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Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review 脂质治疗血脂异常激活21世纪纳米抗氧化剂氢作为潜在的抗covid -19药物:综述
Pub Date : 2023-08-27 DOI: 10.58676/sjmas.v1i7.41
I. Vasilieva, Maria Vasilieva, I. Vasiliev
According to the World Health Organization (WHO), coronavirus infection (COVID-19, (COronaVIrus Disease 2019) is an infectious disease caused by the SARS-CoV-2 virus [1]. SARS-CoV-2 virus, Severe Acute Respiratory Syndrome-related coronavirus 2. Initially considered pulmonary - respiratory pathology, then it turned out to be poly-systemic, with multi-inflammation of many other organs, and central nervous system. Multisystem inflammatory syndrome in adults (MIS-A) [2], SARS-CoV-2 liver infection [3]. In pediatrics Multisystem inflammatory syndrome in children (MIS-C) or PMIS-TS (Pediatric MIS temporarily associated with SARS-CoV-2 infection) [4,5], SARS-COV-2/ COVID-19 in children induce Kawasaki-Like Disease [6]. Neurological manifestations [7], recurrence of COVID-19 infection with meningitis without pulmonary involvement [8]. Brain damage in COVID is primarily neurological, as a material signaling pathway of inflammatory COVID-infection of cerebral vessels. This is important, from the release of these patients, from additional stress, suffering, stigmatization in society, their isolation, intimidation, coercion (bullying) with violation and restriction of their rights. Since, concomitantly with inflammatory lesions of many organs, cognitive deficits are a component of the post-acute consequences of COVID-19 (PASC), where the role of the kynurenine pathway is significant with temporary cognitive impairment [9]. The main pathway for the breakdown of tryptophan is an amino acid, without which the synthesis of serotonin is impossible, which controls the cycles of sleep and wakefulness, which is the precursor of the sleep hormone melatonin In patients with COVID-19, an imbalance of T-helpers 1 and 2 leads to a cytokine storm that can contribute to myocardial damage [10]. MIS is conditioned caused by immunocompromising (IC) CHAOS - [C]ardiovascular Compromise: shock; [H]omeostasis; [A]poptosis; [O]rgan Dysfunction; [S]uppression of the Immune System with the development of Systemic inflammatory response syndrome (SIRS) and Multiple Organ Dysfunction Syndrome (MODS) [11,12]. With pronounced multiple and other symptoms: Electro - Ion Membrane Distress Syndrome (Syndrome Maria & Irina Vasilieva) [13,14] with membrane manifestations of electrical storm or electromembrane paralysis; Capillary Leak Syndrome; Microcirculatory-Mitochondrial Distress Syndrom [15,16]. Also described: Overlap mechanisms of transient global amnesia and COVID-19 infection [17]; Hypokalemia-stroke mimic [18]; Differential diagnosis of cacosmia and dysgeusia in COVID-19 pandemic [19].
