{"title":"A Case Report of Retracted Publications in Pharmaceutical Science as a Remedy for Research Malpractice","authors":"Eric Wei Chiang Chan","doi":"10.5530/ijper.58.1.40","DOIUrl":"https://doi.org/10.5530/ijper.58.1.40","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"82 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weiam Abdul Raheem Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, Weam Mohamed Ali Khojali, N. Khalifa, N. H. Alkefai, Mhdia Elhadi Osman, Ghaliah Alshammari, Tahani S. Albalawi, Zahwah Alshammari, Haya O. Almutairi, Reem M. Alrasheedi, Talal Ahmed Alshammari, Ibrahim Khalid Alhajaji, Fawaz Alheibshy
{"title":"A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region","authors":"Weiam Abdul Raheem Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, Weam Mohamed Ali Khojali, N. Khalifa, N. H. Alkefai, Mhdia Elhadi Osman, Ghaliah Alshammari, Tahani S. Albalawi, Zahwah Alshammari, Haya O. Almutairi, Reem M. Alrasheedi, Talal Ahmed Alshammari, Ibrahim Khalid Alhajaji, Fawaz Alheibshy","doi":"10.5530/ijper.58.1.37","DOIUrl":"https://doi.org/10.5530/ijper.58.1.37","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"10 9","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of the Pro-active Role of Alpha Amyrin Nanoemulsions in Quashing Neurodegeneration, Excitotoxicity, and Neuronal Inflammation-A Combined in vivo and in silico Approach","authors":"Ratna Baburaj, R. Sandur V, Kuntal Das","doi":"10.5530/ijper.58.1.26","DOIUrl":"https://doi.org/10.5530/ijper.58.1.26","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"42 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nawal Tahoon, R. Eid, Saad Aziz Mahgoub, Mohamed Saleh Ismail
{"title":"The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats","authors":"Nawal Tahoon, R. Eid, Saad Aziz Mahgoub, Mohamed Saleh Ismail","doi":"10.5530/ijper.58.1.23","DOIUrl":"https://doi.org/10.5530/ijper.58.1.23","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"12 11","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protective Effects of Hibiscetin on Ethanol-Induced Ulcers in Rats through Inhibition of Prostaglandin Synthesis/ Oxidative Stress/Caspase-3 and 9 Pathways","authors":"Faisal Alotaibi","doi":"10.5530/ijper.58.1.30","DOIUrl":"https://doi.org/10.5530/ijper.58.1.30","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"4 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haranath Chinthaginjala, Varalakshmi Bogavalli, A. A. Hindustan, Jayasree Pathakamuri, Sai Sree Pullaganti, Aswini Gowni, Bandhavi Baktha
{"title":"Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systems","authors":"Haranath Chinthaginjala, Varalakshmi Bogavalli, A. A. Hindustan, Jayasree Pathakamuri, Sai Sree Pullaganti, Aswini Gowni, Bandhavi Baktha","doi":"10.5530/ijper.58.1.3","DOIUrl":"https://doi.org/10.5530/ijper.58.1.3","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"126 19","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meesala Guru Sekhar, K. Shanmugam, Kanchi Siva Prasad, Ramakrishna Chilakala
{"title":"Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats","authors":"Meesala Guru Sekhar, K. Shanmugam, Kanchi Siva Prasad, Ramakrishna Chilakala","doi":"10.5530/ijper.58.1.18","DOIUrl":"https://doi.org/10.5530/ijper.58.1.18","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"27 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Girish Meravanige, Ranjitha Ranjitha B, P. Goudanavar, Gsn Koteswara Rao, B. N. Devi, N. Naveen, A. Asif, Sree Harsha Nagaraja, Mohammed Monirul Islam, Pavan Kumar Pavagada Sreenivasalu, Mallikarjun Telsang, Krishna Swaroop Duddi Sreehari
{"title":"Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing","authors":"Girish Meravanige, Ranjitha Ranjitha B, P. Goudanavar, Gsn Koteswara Rao, B. N. Devi, N. Naveen, A. Asif, Sree Harsha Nagaraja, Mohammed Monirul Islam, Pavan Kumar Pavagada Sreenivasalu, Mallikarjun Telsang, Krishna Swaroop Duddi Sreehari","doi":"10.5530/ijper.58.1.13","DOIUrl":"https://doi.org/10.5530/ijper.58.1.13","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"55 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Aim: To identify the inhibition of Phenylhydrazine (PHZ)-induced hepatotoxicity and anemia by bioconverted ginsenosides. Materials and Methods: We examined the potential benefits of bioconverted ginsenosides on anemia in a phenylhydrazine-induced rat model and described the prolonging effect of erythrocyte life span by focusing on compound K that was confirmed through ex vivo experiments. Results: Hematological analysis demonstrated that all groups treated with bioconverted ginsenosides showed significant recovery results. In the ex vivo experiments, compound K was treated in stored blood, and the erythrocytes half-life was 45 days, 15 days longer than when not treated in blood. In the ICP-OES assay, PHZ-induced erythrocyte hemolysis was significantly inhibited by bioconverted ginsenosides. Conclusion: Based on the present results, it has been demonstrated that bioconverted ginsenoside aids in prolonging the erythrocyte life span and increasing erythrocyte count in vivo. Thus, this material has the potential to develop as a promising drug candidate in the future. Keywords: Anemia, Erythrocyte, Ginsenosides, Hemolysis, Phenylhydrazine.
