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Obesity and prostate cancer: the influence of metabolic syndromes 肥胖与前列腺癌:代谢综合征的影响
Pub Date : 2023-02-10 DOI: 10.58676/sjmas.v1i2.13
Ghassan Salibi
Obesity is a significant issue for public health that is linked to a variety of chronic ailments, including cancer. Prostate cancer is the most frequent disease in men, and there is growing evidence that obesity might impact prostate cancer risk and prognosis. This article reviews the present body of scientific knowledge on the link between obesity and prostate cancer, emphasizing the involvement of metabolic syndromes. It examines the evidence indicating a direct relationship between obesity and prostate cancer risk and the likely processes behind this link, such as alterations in hormonal, immune-modulatory, and metabolic pathways. Furthermore, it investigates the influence of metabolic disorders, including insulin resistance and metabolic syndrome.
肥胖是公共健康的一个重大问题,它与包括癌症在内的多种慢性疾病有关。前列腺癌是男性中最常见的疾病,越来越多的证据表明肥胖可能会影响前列腺癌的风险和预后。本文回顾了目前关于肥胖与前列腺癌之间联系的科学知识,强调了代谢综合征的参与。该研究调查了肥胖和前列腺癌风险之间存在直接关系的证据,以及这种联系背后可能的过程,如激素、免疫调节和代谢途径的改变。此外,它还研究了代谢紊乱的影响,包括胰岛素抵抗和代谢综合征。
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引用次数: 0
Better Strategies For Coronavirus (COVID-19) Vaccination 更好的冠状病毒(COVID-19)疫苗接种战略
Pub Date : 2023-02-09 DOI: 10.58676/sjmas.v1i2.11
N. Tzenios, Mohamad Chahine, Mary E. Tazanios
The first case of COVID-19, a coronavirus disease, was reported in December 2019 in Wuhan, China, and spread globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is regarded as the most challenging pandemic in the current century. COVID-19 has brought scientists together on a platform where they search for different therapeutic and preventive strategies to combat this coronavirus. Scientists and healthcare workers are working on developing new vaccines that are safe and take less time to develop. They are trying to elucidate various target sites on 2019-nCov that could act as potential candidates for adequate vaccine preparation. Besides this, there is also a need for proper community involvement to elicit the coronavirus disease by taking preventive measures and spreading awareness. In this review, we have focused on how scientists can develop vaccines against new variants and convince the public about vaccine acceptance at the community level. This manuscript reviews Strategies for Covid-19 Vaccination Development, Strategies for Covid-19 Vaccination Acceptance, and Community Engagement in Covid-19 Vaccination plans
2019年12月,中国武汉报告了首例COVID-19病例,并在全球传播。严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)被认为是本世纪最具挑战性的大流行。COVID-19将科学家聚集在一个平台上,在那里他们寻找不同的治疗和预防策略来对抗这种冠状病毒。科学家和卫生保健工作者正在致力于开发安全且开发时间更短的新疫苗。他们正试图阐明2019-nCov的各种靶点,这些靶点可能作为充分疫苗制备的潜在候选物。除此之外,还需要适当的社区参与,通过预防措施和宣传来引发新冠病毒。在这篇综述中,我们的重点是科学家如何开发针对新变种的疫苗,并说服公众在社区层面接受疫苗。本文综述了Covid-19疫苗接种发展战略、Covid-19疫苗接种接受战略和社区参与Covid-19疫苗接种计划
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引用次数: 2
Obesity and endometrial cancer: the role insulin resistance and adipokines 肥胖与子宫内膜癌:胰岛素抵抗和脂肪因子的作用
Pub Date : 2023-02-09 DOI: 10.58676/sjmas.v1i2.12
N. Tzenios, Mohamad Chahine, Mary E. Tazanios
Obesity has shaped the global pandemic as a major health problem. It is related to chronic metabolic diseases and cancer development, like endometrial cancer. Recent studies have revealed a strong correlation between higher Body Mass Index (BMI) and endometrial cancer, predicting that a higher BMI is a leading cause of endometrial cancer by disrupting the balance of adipocytokines and hormones. This article reviews the current scientific knowledge on the relationship between obesity and endometrial cancer and the role of insulin resistance and adipokines. It also addresses the necessity for additional studies to thoroughly comprehend the underlying processes and create efficient methods for preventing and treating endometrial cancer in obese people.
