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A Case Report of Retracted Publications in Pharmaceutical Science as a Remedy for Research Malpractice 医药科学中作为研究渎职补救措施的撤稿案例报告
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.40
Eric Wei Chiang Chan
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引用次数: 0
A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region 关于海尔地区药学院学生使用减肥药和草药混合物的问卷调查研究
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.37
Weiam Abdul Raheem Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, Weam Mohamed Ali Khojali, N. Khalifa, N. H. Alkefai, Mhdia Elhadi Osman, Ghaliah Alshammari, Tahani S. Albalawi, Zahwah Alshammari, Haya O. Almutairi, Reem M. Alrasheedi, Talal Ahmed Alshammari, Ibrahim Khalid Alhajaji, Fawaz Alheibshy
{"title":"A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region","authors":"Weiam Abdul Raheem Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, Weam Mohamed Ali Khojali, N. Khalifa, N. H. Alkefai, Mhdia Elhadi Osman, Ghaliah Alshammari, Tahani S. Albalawi, Zahwah Alshammari, Haya O. Almutairi, Reem M. Alrasheedi, Talal Ahmed Alshammari, Ibrahim Khalid Alhajaji, Fawaz Alheibshy","doi":"10.5530/ijper.58.1.37","DOIUrl":"https://doi.org/10.5530/ijper.58.1.37","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"10 9","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the Pro-active Role of Alpha Amyrin Nanoemulsions in Quashing Neurodegeneration, Excitotoxicity, and Neuronal Inflammation-A Combined in vivo and in silico Approach 研究阿尔法阿米林纳米乳剂在抑制神经退行性变、兴奋毒性和神经元炎症中的积极作用--一种体内和硅学相结合的方法
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.26
Ratna Baburaj, R. Sandur V, Kuntal Das
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引用次数: 0
The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats 蜜蜂与小麦胚芽混合物对链脲佐菌素诱导糖尿病大鼠的降血糖和降血脂作用
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.23
Nawal Tahoon, R. Eid, Saad Aziz Mahgoub, Mohamed Saleh Ismail
{"title":"The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats","authors":"Nawal Tahoon, R. Eid, Saad Aziz Mahgoub, Mohamed Saleh Ismail","doi":"10.5530/ijper.58.1.23","DOIUrl":"https://doi.org/10.5530/ijper.58.1.23","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"12 11","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effects of Hibiscetin on Ethanol-Induced Ulcers in Rats through Inhibition of Prostaglandin Synthesis/ Oxidative Stress/Caspase-3 and 9 Pathways 木槿黄素通过抑制前列腺素合成/氧化应激/Caspase-3 和 9 途径对乙醇诱发的大鼠溃疡具有保护作用
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.30
Faisal Alotaibi
{"title":"Protective Effects of Hibiscetin on Ethanol-Induced Ulcers in Rats through Inhibition of Prostaglandin Synthesis/ Oxidative Stress/Caspase-3 and 9 Pathways","authors":"Faisal Alotaibi","doi":"10.5530/ijper.58.1.30","DOIUrl":"https://doi.org/10.5530/ijper.58.1.30","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"4 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systems 纳米结构脂质载体:药物输送系统的潜在时代
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.3
Haranath Chinthaginjala, Varalakshmi Bogavalli, A. A. Hindustan, Jayasree Pathakamuri, Sai Sree Pullaganti, Aswini Gowni, Bandhavi Baktha
{"title":"Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systems","authors":"Haranath Chinthaginjala, Varalakshmi Bogavalli, A. A. Hindustan, Jayasree Pathakamuri, Sai Sree Pullaganti, Aswini Gowni, Bandhavi Baktha","doi":"10.5530/ijper.58.1.3","DOIUrl":"https://doi.org/10.5530/ijper.58.1.3","url":null,"abstract":"","PeriodicalId":13407,"journal":{"name":"Indian Journal of Pharmaceutical Education and Research","volume":"126 19","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats 鹅掌楸中的一种生物活性化合物--川芎素能改善酒精诱导的白化大鼠的脂质代谢状况
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.18
Meesala Guru Sekhar, K. Shanmugam, Kanchi Siva Prasad, Ramakrishna Chilakala
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引用次数: 0
Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing 设计和开发用于伤口愈合的固体脂质纳米颗粒抗真菌外用凝胶
IF 0.8 4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-12-27 DOI: 10.5530/ijper.58.1.13
Girish Meravanige, Ranjitha Ranjitha B, P. Goudanavar, Gsn Koteswara Rao, B. N. Devi, N. Naveen, A. Asif, Sree Harsha Nagaraja, Mohammed Monirul Islam, Pavan Kumar Pavagada Sreenivasalu, Mallikarjun Telsang, Krishna Swaroop Duddi Sreehari
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引用次数: 0
Inhibition of Phenylhydrazine-induced Hematotoxicity by Bioconverted Ginsenosides 生物转化人参皂苷对苯肼致血液毒性的抑制作用
4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.136
Yuseong Chung, Kang Min Kim, Jae Seon Kang
Abstract: Aim: To identify the inhibition of Phenylhydrazine (PHZ)-induced hepatotoxicity and anemia by bioconverted ginsenosides. Materials and Methods: We examined the potential benefits of bioconverted ginsenosides on anemia in a phenylhydrazine-induced rat model and described the prolonging effect of erythrocyte life span by focusing on compound K that was confirmed through ex vivo experiments. Results: Hematological analysis demonstrated that all groups treated with bioconverted ginsenosides showed significant recovery results. In the ex vivo experiments, compound K was treated in stored blood, and the erythrocytes half-life was 45 days, 15 days longer than when not treated in blood. In the ICP-OES assay, PHZ-induced erythrocyte hemolysis was significantly inhibited by bioconverted ginsenosides. Conclusion: Based on the present results, it has been demonstrated that bioconverted ginsenoside aids in prolonging the erythrocyte life span and increasing erythrocyte count in vivo. Thus, this material has the potential to develop as a promising drug candidate in the future. Keywords: Anemia, Erythrocyte, Ginsenosides, Hemolysis, Phenylhydrazine.