根据世界卫生组织(WHO)的定义,冠状病毒感染(COVID-19,冠状病毒病2019)是由SARS-CoV-2病毒引起的传染病[1]。SARS-CoV-2病毒,与严重急性呼吸综合征相关的冠状病毒最初认为是肺呼吸病变,后来发现是多系统的,包括许多其他器官和中枢神经系统的多重炎症。成人多系统炎症综合征(MIS-A) [2], SARS-CoV-2肝脏感染[3]。儿童多系统炎症综合征(multiple system inflammatory syndrome In children, MIS- c)或PMIS-TS (children MIS暂伴SARS-CoV-2感染)[4,5],儿童SARS-CoV-2 / COVID-19可诱发川asaki样病[6]。神经学表现[7],未累及肺部的COVID-19感染伴脑膜炎复发[8]。COVID- 19的脑损伤主要是神经系统损伤,是炎症性脑血管感染的物质信号通路。这一点很重要,因为要释放这些病人,使他们免受额外的压力、痛苦、社会上的污名化、孤立、恐吓、胁迫(欺凌)以及侵犯和限制他们的权利。由于认知缺陷伴随着许多器官的炎性病变,是COVID-19 (PASC)急性后后果的一个组成部分,其中犬尿氨酸途径在暂时性认知障碍中起着重要作用[9]。色氨酸分解的主要途径是一种氨基酸,没有它就不可能合成血清素,它控制睡眠和清醒的周期,是睡眠激素褪黑激素的前体。在COVID-19患者中,t辅助物1和2的失衡会导致细胞因子风暴,从而导致心肌损伤[10]。免疫功能受损(IC)引起的MIS - [C]心血管损伤:休克;[H] omeostasis;[一]poptosis;[O] rgan功能障碍;[S]系统性炎症反应综合征(SIRS)和多器官功能障碍综合征(MODS)发展过程中免疫系统的抑制[11,12]。有明显的多重等症状:电离子膜窘迫综合征(Syndrome Maria & Irina Vasilieva)[13,14],膜表现为电风暴或电膜麻痹;毛细血管渗漏综合征;微循环-线粒体窘迫综合征[15,16]。还描述了:短暂性全身性遗忘与COVID-19感染的重叠机制[17];低钾卒中模拟[18];新冠肺炎大流行患者认知障碍和认知障碍的鉴别诊断[19]。
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引用次数: 0
Analysis of association between childhood overweight/obesity with screen time, sedentary life style and low levels of physical activity 儿童超重/肥胖与屏幕时间、久坐生活方式和低水平体育活动之间的关系分析
Pub Date : 2023-07-24 DOI: 10.58676/sjmas.v1i6.40
Hemanthi Darshana Kumari Ekanayake, Dr.Ghassan Salibi, N. Tzenios
The escalating prevalence of childhood obesity, affecting nearly 40 million children under five globally, has become a pressing public health concern. The high incidence of obesity in this population can be attributed to numerous factors, such as unhealthy eating habits, lack of physical activity, sedentary lifestyle, and increased screen time, which were exacerbated by worldwide lockdowns during the Covid-19 pandemic. These factors, together with obesity, can potentially predispose these children to non-communicable diseases such as coronary artery disease, type 2 diabetes, and cancer, thereby increasing morbidity and mortality rates. This capstone project aims to globally assess the prevalence of obesity or overweight status in children, establish a relationship between screen usage, physical activity levels, and sedentary behavior, and examine the impact of Covid-19 lockdowns on these parameters. The study methodology includes a comprehensive literature review and data collection from global studies on childhood obesity. Findings from this study could be instrumental in identifying risk factors and developing interventions to mitigate the rising rates of childhood obesity, ultimately supporting the WHO's goal of "no rise in childhood overweight by 2025". Additionally, the study would provide valuable recommendations to decrease sedentary behavior in children and increase physical activity levels, promoting healthier lifestyle choices in children.
儿童肥胖症日益流行,影响到全球近4000万5岁以下儿童,已成为一个紧迫的公共卫生问题。这一人群的高肥胖率可归因于多种因素,如不健康的饮食习惯、缺乏身体活动、久坐不动的生活方式和屏幕时间的增加,而在2019冠状病毒病大流行期间,全球范围的封锁加剧了这些因素。这些因素加上肥胖,可能使这些儿童易患冠状动脉疾病、2型糖尿病和癌症等非传染性疾病,从而增加发病率和死亡率。这一顶级项目旨在全球评估儿童肥胖或超重的患病率,建立屏幕使用情况、身体活动水平和久坐行为之间的关系,并研究Covid-19封锁对这些参数的影响。研究方法包括全面的文献综述和全球儿童肥胖研究的数据收集。这项研究的结果可能有助于确定风险因素和制定干预措施,以减缓儿童肥胖率的上升,最终支持世卫组织“到2025年儿童超重率不上升”的目标。此外,该研究将为减少儿童久坐行为和增加体育活动水平提供有价值的建议,促进儿童选择更健康的生活方式。
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引用次数: 0
OMPARISON OF EFFICACY AMONG DIFFERENT THERAPEUTIC APPROACHES IN ECTOPIC PREGNANCY 不同治疗方法对异位妊娠的疗效比较
Pub Date : 2023-07-22 DOI: 10.58676/sjmas.v1i6.38
Lorenzo Ludwig, Poh Omasyarifa Binti Jamal
