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2013 IEEE International Conference on Medical Imaging Physics and Engineering最新文献

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The observation of hip joint cartilage of elderly people based on EPIC Micro-CT 基于EPIC Micro-CT的老年人髋关节软骨观察
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864511
Liang Xiaofei, Fan Fan, Niu Haijun, Fan Yubo
The objective of this study was to observe the age-related changes of sulfated glycosaminoglycan (sGAG) content and surface roughness of hip joint cartilage of elderly people based on Equilibrium Partitioning of an Ionic Contrast Agent (EPIC) Micro-CT. 35 human hip cartilage-bone samples were prepared from hip-fracture patients whose age were from 50 to 100 years old and divided into 5 groups (10 years as an age group). They were first immersed in 20% concentration of the contrast agent Meglumine Diatrizoate (MD) for 6 hours at 37°C, and scanned by Micro-CT after taken out from the contrast agent. The X-ray mean attenuation and hip joint cartilage surface roughness were calculated. The results showed the X-ray mean attenuation of the entire hip joint cartilage increased about 17.44% from the 50 age group to the 80 age group (from 1294.61±97.77HU to 1520.39±184.56HU), but it decreased about 6.43% in the 90 age group compared to the 80 age group (from 1520.39±184.56HU to 1422.55±106.37HU). Moreover, the X-ray mean attenuations of the superficial layer, middle layer and radical layer of cartilage declined successively in the different age groups. Regarding of the superficial layer and middle layer from the 50 age group to the 80 age group, they rose about 31.21 % and 43.02% respectively (from 1472.40±138.96HU to 1931.99±199.69HU and 1271.83±58.36HU to 1819.07±213.55HU), and also reduced 4.64% and 6.03% separately in the 90 age group (from 1931.99±199.69HU to 1798.12±153.32HU, and 1819.07±213.55HU to 1653.22±169.46HU), while the radical layer showed no significant change along with age increase. The hip joint cartilage surface roughness changes only 5.31% with age increase (from 13.64±5.17μm to 14.36±5.21μm).
本研究的目的是基于离子对比剂平衡分配(EPIC)微ct观察老年人髋关节软骨硫酸氨基聚糖(sGAG)含量和表面粗糙度的年龄相关性变化。选取年龄50 ~ 100岁的髋部骨折患者,制备35例人髋软骨骨标本,分为5组(以10岁为年龄组)。首先在浓度为20%的造影剂三聚氰胺(MD)中浸泡6小时,37℃,取出造影剂后进行Micro-CT扫描。计算x线平均衰减和髋关节软骨表面粗糙度。结果显示,全髋关节软骨x线平均衰减从50岁到80岁增加了约17.44%(从1294.61±97.77HU增加到1520.39±184.56HU),而90岁比80岁减少了约6.43%(从1520.39±184.56HU增加到1422.55±106.37HU)。不同年龄组软骨浅层、中间层和根层x线平均衰减量依次下降。随着年龄的增长,髋关节软骨表面粗糙度的变化幅度仅为5.31%(从13.64±5.17μm增加到14.36±5.21μm)。
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引用次数: 0
Nonnegative matrix factorization using target-to-background contrast for fluorescence unmixing 使用目标-背景对比的非负矩阵分解用于荧光解混
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864553
Shaosen Huang, Yong Zhao, Cheng Hu, Binjie Qin
Nonnegative Matrix Factorization (NMF) has been a useful tool to solve the spectral unmixing for fluorescence imaging, which yields a set of constituent spectra, i.e., endmembers, and their corresponding fractional abundances. As observed from the spatial distribution of fluorescence data, target fluorophores are sparse and localized at certain regions while background fluorescence (including autofluorescence) are non-sparse and diffusive over large areas. Based on the different sparsity characteristics of abundances between target fluorophores and background fluorescence, we propose a NMF algorithm based on the target-to-background contrast with entire abundances being divided into a hierarchy of target fluorophores and a hierarchy of background. With the clear distinction between abundances of targets and background fluorescence in the iterative updates of NMF, appropriate sparseness constraint can be easily introduced into the corresponding target hierarchy without interfering with the other background hierarchy. Experimental results based on synthetic and real fluorescence data show the better performances of the proposed algorithm with respect to other state-of-the-art methods.
