between fat intake and cardiovascular health has been well-established, the relationship between fat consumption and mood remains relatively underexplored. This review aims to provide a comprehensive overview of the literature examining the link between dietary fat intake and mood enhancement. Methods: A systematic review of the literature was conducted, focusing on studies that investigated the effects of different types of dietary fat on mood states. Studies were included if they were published between January 2000 and September 2021, and reported on the relationship between fat consumption and mood outcomes in humans. Results: The review identified a number of studies suggesting a positive association between dietary fat intake and mood enhancement. The consumption of omega-3 fatty acids, in particular, was found to have a strong association with improved mood, reduced depression, and enhanced cognitive function. The evidence for saturated fat and mood outcomes was less consistent, with some studies indicating potential detrimental effects on mood. Conclusion: The available evidence suggests that fat consumption, particularly omega-3 fatty acids, may play a role in mood enhancement. However, further research is needed to establish causality and the potential implications for public health and nutrition recommendations.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116028498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Tzenios, Mary E. Tazanios, Mohamad Chahine, Poh Omasyarifa Binti Jamal
The relationship between obesity and depression has been the subject of significant research over the years. This article aims to systematically review the existing literature to provide a comprehensive understanding of the complex interplay between obesity and depression. By examining both epidemiological and experimental evidence, this article highlights the bidirectional nature of this relationship, while also considering potential mediators and moderators. The implications of these findings for prevention and treatment are discussed, with a particular focus on the importance of a multidisciplinary approach to address both conditions simultaneously.
{"title":"The Complex Relationship Between Obesity and Depression","authors":"N. Tzenios, Mary E. Tazanios, Mohamad Chahine, Poh Omasyarifa Binti Jamal","doi":"10.58676/sjmas.v1i3.22","DOIUrl":"https://doi.org/10.58676/sjmas.v1i3.22","url":null,"abstract":"The relationship between obesity and depression has been the subject of significant research over the years. This article aims to systematically review the existing literature to provide a comprehensive understanding of the complex interplay between obesity and depression. By examining both epidemiological and experimental evidence, this article highlights the bidirectional nature of this relationship, while also considering potential mediators and moderators. The implications of these findings for prevention and treatment are discussed, with a particular focus on the importance of a multidisciplinary approach to address both conditions simultaneously.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"os-53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127790133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kavindya V K W Atapattu, Dr.Ghassan Salibi, N. Tzenios
Introduction – Dengue is a mosquito-borne viral disease considered a global health problem. It is considered one of the major health concerns in Sri Lanka because of being a tropical country. Even though dengue cases are being reported throughout the year, there are some significant differences between incident rates in some months. The highest incident rate is usually reported from the western province. Aim – This study aims to understand the relationship between dengue incidences and monsoon seasons in the Colombo District of Sri Lanka, and the effect of the rainy season on spreading the disease. The results of this study are expected to be helpful in the implementation of new dengue prevention methods and in strengthening the existing preventive methods. Study Design – The study is a statistical analysis using SPSS – 16 version. Graphical analysis is carried out between monthly rainfall and dengue incidences in the Colombo District of Sri Lanka from January 1st of, 2010, till December 31st of, 2019. Methodology – The number of reported dengue cases in the Colombo district during the mentioned ten-year period is obtained from the Bureau of Health Information, Colombo municipal council. Those obtained data are analyzed using bivalent graphs opposite the months and rainfalls of the relevant months. The discussion will be based on the results of the graphs.
