Pub Date : 2025-03-01Epub Date: 2024-10-09DOI: 10.1007/s12098-024-05278-9
Mudit Agarwal, Satya Prakash, Deepika Kainth
Reliable estimation of pulse oximetry (SpO2) is indispensable in a neonatal intensive care setting. Along with clinical examination, SpO2 is a validated non-invasive correlate of PaO2 to dictate the level of respiratory support. Any alterations that may interfere with this correlation pose significant challenges and lead to inadvertent over- or under-treatment. The authors report a case with an unusual discrepancy between SpO2 and PaO2 in a neonate with jaundice who developed bronze baby syndrome while receiving phototherapy. A review of similar previous reports suggests that abnormal pigment accumulation in bronze baby syndrome may render pulse oximetry transiently unreliable.
{"title":"Interference in Pulse Oximetry in a Neonate with Bronze Baby Syndrome.","authors":"Mudit Agarwal, Satya Prakash, Deepika Kainth","doi":"10.1007/s12098-024-05278-9","DOIUrl":"10.1007/s12098-024-05278-9","url":null,"abstract":"<p><p>Reliable estimation of pulse oximetry (SpO<sub>2</sub>) is indispensable in a neonatal intensive care setting. Along with clinical examination, SpO<sub>2</sub> is a validated non-invasive correlate of PaO<sub>2</sub> to dictate the level of respiratory support. Any alterations that may interfere with this correlation pose significant challenges and lead to inadvertent over- or under-treatment. The authors report a case with an unusual discrepancy between SpO<sub>2</sub> and PaO<sub>2</sub> in a neonate with jaundice who developed bronze baby syndrome while receiving phototherapy. A review of similar previous reports suggests that abnormal pigment accumulation in bronze baby syndrome may render pulse oximetry transiently unreliable.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"284-286"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: To study the effect of postmeal Fast-acting insulin Aspart (Fiasp®) on the frequency of hypoglycemia compared to premeal injection among preschool children with type 1 diabetes.
Methods: A single-center trial was conducted among 65 pre-school children (6 mo to 6 y) with Type 1 diabetes for at least 6 mo, on multiple daily insulin injections. Children were randomized to receive their meal bolus postmeal or premeal for the first 3 mo, followed by cross-over at 3 mo. The two groups were compared at the end of 6 mo for the change in frequency of hypoglycemia and hyperglycemia, HbA1c, glycemic variability, and parental satisfaction. Ten children (5 in each group) underwent pharmacokinetic studies. The trial was approved by Institutional Ethics Committee and registered with the Controlled Trial Registry of India vide no CTRI/2020/10/028750.
Results: Fifty-four children completed the study, with 27 children in each group. There were no significant differences in the frequency of clinical (p = 0.921), severe (p = 0.167) or serious (p = 0.753) hypoglycemia in the two groups. There were no differences in secondary outcome parameters and pharmacokinetics.
Conclusions: The premeal or postmeal injection of Fiasp® does not affect the frequency of hypoglycemia or other glycemic control parameters among pre-school children with Type 1 diabetes.
Trial registration: The trial is registered with the Controlled Trial Registry of India vide no CTRI/2020/10/028750.
{"title":"Effect of Postmeal Fast-Acting Insulin Aspart Injection on the Frequency of Hypoglycemia among Pre-School Children with Type 1 Diabetes: An Open-Label, Cross-Over, Randomized Control Trial.","authors":"Arti Yadav, Rakesh Kumar, Devi Dayal, Jaivinder Yadav, Smita Pattanaik, Amol Patil","doi":"10.1007/s12098-023-04844-x","DOIUrl":"10.1007/s12098-023-04844-x","url":null,"abstract":"<p><strong>Objectives: </strong>To study the effect of postmeal Fast-acting insulin Aspart (Fiasp<sup>®</sup>) on the frequency of hypoglycemia compared to premeal injection among preschool children with type 1 diabetes.</p><p><strong>Methods: </strong>A single-center trial was conducted among 65 pre-school children (6 mo to 6 y) with Type 1 diabetes for at least 6 mo, on multiple daily insulin injections. Children were randomized to receive their meal bolus postmeal or premeal for the first 3 mo, followed by cross-over at 3 mo. The two groups were compared at the end of 6 mo for the change in frequency of hypoglycemia and hyperglycemia, HbA1c, glycemic variability, and parental satisfaction. Ten children (5 in each group) underwent pharmacokinetic studies. The trial was approved by Institutional Ethics Committee and registered with the Controlled Trial Registry of India vide no CTRI/2020/10/028750.</p><p><strong>Results: </strong>Fifty-four children completed the study, with 27 children in each group. There were no significant differences in the frequency of clinical (p = 0.921), severe (p = 0.167) or serious (p = 0.753) hypoglycemia in the two groups. There were no differences in secondary outcome parameters and pharmacokinetics.</p><p><strong>Conclusions: </strong>The premeal or postmeal injection of Fiasp<sup>®</sup> does not affect the frequency of hypoglycemia or other glycemic control parameters among pre-school children with Type 1 diabetes.</p><p><strong>Trial registration: </strong>The trial is registered with the Controlled Trial Registry of India vide no CTRI/2020/10/028750.</p>","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"235-242"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-11-04DOI: 10.1007/s12098-024-05298-5
Deepa Bhaskaran, Liss Maria Scaria
{"title":"Neurobehavioral Outcomes of Children with Antenatal Exposure to Antiseizure Medications: Authors' Reply.","authors":"Deepa Bhaskaran, Liss Maria Scaria","doi":"10.1007/s12098-024-05298-5","DOIUrl":"10.1007/s12098-024-05298-5","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"317"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catatonia as the Presenting Feature of SSPE in a 10-year-old Child.","authors":"Vishnupriya Veeraraghavan, Shabnam Kalita, Gaurav Gupta, Murchana Khound, Jaya Shankar Kaushik","doi":"10.1007/s12098-024-05371-z","DOIUrl":"10.1007/s12098-024-05371-z","url":null,"abstract":"","PeriodicalId":13320,"journal":{"name":"Indian Journal of Pediatrics","volume":" ","pages":"309"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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