非负矩阵分解(NMF)是解决荧光成像光谱解混的有效工具,它产生一组组成光谱,即端元及其相应的分数丰度。从荧光数据的空间分布来看,目标荧光团是稀疏的,局限于某些区域,而背景荧光(包括自身荧光)是非稀疏的,在大面积上是扩散的。基于目标荧光团与背景荧光丰度的不同稀疏特性,提出了一种基于目标-背景对比的NMF算法,将整个丰度划分为目标荧光团层次和背景层次。在NMF迭代更新中,由于目标荧光丰度与背景荧光丰度有明显的区别,因此可以在不干扰其他背景层次的情况下,在相应的目标层次中引入适当的稀疏性约束。基于合成和真实荧光数据的实验结果表明,该算法相对于其他最新方法具有更好的性能。
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引用次数: 0
A modified FDK with misaligned parameters of flat-panel detector in Cone-Beam CT 锥束CT平板探测器参数失调的改进FDK
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864539
Guo Bin, Liu Bo, Zhou Fugen
FDK reconstruction algorithm is the most widely used for Cone Beam CT imaging system due to its simplicity and fast implementation. However, if misalignments exist in the detector, the original FDK reconstruction algorithm will result in deteriorated reconstruction quality because of the wrong correspondence of the voxels from the object and the pixels from the projection. One way is to apply rotation-based interpolation for each projection, which not only will cause blurring of the details due to the effect of interpolation but also is very time-consuming. In back-projection based reconstruction, the key factor is to correctly relate the voxels from the object and the pixels from the projections. Based on this point of view, we propose a method that will correctly find the correspondence of the voxels and pixels. With this method, reconstruction result can be obtained with good accuracy if all the misaligned parameters of the detector are known. And also, detail information can be better preserved compared with the rotation-based interpolation method. In the validation period, a simulation program of Cone-Beam CT was developed. In this program, all misaligned parameters of detector are able to be set. And the simulated result proves that our method is efficient and feasible although it suffers a little deterioration, and can further be used in online calibration of CBCT.
FDK重构算法以其简单、快速的特点,在锥形束CT成像系统中应用最为广泛。但是,如果检测器存在不对中,原始的FDK重建算法会因为物体体素与投影像素的对应错误而导致重建质量下降。一种方法是对每个投影应用基于旋转的插值,这不仅会由于插值的影响而导致细节模糊,而且非常耗时。在基于反投影的重建中,关键是正确地将物体的体素与投影的像素相关联。基于这一观点,我们提出了一种能够正确找到体素和像素对应关系的方法。利用该方法,在已知探测器所有失联参数的情况下,可以获得精度较高的重建结果。与基于旋转的插值方法相比,可以更好地保留细节信息。在验证阶段,开发了锥束CT的仿真程序。在这个程序中,可以设置探测器的所有失调参数。仿真结果证明了该方法的有效性和可行性,并可进一步用于CBCT的在线标定。
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引用次数: 0
CT-guided lung biopsy: Assessment of fiducials registration accuracy ct引导下的肺活检:基准登记准确性的评估
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864500
Xiaozhao Chen, Yu Chen, Baolin Mao, Xin Xiong, Nan Bao, Yan Kang
CT-guided interventions have been widely used in lung biopsy procedures to minimize invasion and to improve biopsy accuracy. The basic mathematical statement of the point-based registration problem remains the same in most applications, whereas there are variations on the size and shape of the fiducial markers. In this paper, we measured registration error FLEp and TRE respectively using two types of fiducial markers, ectrocardiograph electrode and steel bead. The TRE using ECG electrodes is lower than using steel beads. These experimental findings of registration accuracy indicate that ECG electrodes as fiducial markers can be accepted in the lung biopsy.
ct引导干预已广泛应用于肺活检程序,以尽量减少侵入和提高活检的准确性。在大多数应用中,基于点的配准问题的基本数学表述是相同的,而基准标记的大小和形状则有所不同。本文分别使用心电图电极和钢珠两种基准标记测量了配准误差FLEp和TRE。使用ECG电极的TRE比使用钢珠的TRE低。这些配准精度的实验结果表明,心电图电极作为肺活检的基准标记是可以接受的。
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引用次数: 1
Accelerating ring artifacts reduction for cone beam CT based on projection data using CUDA 基于CUDA的锥束CT投影数据加速环伪影还原
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864497
Baolin Mao, Dayu Xiao, Xin Xiong, Xiaozhao Chen, Wei Zhang, Yan Kang
Ring artifacts are among of the most common artifacts in cone beam computed tomography (CT). High resolution images are often disturbed by these artifacts. In this paper, a ring artifacts reduction method is proposed based on cone beam projection images. CUDA technique is used to accelerate the method. The performance of the proposed algorithm is evaluated using real cone beam CT images. Experiment results demonstrate that the proposed technique effectively eliminates the ring artifactsand has superior calculation speed using CUDA than the calculation speed of CPU.
