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Response to Pyridostigmine in Congenital Myasthenia with LRP4 Mutation. 吡哆斯的明治疗先天性重症肌无力伴LRP4突变的疗效。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-12-30 DOI: 10.1007/s12098-024-05381-x
Deepthi R, Darisa Harikrishna, Nisha Narendran, Ajith Kumar Vt, Padma Jp, Febi Francis
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引用次数: 0
Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial. 补充高强度口服益生菌可改善新发 1 型糖尿病儿童的免疫调节并保护 Beta 细胞:随机双盲安慰剂对照试验》。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-04-01 DOI: 10.1007/s12098-024-05074-5
M N Lokesh, Rakesh Kumar, Neenu Jacob, Naresh Sachdeva, Amit Rawat, Jaivinder Yadav, Devi Dayal

Objectives: To investigate the mechanism of glycemic control in children with type 1 diabetes (T1D) following high-strength probiotics supplementation by assessing immune-regulatory markers.

Methods: In this single-centre randomised double-blinded placebo-controlled study, children with new-onset T1D on regular insulin therapy were randomised into probiotic or placebo groups with 30 children each. The probiotics group received oral powder of Vivomixx®, and the placebo group received corn starch for six months. The primary outcome parameters included induced T regulatory cells (i-Tregs) percentage, insulin autoantibodies (IAA), insulinoma associated 2 autoantibodies (IA2), glutamic acid decarboxylase autoantibodies (GAD 65) and plasma interleukin-10 (IL-10) levels. The secondary outcome variables were changes in plasma C-peptide levels and glycemic control parameters.

Results: Twenty-three children in the placebo group and 27 in the probiotic group completed the study. There was a significant increase in the percentage of iTregs (3.40 in the probiotic vs. 2.46 in the placebo group; p = 0.034). Median glycated hemoglobin (HbA1c) levels significantly decreased from 68 mmol/mol (8.35%) in the placebo group to 60 mmol/mol (7.55%) in the probiotic group (p = 0.017). Median C-peptide levels were significantly higher in probiotics (0.72 ng/ml) vs. placebo group (0.11 ng/ml) (p = 0.036). The plasma IL-10 levels significantly increased in the probiotic group after six months of treatment (p = 0.002).

Conclusions: The high-strength probiotics improved the immunoregulatory milieu, thereby preserving the beta-cell function and better glycemic control.

目的通过评估免疫调节标志物,研究补充高强度益生菌后1型糖尿病(T1D)患儿血糖控制的机制:在这项单中心随机双盲安慰剂对照研究中,接受常规胰岛素治疗的新发T1D儿童被随机分为益生菌组和安慰剂组,每组30名儿童。益生菌组口服 Vivomixx® 粉剂,安慰剂组口服玉米淀粉,为期六个月。主要结果参数包括诱导T调节细胞(i-Tregs)百分比、胰岛素自身抗体(IAA)、胰岛素瘤相关2型自身抗体(IA2)、谷氨酸脱羧酶自身抗体(GAD 65)和血浆白细胞介素-10(IL-10)水平。次要结果变量为血浆C肽水平和血糖控制参数的变化:安慰剂组和益生菌组分别有 23 名和 27 名儿童完成了研究。iTregs的比例明显增加(益生菌组为3.40,安慰剂组为2.46;p = 0.034)。糖化血红蛋白(HbA1c)中位水平从安慰剂组的 68 mmol/mol(8.35%)显著降至益生菌组的 60 mmol/mol(7.55%)(p = 0.017)。益生菌组的 C 肽中位数(0.72 纳克/毫升)明显高于安慰剂组(0.11 纳克/毫升)(p = 0.036)。治疗 6 个月后,益生菌组的血浆 IL-10 水平明显升高(p = 0.002):结论:高浓度益生菌改善了免疫调节环境,从而保护了β细胞功能,提高了血糖控制效果。
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引用次数: 0
"Leonine Dermatitis": A Birthday Party Peril. "莱昂宁皮炎":生日派对的危险
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-09-26 DOI: 10.1007/s12098-024-05261-4
Saritha Mohanan, C Udayashankar
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引用次数: 0
Retinopathy of Prematurity in Very Low Birthweight Neonates of Gestation Less Than 32 weeks in Malaysia. 马来西亚妊娠不足 32 周的超低出生体重新生儿的早产儿视网膜病变。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-01-11 DOI: 10.1007/s12098-023-04997-9

