首页 > 最新文献

Indian Journal of Pediatrics最新文献

英文 中文
Effect of Regularity, Semantic Context and Mode of Presentation on Verbal Learning and Memory in Children with Specific Learning Disability. 规则性、语义语境和呈现方式对特殊学习障碍儿童言语学习记忆的影响。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1007/s12098-024-05373-x
Arushee Wahi, Bangalore N Roopesh
{"title":"Effect of Regularity, Semantic Context and Mode of Presentation on Verbal Learning and Memory in Children with Specific Learning Disability.","authors":"Arushee Wahi, Bangalore N Roopesh","doi":"10.1007/s12098-024-05373-x","DOIUrl":"10.1007/s12098-024-05373-x","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"310"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Profile and Outcomes of Children with H1N1 Influenza Pneumonia. 甲型H1N1流感肺炎儿童的临床概况和结局
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-12-27 DOI: 10.1007/s12098-024-05382-w
Pradeep Kumar Gunasekaran, Sanjay Verma, Arushi Gahlot Saini, Deepanjan Bhattacharya, Kapil Goyal, Radha Kanta Ratho, Jayashree Muralidharan, Meenu Singh
{"title":"Clinical Profile and Outcomes of Children with H1N1 Influenza Pneumonia.","authors":"Pradeep Kumar Gunasekaran, Sanjay Verma, Arushi Gahlot Saini, Deepanjan Bhattacharya, Kapil Goyal, Radha Kanta Ratho, Jayashree Muralidharan, Meenu Singh","doi":"10.1007/s12098-024-05382-w","DOIUrl":"10.1007/s12098-024-05382-w","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"313"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Influencing Postgraduates' Pursuit of Pediatrics Super-Specialty Training. 影响研究生追求儿科超级专科培养的因素。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2025-01-02 DOI: 10.1007/s12098-024-05366-w
Bipul Kumar Das, Himesh Barman, Diganta Barman
{"title":"Factors Influencing Postgraduates' Pursuit of Pediatrics Super-Specialty Training.","authors":"Bipul Kumar Das, Himesh Barman, Diganta Barman","doi":"10.1007/s12098-024-05366-w","DOIUrl":"10.1007/s12098-024-05366-w","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"320"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinico-Radiological and Genotypic Spectrum of Nuclear Mitochondriopathies. 核线粒体病的临床放射学和基因型谱。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-10-09 DOI: 10.1007/s12098-024-05266-z
Neerja Gupta, Bhawana Aggarwal, Anushree Mishra, Madhumita Roy Chowdhury, Sheffali Gulati, Atin Kumar, Madhulika Kabra

Mitochondrial disorders are a diverse group of diseases caused by mutations in genes encoded by either nuclear or mitochondrial DNA. In a group of patients with nuclear mitochondriopathies, the authors analysed the clinico-radiological and genotypic spectrum. The study included 25 patients with a genetic diagnosis of nuclear mitochondrial cytopathy who were seen over a 5 y period. There were 25 patients in the study cohort (Mean age of presentation- 14 mo). Biallelic mutations involving nuclear mitochondrial genes were identified in all 25 of them. In 13 and 9 patients, respectively, respiratory chain defects (complex I and complex IV) and mitochondrial DNA depletion syndromes were identified. Twelve novel variants were identified. Interestingly, NDUFV1 with a south Indian founder variant c.1156 C > T (p.Arg386Cys) was the commonest variant. Accurate phenotyping combined with next generation sequencing aids in the precise diagnosis of mitochondrial nuclear gene defects and provides the opportunity for appropriate counseling.