环形伪影是锥束计算机断层扫描(CT)中最常见的伪影之一。高分辨率的图像经常受到这些伪影的干扰。提出了一种基于锥束投影图像的环形伪影去除方法。采用CUDA技术对该方法进行加速。利用真实的锥束CT图像对该算法的性能进行了评价。实验结果表明,该方法有效地消除了环形伪影,并且CUDA的计算速度优于CPU的计算速度。
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引用次数: 1
V5/hMT responds to the stereoscopic motion induced by binocular disparity: A preliminary fMRI study V5/hMT响应双眼视差诱导的立体运动:fMRI的初步研究
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864524
Wang Fei, Yang Wenchao, Liu Yong, L. Jiajia, Ma Jingfeng, Bao Shanglian, Gao Song
Purpose: To identify the regions responding to the stereoscopic motion induced by binocular disparity and investigate the relationship between the response intensity of these regions and speeds of spatial motion. Methods: The stereoscopic stimulus applied Random Dot Stereogram (RDS) distributed as checkerboard and a series of continuous disparities formed a dynamic stereoscopic stimulus. Observer needed to watch some static stimuli and dynamic stimuli moving in depth direction. The speeds of dynamic stimulus consisted of three levels: 0.315 degree/s, 0.63 degree/s, 1.26 degree/s. The functional Magnetic Resonance Imaging (fMRI) was used to sample the Blood Oxygen Level-Dependent (BOLD) signals and identify the regions sensitive to stereoscopic motion. Results: The dynamic stereoscopic stimulus can activate the hMT/V5 in a stronger degree than static stereoscopic stimulus. Besides, the signal intensity increased with the speed. The most reasonable explanation is that a large number of neurons sensitive to spatial motion exist in this region. Conclusion: The study reveals preliminarily that the human cortex hMT/V5 processes the information of spatial motion.
目的:确定双眼视差诱导立体运动的响应区域,并探讨这些区域的响应强度与空间运动速度的关系。方法:立体刺激采用棋盘状随机点立体图(RDS),一系列连续的差异形成动态立体刺激。观察者需要观察一些静态刺激和动态刺激在深度方向上的移动。动态刺激速度分为0.315度/s、0.63度/s、1.26度/s三个水平。使用功能磁共振成像(fMRI)对血氧水平依赖(BOLD)信号进行采样,并识别对立体运动敏感的区域。结果:动态立体刺激对hMT/V5的激活程度强于静态立体刺激。信号强度随速度增大而增大。最合理的解释是该区域存在大量对空间运动敏感的神经元。结论:本研究初步揭示了人类hMT/V5皮层处理空间运动信息。
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引用次数: 0
Phase retrieval for grating phase-contrast CT 光栅相衬CT相位检索
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864555
Haiyang Li, Weiguo Cao, Siyuan Wang, Shirui Li, Hua Li
Grating phase-contrast CT obtains differential phase, which is different from conventional CT (absorb-contrast CT). How to retrieve phase of object becomes a new topic. Nowadays, many algorithms have appeared to retrieve and reconstruct materials' phase information. We design a new filter to retrieve phase but not increase the dose of X-ray. The result of phase retrieved shows the validity and correctness of the filter.
光栅相衬CT与传统CT(吸收相衬CT)不同,得到的是差相。如何检索对象的相位成为一个新的课题。目前,出现了许多检索和重建材料相位信息的算法。我们设计了一种新的滤光器,在不增加x射线剂量的情况下恢复相位。相位检索结果表明了滤波器的有效性和正确性。
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引用次数: 0
Vibration measurement of dental CBCT based on 3D accelerometer 基于三维加速度计的牙科CBCT振动测量
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864512
Quanhai Fu, Chaojie Li, Yaofang Hou
Currently, dental CBCT(Cone-Beam Computed Tomography) is wildly used in the tooth implantation, maxillofacial surgery and the treatment of temporomandibular joint disorders. The three-dimensional images of Dental CBCT are reconstructed based on the projection images, which are obtained at each degree of 360°. The projected image should have a precise correspondence with the angle of rotation of arm. If vibration occurs during the rotation, artifacts will be caused from reconstruction, thus affecting the image quality. It has a very important significance on the image reconstruction if vibration information of CBCT arm can be detected and evaluated. This paper presented a vibration measuring device based 3D accelerometer, which can measure and evaluate vibration of CBCT during operation. With this device, vibration information can be sensed by 3D accelerometer. The analog signals are sampled by Microprocessor with internal ADC converter. Then, all data are sent to PC via wireless communication way. Software written by MATLAB will acquire, display, save and analyze data from measurement device, which makes it possible that evaluates vibration information from CBCT.