Ectopic pregnancy (EP) occurs when the fertilized ovum implants outside the endometrial cavity, with an incidence of 1% of all pregnancies [2,5,8]. Frequently, the products of conception grow in the fallopian tube. Other implantation sites are the ovaries or the cervix. The vast majority of EP cases affect the fallopian tube, with 70-76 % of these tubal EPs occurring in the ampullary portion, 11-16 % in the isthmic portion and about 2-10 % of in the fallopian tube’s fimbrial end. Affected patients may face significant morbidity or even mortality. Prior tubal surgery or a prior tubal pregnancy are the most important risk factors for tubal pregnancy. Women with an active or prior ascending infection with Chlamydia trachomatis or Neisseria gonorrhoeae are at an elevated risk of extrauterine pregnancy. Extrauterine pregnancy may be wholly asymptomatic (intact tubal pregnancy),or it may present with pelvic pain that is worse on one side (tubal abortion) or with severe hemorrhagic shock (tubal rupture). Extrauterine pregnancies are most diagnosed in the 6th through 9th week of gestation . Most patients present with nonspecific complaints. The symptom triad of mild vaginal spotting in the first trimester, aching pelvic pain, and secondary amenorrhea may indicate extrauterine pregnancy but can also arise in an intact intrauterine pregnancy or because of early miscarriage. Further suggestive manifestations include abdominal pain radiating to the shoulder(s), abdominal guarding or an acute abdomen, pain on the displacement of the vaginal portion of the cervix, hemorrhagic shock/hemodynamic instability (dyspnea, hypotension, tachycardia), and syncope. During the last decades, transvaginal ultrasound and beta-human chorionic gonadotropin (beta-HCG) levels became part of the clinical routine leading to the timely detection of ectopic pregnancies and better patient outcomes.
异位妊娠发生在受精卵植入子宫内膜腔外,发生率为1%[2,5,8]。通常,受精卵在输卵管中生长。其他着床部位是卵巢或子宫颈。绝大多数EP病例影响输卵管,其中70- 76%的输卵管EP发生在壶腹部分,11- 16%发生在峡部,约2- 10%发生在输卵管边缘端。受影响的患者可能面临显著的发病率甚至死亡率。输卵管手术史或输卵管妊娠史是输卵管妊娠最重要的危险因素。沙眼衣原体或淋病奈瑟菌感染活跃或既往上升的妇女发生宫外妊娠的风险较高。宫外妊娠可能完全无症状(完整输卵管妊娠),也可能表现为一侧更严重的盆腔疼痛(输卵管流产)或严重的失血性休克(输卵管破裂)。宫外妊娠大多在妊娠第6 - 9周确诊。大多数患者表现为非特异性主诉。妊娠早期轻度阴道斑点、盆腔疼痛和继发性闭经的三联症状可能提示宫外妊娠,但也可能出现在完整的宫内妊娠或由于早期流产。进一步的提示表现包括放射至肩部的腹痛、腹部保护或急腹症、宫颈阴道部分移位疼痛、失血性休克/血流动力学不稳定(呼吸困难、低血压、心动过速)和晕厥。在过去的几十年里,经阴道超声和β -人绒毛膜促性腺激素(β - hcg)水平成为临床常规的一部分,导致及时发现异位妊娠和更好的患者预后。
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引用次数: 0
Modern approaches of rehabilitation in COPD patients COPD患者康复的现代方法
Pub Date : 2023-07-20 DOI: 10.58676/sjmas.v1i6.39
Shivanshu Sharma, Dr.Ghassan Salibi, N. Tzenios
Chronic Obstructive Pulmonary Disease (COPD) presents a significant challenge to public health, impairing the quality of life for affected individuals. Traditionally, the management of COPD primarily involved pharmacological interventions and symptom management, but a shift towards comprehensive rehabilitation programs has been observed in recent times. This study focuses on exploring these modern approaches to COPD rehabilitation, including exercise training, education, psychosocial support, and self-management strategies. By emphasizing patient-centered and multidisciplinary methodologies, modern rehabilitation approaches aim to address the individual needs of COPD patients. Previous studies affirm the positive impacts of these comprehensive programs, including improved exercise capacity, reduced symptoms, and enhanced overall well-being. This current investigation aims to further analyze the effects of various pulmonary rehabilitation methods on COPD management within a modern medical context. By critically evaluating literature and research databases like SCOPUS, PubMed, SciELO, Google Scholar, and Cochrane Library, this study seeks to provide unique insights into the efficacy and benefits of pulmonary rehabilitation for COPD patients. The implications of this research could contribute significantly to evidence-based practices, assisting healthcare professionals in optimizing the selection and implementation of pulmonary rehabilitation interventions for improved patient outcomes.