肥胖已经成为全球流行病,成为一个主要的健康问题。它与慢性代谢性疾病和癌症发展有关,如子宫内膜癌。最近的研究表明,较高的身体质量指数(BMI)与子宫内膜癌之间存在很强的相关性,预测高BMI通过破坏脂肪细胞因子和激素的平衡而成为子宫内膜癌的主要原因。本文综述了肥胖症与子宫内膜癌之间的关系以及胰岛素抵抗和脂肪因子在其中的作用。它还解决了进一步研究的必要性,以彻底了解潜在的过程,并创造有效的方法来预防和治疗肥胖人群的子宫内膜癌。
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引用次数: 3
CHILDREN’S NUTRITION IMPACT ON COGNITIVE DEVELOPMENT 儿童营养对认知发展的影响
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.6
Abshana Abdul hameed, Ghassan Salibi
Babies’ brains are ready to absorb information when they are born. However, babies may comprehend some concepts about items and their connections to one another. They can touch, feel, watch, listen, and feels everything. This enables them to understand their older; they may discover that mixing yellow and blue paint produces green. Children learn through exploring and experimenting. This is the way they improve their cognitive abilities. Human brain development is extremely fast between the ages of 20 and 36 weeks and proceeds until 20 months. The brain includes all the neurons required for life at birth. Of course, if the baby is brought to term, an infant's brain is 25% of its adult weight at birth. The brain would be 75 % of its body weight by age 2 (90 percent by age 6). Children will go through various phases of cognitive growth between birth and the age of two, such as sensory growth and learning ability. Children naturally choose the meals they like the most, so the difficulty is to make healthy options enticing. Of course, no issue how excellent our motives are; convincing your eight-year-old that an apple is as sweet as a biscuit is going to be tough. Therefore, you might ensure that your child's food is as healthy and wholesome as possible while letting them enjoy a few of their preferred delights. Development.
婴儿的大脑在出生时就已经准备好吸收信息了。然而,婴儿可能会理解一些关于物品的概念以及它们之间的联系。他们可以触摸、感觉、观看、倾听和感受一切。这使他们能够理解他们的长辈;他们可能会发现,把黄色和蓝色颜料混合在一起会产生绿色。孩子们通过探索和实验来学习。这是他们提高认知能力的方式。人类大脑的发育在20到36周之间非常快,一直持续到20个月。大脑包含了出生时生命所需的所有神经元。当然,如果婴儿足月出生,婴儿的大脑是其出生时成人体重的25%。到2岁时,大脑的重量将达到体重的75%(到6岁时将达到体重的90%)。从出生到两岁,儿童将经历认知发展的各个阶段,如感官发展和学习能力。孩子们自然会选择他们最喜欢的食物,所以困难在于做出诱人的健康选择。当然,不管我们的动机有多好;让你八岁的孩子相信苹果和饼干一样甜是很困难的。因此,你可以确保你的孩子的食物是尽可能健康和有益健康的,同时让他们享受一些他们喜欢的乐趣。发展。
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引用次数: 0
A New Hallmark of Cancer: Stemness 癌症的新标志:干性
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.3
N. Tzenios
cer’ often describes malignant tumors. The issue of cancerous stem cells is not a novelty but has existed for centuries. Different civilizations have handled the stem cell subject depending on the knowledge at hand. A hallmark is a distinguishing factor that separates cancers from other conditions. Hence, there have been arguments about the exclusion or inclusion criteria for the six original hallmarks. This review will introduce stemness as a new hallmark for cancer and argue why it should get included. Thus, future studies will focus on how the tumor microenvironment can get used to fight cancer. Methodology. A methodology of literature search using "stemness" as the keyword gets used in the review to avoid biasedness. Results. Stem cells can undergo physiological changes to form malignant cells. Cancer cells are in a variety of cells in the body. The microenvironment of the tumor cells promotes their progression by nourishing them. Conclusions. The results imply that stemness is the behavior of stem cells to self-renew and differentiate to form cells in all organisms. Stem cells are present in all types of hematological and solid cancers. It means that a problem in the self-renewal or differentiation process can lead to the formation of tumors or tumorigenic.
