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Antioxidant and cytotoxic potential of potentized preparation of Cordyceps sinensis in vitro in cancer cell lines 冬虫夏草强化制剂体外对癌细胞的抗氧化和细胞毒性研究
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1131
Vettrivel Arul, R. Kandasamy, Marynick Sp
Background: The parasitic fungus Cordyceps sinensis (Ophiocordyceps sinensis) has been discovered in lepidopteran larvae, having known antitumor effects. Testing potentized Cordyceps sinensis in cancer cells could help broaden Homoeopathy cancer therapeutics. Objectives: The objectives of the study were to evaluate the antioxidant and cytotoxicity activity of potentized preparation of Cordyceps sinensis in carcinoma cell-lines. Methods: In this in vitro study, antioxidant activity was analyzed by the 2,2-diphenyl-1-picryl-hydrazylhydrate assay and the dilution with more antioxidant potential was further analyzed for cytotoxicity, using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on various carcinoma cell lines: Breast cancer cell line (MCF-7), liver cancer cell line (HePG2), lung cancer cell line (A-549), and prostate cancer cell line (PC3). All experiments were carried out in triplicates. Data were analyzed by one-way analysis of variance and the means were compared by Duncan’s new multiple range test. Results: A higher antioxidant potential 377.40 μL/mL was seen in Cordyceps sinensis 30C, which was further analyzed for cytotoxicity in cell lines (MCF-7), (HePG2), (A-549), and (PC3) which it inhibited at concentrations 596.21 ± 3.32 μL/mL, 438.10 ± 2.39 μL/mL, 555.40 ± 3.08 μL/mL, and 656.42 ± 2.68 μL/ mL, respectively. When comparing Cordyceps sinensis 30C to other cell lines, its cytotoxic activity against HEPG2 is particularly potent. Conclusion: This research demonstrates the usefulness of potentized preparation of Cordyceps sinensis, it will take additional studies comparing it to currently used drugs to determine whether or not it is significantly more efficient. Acknowledgments and Source of Funding The authors are thankful to Alpha Omega Research Foundation, Salem, Tamil Nadu for the facilities provided. This original article is available in Indian Journal of Research in Homoeopathy: https://www.ijrh.org/journal/vol17/ iss1/2 3 © 2023 Indian Journal of Research in Homoeopathy | Hosted online by Digital Commons (Bepress) Abstract Original Article
背景:寄生真菌冬虫夏草(Ophiocordyceps sinensis)已在鳞翅目幼虫中发现,具有已知的抗肿瘤作用。在癌细胞中测试潜在的冬虫夏草可能有助于拓宽顺势疗法的癌症治疗。目的:研究冬虫夏草增强制剂对癌细胞的抗氧化活性和细胞毒活性。方法:采用2,2-二苯基-1-picryl-hydrazylhydrate法分析其体外抗氧化活性,并采用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑法分析其体外抗氧化活性对乳腺癌细胞系(MCF-7)、肝癌细胞系(HePG2)、肺癌细胞系(A-549)和前列腺癌细胞系(PC3)的细胞毒性。所有的实验都是分三次进行的。数据分析采用单因素方差分析,均数比较采用Duncan新多元极差检验。结果:冬虫夏草30C对MCF-7、HePG2、A-549和PC3细胞株的抗氧化能力分别为596.21±3.32 μL/mL、438.10±2.39 μL/mL、555.40±3.08 μL/mL和656.42±2.68 μL/mL,抗氧化能力为377.40 μL/mL。将冬虫夏草30C与其他细胞系进行比较,发现其对HEPG2的细胞毒活性特别强。结论:本研究证实了冬虫夏草强化制剂的有效性,还需要进一步的研究将其与目前使用的药物进行比较,以确定其是否明显更有效。作者感谢Alpha Omega研究基金会,Salem, Tamil Nadu提供的设施。这篇原创文章可以在印度顺势疗法研究杂志上找到:https://www.ijrh.org/journal/vol17/ iss1/2 3©2023印度顺势疗法研究杂志|由Digital Commons (Bepress)在线托管摘要原创文章
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引用次数: 0
Homoeopathy in the management of generalised anxiety disorder: A case report 顺势疗法治疗广泛性焦虑障碍1例报告
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1116
K. Moorthi, R. P