慢性阻塞性肺疾病(COPD)对公共卫生构成重大挑战,影响患者的生活质量。传统上,慢性阻塞性肺病的治疗主要涉及药物干预和症状管理,但近年来已观察到向综合康复计划的转变。本研究的重点是探索COPD康复的现代方法,包括运动训练、教育、社会心理支持和自我管理策略。通过强调以患者为中心和多学科方法,现代康复方法旨在解决COPD患者的个体需求。先前的研究证实了这些综合项目的积极影响,包括提高运动能力、减轻症状和增强整体幸福感。本研究旨在进一步分析现代医学背景下各种肺康复方法对COPD管理的影响。通过批判性地评估文献和研究数据库,如SCOPUS、PubMed、SciELO、Google Scholar和Cochrane Library,本研究旨在为COPD患者肺康复的疗效和益处提供独特的见解。本研究的意义可以为循证实践做出重大贡献,帮助医疗保健专业人员优化肺康复干预措施的选择和实施,以改善患者的预后。
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引用次数: 0
Uncovering the Neglected Meal: Medical Students in Sri Lanka and Skipping Meals 揭露被忽视的一餐:斯里兰卡的医科学生和不吃饭
Pub Date : 2023-06-25 DOI: 10.58676/sjmas.v1i5.36
N. Tzenios, Ghassan Salibi, Roshelle Nirusha Hemantraj
Background: To figure out why a lot of students who are at risk for food insecurity consistently skip meals in university, this research follows the daily food travels of those students. to find the reasons for skipping meals. Purpose: The aim of this study is to analyse how a daily routine of a medical student of Sri Lanka, affects their eating patterns. Design/ methodology/Approach- A Survey study was implemented using convenient sampling technique where 170 questionnaires were distributed through google forms from which 148 responses were obtained. To test the hypothesis, Cronbach alpha and correlation analysis IBM SPSS 21.0 package was utilized. Findings- This article analyses how a daily routine of a medical student of Sri Lanka affects their eating patterns. The findings demonstrate that university lecture schedules, stress, depression, and loneliness are making students skip at least one of the main meals daily. The authors’ research shows that frequently skipped meals of the students is breakfast. Conclusion- This research provides information to medical university administrations, families, and friends. Therefore, university administration, families and other students may take required decision regarding the quality of life of medical students based on their university lecture schedules, stress, depression, and loneliness. This research study contributes significantly to this aspect telling universities and families the substantial requirement for stress and time management these days to generate a healthy eating pattern.