线粒体疾病是由核DNA或线粒体DNA编码的基因突变引起的一类多种疾病。作者对一组核线粒体疾病患者的临床放射学和基因型谱进行了分析。研究对象包括 25 名经基因诊断为核线粒体细胞病变的患者,他们的就诊时间长达 5 年。研究队列中有 25 名患者(平均发病年龄为 14 个月)。在所有 25 名患者中,均发现了涉及核线粒体基因的双拷贝突变。分别在 13 名和 9 名患者中发现了呼吸链缺陷(复合体 I 和复合体 IV)和线粒体 DNA 缺失综合征。此外,还发现了 12 个新的变异基因。有趣的是,带有南印度创始变异体 c.1156 C > T(p.Arg386Cys)的 NDUFV1 是最常见的变异体。准确的表型分析与新一代测序相结合,有助于线粒体核基因缺陷的精确诊断,并为适当的咨询提供了机会。
{"title":"Clinico-Radiological and Genotypic Spectrum of Nuclear Mitochondriopathies.","authors":"Neerja Gupta, Bhawana Aggarwal, Anushree Mishra, Madhumita Roy Chowdhury, Sheffali Gulati, Atin Kumar, Madhulika Kabra","doi":"10.1007/s12098-024-05266-z","DOIUrl":"10.1007/s12098-024-05266-z","url":null,"abstract":"<p><p>Mitochondrial disorders are a diverse group of diseases caused by mutations in genes encoded by either nuclear or mitochondrial DNA. In a group of patients with nuclear mitochondriopathies, the authors analysed the clinico-radiological and genotypic spectrum. The study included 25 patients with a genetic diagnosis of nuclear mitochondrial cytopathy who were seen over a 5 y period. There were 25 patients in the study cohort (Mean age of presentation- 14 mo). Biallelic mutations involving nuclear mitochondrial genes were identified in all 25 of them. In 13 and 9 patients, respectively, respiratory chain defects (complex I and complex IV) and mitochondrial DNA depletion syndromes were identified. Twelve novel variants were identified. Interestingly, NDUFV1 with a south Indian founder variant c.1156 C > T (p.Arg386Cys) was the commonest variant. Accurate phenotyping combined with next generation sequencing aids in the precise diagnosis of mitochondrial nuclear gene defects and provides the opportunity for appropriate counseling.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"287-291"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the Compliance and Quality in Documentation in the Neonatal Intensive Care Unit: A Quality Improvement Study. 提高新生儿重症监护室文件记录的合规性和质量:质量改进研究。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1007/s12098-024-05383-9
Meenakshi Dadwal, Vimlesh Soni, Saranjit Kaur, Kunal Garg, Mandeep Goriya
{"title":"Improving the Compliance and Quality in Documentation in the Neonatal Intensive Care Unit: A Quality Improvement Study.","authors":"Meenakshi Dadwal, Vimlesh Soni, Saranjit Kaur, Kunal Garg, Mandeep Goriya","doi":"10.1007/s12098-024-05383-9","DOIUrl":"10.1007/s12098-024-05383-9","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"314"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Absolute and Functional Iron Deficiency in Non-Dialyzed Children with Chronic Kidney Disease. 慢性肾病非透析儿童绝对缺铁和功能性缺铁的患病率
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2025-01-18 DOI: 10.1007/s12098-024-05408-3
Swati Rani, Puneet Kaur Sahi, Mukta Mantan, Sarika Singh, Vineeta Vijay Batra
{"title":"Prevalence of Absolute and Functional Iron Deficiency in Non-Dialyzed Children with Chronic Kidney Disease.","authors":"Swati Rani, Puneet Kaur Sahi, Mukta Mantan, Sarika Singh, Vineeta Vijay Batra","doi":"10.1007/s12098-024-05408-3","DOIUrl":"10.1007/s12098-024-05408-3","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"337"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of Multidrug-Resistant Organisms in Surveillance Stool Culture at Diagnosis Fails to Predict Mortality or Subsequent Sepsis due to Multidrug-Resistant Organisms in Children with Acute Leukemia: A Single-Center, Prospective, Observational Study. 一项单中心、前瞻性、观察性研究:诊断时监测粪便培养中多药耐药菌的分离不能预测急性白血病儿童多药耐药菌引起的死亡率或随后的败血症。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2023-06-24 DOI: 10.1007/s12098-023-04683-w
Surendra Babu Gundluru, Pritam Singha Roy, Manisha Biswal, Amita Trehan, Jasleen Kaur, Pallab Ray, Deepak Bansal

The utility of surveillance stool culture (SSC) to guide antibiotics for febrile neutropenia (FN) is unresolved in non-transplant settings. The prospective study explored the prevalence of multidrug-resistant organisms (MDRO) in SSCs, its correlation with mortality, and the concordance of SSCs with cultures obtained during subsequent episodes of FN amongst children with acute leukemia. SSCs were obtained at presentation and 2 mo into chemotherapy. Seventy-nine patients (mean age: 5.9±3.2 y) with acute lymphoblastic leukemia (ALL) (80%), acute myeloid leukemia (AML) (16%), or biphenotypic leukemia (4%) were enrolled. MDROs were isolated from 14 (17.5%) patients in the first SSCs, including E.coli (80%), K. pneumoniae (10%), and E. faecium (10%). Three (3.8%) patients developed MDRO sepsis; none concorded with the SSCs. Eleven (14%) patients died; 4/14 (28.5%) with MDRO-colonization vis-à-vis 7/66 (10.6%) without MDRO-colonization (OR: 3.37, 95% CI: 0.8-13.6; p = 0.095). MDRO-colonization failed to predict MDRO-sepsis, bloodstream infection, or mortality. SSC failed to guide the choice of antibiotics for FN in children with acute leukemia.