Abstract Introduction:Introduction: Generalised anxiety disorder (G.A.D.) is characterised by excessive, pervasive and uncontrollable worry. G.A.D. is a chronic and recurrent disorder with a low rate of remission with a considerable impact on quality of life. There is a scarcity of literature published on homoeopathy on G.A.D. This case report illustrates an improvement without recurrence of a G.A.D. case treated exclusively with homoeopathic medicine. Case Summary: Case Summary: A 36-year-old man presented with anxiety about least trifles, easily irritable, palpitation, gastric disturbances, tension, excessive sweating, sleep disturbances and difficulty in concentration. After thorough case-taking, homoeopathic treatment with Lycopodium 200C and Sulphur 1000C led to a remarkable improvement. He was free of symptoms from the 10th month of treatment. He was functionally and socially improved, as reflected in the Hamilton Anxiety Rating Scale and there was no relapse for 8 months. Individualised homoeopathic treatment showed a positive result in the treatment of G.A.D. It brought about considerable improvement in the patient’s social, occupational and familial life without any adverse effects.
摘要简介:广泛性焦虑障碍(gad)以过度、普遍和无法控制的担忧为特征。广泛性焦虑症是一种慢性复发性疾病,缓解率低,对生活质量有相当大的影响。关于顺势疗法治疗广泛性焦虑症的文献很少。本病例报告表明,仅用顺势疗法治疗广泛性焦虑症患者无复发。病例总结:男性,36岁,表现为小事焦虑,易烦躁,心悸,胃功能障碍,紧张,多汗,睡眠障碍,注意力不集中。经过彻底的病例采集,用石蒜200C和硫1000C进行顺势疗法治疗,效果显著。治疗10个月后症状消失。根据汉密尔顿焦虑评定量表,他的功能和社交能力得到了改善,8个月内没有复发。个体化的顺势疗法在治疗广泛性焦虑症方面显示出积极的效果,它给患者的社会、职业和家庭生活带来了相当大的改善,没有任何不良反应。
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引用次数: 1
Research Highlights 研究突出了
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1836
Lalit Tyagi, Navita Bagdi
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引用次数: 0
Embarking on the journey of pharmacovigilance of homoeopathic drugs 开启顺势疗法药物警戒之旅
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1859
Subhash Kaushik
Abstract Embarking on the journey of pharmacovigilance of homoeopathic drugs
摘要开启顺势疗法药物警戒之旅
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引用次数: 0
Knowledge, awareness, attitude and practice of Indian Homoeopathic Physicians about pharmacovigilance in homoeopathy: A web-based cross-sectional study 印度顺势疗法医生对顺势疗法药物警戒的知识、意识、态度和实践:一项基于网络的横断面研究
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1244
Rajib Purkait, Baidurjya Bhattacharjee, A. Banerjee, Gurudev Choubey
Abstract Background:Background: Pharmacovigilance (Pv) is the science and activities relating to detecting, assessing, understanding and preventing adverse effects or any other drug-related problems. The subject is essential for developing reliable information on the safety of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy medicines. Objectives:Objectives: This study explored the homoeopathic physicians’ knowledge, awareness, attitude and practice (KAAP) towards the Pv programme in homoeopathy. Methods:Methods: An online cross-sectional survey was conducted among 274 Indian homoeopathic practitioners for 2 months. The study team developed the questionnaire in consultation with three subject experts and the same was circulated as a generated link among different social media handles. The interested participants consenting to the study were directed to the data collection format through an online portal. The data were collected in four domains: KAAP. Descriptive statistics were used in data analysis and independent t-tests for the subgroup analysis. Results:Results: A total of 274 homoeopathic practitioners were approached, of which 265 consented to fill out the questionnaire, yielding a response rate of 96.7%. Most of the study participants had obtained low scores in knowledge and awareness of the programme. Statistically significant differences were observed among postgraduates and those with prior training in Pv. The attitude towards acceptance of the programme was relatively high among the participants, but the low awareness led to reduced observations and reporting of the adverse drug reactions (ADRs) in homoeopathy. Conclusion:Conclusion: Despite the good attitude of homoeopathic practitioners to the Pv programme, sufficient hands-on training is required to identify and report ADRs in homoeopathy.