摘要:目的:探讨生物转化人参皂苷对苯肼(PHZ)诱导的肝毒性和贫血的抑制作用。材料和方法:我们在苯肼诱导的贫血大鼠模型中研究了生物转化人参皂苷对贫血的潜在益处,并通过离体实验重点描述了化合物K对红细胞寿命的延长作用。结果:血液学分析表明,生物转化人参皂苷治疗各组均有显著的恢复效果。在离体实验中,化合物K在储存的血液中处理,红细胞半衰期为45天,比未在血液中处理的半衰期长15天。在ICP-OES实验中,生物转化人参皂苷明显抑制phz诱导的红细胞溶血。结论:生物转化人参皂苷在体内具有延长红细胞寿命和增加红细胞计数的作用。因此,这种材料在未来有潜力成为一种有前途的候选药物。关键词:贫血,红细胞,人参皂苷,溶血,苯肼
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引用次数: 0
In silico Discovering STRA 6 Vitamin A Receptor, as a Novel Binding Receptor of COVID-19 新发现STRA - 6维生素A受体作为新型COVID-19结合受体
4区 医学 Q3 EDUCATION, SCIENTIFIC DISCIPLINES Pub Date : 2023-10-04 DOI: 10.5530/ijper.57.4.126
Mahmoud Elkazzaz, Amr Ahmed, Yousry Esam Eldin Abo Amer, Tamer Haydara, Wafa Ali ELtayb, Mohammad Shahbaz Khan, Kunal Bhattacharya, Salma Alkhammash, Hadeer Mattar, Saba Beigh, Mohammed F Abo El Magd, Abdullah Haikal, Islem Abid, Amr S Abouzied, Israa M Shamkh
Abstract: A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry receptor of COVID-19, but our docking analysis, predicted and discovered a novel receptor termed STRA 6 that may play a critical role in the pathogenicity of COVID-19. STRA6 receptor expressed in many organs and immune cells, upregulated by retinoic acid jm6 (STRA 6) was the first protein to be identified in a novel category of proteins, cytokine signaling transporters, due to its ability to function as both a cell surface receptor and a membrane protein that binds to retinol binding protein facilitating cellular uptake of retinol. The primary ligand of STRA6 (vitamin/retinol) was shown to be drastically reduced during COVID-19 infection, which agrees with our findings. We analyze the STRA6 and ACE2 receptor networks to predict the specific association among certain other proteins which might rely on similar functionality. Molecular docking showed a high affinity between the Spike protein with STRA6, the docking score of COVID-19 spike protein with STRA6 (-354.68) kcal/mol was higher than the docking score of spike protein with ACE2 (-341.21) kcal/mol. Results of MD simulations revealed significant stability of the spike protein with STRA6 up to 100 ns. SARS-CoV-2 spike protein binds strongly and directly to STRA6. Which are highly expressed in Lymphatic system and Immune cells. This study paves the way towards understanding the complex mechanism of existing of covid-19 infection complications such as immune suppression and ineffective RIG-I pathway. Restoring the balance between the STRA6 and ACE2 in the context of spike protein RBD may be promising target in SARS CoV-2 Pathogenesis and may reveal new drug targets for new variants of COVID-19. Keywords: COVID-19, STRA6, ACE2, Molecular docking.
摘要2019年底,由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的全球肺炎大流行始于中国武汉。虽然ACE2受体已被证明是COVID-19的主要进入受体,但我们的对接分析预测并发现了一种名为STRA 6的新受体,该受体可能在COVID-19的致病性中发挥关键作用。STRA6受体在许多器官和免疫细胞中表达,受视黄酸jm6 (STRA 6)上调,是第一个被鉴定为一种新的蛋白质类别的蛋白质,细胞因子信号转运蛋白,因为它能够作为细胞表面受体和膜蛋白结合视黄醇结合蛋白促进细胞摄取视黄醇。在COVID-19感染期间,STRA6(维生素/视黄醇)的初级配体被证明急剧减少,这与我们的发现一致。我们分析了STRA6和ACE2受体网络,以预测可能依赖于类似功能的某些其他蛋白质之间的特定关联。新型冠状病毒钉蛋白与STRA6的分子对接显示出较高的亲和力,钉蛋白与STRA6的对接评分(-354.68)kcal/mol高于与ACE2的对接评分(-341.21)kcal/mol。MD模拟结果显示,当STRA6达到100 ns时,刺突蛋白具有显著的稳定性。SARS-CoV-2刺突蛋白直接与STRA6紧密结合。在淋巴系统和免疫细胞中高度表达。本研究为理解covid-19感染并发症存在的免疫抑制、RIG-I通路无效等复杂机制奠定了基础。在刺突蛋白RBD的背景下,恢复STRA6和ACE2之间的平衡可能是SARS - CoV-2发病机制的有希望的靶点,并可能为COVID-19新变体揭示新的药物靶点。关键词:COVID-19, STRA6, ACE2,分子对接
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引用次数: 1
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Indian Journal of Pharmaceutical Education and Research
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