监测粪便培养(SSC)对指导发热性中性粒细胞减少症(FN)抗生素的效用在非移植环境中尚未得到解决。这项前瞻性研究探讨了SSCs中多药耐药生物(MDRO)的患病率、与死亡率的相关性,以及急性白血病儿童中SSCs与随后FN发作期间获得的培养物的一致性。ssc分别于出诊时和化疗后2个月获得。79例急性淋巴细胞白血病(ALL)(80%)、急性髓性白血病(AML)(16%)和双表型白血病(4%)患者(平均年龄:5.9±3.2岁)入组。在首批ssc患者中,从14例(17.5%)患者中分离到MDROs,包括大肠杆菌(80%)、肺炎克雷伯菌(10%)和屎肠杆菌(10%)。3例(3.8%)患者发生MDRO脓毒症;没有一个与ssc相符。11例(14%)患者死亡;4/14(28.5%)有mdro定植vs -à-vis 7/66(10.6%)没有mdro定植(OR: 3.37, 95% CI: 0.8-13.6;p = 0.095)。mdro定植不能预测mdro败血症、血液感染或死亡率。SSC不能指导急性白血病患儿FN的抗生素选择。
{"title":"Isolation of Multidrug-Resistant Organisms in Surveillance Stool Culture at Diagnosis Fails to Predict Mortality or Subsequent Sepsis due to Multidrug-Resistant Organisms in Children with Acute Leukemia: A Single-Center, Prospective, Observational Study.","authors":"Surendra Babu Gundluru, Pritam Singha Roy, Manisha Biswal, Amita Trehan, Jasleen Kaur, Pallab Ray, Deepak Bansal","doi":"10.1007/s12098-023-04683-w","DOIUrl":"10.1007/s12098-023-04683-w","url":null,"abstract":"<p><p>The utility of surveillance stool culture (SSC) to guide antibiotics for febrile neutropenia (FN) is unresolved in non-transplant settings. The prospective study explored the prevalence of multidrug-resistant organisms (MDRO) in SSCs, its correlation with mortality, and the concordance of SSCs with cultures obtained during subsequent episodes of FN amongst children with acute leukemia. SSCs were obtained at presentation and 2 mo into chemotherapy. Seventy-nine patients (mean age: 5.9±3.2 y) with acute lymphoblastic leukemia (ALL) (80%), acute myeloid leukemia (AML) (16%), or biphenotypic leukemia (4%) were enrolled. MDROs were isolated from 14 (17.5%) patients in the first SSCs, including E.coli (80%), K. pneumoniae (10%), and E. faecium (10%). Three (3.8%) patients developed MDRO sepsis; none concorded with the SSCs. Eleven (14%) patients died; 4/14 (28.5%) with MDRO-colonization vis-à-vis 7/66 (10.6%) without MDRO-colonization (OR: 3.37, 95% CI: 0.8-13.6; p = 0.095). MDRO-colonization failed to predict MDRO-sepsis, bloodstream infection, or mortality. SSC failed to guide the choice of antibiotics for FN in children with acute leukemia.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"295-298"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Pyridostigmine in Congenital Myasthenia with LRP4 Mutation. 吡哆斯的明治疗先天性重症肌无力伴LRP4突变的疗效。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-12-30 DOI: 10.1007/s12098-024-05381-x
Deepthi R, Darisa Harikrishna, Nisha Narendran, Ajith Kumar Vt, Padma Jp, Febi Francis
{"title":"Response to Pyridostigmine in Congenital Myasthenia with LRP4 Mutation.","authors":"Deepthi R, Darisa Harikrishna, Nisha Narendran, Ajith Kumar Vt, Padma Jp, Febi Francis","doi":"10.1007/s12098-024-05381-x","DOIUrl":"10.1007/s12098-024-05381-x","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"327"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial. 补充高强度口服益生菌可改善新发 1 型糖尿病儿童的免疫调节并保护 Beta 细胞:随机双盲安慰剂对照试验》。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-04-01 DOI: 10.1007/s12098-024-05074-5
M N Lokesh, Rakesh Kumar, Neenu Jacob, Naresh Sachdeva, Amit Rawat, Jaivinder Yadav, Devi Dayal

Objectives: To investigate the mechanism of glycemic control in children with type 1 diabetes (T1D) following high-strength probiotics supplementation by assessing immune-regulatory markers.

Methods: In this single-centre randomised double-blinded placebo-controlled study, children with new-onset T1D on regular insulin therapy were randomised into probiotic or placebo groups with 30 children each. The probiotics group received oral powder of Vivomixx®, and the placebo group received corn starch for six months. The primary outcome parameters included induced T regulatory cells (i-Tregs) percentage, insulin autoantibodies (IAA), insulinoma associated 2 autoantibodies (IA2), glutamic acid decarboxylase autoantibodies (GAD 65) and plasma interleukin-10 (IL-10) levels. The secondary outcome variables were changes in plasma C-peptide levels and glycemic control parameters.