摘要背景:背景:药物警戒是一门与检测、评估、理解和预防不良反应或任何其他药物相关问题有关的科学和活动。该主题对于开发关于阿育吠陀、瑜伽和自然疗法、Unani、Siddha和顺势疗法药物安全性的可靠信息至关重要。目的:本研究探讨顺势疗法医生对顺势疗法Pv项目的知识、意识、态度和实践(KAAP)。方法:方法:对274名印度顺势疗法从业者进行为期2个月的在线横断面调查。研究小组在与三位主题专家协商后制定了这份问卷,并将其作为不同社交媒体处理之间的链接分发。同意该研究的感兴趣的参与者通过在线门户网站被引导到数据收集格式。数据收集在四个领域:KAAP。数据分析采用描述性统计,亚组分析采用独立t检验。结果:共接触了274名顺势疗法从业者,其中265人同意填写问卷,回复率为96.7%。大多数研究参与者对该计划的知识和意识得分较低。研究生和受过Pv培训的研究生之间存在统计学上的显著差异。参与者对接受该方案的态度相对较高,但认识不足导致对顺势疗法药物不良反应(ADR)的观察和报告减少。结论:结论:尽管顺势疗法从业者对Pv计划态度良好,但需要足够的实践培训来识别和报告顺势疗法中的不良反应。
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引用次数: 1
Can the sweet pills restore the smiles of autistic children? 这些甜药片能恢复自闭症儿童的笑容吗?
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1827
D. Gilla, K. Muraleedharan
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引用次数: 0
Obviating surgical amputation of diabetic gangrene through homoeopathy – A case report 顺势疗法治疗糖尿病坏疽截肢1例
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1163
Poojitha Ankerela, Sangeeta Belgavimath, P. Rotti
Abstract Introduction:Introduction: Gangrene is defined as the decay or death of an organ or tissue due to a compromised blood supply. It is a perilous and fatal condition occurring most commonly due to diabetes. In general, people with diabetes have a significantly increased risk of lower extremity gangrene leading to amputation. Case Summary Case Summary: A 70-year-old woman presented with diabetic gangrene of her right leg and foot since 4 months. The patient complained of swelling and blackish discoloration of the right foot and leg with offensive discharging ulcers on the first and third toes. She was diagnosed with diabetic foot gangrene and advised to undergo surgical amputation of the foot and debridement of the leg by a local surgeon within 4–5 days to stop the spread of gangrene. After an unsatisfactory outcome, the patient turned to homoeopathy to avoid amputation. After a detailed case-taking, analysis and repertorisation, Arsenic album 30C was prescribed. Within 3–4 months, there was an improvement in the limb without any surgical intervention. Calendula officinalis Q was used for cleaning the wound and regular dressing. This case depicts the importance of individualised homoeopathic medicine in treating gangrene effectively, thus obviating amputation.