目前,牙科CBCT(Cone-Beam Computed Tomography,锥形束计算机断层扫描)广泛应用于牙种植、颌面外科及颞下颌关节疾病的治疗。在360°各角度投影图像的基础上,重建牙科CBCT三维图像。投影图像应与手臂的旋转角度精确对应。如果在旋转过程中产生振动,则会因重建而产生伪影,从而影响图像质量。对CBCT臂的振动信息进行检测和评估,对图像重建具有十分重要的意义。本文提出了一种基于三维加速度计的振动测量装置,可以对CBCT运行过程中的振动进行测量和评估。利用该装置,可以通过三维加速度计感知振动信息。模拟信号由内置ADC转换器的微处理器进行采样。然后,将所有数据通过无线通信方式发送到PC机。利用MATLAB编写的软件对测量装置的数据进行采集、显示、保存和分析,使CBCT振动信息的评估成为可能。
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引用次数: 2
A comparison of two novel similarity measures based on mutual information in 2D/3D image registration 二维/三维图像配准中基于互信息的两种新型相似性度量方法的比较
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864537
Lei Wang, Xin Gao, Ran Zhang, W. Xia
In image-guided intervention, 2D/3D medical image registration is crucial to assist the clinician to locate precisely the lesions of the patient, which involves many aspects, such as similarity measure. In this paper, two similarity measures, distance coefficient mutual information (DCMI) and distance weighted mutual information (DWMI), were compared for 2D/3D rigid registrations by applying them to porcine skull phantom datasets from the Medical University Vienna. The results showed that DWMI was more accurate than DCMI with lower by 5.25% mean of mTRE and higher by 5.06% success rate but greater 7.74% average iterations. This indicates that the two similarity measures, in which space distance information was used to restrict mutual information in different ways, have no dramatically difference in precision of 2D/3D registration.
在图像引导干预中,二维/三维医学图像配准是帮助临床医生准确定位患者病变的关键,涉及到相似度测量等诸多方面。本文采用距离系数互信息(DCMI)和距离加权互信息(DWMI)两种相似性度量方法,对维也纳医科大学猪颅骨幻像数据集进行二维/三维刚性配准比较。结果表明,DWMI比DCMI准确率高,平均迭代次数低5.25%,成功率高5.06%,平均迭代次数高7.74%。这表明使用空间距离信息对互信息进行不同方式限制的两种相似性测度在2D/3D配准精度上没有显著差异。
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引用次数: 3
Denoising low dose CT images via 3D total variation using CUDA 利用CUDA对低剂量CT图像进行三维全变差去噪
Pub Date : 2013-10-01 DOI: 10.1109/ICMIPE.2013.6864501
Baolin Mao, Dayu Xiao, Xin Xiong, Xiaozhao Chen, Wei Zhang, Yan Kang
The purpose of this paper is to improve the quality of low dose Computed Tomography (CT) images. Low dose artifacts are the Gaussian noises superimposed on the CT images and are often caused by insufficient calibrated detector and photon starvation. A noise reduction method via three dimensional total variation using Compute Unified Device Architecture (CUDA) is proposed on the three dimensional image. This method can also be employed for low dose noise removal of the two dimensional CT images by decreasing a total variation dimension processing technique. The performance of the proposed algorithm has been tested by using quantitative measures. For quantitative analysis, the quality assessment parameter Peak-signal-to-noise-ratio (PSNR) is used in this paper. Both simulation and real experiment results show that the proposed technique increases the image quality and has high calculation speed.
本文旨在提高低剂量计算机断层扫描(CT)图像的质量。低剂量伪影是叠加在CT图像上的高斯噪声,通常是由未校准的检测器和光子饥饿引起的。提出了一种基于CUDA的三维全变分降噪方法。该方法还可以通过减小总变维处理技术对二维CT图像进行低剂量噪声去除。通过定量测试,验证了该算法的性能。为了进行定量分析,本文采用峰值信噪比(PSNR)作为质量评价参数。仿真和实际实验结果表明,该方法提高了图像质量,并具有较高的计算速度。
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引用次数: 6
期刊
2013 IEEE International Conference on Medical Imaging Physics and Engineering
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