Results: Twenty-three children in the placebo group and 27 in the probiotic group completed the study. There was a significant increase in the percentage of iTregs (3.40 in the probiotic vs. 2.46 in the placebo group; p = 0.034). Median glycated hemoglobin (HbA1c) levels significantly decreased from 68 mmol/mol (8.35%) in the placebo group to 60 mmol/mol (7.55%) in the probiotic group (p = 0.017). Median C-peptide levels were significantly higher in probiotics (0.72 ng/ml) vs. placebo group (0.11 ng/ml) (p = 0.036). The plasma IL-10 levels significantly increased in the probiotic group after six months of treatment (p = 0.002).

Conclusions: The high-strength probiotics improved the immunoregulatory milieu, thereby preserving the beta-cell function and better glycemic control.

目的通过评估免疫调节标志物,研究补充高强度益生菌后1型糖尿病(T1D)患儿血糖控制的机制:在这项单中心随机双盲安慰剂对照研究中,接受常规胰岛素治疗的新发T1D儿童被随机分为益生菌组和安慰剂组,每组30名儿童。益生菌组口服 Vivomixx® 粉剂,安慰剂组口服玉米淀粉,为期六个月。主要结果参数包括诱导T调节细胞(i-Tregs)百分比、胰岛素自身抗体(IAA)、胰岛素瘤相关2型自身抗体(IA2)、谷氨酸脱羧酶自身抗体(GAD 65)和血浆白细胞介素-10(IL-10)水平。次要结果变量为血浆C肽水平和血糖控制参数的变化:安慰剂组和益生菌组分别有 23 名和 27 名儿童完成了研究。iTregs的比例明显增加(益生菌组为3.40,安慰剂组为2.46;p = 0.034)。糖化血红蛋白(HbA1c)中位水平从安慰剂组的 68 mmol/mol(8.35%)显著降至益生菌组的 60 mmol/mol(7.55%)(p = 0.017)。益生菌组的 C 肽中位数(0.72 纳克/毫升)明显高于安慰剂组(0.11 纳克/毫升)(p = 0.036)。治疗 6 个月后,益生菌组的血浆 IL-10 水平明显升高(p = 0.002):结论:高浓度益生菌改善了免疫调节环境,从而保护了β细胞功能,提高了血糖控制效果。
{"title":"Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial.","authors":"M N Lokesh, Rakesh Kumar, Neenu Jacob, Naresh Sachdeva, Amit Rawat, Jaivinder Yadav, Devi Dayal","doi":"10.1007/s12098-024-05074-5","DOIUrl":"10.1007/s12098-024-05074-5","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the mechanism of glycemic control in children with type 1 diabetes (T1D) following high-strength probiotics supplementation by assessing immune-regulatory markers.</p><p><strong>Methods: </strong>In this single-centre randomised double-blinded placebo-controlled study, children with new-onset T1D on regular insulin therapy were randomised into probiotic or placebo groups with 30 children each. The probiotics group received oral powder of Vivomixx<sup>®</sup>, and the placebo group received corn starch for six months. The primary outcome parameters included induced T regulatory cells (i-Tregs) percentage, insulin autoantibodies (IAA), insulinoma associated 2 autoantibodies (IA2), glutamic acid decarboxylase autoantibodies (GAD 65) and plasma interleukin-10 (IL-10) levels. The secondary outcome variables were changes in plasma C-peptide levels and glycemic control parameters.</p><p><strong>Results: </strong>Twenty-three children in the placebo group and 27 in the probiotic group completed the study. There was a significant increase in the percentage of iTregs (3.40 in the probiotic vs. 2.46 in the placebo group; p = 0.034). Median glycated hemoglobin (HbA1c) levels significantly decreased from 68 mmol/mol (8.35%) in the placebo group to 60 mmol/mol (7.55%) in the probiotic group (p = 0.017). Median C-peptide levels were significantly higher in probiotics (0.72 ng/ml) vs. placebo group (0.11 ng/ml) (p = 0.036). The plasma IL-10 levels significantly increased in the probiotic group after six months of treatment (p = 0.002).</p><p><strong>Conclusions: </strong>The high-strength probiotics improved the immunoregulatory milieu, thereby preserving the beta-cell function and better glycemic control.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"277-283"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Leonine Dermatitis": A Birthday Party Peril. "莱昂宁皮炎":生日派对的危险
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-09-26 DOI: 10.1007/s12098-024-05261-4
Saritha Mohanan, C Udayashankar
{"title":"\"Leonine Dermatitis\": A Birthday Party Peril.","authors":"Saritha Mohanan, C Udayashankar","doi":"10.1007/s12098-024-05261-4","DOIUrl":"10.1007/s12098-024-05261-4","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"301"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Indian Journal of Pediatrics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1