Objectives: To determine the screening rates and incidence of retinopathy of prematurity (ROP), and risk factors associated with ROP in very low birthweight (VLBW, <1500 g) neonates of gestation <32 wk admitted to neonatal intensive care units (NICUs) in a middle-income country.

Methods: It was a retrospective cohort study of prospectively submitted data by 44 Malaysian NICUs participating in the Malaysian National Neonatal Registry. All VLBW neonates of gestation <32 wk born in 2015-2020 and survived to discharge were included.

Results: Of 11768 survivors, 90.5% (n = 10436) had ROP screening; 16.1% (1685/10436) had ROP. ROP was significantly more common in neonates <28 wk gestation (extremely preterm, EPT) than ≥28 wk gestation (37.7% vs. 9.7%; p <0.001), and more common in those with birthweight <1000 g (extremely low birthweight, ELBW) than ≥1000 g (32.9% vs. 9.1%; p <0.001). Multiple logistic regression analysis showed that the significant independent factors associated with increased risk of ROP were ELBW, EPT, Indian ethnic group, vaginal delivery, mechanical ventilation >5 d, high frequency ventilation, total parenteral nutrition, late-onset sepsis, bronchopulmonary dysplasia, and intraventricular hemorrhage. Receiving oxygen therapy at birth was associated with significantly lower risk of ROP.

Conclusions: The incidence and severity of ROP increased with decreasing gestation and birthweight. Prolonged duration of oxygen therapy, infection, invasive respiratory support, and conditions commonly causing fluctuations of oxygenation were significant factors associated with increased risk of ROP. Receiving oxygen at birth did not increase risk.

目的确定极低出生体重儿的早产儿视网膜病变(ROP)筛查率和发病率,以及与早产儿视网膜病变相关的风险因素:这是一项回顾性队列研究,研究对象是参与马来西亚全国新生儿登记的 44 所马来西亚新生儿重症监护室所提交的前瞻性数据。所有 VLBW 新生儿的妊娠结果:在 11768 名存活的新生儿中,90.5%(n = 10436)进行了早产儿视网膜病变筛查;16.1%(1685/10436)患有早产儿视网膜病变。在出生 5 d、高频通气、全胃肠外营养、晚发败血症、支气管肺发育不良和脑室内出血的新生儿中,早产儿视网膜病变的发生率明显更高。出生时接受氧疗与发生 ROP 的风险显著降低有关:结论:视网膜病变的发生率和严重程度随着妊娠期和出生体重的降低而增加。氧疗持续时间过长、感染、侵入性呼吸支持以及常见的导致氧合波动的情况是导致视网膜病变风险增加的重要因素。出生时吸氧不会增加风险。
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引用次数: 0
Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial: Correspondence. 补充高强度口服益生菌可改善新发 1 型糖尿病儿童的免疫调节并保护 Beta 细胞:随机双盲安慰剂对照试验》:通讯。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-08-24 DOI: 10.1007/s12098-024-05243-6
Anju Bala, Arun George, Sayan Banerjee, Mohit Kumar
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引用次数: 0
Neurobehavioral Outcomes of Children with Antenatal Exposure to Antiseizure Medications: Correspondence. 产前接触抗癫痫药物的儿童的神经行为结果:通信。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI: 10.1007/s12098-024-05297-6
Prateek Kumar Panda, Indar Kumar Sharawat
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引用次数: 0
School Children with Epilepsy: A Need for Telehealth Enabled Epilepsy Smart School Program. 患有癫痫的学龄儿童:需要远程医疗支持的癫痫智能学校计划。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-10-16 DOI: 10.1007/s12098-024-05283-y
Jitendra Kumar Sahu, J M K Murthy
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引用次数: 0
Ultrashort Time Echo (UTE) MR Sequence - New MRI Sequence with CT Alike Images as a Radiation-Free Alternative to CT in Children with Febrile Neutropenia. 超短时间回声(UTE) MR序列-新的MRI序列与CT相似图像作为无辐射替代CT治疗发热性中性粒细胞减少症儿童。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-12-26 DOI: 10.1007/s12098-024-05379-5
Anmol Bhatia, Pratyaksha Rana, Joseph L Mathew, Deepak Bansal, Akshay Kumar Saxena, Kushaljit Singh Sodhi
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引用次数: 0
Role of Ultra-Rapid Acting Insulins in Management of Preschool Children with Type 1 Diabetes. 超速效胰岛素在 1 型糖尿病学龄前儿童管理中的作用。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-09-27 DOI: 10.1007/s12098-024-05269-w
Anju Seth, Rajeev Kumar Malhotra
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引用次数: 0
Enteroviruses Associated with Hand Foot and Mouth Disease in Navi Mumbai, Maharashtra, India in 2022. 2022 年印度马哈拉施特拉邦纳维孟买与手足口病相关的肠道病毒。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-07-03 DOI: 10.1007/s12098-024-05195-x
Madhu Chhanda Mohanty, Dhanya Dharmapalan, Pooja Vengurlekar, Swapnil Varose, Anita Shete, Yash Joshi, Savita Yadav, Pragya Yadav, Ketki Jawade, Manogat Tatkare, Jeetendra Gavhane, Asmita Patil, Satish Shahane, Suhas Warad, Yashank Yewale, Praveen Mody, Shrikrishna Joshi, Vijay Yewale, Vinay Kumar Saxena