Cer常用于描述恶性肿瘤。癌症干细胞的问题并不是一个新鲜事物,而是已经存在了几个世纪。不同的文明已经根据手头的知识处理了干细胞课题。标志是将癌症与其他疾病区分开来的一个显著因素。因此,关于六个原始标志的排除或包含标准一直存在争议。这篇综述将介绍干细胞作为癌症的新标志,并讨论为什么它应该被包括在内。因此,未来的研究将集中在如何利用肿瘤微环境来对抗癌症。方法。在综述中采用以“干性”为关键词的文献检索方法,以避免偏颇。结果。干细胞可以通过生理变化形成恶性细胞。癌细胞存在于人体的多种细胞中。肿瘤细胞的微环境通过滋养它们来促进它们的发展。结论。这一结果表明,在所有生物体中,干细胞都具有自我更新和分化形成细胞的行为。干细胞存在于所有类型的血液学和实体癌中。它是指在自我更新或分化过程中出现问题可能导致肿瘤的形成或致瘤性。
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引用次数: 2
Contemporary techniques to the laboratory diagnosis of cognitive dysfunction (Dementia) in elderly patients. 当代技术对老年认知功能障碍(痴呆)患者的实验室诊断。
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.5
S. Ali
Dementia is a severe condition affecting more than 55 million people worldwide. In elderly patients, it leads to an overall decline in memory and thinking skills. It affects the patient and those around the patient, including family and caregivers. The symptoms can become so severe that the person's ability to perform everyday activities becomes compromised. This study aims to search and collect information about the sensitivity and specificity of available laboratory diagnostic methods for patients with Dementia and identify if these methods will be effective in giving a specific and definitive diagnosis. The specificity and sensitivity of four main laboratory testing methods have been included in this review: blood panels, cerebrospinal fluid, plasma biomarkers, hormone testing, and genetic testing. The methods are each explained separately with details of their importance and which specific parameters they screen for have haven included. Numerous blood panels and laboratory diagnostic techniques have been suggested for the timely and accurate diagnosis of Dementia and its various types; however, when the sensitivity and specificity of these techniques are considered, cerebrospinal fluid (CSF) and plasma biomarkers are found to be the most effective. Alzheimer's disease (AD) and other types of Dementia are now diagnosed using the biomarkers amyloid- (A), tau, and phosphorylated tau (p-tau181). With 93 percent accuracy in diagnosis, the innovative Precivity AD test created by the Washington University School of Medicine in St. Louis might be regarded as both highly sensitive and specific.
痴呆症是一种严重的疾病,影响着全世界5500多万人。在老年患者中,它会导致记忆力和思维能力的全面下降。它会影响患者和患者周围的人,包括家人和护理人员。症状可能会变得非常严重,以至于患者进行日常活动的能力受到损害。本研究旨在搜索和收集有关现有实验室诊断方法对痴呆症患者的敏感性和特异性的信息,并确定这些方法是否能有效地给出具体和明确的诊断。本文综述了四种主要实验室检测方法的特异性和敏感性:血检、脑脊液、血浆生物标志物、激素检测和基因检测。每种方法都单独解释,详细说明了它们的重要性以及它们所筛选的具体参数。为了及时准确地诊断痴呆症及其各种类型,已经提出了许多血检和实验室诊断技术;然而,当考虑到这些技术的敏感性和特异性时,脑脊液(CSF)和血浆生物标志物被发现是最有效的。阿尔茨海默病(AD)和其他类型的痴呆症现在使用生物标志物淀粉样蛋白- (A)、tau和磷酸化tau (p-tau181)进行诊断。位于圣路易斯的华盛顿大学医学院(Washington University School of Medicine)发明的创新的precisivity AD测试,诊断准确率高达93%,可能被认为是高度敏感和特异的。
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引用次数: 0
Modern methods for the instrumental detection of cognitive impairment in Alzheimer's and dementia patients 阿尔茨海默氏症和痴呆患者认知功能障碍的现代仪器检测方法
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.9
Aminath Samha, Dr.Ghassan Salibi
Patients with cognitive impairment diseases are no longer fully oriented to time and space. The disease may be the root cause of all cognitive impairments (CI). Depending on the precise diagnosis, different cognitive disorders require different treatments. The three major goals of neuroimaging in Alzheimer's disease (AD) are to detect very early AD at a prodromal stage of moderate cognitive impairment, to differentiate AD from other dementia-causing illnesses, and to forecast the progression of MCI to AD. Consequently, this study's objective is to examine the most sensitive instrumental testing techniques for the early identification of cognitive deterioration in AD and dementia patients.