背景:为了弄清楚为什么很多有食物不安全风险的学生在大学里总是不吃饭,这项研究跟踪了这些学生的日常食物旅行。找到不吃饭的理由。目的:本研究的目的是分析斯里兰卡医学生的日常生活如何影响他们的饮食模式。设计/方法/方法-采用方便的抽样技术实施了一项调查研究,其中通过谷歌表格分发了170份问卷,从中获得了148份回复。采用IBM SPSS 21.0软件包进行Cronbach alpha和相关分析。研究结果-这篇文章分析了斯里兰卡一名医学生的日常生活如何影响他们的饮食模式。研究结果表明,大学的课程表、压力、抑郁和孤独让学生们每天至少少吃一顿正餐。作者的研究表明,学生们经常不吃的一餐是早餐。结论:本研究为医科大学管理层、家属和朋友提供了信息。因此,大学管理部门、家庭和其他学生可能会根据医学生的大学课程安排、压力、抑郁和孤独,对他们的生活质量做出必要的决定。这项研究在这方面做出了重大贡献,告诉大学和家庭,现在需要压力和时间管理,以形成健康的饮食模式。
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引用次数: 0
Impact of AIDS in West Africa: The Nigerian Society 艾滋病在西非的影响:尼日利亚社会
Pub Date : 2023-05-24 DOI: 10.58676/sjmas.v1i5.35
N. Tzenios, Ghassan Salibi, Fabiyi Tolani Fathia
Nigeria has experienced a tremendous impact from HIV/AIDS on both a personal and societal level. The report presents a comprehensive problem overview referencing existing research, relevant literature, and expert insights. Due to HIV/AIDS, the Nigerian healthcare industry has experienced significant difficulties. With rising demand for testing, counseling, anti-retroviral medication (ART), and supportive care, the disease has strained healthcare resources. The disease has decreased production and resulted in a loss of human capital. The workforce has been impacted, which has reduced output across several industries, including agriculture. Concerns about the disease's prevalence have hurt foreign investment, preventing economic expansion and employment development. HIV/AIDS has impacted communities' social dynamics. Discrimination and stigma still exist, putting obstacles in support, treatment, and testing. The disease has put a strain on social welfare institutions, needing assistance for those who are afflicted and their families. Fighting the epidemic and lessening its effects require coordinated efforts from the government, civil society organizations, healthcare providers, and communities.
尼日利亚在个人和社会层面都经历了艾滋病毒/艾滋病的巨大影响。该报告提出了一个全面的问题概述,参考现有的研究,相关文献和专家的见解。由于艾滋病毒/艾滋病,尼日利亚医疗保健行业经历了重大困难。随着对检测、咨询、抗逆转录病毒药物(ART)和支持性护理的需求不断增加,该疾病已使医疗资源紧张。这种疾病减少了生产,造成人力资本的损失。劳动力受到影响,导致包括农业在内的多个行业的产出减少。对这种疾病流行的担忧损害了外国投资,阻碍了经济扩张和就业发展。艾滋病毒/艾滋病影响了社区的社会动态。歧视和污名仍然存在,给支持、治疗和检测带来障碍。这种疾病给社会福利机构带来了压力,需要为患者及其家庭提供援助。抗击这一流行病并减轻其影响需要政府、民间社会组织、医疗保健提供者和社区的协调努力。
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引用次数: 0
The PHYSIOLOGY OF MENSTRUAL PAIN AND THE EFFECTIVENESS OF TECHNOLOGY-BASED PAIN MANAGEMENT TECHNIQUES 经期疼痛的生理学和基于技术的疼痛管理技术的有效性
Pub Date : 2023-05-24 DOI: 10.58676/sjmas.v1i5.32
Kshitij Prakash Korekar, Poh Omasyarifa Binti Jamal, Khuraseva Anna Borisovna
Dysmenorrhea or menstrual pain significantly affects the quality of life for many women, necessitating effective and non-invasive pain management strategies. This study systematically reviewed existing literature on the physiological causes of menstrual pain and the effectiveness of technology-based pain relief techniques. The review shows that menstrual pain is mainly regulated by the hypothalamus-pituitary-ovary axis, with prostaglandins and inflammatory cytokines playing key roles. Also, stress and anxiety can amplify menstrual discomfort. It also uncovers several technology-based interventions for effective pain management, including Transcutaneous Electrical Nerve Stimulation (TENS), heat therapy, mobile apps, virtual reality (VR), and wearable tech. However, potential risks and limitations of these interventions, such as overreliance, data security, limited accessibility, varying effectiveness, cost, user acceptance, and lack of human contact, were also identified. Despite these limitations, technology-based pain management techniques represent promising non-invasive alternatives for managing menstrual discomfort. Additional high-quality research is needed to further validate the efficacy of these approaches and address potential risks.