An outbreak of Hand Foot and Mouth Disease (HFMD) which occurred in August-September, 2022 in Navi Mumbai, India was prospectively investigated, to delineate the clinical manifestations and identify the etiological agent. Molecular characterization at ICMR-National Institute of Virology (NIV), Mumbai unit reported 69 (88.5%) cases out of 78 clinically diagnosed HFMD cases positive for enteroviruses. Thirty-nine (56.5%) children were positive for CVA6, 11 (15.9%) for CVA16, and one for CVA4 (1.4%). One case of co-infection (CVA16, CVA6) was reported. Fourteen (17.9%) cases had recurrent disease in the same season. CVA6 was associated with unusual extension of the rash beyond the conventional areas of hands, feet, and mouth, with involvement of body areas including face, axillae and trunk. Whole genome sequencing classified CVA6 as group D3 and CVA16 isolates as group B1c. Co-infection and recurrence of disease with atypical symptoms observed in this study highlight the need for continued vigilance of the evolutionary clinical characteristics of the enteroviruses causing HFMD.

我们对 2022 年 8 月至 9 月在印度纳维孟买爆发的手足口病(HFMD)进行了前瞻性调查,以确定手足口病的临床表现和病原体。孟买国家病毒研究所(ICMR-National Institute of Virology,NIV)的分子特征分析报告称,在 78 例临床诊断的手足口病病例中,有 69 例(88.5%)对肠道病毒呈阳性反应。其中 39 名儿童(56.5%)对 CVA6 呈阳性,11 名儿童(15.9%)对 CVA16 呈阳性,1 名儿童(1.4%)对 CVA4 呈阳性。报告了一例合并感染病例(CVA16、CVA6)。14例(17.9%)在同一季节复发。CVA6的皮疹异常扩展,超出了手、脚和口腔等常规部位,累及面部、腋窝和躯干等身体部位。全基因组测序将 CVA6 分为 D3 组,CVA16 分为 B1c 组。本研究中观察到的非典型症状的合并感染和疾病复发突出表明,有必要继续警惕引起手足口病的肠道病毒的临床演变特征。
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Indian Journal of Pediatrics
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