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Improving the Compliance and Quality in Documentation in the Neonatal Intensive Care Unit: A Quality Improvement Study. 提高新生儿重症监护室文件记录的合规性和质量:质量改进研究。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1007/s12098-024-05383-9
Meenakshi Dadwal, Vimlesh Soni, Saranjit Kaur, Kunal Garg, Mandeep Goriya
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引用次数: 0
Prevalence of Absolute and Functional Iron Deficiency in Non-Dialyzed Children with Chronic Kidney Disease. 慢性肾病非透析儿童绝对缺铁和功能性缺铁的患病率
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2025-01-18 DOI: 10.1007/s12098-024-05408-3
Swati Rani, Puneet Kaur Sahi, Mukta Mantan, Sarika Singh, Vineeta Vijay Batra
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引用次数: 0
Isolation of Multidrug-Resistant Organisms in Surveillance Stool Culture at Diagnosis Fails to Predict Mortality or Subsequent Sepsis due to Multidrug-Resistant Organisms in Children with Acute Leukemia: A Single-Center, Prospective, Observational Study. 一项单中心、前瞻性、观察性研究:诊断时监测粪便培养中多药耐药菌的分离不能预测急性白血病儿童多药耐药菌引起的死亡率或随后的败血症。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2023-06-24 DOI: 10.1007/s12098-023-04683-w
Surendra Babu Gundluru, Pritam Singha Roy, Manisha Biswal, Amita Trehan, Jasleen Kaur, Pallab Ray, Deepak Bansal

The utility of surveillance stool culture (SSC) to guide antibiotics for febrile neutropenia (FN) is unresolved in non-transplant settings. The prospective study explored the prevalence of multidrug-resistant organisms (MDRO) in SSCs, its correlation with mortality, and the concordance of SSCs with cultures obtained during subsequent episodes of FN amongst children with acute leukemia. SSCs were obtained at presentation and 2 mo into chemotherapy. Seventy-nine patients (mean age: 5.9±3.2 y) with acute lymphoblastic leukemia (ALL) (80%), acute myeloid leukemia (AML) (16%), or biphenotypic leukemia (4%) were enrolled. MDROs were isolated from 14 (17.5%) patients in the first SSCs, including E.coli (80%), K. pneumoniae (10%), and E. faecium (10%). Three (3.8%) patients developed MDRO sepsis; none concorded with the SSCs. Eleven (14%) patients died; 4/14 (28.5%) with MDRO-colonization vis-à-vis 7/66 (10.6%) without MDRO-colonization (OR: 3.37, 95% CI: 0.8-13.6; p = 0.095). MDRO-colonization failed to predict MDRO-sepsis, bloodstream infection, or mortality. SSC failed to guide the choice of antibiotics for FN in children with acute leukemia.

监测粪便培养(SSC)对指导发热性中性粒细胞减少症(FN)抗生素的效用在非移植环境中尚未得到解决。这项前瞻性研究探讨了SSCs中多药耐药生物(MDRO)的患病率、与死亡率的相关性,以及急性白血病儿童中SSCs与随后FN发作期间获得的培养物的一致性。ssc分别于出诊时和化疗后2个月获得。79例急性淋巴细胞白血病(ALL)(80%)、急性髓性白血病(AML)(16%)和双表型白血病(4%)患者(平均年龄:5.9±3.2岁)入组。在首批ssc患者中,从14例(17.5%)患者中分离到MDROs,包括大肠杆菌(80%)、肺炎克雷伯菌(10%)和屎肠杆菌(10%)。3例(3.8%)患者发生MDRO脓毒症;没有一个与ssc相符。11例(14%)患者死亡;4/14(28.5%)有mdro定植vs -à-vis 7/66(10.6%)没有mdro定植(OR: 3.37, 95% CI: 0.8-13.6;p = 0.095)。mdro定植不能预测mdro败血症、血液感染或死亡率。SSC不能指导急性白血病患儿FN的抗生素选择。
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引用次数: 0
Response to Pyridostigmine in Congenital Myasthenia with LRP4 Mutation. 吡哆斯的明治疗先天性重症肌无力伴LRP4突变的疗效。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-12-30 DOI: 10.1007/s12098-024-05381-x
Deepthi R, Darisa Harikrishna, Nisha Narendran, Ajith Kumar Vt, Padma Jp, Febi Francis
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引用次数: 0
Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial. 补充高强度口服益生菌可改善新发 1 型糖尿病儿童的免疫调节并保护 Beta 细胞:随机双盲安慰剂对照试验》。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-04-01 DOI: 10.1007/s12098-024-05074-5
M N Lokesh, Rakesh Kumar, Neenu Jacob, Naresh Sachdeva, Amit Rawat, Jaivinder Yadav, Devi Dayal