患有认知障碍疾病的患者不再完全以时间和空间为导向。这种疾病可能是所有认知障碍(CI)的根本原因。根据准确的诊断,不同的认知障碍需要不同的治疗方法。阿尔茨海默病(AD)神经影像学的三个主要目标是在中度认知障碍的前驱阶段发现非常早期的AD,将AD与其他痴呆症引起的疾病区分出来,并预测MCI向AD的进展。因此,本研究的目的是研究最敏感的仪器测试技术,用于早期识别阿尔茨海默病和痴呆患者的认知退化。
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引用次数: 0
Football Training: Prophylaxis of Hypertension and Prediabetes in Malaysia 足球训练:预防高血压和前驱糖尿病在马来西亚
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.4
Muhammad Danish Bin Jazlan
According to the 2019 National Health and Morbidity Survey (NHMS), 3.4 million Malaysians are affected by at least two of the three major noncommunicable diseases (NCDs), i.e., diabetes, hypertension, and high cholesterol. The fundamental issue in Malaysia is that individuals are unwilling to attend the hospital for periodic examinations and to seek preventative medical care. It is necessary to adapt football training as a hobby and concurrently as a preventative measure against the NCDs as it appears to be the optimal strategy. In Germany, a prospective interventional study was conducted. Statistical analysis using IBM SPSS Statistics version 26 revealed that providing middle-aged hypertensive patients with football training can improve blood pressure control and minimize the need for antihypertensive medication. Using SPSS version 22, it has been demonstrated in a randomized control trial in the Faroe Islands that football training combined with professional nutrition counseling had a greater effect on metabolic and cardiovascular health prediabetes individuals aged 55 to 70 than expert dietary advice alone. At the state level, Selangor has greatly progressed in health sector reform. Initiatives to minimize noncommunicable diseases have received special attention. This study implies that the mission and vision of the Selangor Health and Sports Council align. After a comprehensive assessment, a viable policy for integrating football training as a preventative intervention should be considered.
