Inorganica Chimica Acta最新文献

{"title":"Dehydroacetic acid benzoyl hydrazone complexes of Ni(II) and Pd(II): Synthesis, characterization, computational studies, biomolecular interaction, and dual anticancer–antimicrobial activities","authors":"Islam M. Elnabky ,&nbsp;Mohamed M. Aboelnga ,&nbsp;Hoda M. El-Gharabawy ,&nbsp;Shadia A. Elsayed ,&nbsp;Ahmed M. El-Hendawy","doi":"10.1016/j.ica.2025.123047","DOIUrl":"10.1016/j.ica.2025.123047","url":null,"abstract":"<div><div>Four new Nickel(II) and Palladium(II) complexes of a dehydroacetic acid benzoyl hydrazone Schiff base ligand (H₂L) with composition [M(L)(X)] (M = Ni or Pd; X = H₂O for <strong>Ni1</strong>, <strong>Pd1,</strong> or imidazole for <strong>Ni2</strong>, <strong>Pd2</strong>) were synthesized. Elemental analyses (CHN), spectroscopic tools (FTIR, ¹H NMR, HRMS, and UV–Vis spectroscopy), thermal analysis, and magnetic measurements were used to elucidate their molecular structures. The data obtained confirmed the bi-negative tridentate coordination nature of the ligand <em>via</em> deprotonated hydroxyl group/amide oxygen, and azomethine nitrogen as (ONO-donor). The complex Ni1) displayed a tetrahedral geometry, while the complexes (<strong>Ni2</strong> and <strong>Pd1,2</strong>) displayed square planar geometry, which was also confirmed by DFT calculations. Their binding affinity towards DNA and BSA was investigated by UV–Vis and fluorescence spectroscopy revealed strong binding affinities (1.2–4.3 × 10⁴ M⁻¹). Molecular docking further confirmed stable interactions with both biomolecules. The <em>in vitro</em> cytotoxic of all complexes was evaluated using MTT assay against human breast cancer (MCF7 and MDA-MB-231), and hepatocellular (HepG2) cell line, as well as a normal human lung fibroblast cell line (WI-38), and cisplatin was used as a standard reference drug. Among these complexes, the <strong>Pd2</strong> complex exhibited the most potent activity, especially against MDA-MB-231 (IC₅₀ = 5.53 ± 0.4 μM; selectivity index = 12.07). Antimicrobial activity was assessed against Gram-positive/negative bacteria, yeasts, and filamentous fungi. The <strong>Ni1</strong> and <strong>Ni2</strong> complexes showed superior antimicrobial effects compared to Pd complexes and the free ligand. These findings highlight the promising biological potential of these metal complexes, particularly <strong>Pd2</strong>, as anticancer and antimicrobial agents, warranting further exploration for biomedical applications.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"593 ","pages":"Article 123047"},"PeriodicalIF":3.2,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145882484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-infrared (NIR) luminescence of two Tm(III)-based dicarboxylate coordination polymers","authors":"Liying Zhang ,&nbsp;Yan Li ,&nbsp;Wenzhe Zhou ,&nbsp;Lu Gao ,&nbsp;Yong Fan ,&nbsp;Li Wang","doi":"10.1016/j.ica.2025.123044","DOIUrl":"10.1016/j.ica.2025.123044","url":null,"abstract":"<div><div>Two novel Tm(III)-based coordination polymers formulated as [Tm(2,5-dtc)(NO₃)(H₂O)]_<em>n</em> (<strong>1</strong>) (2,5-H₂dtc = thiophene-2,5-dicarboxylic acid) and {[Tm₂(OH-bdc)₂(H₂O)₁₀]·OH-bdc·H₂O}_<em>n</em> (<strong>2</strong>) (OH-H₂bdc = 5-hydroxyisophthalic acid) were synthesized hydrothermally. Compound <strong>1</strong> features a three dimensional (3D) pillared layer network containing [Tm₂(NO₃)₂]⁴⁺ units and 2,5-dtc²⁻ ligands. Compound <strong>2</strong> exhibits a 2D layer structure which is accomplished by connecting the 1D chain [Tm₂(bdc)₂(H₂O)₁₀]²⁺ to uncoordinated OH-bdc²⁻ ligands via <em>π···π</em> stacking interactions. The striking feature of compounds <strong>1</strong> and <strong>2</strong> is near-infrared (NIR) luminescence of Tm(III) ions with microseconds luminescence lifetimes, after being excitated at the maximum absorption of ligands. This may be attributed to the efficient energy transfer from the ligands (2,5-H₂dtc and OH-H₂bdc) to central Tm(III) ions via an antenna effect. In addition, compounds <strong>1</strong> and <strong>2</strong> display antiferromagnetic coupling in the solid state at room temperature.