痛经或经期疼痛严重影响许多妇女的生活质量,因此需要有效和非侵入性的疼痛管理策略。本研究系统地回顾了现有文献关于生理原因的月经疼痛和基于技术的疼痛缓解技术的有效性。综述表明,经期疼痛主要受下丘脑-垂体-卵巢轴调控,前列腺素和炎性细胞因子在其中起关键作用。此外,压力和焦虑会加剧经期不适。它还揭示了几种有效疼痛管理的基于技术的干预措施,包括经皮神经电刺激(TENS)、热疗法、移动应用程序、虚拟现实(VR)和可穿戴技术。然而,这些干预措施的潜在风险和局限性,如过度依赖、数据安全、有限的可访问性、不同的有效性、成本、用户接受度和缺乏人类接触,也被确定。尽管有这些限制,基于技术的疼痛管理技术为管理月经不适提供了有前途的非侵入性替代方法。需要更多的高质量研究来进一步验证这些方法的有效性并解决潜在风险。
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引用次数: 0
Finances of healthcare around the globe and its outcomes 全球医疗保健财务状况及其结果
Pub Date : 2023-05-23 DOI: 10.58676/sjmas.v1i5.31
Kshitij Prakash Korekar, Dr.Ghassan Salibi
The research aim of this article is to comprehend how healthcare systems are financed globally and how that affects patient outcomes. The project's objective is to explore various financial models used to cover healthcare services in different countries and the effects these models have on accessibility and care quality. Analyzing numerous research materials for this study will involve reviewing financial reports, governmental legislation, academic studies, and statistical data. The project's goals include analyzing health funding models in-depth, connecting health outcomes to financial models, and determining variables that influence financial success. The project's objectives are to develop a knowledge base that stakeholders may utilize to better understand the global healthcare funding system and to provide recommendations for enhancing healthcare funding systems. The essay also studies healthcare spending in various nations in 2019, 2020, and 2021, noting the variations in healthcare coverage between nations.
本文的研究目的是了解全球医疗保健系统是如何融资的,以及这如何影响患者的结果。该项目的目标是探索不同国家用于医疗保健服务的各种财务模式,以及这些模式对可及性和护理质量的影响。本研究将分析大量的研究资料,包括审查财务报告、政府立法、学术研究和统计数据。该项目的目标包括深入分析卫生筹资模式,将卫生成果与财务模式联系起来,并确定影响财务成功的变量。该项目的目标是建立一个知识库,供利益攸关方更好地了解全球卫生保健筹资系统,并为加强卫生保健筹资系统提供建议。本文还研究了2019年、2020年和2021年各国的医疗保健支出,并指出了各国医疗保健覆盖范围的差异。
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引用次数: 0
GLOBAL SYSTEMATIC REVIEW AND META-ANALYSIS OF FOETAL AND MATERNAL OUTCOMES IN PREGNANT WOMEN INFECTED WITH COVID-19 感染COVID-19孕妇胎儿和孕产妇结局的全球系统回顾和荟萃分析
Pub Date : 2023-04-24 DOI: 10.58676/sjmas.v1i4.28
Poh Omasyarifa Binti Jamal, P. Puneet
This study aimed to systematically review the effects of COVID-19 infection on pregnant women and their neonatal outcomes in eight countries: UK, USA, China, France, India, Russia, Italy, and Iran. Data from various registries worldwide were analyzed, focusing on preterm births, maternal and neonatal mortality rates, and mode of delivery. The results showed that all countries experienced a significant increase in preterm birth rates among COVID-19-infected pregnant women compared to non-infected pregnant women. No significant difference was observed in maternal mortality rates across the countries, but India had the highest neonatal mortality rate. The rate of vertical transmission from infected mothers in the third trimester to their infants was estimated at 3.2%. In conclusion, COVID-19 has the most significant impact on the increase of preterm birth rates, with India experiencing the highest neonatal mortality rate compared to the other country.