根据2019年全国健康和发病率调查(NHMS), 340万马来西亚人受到三种主要非传染性疾病(NCDs)中的至少两种的影响,即糖尿病、高血压和高胆固醇。马来西亚的根本问题是,个人不愿到医院定期检查和寻求预防性医疗护理。有必要将足球训练作为一种爱好,同时作为一种预防非传染性疾病的措施,因为它似乎是最佳策略。在德国进行了一项前瞻性介入研究。利用IBM SPSS Statistics version 26进行统计分析发现,对中年高血压患者进行足球训练可以改善血压控制,减少降压药的需求。使用SPSS version 22,在法罗群岛的一项随机对照试验中证明,足球训练结合专业营养咨询对55至70岁的前驱糖尿病患者的代谢和心血管健康的影响大于单独的专家饮食建议。在州一级,雪兰莪州在卫生部门改革方面取得了很大进展。尽量减少非传染性疾病的举措受到了特别关注。这项研究表明,雪兰莪州卫生和体育理事会的使命和愿景是一致的。在综合评估后,应考虑将足球训练作为一种预防性干预手段进行整合的可行政策。
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引用次数: 0
Modern approaches to the special education programs for the prevention of cognitive dysfunction in elderly people in the practice of GPs from the point of view of evidence-based medicine 从循证医学的角度探讨全科医生实践中预防老年人认知功能障碍的现代特殊教育方案
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.7
Eduardo Gomes Franca Freitas, Ghassan Salibi
People worldwide are living longer. Today most people can expect to live into their sixties and beyond. Every country in the world is experiencing growth in both the size and the proportion of older persons. By 2030, 1 in 6 people worldwide will be 60 years or over. The share of the population aged 60 years and over will increase from 1 billion in 2020 to 1.4 billion. By 2050, the world's population of people aged 60 years and older will double (2.1 billion). The number of persons aged 80 years or older is expected to triple between 2020 and 2050 to reach 426 million. While this shift in the distribution of a country's population towards older ages – known as population aging – started in high-income countries (for example, in Japan, 30% of the population is already over 60 years old), it is now low- and middle-income countries that are experiencing the greatest change. By 205the 0, two-thirds of the world's population over 60 years will live in low- and aging-income countries. In Brazil, the population is getting older. Data released on 22/07/2022 at 10:00 am by the Brazilian Institute of Geography and Statistics (IBGE) show that, in 2021, Brazil had more than 10% of its population formed by elderly people aged 65 or over the deity. According to the survey, last year (2021), the Brazilian population was estimated at 212.5 million people. Of these, 21.6 million were aged 65 or over, representing 10.2%.
全世界的人都活得更长了。今天,大多数人都能活到六十多岁甚至更久。世界上每个国家都在经历老年人规模和比例的增长。到2030年,全球将有六分之一的人年龄在60岁或以上。60岁及以上人口比例将从2020年的10亿增加到14亿。到2050年,世界60岁及以上人口将翻一番(21亿)。预计在2020年至2050年间,80岁及以上的人口数量将增加两倍,达到4.26亿。虽然一个国家人口向老年化分布的这种转变——即所谓的人口老龄化——始于高收入国家(例如,在日本,30%的人口已经超过60岁),但目前正在经历最大变化的是中低收入国家。到2050年,世界60岁以上人口的三分之二将生活在低收入和老龄化国家。在巴西,人口正在老龄化。巴西地理与统计研究所(IBGE)于2022年7月22日上午10点发布的数据显示,到2021年,巴西65岁及以上的老年人占总人口的10%以上。根据调查,去年(2021年),巴西人口估计为2.125亿人。其中,65岁及以上的有2160万人,占10.2%。
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引用次数: 0
Impact of Cirrhosis and Alcohol on Mortality Rates and Mitigation Efforts 肝硬化和酒精对死亡率的影响及缓解措施
Pub Date : 2023-01-16 DOI: 10.58676/sjmas.v1i1.10
P. R. Sharma, N. Tzenios
The present study aimed to investigate the impact of national policies and awareness programs on the incidence and mortality of chronic liver diseases, specifically cirrhosis. A multi-year retrospective analysis was conducted utilizing data collected between 1990 and 2017. Results indicate that implementing these interventions was associated with a significant decrease in overall mortality and an estimated annual percentage change in cases of cirrhosis. Furthermore, the data revealed that in 2017, alcohol consumption was a leading contributor to deaths and disability-adjusted life years (DALYs) among individuals aged 15-49 years. These findings highlight the importance of continued efforts to address the issue of chronic liver disease through targeted public health interventions.
本研究旨在探讨国家政策和认识计划对慢性肝病,特别是肝硬化的发病率和死亡率的影响。利用1990年至2017年收集的数据进行了多年回顾性分析。结果表明,实施这些干预措施与总体死亡率的显著降低和肝硬化病例的估计年百分比变化有关。此外,数据显示,2017年,酒精消费是15-49岁人群死亡和残疾调整生命年(DALYs)的主要因素。这些发现强调了通过有针对性的公共卫生干预措施继续努力解决慢性肝病问题的重要性。
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引用次数: 0
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Special journal of the Medical Academy and other Life Sciences
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