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"593 ","pages":"Article 123044"},"PeriodicalIF":3.2,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional behavior of alkaline selenite oxo-fluoro compounds, investigated by DFT for green tech applications","authors":"Nawishta Jabeen ,&nbsp;Ali Yaqoob ,&nbsp;Ahmad Hussain ,&nbsp;Aseel Smerat ,&nbsp;Mohamed A. Nassan ,&nbsp;Nidhal Ben Khedher","doi":"10.1016/j.ica.2025.123046","DOIUrl":"10.1016/j.ica.2025.123046","url":null,"abstract":"<div><div>DFT based simulations have been performed to investigate the structural, optoelectronics, thermodynamics and mechanical properties of double anionic structured (alkaline selenite oxo-fluoro) compounds (XSeO₃F where X = Y, Sc, La and Lu), which can present their potentials for the green energy applications. The choice of metallic cationic replacements within these structures is greatly influenced their dynamics stability and the ionic character. Among these compounds, SeO₃ counterpart is responsible for enhanced optical characteristics. All these compounds have presented wide indirect band gaps from 3.31 eV to 3.93 eV, followed by high values of optical properties like absorption (10⁵ cm⁻¹), optical conductivity (3 fs⁻¹–5 fs⁻¹). Moreover, no transparency is observed for the incident radiations range from 0 eV to 10 eV, which is confirmed by the values ε₁(ω) &gt; 0, and n(ω) &gt; 1. Reflectivity remains as low as 10 % within the visible region of incident light which is followed by low loss of dissipated energy within the compounds. Lower value of zero-point energy 0.767 eV for LuSeO₃F shows less vibrational frequencies indicating more stability as compared to other compounds. The convergence of heat capacity near the Dulong-Petit limit (74.9 cal/cell. K) reveals the thermal resistance showing potentials for high temperature electronics devices. Ductile nature has been confirmed for XSeO₃F (X = Y, Sc, and Lu) compounds by Poisson's and Pugh's ratios, but LaSeO₃F compound has demonstrated the more unique auxetic nature. These results suggest that alkaline selenite based oxo-fluoro compounds possess promising potential for next generation green technologies such as optoelectronic, tendon cells, and sustainable energy conversion devices.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"593 ","pages":"Article 123046"},"PeriodicalIF":3.2,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145882483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent detection and removal of Hg2+ from potable water using ZnAl2O4 modified end off Schiff base ligand: Experimental and theoretical investigation","authors":"Sneha Biswas ,&nbsp;Jaydeep Adhikary ,&nbsp;Rama Rathi ,&nbsp;Sreejeeb Ganguly ,&nbsp;Ennio Zangrando ,&nbsp;Abhijit Kumar Das","doi":"10.1016/j.ica.2025.123045","DOIUrl":"10.1016/j.ica.2025.123045","url":null,"abstract":"<div><div>A Schiff base ligand, <em>[4-Methyl-2,6-bis((E)-((2-(pyridin-2-yl)ethyl)imino)methyl)phenol]</em>, shortly Diformyl Amino Pyridine (<strong>DAP</strong>), has been developed as a homogeneous probe and characterized by different spectroscopic technique. Its fluorescence is quenched by Hg²⁺ binding, a process governed by multiple non-radiative pathways, including photoinduced electron transfer (PET) and heavy-atom effects, with a Stern-Volmer constant of 8.83 × 10⁸ M⁻¹ and a detection limit of 1.35 μM. To address limitations like reusability and sample matrix separation, the homogeneous probe <strong>DAP</strong> was converted into a heterogeneous solid-state material, ZnAl₂O₄ (<strong>ZA</strong>) conjugated <strong>DAP</strong> (<strong>ZDAP</strong>), by anchoring the imine ligand onto a ZA spinel. Surprisingly, this modification fundamentally altered the sensing mechanism. In contrast to <strong>DAP</strong>'s quenching, <strong>ZDAP</strong> exhibits a “turn-on” response via Aggregation-Induced Emission (AIE), where Hg²⁺ binding restricts intramolecular motion and enhances fluorescence. This results in a superior detection limit of 1.01 nM. ICP-MS analysis confirmed that treatment with the sensor resulted in nearly complete mercury removal, achieving up to 