{"title":"Inhibition of Phenylhydrazine-induced Hematotoxicity by Bioconverted Ginsenosides","authors":"Yuseong Chung, Kang Min Kim, Jae Seon Kang","doi":"10.5530/ijper.57.4.136","DOIUrl":"https://doi.org/10.5530/ijper.57.4.136","url":null,"abstract":"Abstract: Aim: To identify the inhibition of Phenylhydrazine (PHZ)-induced hepatotoxicity and anemia by bioconverted ginsenosides. Materials and Methods: We examined the potential benefits of bioconverted ginsenosides on anemia in a phenylhydrazine-induced rat model and described the prolonging effect of erythrocyte life span by focusing on compound K that was confirmed through ex vivo experiments. Results: Hematological analysis demonstrated that all groups treated with bioconverted ginsenosides showed significant recovery results. In the ex vivo experiments, compound K was treated in stored blood, and the erythrocytes half-life was 45 days, 15 days longer than when not treated in blood. In the ICP-OES assay, PHZ-induced erythrocyte hemolysis was significantly inhibited by bioconverted ginsenosides. Conclusion: Based on the present results, it has been demonstrated that bioconverted ginsenoside aids in prolonging the erythrocyte life span and increasing erythrocyte count in vivo. Thus, this material has the potential to develop as a promising drug candidate in the future. Keywords: Anemia, Erythrocyte, Ginsenosides, Hemolysis, Phenylhydrazine.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahmoud Elkazzaz, Amr Ahmed, Yousry Esam Eldin Abo Amer, Tamer Haydara, Wafa Ali ELtayb, Mohammad Shahbaz Khan, Kunal Bhattacharya, Salma Alkhammash, Hadeer Mattar, Saba Beigh, Mohammed F Abo El Magd, Abdullah Haikal, Islem Abid, Amr S Abouzied, Israa M Shamkh
Abstract: A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry receptor of COVID-19, but our docking analysis, predicted and discovered a novel receptor termed STRA 6 that may play a critical role in the pathogenicity of COVID-19. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA 6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. The primary ligand of STRA6 (vitamin/retinol) was shown to be drastically reduced during COVID-19 infection, which agrees with our findings. We analyze the STRA6 and ACE2 receptor networks to predict the specific association among certain other proteins which might rely on similar functionality. Molecular docking showed a high affinity between the Spike protein with STRA6, the docking score of COVID-19 spike protein with STRA6 (-354.68) kcal/mol was higher than the docking score of spike protein with ACE2 (-341.21) kcal/mol. Results of MD simulations revealed significant stability of the spike protein with STRA6 up to 100 ns. SARS-CoV-2 spike protein binds strongly and directly to STRA6. Which are highly expressed in Lymphatic system and Immune cells. This study paves the way towards understanding the complex mechanism of existing of covid-19 infection complications such as immune suppression and ineffective RIG-I pathway. Restoring the balance between the STRA6 and ACE2 in the context of spike protein RBD may be promising target in SARS CoV-2 Pathogenesis and may reveal new drug targets for new variants of COVID-19. Keywords: COVID-19, STRA6, ACE2, Molecular docking.
{"title":"In silico Discovering STRA 6 Vitamin A Receptor, as a Novel Binding Receptor of COVID-19","authors":"Mahmoud Elkazzaz, Amr Ahmed, Yousry Esam Eldin Abo Amer, Tamer Haydara, Wafa Ali ELtayb, Mohammad Shahbaz Khan, Kunal Bhattacharya, Salma Alkhammash, Hadeer Mattar, Saba Beigh, Mohammed F Abo El Magd, Abdullah Haikal, Islem Abid, Amr S Abouzied, Israa M Shamkh","doi":"10.5530/ijper.57.4.126","DOIUrl":"https://doi.org/10.5530/ijper.57.4.126","url":null,"abstract":"Abstract: A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry receptor of COVID-19, but our docking analysis, predicted and discovered a novel receptor termed STRA 6 that may play a critical role in the pathogenicity of COVID-19. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA 6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. The primary ligand of STRA6 (vitamin/retinol) was shown to be drastically reduced during COVID-19 infection, which agrees with our findings. We analyze the STRA6 and ACE2 receptor networks to predict the specific association among certain other proteins which might rely on similar functionality. Molecular docking showed a high affinity between the Spike protein with STRA6, the docking score of COVID-19 spike protein with STRA6 (-354.68) kcal/mol was higher than the docking score of spike protein with ACE2 (-341.21) kcal/mol. Results of MD simulations revealed significant stability of the spike protein with STRA6 up to 100 ns. SARS-CoV-2 spike protein binds strongly and directly to STRA6. Which are highly expressed in Lymphatic system and Immune cells. This study paves the way towards understanding the complex mechanism of existing of covid-19 infection complications such as immune suppression and ineffective RIG-I pathway. Restoring the balance between the STRA6 and ACE2 in the context of spike protein RBD may be promising target in SARS CoV-2 Pathogenesis and may reveal new drug targets for new variants of COVID-19. Keywords: COVID-19, STRA6, ACE2, Molecular docking.","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135645395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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