Objectives: To investigate the mechanism of glycemic control in children with type 1 diabetes (T1D) following high-strength probiotics supplementation by assessing immune-regulatory markers.

Methods: In this single-centre randomised double-blinded placebo-controlled study, children with new-onset T1D on regular insulin therapy were randomised into probiotic or placebo groups with 30 children each. The probiotics group received oral powder of Vivomixx®, and the placebo group received corn starch for six months. The primary outcome parameters included induced T regulatory cells (i-Tregs) percentage, insulin autoantibodies (IAA), insulinoma associated 2 autoantibodies (IA2), glutamic acid decarboxylase autoantibodies (GAD 65) and plasma interleukin-10 (IL-10) levels. The secondary outcome variables were changes in plasma C-peptide levels and glycemic control parameters.

Results: Twenty-three children in the placebo group and 27 in the probiotic group completed the study. There was a significant increase in the percentage of iTregs (3.40 in the probiotic vs. 2.46 in the placebo group; p = 0.034). Median glycated hemoglobin (HbA1c) levels significantly decreased from 68 mmol/mol (8.35%) in the placebo group to 60 mmol/mol (7.55%) in the probiotic group (p = 0.017). Median C-peptide levels were significantly higher in probiotics (0.72 ng/ml) vs. placebo group (0.11 ng/ml) (p = 0.036). The plasma IL-10 levels significantly increased in the probiotic group after six months of treatment (p = 0.002).

Conclusions: The high-strength probiotics improved the immunoregulatory milieu, thereby preserving the beta-cell function and better glycemic control.

目的通过评估免疫调节标志物,研究补充高强度益生菌后1型糖尿病(T1D)患儿血糖控制的机制:在这项单中心随机双盲安慰剂对照研究中,接受常规胰岛素治疗的新发T1D儿童被随机分为益生菌组和安慰剂组,每组30名儿童。益生菌组口服 Vivomixx® 粉剂,安慰剂组口服玉米淀粉,为期六个月。主要结果参数包括诱导T调节细胞(i-Tregs)百分比、胰岛素自身抗体(IAA)、胰岛素瘤相关2型自身抗体(IA2)、谷氨酸脱羧酶自身抗体(GAD 65)和血浆白细胞介素-10(IL-10)水平。次要结果变量为血浆C肽水平和血糖控制参数的变化:安慰剂组和益生菌组分别有 23 名和 27 名儿童完成了研究。iTregs的比例明显增加(益生菌组为3.40,安慰剂组为2.46;p = 0.034)。糖化血红蛋白(HbA1c)中位水平从安慰剂组的 68 mmol/mol(8.35%)显著降至益生菌组的 60 mmol/mol(7.55%)(p = 0.017)。益生菌组的 C 肽中位数(0.72 纳克/毫升)明显高于安慰剂组(0.11 纳克/毫升)(p = 0.036)。治疗 6 个月后,益生菌组的血浆 IL-10 水平明显升高(p = 0.002):结论:高浓度益生菌改善了免疫调节环境,从而保护了β细胞功能,提高了血糖控制效果。
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引用次数: 0
"Leonine Dermatitis": A Birthday Party Peril. "莱昂宁皮炎":生日派对的危险
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-09-26 DOI: 10.1007/s12098-024-05261-4
Saritha Mohanan, C Udayashankar
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引用次数: 0
Retinopathy of Prematurity in Very Low Birthweight Neonates of Gestation Less Than 32 weeks in Malaysia. 马来西亚妊娠不足 32 周的超低出生体重新生儿的早产儿视网膜病变。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-01-11 DOI: 10.1007/s12098-023-04997-9
Nem Yun Boo, Ee Lee Ang, Eric Boon-Kuang Ang

Objectives: To determine the screening rates and incidence of retinopathy of prematurity (ROP), and risk factors associated with ROP in very low birthweight (VLBW, <1500 g) neonates of gestation <32 wk admitted to neonatal intensive care units (NICUs) in a middle-income country.