98.46 % elimination of mercury. The sensing mechanisms for both systems have been confirmed through DFT calculations and experimental techniques like Stern-Volmer analysis and time-resolved fluorescence spectroscopy. Theoretical calculations show excellent agreement with experimental HOMO-LUMO transitions, where the energy gap decreases from 2.28 eV (ZA) to 2.15 eV (<strong>ZDAP</strong>), causing a bathochromic shift in emission. The observed fluorescence quenching of <strong>DAP</strong> upon anchoring to ZA arises from strong ligand-metal interactions, charge transfer–induced non-radiative decay, structural rigidification, and surface defect trapping, consistent with the experimental (2.93 eV) band gap. Crucially, <strong>ZDAP</strong> demonstrated outstanding reusability, maintaining its sensing efficiency and structural integrity for at least five cycles after regeneration with a chelating agent. This work demonstrates how a single Schiff base platform can be engineered to deliver two complementary sensing modes, offering a sensitive, selective, and sustainable solution for mercury detection and removal.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"593 ","pages":"Article 123045"},"PeriodicalIF":3.2,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiophene based chemosensors: a comprehensive review on synthesis and detection of cations and anions","authors":"Zuverya Zareen ,&nbsp;Aram Rahman ,&nbsp;Anzar Jahan ,&nbsp;Salahuddin Syed ,&nbsp;Mohammad Arifuddin","doi":"10.1016/j.ica.2025.123042","DOIUrl":"10.1016/j.ica.2025.123042","url":null,"abstract":"<div><div>Thiophene based chemosensors have emerged as versatile and efficient molecular tools for the selective detection of a wide range of analytes, including metal cations and anions. The unique electronic properties, structural flexibility, and strong π-conjugation of thiophene derivatives make them highly suitable scaffolds for designing colorimetric and fluorescent probes. Reported thiophene based sensors have demonstrated remarkable sensitivity towards cations such as Hg²⁺, Cu²⁺, Zn²⁺, Ag⁺, Al³⁺, Pb²⁺,Fe³⁺,Cd²⁺, Au³⁺, Pd²⁺, Ni²⁺, Cr³⁺, Ga³⁺, Zr⁴⁺ as well as anions including I⁻, F⁻ and CN⁻. Their sensing mechanisms involve diverse photophysical processes including excited-state intramolecular proton transfer (ESIPT), intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET) and photoinduced electron transfer (PET). Several thiophene based chemosensors exhibit dual analyte recognition, enabling simultaneous detection of both cations and anions through reversible and selective interactions. Beyond fundamental sensing, applications extend to environmental monitoring and real sample analysis, underscoring their practical significance. The review concludes with detection mechanism of several thiophene based chemosensors as well as their practical applicability which may be useful for the synthesis of novel thiophene based chemosensor. Also highlights the sensing performances and comparison of them with some reported organic chemosensors.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"593 ","pages":"Article 123042"},"PeriodicalIF":3.2,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145882482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of gas-phase, group II metal hydride cations using preparative tandem mass spectrometry","authors":"Madeline R. Handel ,&nbsp;Samuel J. Lenze ,&nbsp;Lucas G. Fuller ,&nbsp;Theodore A. Corcovilos ,&nbsp;Michael J. van Stipdonk","doi":"10.1016/j.ica.2025.123043","DOIUrl":"10.1016/j.ica.2025.123043","url":null,"abstract":"<div><div>Interest in Main Group metal hydrides remains high because of their potential use as hydrogen storage materials and as green catalysts. However, the high reactivity of metal hydrides along with the solvent effects and complex equilibria of condensed phase studies makes study of their intrinsic chemistry a challenge. In principle, the challenge can be overcome by using ion preparation methods such as collision-induced dissociation to synthesize species within the relatively inert gas-phase environment of ion-trapping mass spectrometers. In this study, preparative (ion trap) tandem mass spectrometry (PTMSⁿ) was used to generate a series of binary, gas-phase metal hydride cations. In particular, we show that the relatively inert environment of a quadrupole ion trap permits (a) the synthesis of discrete, group II metal hydride cations, [MetH]⁺ (Met = Ca, Sr, Ba) and (b) allows for monitoring of intrinsic reactions with neutral species such as H₂O and CH₂Cl₂. When exposed to H₂O, the [MetH]⁺ cations undergo a hydrolysis reaction to form the respective cationic, metal hydroxides. When allowed to react with CH₂Cl₂, two reaction pathways are observed, one leading to formation of [Met(CHCl₂)]⁺ (with elimination of neutral H₂) and the other producing [MetCl]⁺ (by elimination of CH₃Cl). The reactions to generate the [MetH]⁺ cations, and the ion-molecule reactions with H₂O and CH₂Cl₂, were modeled using density functional theory (DFT) and 2nd – order Moller-Plesset (MP2) calculations to provide optimized structures of reactants, intermediates, products and transition states. In general, the computed enthalpies and free energies for the reactions are in good qualitative agreement with the experimental outcomes.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"592 ","pages":"Article 123043"},"PeriodicalIF":3.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, structure and photooxidative dehydrogenation of chiral Ir(III) valine complexes based on precursor [Λ-Ir(dfppy)2(MeCN)2](PF6)","authors":"Manli Cao ,&nbsp;Suyang Yao ,&nbsp;Lulu Ren,&nbsp;Zhiyu Zhao,&nbsp;Shaojun Mao,&nbsp;Shengqiang Jiang","doi":"10.1016/j.ica.2025.123041","DOIUrl":"10.1016/j.ica.2025.123041","url":null,"abstract":"<div><div>Octahedral chiral-at-Ir(III) complexes exhibit high structural stability and stereoselectivity in asymmetric synthesis. These properties enable them to serve as efficient chiral templates, inducing asymmetry in coordinated ligands. In our previous work, we have proved such chiral-at-Ir(III) complexes could coordinate to commercial amino acids and further oxidative dehydrogenation to imines. To further investigate this oxidative dehydrogenation process in complexes with different cyclometalating ligands, here we employed a fluoro-substituted 2-(2,4-difluorophenyl)pyridine (dfppy) as a cyclometalating ligand to synthesize the chiral Ir(III) precursor Λ-[Ir(dfppy)₂(MeCN)₂]PF₆. This complex was coordinated with <em>D</em>- and <em>L</em>-valine to yield two diastereomeric complexes, Λ-[Ir(dfppy)₂(<em>D</em>-val)] and Λ-[Ir(dfppy)₂(<em>L</em>-val)] (Val is Valine). The structure and oxidative dehydrogenation ability of these obtained diastereomers were investigated. Under visible-light irradiation, both complexes underwent dehydrogenative oxidation of the valine moiety and Λ-[Ir(dfppy)₂(<em>D</em>-val)] exhibited faster photooxidation kinetics than its L-valine counterpart. Their component, structural and photophysical properties were characterized by ¹H NMR, mass spectrometry, single-crystal X-ray diffraction, UV–vis spectra and emission spectra.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"593 ","pages":"Article 123041"},"PeriodicalIF":3.2,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145882485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, photophysicochemical and electrochemical properties of new peripheral tetra-substituted Zn(II) phthalocyanines bearing quinoline groups","authors":"Barış Seçkin Arslan ,&nbsp;Nagihan Öztürk ,&nbsp;Mehmet Nebioğlu ,&nbsp;İlkay Şişman","doi":"10.1016/j.ica.2025.123040","DOIUrl":"10.1016/j.ica.2025.123040","url":null,"abstract":"<div><div>This study focuses on the synthesis of novel zinc phthalocyanines containing tetra-((6,7,8-trimethoxytetrazolo[1,5-<em>a</em>]quinolin-4-yl)methoxy) and tetra-((2,5,6,7-tetramethoxyquinolin-3-yl)methoxy) substituents and the investigation of their photodynamic therapy (PDT) properties. Two novel phthalonitrile derivatives bearing trimethoxytetrazolo (<strong>5a</strong>) and tetramethoxy (<strong>5b</strong>) quinoline moieties and their corresponding peripherally substituted zinc(II) phthalocyanine complexes (<strong>BIM8</strong> and <strong>BIM9</strong>) were