摘要简介简介:坏疽被定义为由于血液供应受损而导致的器官或组织的腐烂或死亡。这是一种危险和致命的疾病,最常见的原因是糖尿病。一般来说,糖尿病患者下肢坏疽导致截肢的风险明显增加。病例摘要:一名70岁女性,因右腿和右脚糖尿病坏疽4个月。患者主诉右脚和腿部肿胀和发黑,第一和第三趾有进攻性脓性溃疡。她被诊断为糖尿病足坏疽,并建议在4-5天内由当地外科医生进行足部截肢手术和腿部清创,以阻止坏疽的扩散。结果不理想后,病人转而采用顺势疗法以避免截肢。经过详细的病例采集、分析和复查,开具了30C砷相册。在3-4个月内,在没有任何手术干预的情况下,肢体得到改善。金盏菊Q用于伤口清洁和常规敷料。本病例说明个体化顺势疗法药物在有效治疗坏疽,从而避免截肢的重要性。
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引用次数: 1
Good clinical practice guidelines for clinical trials in homoeopathy 顺势疗法临床试验良好临床实践指南
Q3 Medicine Pub Date : 2023-03-24 DOI: 10.53945/2320-7094.1828
Dastagiri P
Abstract
摘要
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引用次数: 0
Scope of homoeopathy in the treatment of depression: A narrative synthesis 顺势疗法治疗抑郁症的范围:叙述综合
Q3 Medicine Pub Date : 2022-12-27 DOI: 10.53945/2320-7094.1070
K. Moorthi, R. P, M. Chandran, K.C. Muraleedharan
Abstract BackgroundBackground: Depression is a disorder of major public health importance, in terms of its prevalence and suffering, dysfunction, morbidity and economic burden. Depression is one of the most common conditions for which people seek homoeopathic treatment. ObjectiveObjective: This study is aimed to understand the scope of homoeopathy in depression based on the results of previous studies. MethodsMethods: A study was done to evince the scope of homoeopathic medicines in the treatment of depression. Searches were done in both general and specialised databases. The data were collected from peer-reviewed journals published between January 2001 and January 2021. Efforts were made to identify published articles on ‘depression and homoeopathy, homoeopathy for depression, depressive disorder and homoeopathy, dysthymia in homoeopathy’. ResultsResults: Twenty-one relevant studies were found and included in the review. These included systematic reviews, randomised control trials, observational studies, case series and case reports. Even though the studies considered in the review indicate the effectiveness of Homoeopathy, it is difficult to assess the overall effect of homoeopathy systematically, mostly because of compromised study designs. ConclusionConclusion: This review has helped in synthesising the existing literature on the scope of homoeopathy in the treatment of depression. However, in order to obtain more reliable results, better-designed researches, with long-term follow-ups may be planned.
摘要背景:就其患病率和痛苦、功能障碍、发病率和经济负担而言,抑郁症是一种具有重大公共卫生意义的疾病。抑郁症是人们寻求顺势疗法治疗的最常见的疾病之一。目的:在总结前人研究成果的基础上,了解抑郁症中顺势疗法的范围。方法:研究顺势疗法药物治疗抑郁症的作用范围。搜索是在通用数据库和专业数据库中进行的。数据收集自2001年1月至2021年1月期间发表的同行评审期刊。努力确定已发表的关于“抑郁症和顺势疗法、抑郁症的顺势疗法、抑郁障碍和顺势疗法以及顺势疗法中的心境恶劣”的文章。结果:发现21项相关研究并纳入综述。其中包括系统综述、随机对照试验、观察性研究、病例系列和病例报告。尽管综述中考虑的研究表明了顺势疗法的有效性,但很难系统地评估顺势疗法的总体效果,主要是因为研究设计存在缺陷。结论:这篇综述有助于综合现有关于顺势疗法治疗抑郁症范围的文献。然而,为了获得更可靠的结果,可以计划进行设计更好的研究,并进行长期随访。
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引用次数: 1
Homoeopathy in plantar psoriasis: An evidence-based case report 足底银屑病的顺势疗法:一例循证病例报告
Q3 Medicine Pub Date : 2022-12-27 DOI: 10.53945/2320-7094.1127
GR Kiranmayee Rompicherla, H. Ponnam
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引用次数: 2
期刊
Indian Journal of Research in Homoeopathy
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