{"title":"A study on the Relationship between the rainy season and Dengue outbreak in the Colombo District of Sri Lanka","authors":"Kavindya V K W Atapattu, Dr.Ghassan Salibi, N. Tzenios","doi":"10.58676/sjmas.v1i3.21","DOIUrl":"https://doi.org/10.58676/sjmas.v1i3.21","url":null,"abstract":"Introduction – Dengue is a mosquito-borne viral disease considered a global health problem. It is considered one of the major health concerns in Sri Lanka because of being a tropical country. Even though dengue cases are being reported throughout the year, there are some significant differences between incident rates in some months. The highest incident rate is usually reported from the western province. Aim – This study aims to understand the relationship between dengue incidences and monsoon seasons in the Colombo District of Sri Lanka, and the effect of the rainy season on spreading the disease. The results of this study are expected to be helpful in the implementation of new dengue prevention methods and in strengthening the existing preventive methods. Study Design – The study is a statistical analysis using SPSS – 16 version. Graphical analysis is carried out between monthly rainfall and dengue incidences in the Colombo District of Sri Lanka from January 1st of, 2010, till December 31st of, 2019. Methodology – The number of reported dengue cases in the Colombo district during the mentioned ten-year period is obtained from the Bureau of Health Information, Colombo municipal council. Those obtained data are analyzed using bivalent graphs opposite the months and rainfalls of the relevant months. The discussion will be based on the results of the graphs.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121777955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effectiveness of Intralipid against SARS-Cov2/COVID/19 with Multiple Organ Dysfunction Syndrome (MODS) prevention or regression is described in the original scientific paper [1]. Intralipid at Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 / COVID /19, favors the predominance of the membrane-cytoprotective action of Reactive Oxygen Species (ROS) / Reactive Nitrogen Species (ROS/RNS) over the membrane-to-destructive action, restoring the balance between [ROS /AS] / [RNS / ANOS]. Membrane-cytoprotective mechanism Intralipid is due to a decrease in ROS and RNS and an increase in the activity of the Antioxidant System (AS) and Anti Nitro Oxidant System (ANOS), stopping lipid peroxidation (LPO), reducing Electro-Ion Membrane Distress Syndrome (Maria&Irina Vasilieva syndrome) [2], accelerates the regeneration of endothelial and epithelial cells of the alveolar acinus, restoring gas-respiratory metabolism and the predominance of physiological cell apoptosis over necrosis. Intralipid at SARS-Cov 2 / COVID / 19 opposes Microcirculatory Mitochondrial Distress syndrome (MMDS) by Microcirculatory - Mitochondrial Recruitment; as a result of which pCO2 (AVgap) <6 mm Hg, since LPO decreases and at the level of mitochondrial membranes, improving the function of Mitochondrial permeability transition pore-dependent Ca uniporter, mPT pore, support energy metabolism, eliminating energy deficits, restoring Extreme / Abnormal myelopoiesis and impaired autophagy (mitophagy). Thus, Intralipid has been shown in the strategy of targeted treatment of LPO in Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 /COVID / 19.
{"title":"Intralipid blocks the entry of the SARS-Cov2/COVID/19 virus into cells by maintaining receptor a leucine-rich repeat containing 15 (LRRC15), an angiotensin-converting enzyme 2 receptor competitor.","authors":"I. Vasilieva, M. Vasilieva, I. Vasiliev","doi":"10.58676/sjmas.v1i1.15","DOIUrl":"https://doi.org/10.58676/sjmas.v1i1.15","url":null,"abstract":"The effectiveness of Intralipid against SARS-Cov2/COVID/19 with Multiple Organ Dysfunction Syndrome (MODS) prevention or regression is described in the original scientific paper [1]. Intralipid at Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 / COVID /19, favors the predominance of the membrane-cytoprotective action of Reactive Oxygen Species (ROS) / Reactive Nitrogen Species (ROS/RNS) over the membrane-to-destructive action, restoring the balance between [ROS /AS] / [RNS / ANOS]. Membrane-cytoprotective mechanism Intralipid is due to a decrease in ROS and RNS and an increase in the activity of the Antioxidant System (AS) and Anti Nitro Oxidant System (ANOS), stopping lipid peroxidation (LPO), reducing Electro-Ion Membrane Distress Syndrome (Maria&Irina Vasilieva syndrome) [2], accelerates the regeneration of endothelial and epithelial cells of the alveolar acinus, restoring gas-respiratory metabolism and the predominance of physiological cell apoptosis over necrosis. Intralipid at SARS-Cov 2 / COVID / 19 opposes Microcirculatory Mitochondrial Distress syndrome (MMDS) by Microcirculatory - Mitochondrial Recruitment; as a result of which pCO2 (AVgap) <6 mm Hg, since LPO decreases and at the level of mitochondrial membranes, improving the function of Mitochondrial permeability transition pore-dependent Ca uniporter, mPT pore, support energy metabolism, eliminating energy deficits, restoring Extreme / Abnormal myelopoiesis and impaired autophagy (mitophagy). Thus, Intralipid has been shown in the strategy of targeted treatment of LPO in Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 /COVID / 19.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"44 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120905961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effectiveness of Intralipid against SARS-Cov2/COVID/19 with Multiple Organ Dysfunction Syndrome (MODS) prevention or regression is described in the original scientific paper [1]. Intralipid at Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 / COVID /19, favors the predominance of the membrane-cytoprotective action of Reactive Oxygen Species (ROS) / Reactive Nitrogen Species (ROS/RNS) over the membrane-to-destructive action, restoring the balance between [ROS /AS] / [RNS / ANOS]. Membrane-cytoprotective mechanism Intralipid is due to a decrease in ROS and RNS and an increase in the activity of the Antioxidant System (AS) and Anti Nitro Oxidant System (ANOS), stopping lipid peroxidation (LPO), reducing Electro-Ion Membrane Distress Syndrome (Maria&Irina Vasilieva syndrome) [2], accelerates the regeneration of endothelial and epithelial cells of the alveolar acinus, restoring gas-respiratory metabolism and the predominance of physiological cell apoptosis over necrosis. Intralipid at SARS-Cov 2 / COVID / 19 opposes Microcirculatory Mitochondrial Distress syndrome (MMDS) by Microcirculatory - Mitochondrial Recruitment; as a result of which pCO2 (AVgap) <6 mm Hg, since LPO decreases and at the level of mitochondrial membranes, improving the function of Mitochondrial permeability transition pore-dependent Ca uniporter, mPT pore, support energy metabolism, eliminating energy deficits, restoring Extreme / Abnormal myelopoiesis and impaired autophagy (mitophagy). Thus, Intralipid has been shown in the strategy of targeted treatment of LPO in Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 /COVID / 19.