synthesized. The molecular structures of these compounds were verified by FT-IR, NMR, UV–Vis spectroscopy, and mass spectrometry. The photophysical, photochemical, and electrochemical properties of the zinc phthalocyanines were systematically investigated to evaluate their potential application in PDT. Compared to <strong>BIM8</strong>, <strong>BIM9</strong> exhibited superior photochemical performance, including a high singlet oxygen quantum yield (ɸ_Δ = 0.89), negligible aggregation tendency, sufficient fluorescence emission for imaging purposes, and notable photostability. These results demonstrate that <strong>BIM9</strong> is a promising photosensitizer candidate for PDT.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"592 ","pages":"Article 123040"},"PeriodicalIF":3.2,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligand design and catalytic performance of Quinone-oxime copper complexes: role of intramolecular hydrogen bonding","authors":"Vivek Mokashi ,&nbsp;Sourav Datta ,&nbsp;Swapan Patra ,&nbsp;Priyabrata Banerjee ,&nbsp;Sunita Salunke-Gawali","doi":"10.1016/j.ica.2025.123039","DOIUrl":"10.1016/j.ica.2025.123039","url":null,"abstract":"<div><div>Transition metal complexes bearing redox-active ligands often exhibit multiple accessible oxidation states resulting from the electronic interplay between the metal center and the coordinated ligand framework. This study focused on the synthesis and characterization of two mononuclear copper (II) complexes incorporating redox active ligands, 3-hydroxy-4-(hydroxyimino)naphthalen-1(4H)-one(<strong>LwOx</strong>) and 3-hydroxy-4-(methoxyimino)naphthalen-1(4H)-one (<strong>LwOx-Me</strong>), the ligands differ structurally by the substitution of hydrogen atom with a methyl group in the ligand oxime backbone, this small change affects the ability of the ligand to form intramolecular hydrogen bonds within metal complexes. Remarkably, both metal complexes display multiple redox events attributed to the combined redox-active nature of quinoneoxime-based ligands and the copper(II) center. Furthermore, both complexes were evaluated as catalysts in the oxidation of alcohols. <strong>[Cu(LwOx)</strong>_{<strong>2</strong>}<strong>]</strong> exhibited excellent catalytic activity, whereas <strong>[Cu(LwOx-Me)</strong>_{<strong>2</strong>}<strong>]</strong> showed negligible activity; DFT studies suggest the crucial role of intramolecular hydrogen bonding in modulating the catalytic activity of Cu(II) complexes.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"592 ","pages":"Article 123039"},"PeriodicalIF":3.2,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145787876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic strategy, structural aspects and biological applications of multinuclear cadmium complexes using salen type N2O2 donor ligands and N2O2O2′ donor compartmental ligands: A review","authors":"Puspendu Middya ,&nbsp;Siddhartha Majhi ,&nbsp;Shouvik Chattopadhyay","doi":"10.1016/j.ica.2025.123029","DOIUrl":"10.1016/j.ica.2025.123029","url":null,"abstract":"<div><div>Cadmium(II) complexes with salen- and salpn-type Schiff base ligands have gained increasing attention for their structural versatility, diverse coordination geometries, and notable biological potential. This review summarizes recent advances in their synthesis, spectral and structural characterization, and bioactivity. The flexible coordination of Cd(II) and the chelating nature of Schiff bases promote the formation of di- and polynuclear architectures, often stabilized by bridging ligands. Structural insights from X-ray studies and their correlation with antimicrobial, antifungal, anticancer, and enzyme-inhibitory activities are discussed. Despite cadmium's inherent toxicity, rational ligand design has yielded complexes with enhanced bioactivity and reduced cytotoxicity. Key challenges and prospects for developing Cd(II) Schiff base complexes as therapeutic and functional materials are also highlighted.</div></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"592 ","pages":"Article 123029"},"PeriodicalIF":3.2,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}