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Renal Metastasis from Submandibular Gland Adenocarcinoma First Reported Patient in Literature History 文献报道首例颌下腺腺癌肾转移病例
Pub Date : 2019-07-02 DOI: 10.22374/JELEU.V2I3.30
M. Ahmed, N. Tofazzal, R. Nirula, J. Thomas, A. Dhanasekaran
This paper presents a patient of primary submandibular gland adenocarcinoma later presenting with renal metastasis. Renal cancers are known for its predisposition to unusual metastasis to other organs. On the contrary, renal metastasis from salivary gland tumours are extremely rare with none reported from the submandibular gland to date. Hence the significance of adequate history taking, immunohistochemical identification of pathology and multidisciplinary approach in the management of such rare clinical presentation is discussed here. Metastatic disease should always be a differential when evaluating cancer patients regardless of the interval since previous disease or rarity of occurrence.
本文报告一例原发性颌下腺腺癌后出现肾转移的病例。众所周知,肾癌易发生不寻常的器官转移。相反,唾液腺肿瘤的肾转移极为罕见,迄今为止尚未有颌下腺肿瘤转移的报道。因此,本文讨论了充分的病史记录、病理免疫组织化学鉴定和多学科方法在治疗这种罕见临床表现中的重要性。在评估癌症患者时,转移性疾病应始终作为一种鉴别因素,而不管之前疾病发生的时间间隔或罕见程度。
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引用次数: 0
Spindle Cell Lipoma of Scrotum 阴囊梭形细胞脂肪瘤
Pub Date : 2019-06-11 DOI: 10.22374/JELEU.V2I2.46
M. Iqbal, S. Agarwal, I. Shergill
Spindle cell lipoma (SCL) in the scrotum is a very rare presentation with only a few cases reported in the literature. The most common sites for this benign lesion are the neck, shoulder, and back. We present a 72-year-old male patient with painless swelling on the left half of the scrotum with a histopathological diagnosis of SCL.
在阴囊梭形细胞脂肪瘤(SCL)是一个非常罕见的表现,只有少数病例报道在文献中。这种良性病变最常见的部位是颈部、肩部和背部。我们提出一个72岁的男性患者无痛肿胀的左半阴囊与组织病理学诊断为SCL。
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引用次数: 0
A Retrospective Audit of the TURBT Quality in Two Major Cancer Centres in Lancashire 兰开夏郡两个主要癌症中心TURBT质量的回顾性审计
Pub Date : 2019-06-03 DOI: 10.22374/JELEU.V2I2.41
K. Hosny, Jennifer Clark, M. Nosseir, M. Al-Attar, Mohammad Masaarane, N. Cockburn, Izzati Samsudin
Transurethral resection of bladder tumour (TURBT) is the first step in management of bladder cancers. A urology trainee in the UK must do at least 120 procedures during their training years before being a consultant. In our article, we are reporting a retrospective audit of the quality of TURBT across 2 major cancer centres in Lancashire. We assessed the adherence of surgical procedure to the national and international guidelines among different grades of urological surgeons who work in the 2 trusts.
经尿道膀胱肿瘤切除术(turt)是治疗膀胱癌的第一步。在英国,一名泌尿外科实习生在成为一名顾问之前,必须在培训期间至少做过120次手术。在我们的文章中,我们报告了对兰开夏郡2个主要癌症中心的TURBT质量的回顾性审计。我们评估了在两家医院工作的不同级别的泌尿外科医生对国家和国际指南的手术依从性。
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引用次数: 0
Comparison of Efficacy and Safety between Post-operative Intra-vesical Instillation of Mitomycin-C and Continuous Saline Bladder Irrigation (CSBI) after TURBT in Non-muscle Invasive Bladder Cancers 非肌性浸润性膀胱癌TURBT术后膀胱内灌注丝裂霉素c与持续膀胱盐水冲洗(CSBI)的疗效和安全性比较
Pub Date : 2019-05-27 DOI: 10.22374/JELEU.V2I2.40
A. Bhat, Z. Bhat
ObjectiveTo critically analyse the efficacy and safety of continuous saline bladder irrigation versus single installation of mitomycin-C (MMC) after transurethral resection of bladder tumour (TURBT) in patients with low to intermediate risk non-muscle invasive bladder cancer. Materials and MethodsThe question in consideration best merits answer by critically reviewing and analyzing the literature and finally to provide the recommendation about the relevance of the conclusions from the literature. A search study identifies the relevant literature from the well-known academic databases in the context of the re-search question. The particular sets of the key words are used in different formats to search the literature. The literature has been thoroughly reviewed and analyzed for the strengths and limitations. Specific data was critically taken for analysis depending upon the type of literature articles with special reference to their usefulness, knowledge, attitudes, transferability, validity/reliability and strength of conclusions. ResultsA total of 6 papers meeting the inclusion criteria, which compared the results of the efficacy and safety between intravesical chemotherapy and continuous saline bladder irrigation (CSBI) were critically analyzed. ConclusionCSBI cannot replace MMC in terms of its efficacy in the prevention of recurrence and progression but because of the better safety profile can be used as an alternative in patients with low to intermediate risk bladder cancers after TURBT.