{"title":"Intralipid blocks the entry of the SARS-Cov2/COVID/19 virus into cells by maintaining receptor a leucine-rich repeat containing 15 (LRRC15), an angiotensin-converting enzyme 2 receptor competitor.","authors":"Irina Vasilieva, Maria Vasilieva, Ilie Vasiliev","doi":"10.58676/sjmas.v1i3.15","DOIUrl":"https://doi.org/10.58676/sjmas.v1i3.15","url":null,"abstract":"The effectiveness of Intralipid against SARS-Cov2/COVID/19 with Multiple Organ Dysfunction Syndrome (MODS) prevention or regression is described in the original scientific paper [1]. Intralipid at Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 / COVID /19, favors the predominance of the membrane-cytoprotective action of Reactive Oxygen Species (ROS) / Reactive Nitrogen Species (ROS/RNS) over the membrane-to-destructive action, restoring the balance between [ROS /AS] / [RNS / ANOS]. Membrane-cytoprotective mechanism Intralipid is due to a decrease in ROS and RNS and an increase in the activity of the Antioxidant System (AS) and Anti Nitro Oxidant System (ANOS), stopping lipid peroxidation (LPO), reducing Electro-Ion Membrane Distress Syndrome (Maria&Irina Vasilieva syndrome) [2], accelerates the regeneration of endothelial and epithelial cells of the alveolar acinus, restoring gas-respiratory metabolism and the predominance of physiological cell apoptosis over necrosis. Intralipid at SARS-Cov 2 / COVID / 19 opposes Microcirculatory Mitochondrial Distress syndrome (MMDS) by Microcirculatory - Mitochondrial Recruitment; as a result of which pCO2 (AVgap) <6 mm Hg, since LPO decreases and at the level of mitochondrial membranes, improving the function of Mitochondrial permeability transition pore-dependent Ca uniporter, mPT pore, support energy metabolism, eliminating energy deficits, restoring Extreme / Abnormal myelopoiesis and impaired autophagy (mitophagy). Thus, Intralipid has been shown in the strategy of targeted treatment of LPO in Oxidative and Nitro-Galogenic stress in patients with SARS-Cov2 /COVID / 19.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135183932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity has emerged as a severe public health concern worldwide, with an increasing number of studies linking it to an increased risk of various forms of cancer, including pancreatic cancer. Although the underlying pathways behind this relationship are unknown, different putative biological and metabolic pathways have been discovered. These are examples of chronic low-grade inflammation, insulin resistance, altered hormone levels, and exposure to external environmental risk factors. These underlying processes are believed to combine with genetic and environmental variables in obese individuals to contribute to the development and progression of pancreatic cancer. More study is needed to thoroughly understand the complicated relationship between obesity and pancreatic cancer to create effective preventive and early detection measures for this fatal illness.
{"title":"Obesity and pancreatic cancer: the underlying mechanisms","authors":"Ghassan Salibi","doi":"10.58676/sjmas.v1i2.14","DOIUrl":"https://doi.org/10.58676/sjmas.v1i2.14","url":null,"abstract":"Obesity has emerged as a severe public health concern worldwide, with an increasing number of studies linking it to an increased risk of various forms of cancer, including pancreatic cancer. Although the underlying pathways behind this relationship are unknown, different putative biological and metabolic pathways have been discovered. These are examples of chronic low-grade inflammation, insulin resistance, altered hormone levels, and exposure to external environmental risk factors. These underlying processes are believed to combine with genetic and environmental variables in obese individuals to contribute to the development and progression of pancreatic cancer. More study is needed to thoroughly understand the complicated relationship between obesity and pancreatic cancer to create effective preventive and early detection measures for this fatal illness.","PeriodicalId":132909,"journal":{"name":"Special journal of the Medical Academy and other Life Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129882602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：