Methods: It was a retrospective cohort study of prospectively submitted data by 44 Malaysian NICUs participating in the Malaysian National Neonatal Registry. All VLBW neonates of gestation <32 wk born in 2015-2020 and survived to discharge were included.

Results: Of 11768 survivors, 90.5% (n = 10436) had ROP screening; 16.1% (1685/10436) had ROP. ROP was significantly more common in neonates <28 wk gestation (extremely preterm, EPT) than ≥28 wk gestation (37.7% vs. 9.7%; p <0.001), and more common in those with birthweight <1000 g (extremely low birthweight, ELBW) than ≥1000 g (32.9% vs. 9.1%; p <0.001). Multiple logistic regression analysis showed that the significant independent factors associated with increased risk of ROP were ELBW, EPT, Indian ethnic group, vaginal delivery, mechanical ventilation >5 d, high frequency ventilation, total parenteral nutrition, late-onset sepsis, bronchopulmonary dysplasia, and intraventricular hemorrhage. Receiving oxygen therapy at birth was associated with significantly lower risk of ROP.

Conclusions: The incidence and severity of ROP increased with decreasing gestation and birthweight. Prolonged duration of oxygen therapy, infection, invasive respiratory support, and conditions commonly causing fluctuations of oxygenation were significant factors associated with increased risk of ROP. Receiving oxygen at birth did not increase risk.

目的确定极低出生体重儿的早产儿视网膜病变(ROP)筛查率和发病率,以及与早产儿视网膜病变相关的风险因素:这是一项回顾性队列研究,研究对象是参与马来西亚全国新生儿登记的 44 所马来西亚新生儿重症监护室所提交的前瞻性数据。所有 VLBW 新生儿的妊娠结果:在 11768 名存活的新生儿中,90.5%(n = 10436)进行了早产儿视网膜病变筛查;16.1%(1685/10436)患有早产儿视网膜病变。在出生 5 d、高频通气、全胃肠外营养、晚发败血症、支气管肺发育不良和脑室内出血的新生儿中,早产儿视网膜病变的发生率明显更高。出生时接受氧疗与发生 ROP 的风险显著降低有关:结论:视网膜病变的发生率和严重程度随着妊娠期和出生体重的降低而增加。氧疗持续时间过长、感染、侵入性呼吸支持以及常见的导致氧合波动的情况是导致视网膜病变风险增加的重要因素。出生时吸氧不会增加风险。
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引用次数: 0
Supplementation of High-Strength Oral Probiotics Improves Immune Regulation and Preserves Beta Cells among Children with New-Onset Type 1 Diabetes Mellitus: A Randomised, Double-Blind Placebo Control Trial: Correspondence. 补充高强度口服益生菌可改善新发 1 型糖尿病儿童的免疫调节并保护 Beta 细胞:随机双盲安慰剂对照试验》:通讯。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-08-24 DOI: 10.1007/s12098-024-05243-6
Anju Bala, Arun George, Sayan Banerjee, Mohit Kumar
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引用次数: 0
Neurobehavioral Outcomes of Children with Antenatal Exposure to Antiseizure Medications: Correspondence. 产前接触抗癫痫药物的儿童的神经行为结果:通信。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI: 10.1007/s12098-024-05297-6
Prateek Kumar Panda, Indar Kumar Sharawat
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引用次数: 0
School Children with Epilepsy: A Need for Telehealth Enabled Epilepsy Smart School Program. 患有癫痫的学龄儿童:需要远程医疗支持的癫痫智能学校计划。
IF 2.1 4区 医学 Q2 PEDIATRICS Pub Date : 2025-03-01 Epub Date: 2024-10-16 DOI: 10.1007/s12098-024-05283-y
Jitendra Kumar Sahu, J M K Murthy
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引用次数: 0
期刊
Indian Journal of Pediatrics
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