本研究旨在系统回顾COVID-19感染对英国、美国、中国、法国、印度、俄罗斯、意大利和伊朗八个国家孕妇及其新生儿结局的影响。分析了来自世界各地各种登记机构的数据,重点关注早产、孕产妇和新生儿死亡率以及分娩方式。结果显示,与未感染covid -19的孕妇相比,所有国家感染covid -19的孕妇早产率都显著增加。各国的产妇死亡率没有显著差异,但印度的新生儿死亡率最高。据估计,受感染母亲在妊娠晚期向其婴儿垂直传播的比率为3.2%。总之,2019冠状病毒病对早产率上升的影响最为显著,与其他国家相比,印度的新生儿死亡率最高。
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引用次数: 0
THE EXISTENCE OF HPV VACCINATION PROGRAM AND ITS RELEVANCE IN THE PREVENTION OF CERVICAL CANCER IN RUSSIAN FEDERATION, BRAZIL, INDIA, JAPAN, CHINA, MALAYSIA, NIGERIA AND SWITZERLAND Authors 在俄罗斯联邦、巴西、印度、日本、中国、马来西亚、尼日利亚和瑞士,HPV疫苗接种计划的存在及其与宫颈癌预防的相关性
Pub Date : 2023-04-24 DOI: 10.58676/sjmas.v1i4.29
Poh Omasyarifa Binti Jamal, Nascimento dos Santos
Background: Cervical cancer remains a significant health concern globally. The introduction of the Human Papilloma Virus (HPV) vaccine and the Papanicolaou smear (Pap smear) screening test have contributed to reducing cervical cancer morbidity and mortality. This study aims to evaluate the impact of these preventive measures on cervical cancer mortality rates in eight countries: Russia, Nigeria, India, China, Japan, Switzerland, Brazil, and Malaysia. Methods: We conducted a systematic review and meta-analysis using data from the World Health Organization (WHO), United Nations, World Bank, International Agency for Research on Cancer (IARC), and other sources for 2019 and 2020. Mortality rates, HPV vaccination programs, screening usage, and cervical cancer risk among females aged 0-74 years were analyzed and compared. Results: China reported the highest number of cervical cancer deaths (51,600), but Brazil had the highest mortality rate (1.56%). The lowest mortality rate was observed in Switzerland (0.30%). HPV vaccination was included in the national schedule for Japan, Switzerland, Brazil, and Malaysia. Screening for cervical cancer was implemented in all eight countries, with Russia and Switzerland having the highest frequency (8:10 each) and India having the least (<1:10). Conclusion: The combination of HPV vaccination programs and active screening is the most effective measure for preventing cervical cancer mortality, as demonstrated by Switzerland. However, the importance of screening cannot be understated, as seen in Russia, where screening alone plays a significant role in cervical cancer prevention. Further efforts should focus on integrating both preventive strategies to reduce the global burden of cervical cancer.
背景:宫颈癌在全球范围内仍然是一个重要的健康问题。人类乳头瘤病毒(HPV)疫苗和巴氏涂片(巴氏涂片)筛查试验的引入有助于降低宫颈癌的发病率和死亡率。本研究旨在评估这些预防措施对八个国家宫颈癌死亡率的影响:俄罗斯、尼日利亚、印度、中国、日本、瑞士、巴西和马来西亚。方法:我们对2019年和2020年来自世界卫生组织(WHO)、联合国、世界银行、国际癌症研究机构(IARC)和其他来源的数据进行了系统回顾和荟萃分析。对0-74岁女性的死亡率、HPV疫苗接种计划、筛查使用和宫颈癌风险进行了分析和比较。结果:中国报告的宫颈癌死亡人数最多(51,600人),但巴西的死亡率最高(1.56%)。瑞士的死亡率最低(0.30%)。HPV疫苗接种被列入日本、瑞士、巴西和马来西亚的国家计划。所有8个国家都实施了宫颈癌筛查,其中俄罗斯和瑞士的筛查频率最高(各为8:10),印度的筛查频率最低(<1:10)。结论:结合HPV疫苗接种规划和主动筛查是预防宫颈癌死亡率的最有效措施,瑞士证明了这一点。然而,筛查的重要性不能被低估,正如在俄罗斯所看到的那样,在那里,仅筛查就在预防宫颈癌方面发挥了重要作用。进一步的努力应集中于整合这两种预防战略,以减少宫颈癌的全球负担。
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引用次数: 0
期刊
Special journal of the Medical Academy and other Life Sciences
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