目的比较低至中危非肌肉浸润性膀胱癌经尿道膀胱肿瘤切除术(TURBT)后持续盐水膀胱冲洗与单次应用丝裂霉素c (MMC)的疗效和安全性。材料和方法考虑的问题最好通过批判性地回顾和分析文献来回答,最后提供有关文献结论相关性的建议。在研究问题的背景下,搜索研究从知名的学术数据库中识别相关文献。以不同的格式使用特定的关键字集来搜索文献。文献已经彻底审查和分析的优势和局限性。根据文献文章的类型,特别参考文献文章的有用性、知识、态度、可转移性、有效性/可靠性和结论的强度,严格地采用具体数据进行分析。结果对符合入选标准的6篇论文进行了批判性分析,比较了膀胱内化疗与持续盐水膀胱灌洗(CSBI)的疗效和安全性。结论csbi在预防复发和进展方面不能替代MMC,但由于csbi具有更好的安全性,可作为低至中危膀胱癌患者TURBT术后的替代方案。
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引用次数: 0
Connecting the Urological Community : The #UroSoMe Experience 连接泌尿外科社区:#UroSoMe体验
Pub Date : 2019-05-14 DOI: 10.22374/JELEU.V2I2.44
Kalyan Gudaru, L. T. Blanco, D. Castellani, Hegel Trujillo Santamaria, M. Pelayo-Nieto, E. Linden‐Castro, M. Wroclawski, Mateus Cosentino Bellote, J. Inarritu, R. D. da Silva, V. Gauhar, Zainal Adwin, J. Teoh
Background and Objectives There is an increasing use of social media amongst the urological community. However, it is difficult to identify urological data on various social media platforms in an efficient manner. We proposed a hashtag, #UroSoMe, to be used when posting urology-related content in the social media platforms. The objectives of this article are to describe how #UroSoMe was developed, and to report the data of the first month of #UroSoMe.   Material and Methods The hashtag, #UroSoMe, was introduced to the urological community. The #UroSoMe working group was formed, and the members actively invited and encouraged people to use the hashtag #UroSoMe when posting urology-related contents. After the #UroSoMe (@so_uro) platform on twitter had grown to more than 300 users, the first live event of online case discussion, i.e. #LiveCaseDiscussions, was conducted. A prospective observational study of the hashtag #UroSoMe Twitter activity during the first month of its usage from 14 December 2018 to 13 January 2019 was evaluated. Outcome measures included number of users, number of tweets, user location, top tweeters, top hashtags used and interactions. Analysis was performed using NodeXL (Social Media Research Foundation; California, USA; https://www.smrfoundation.org/nodexl/), Symplur (https:// www.symplur.com) and Twitonomy (https://www.twitonomy.com).   Results The first month of #UroSoMe activity documented 1373 tweets/retweets by 1008 tweeters with 17698 mentions and 1003 replies. The #LiveCaseDiscussions was able to achieve a potential reach of 2,033,352 Twitter users. The top tweets mainly included cases presented by #UroSoMe working group members during #LiveCaseDiscussions. The twitonomy map showed participation from 214 geographical locations. The major groups of participants using the hashtag #UroSoMe were ‘Researcher/Academic’ and ‘Doctor’. The twitter account of #UroSoMe (@so_uro) has now grown to more than 1000 followers.   Conclusions Social media is an excellent platform for interaction amongst the urological community. The results demonstrated that #UroSoMe was able to achieve wide spread engagement from all over the world.
背景与目的泌尿外科社区越来越多地使用社交媒体。然而,很难有效地识别各种社交媒体平台上的泌尿科数据。我们提议在社交媒体平台上发布泌尿科相关内容时使用#UroSoMe标签。本文的目的是描述#UroSoMe是如何发展的,并报告#UroSoMe第一个月的数据。#UroSoMe标签被引入泌尿界。#UroSoMe工作组成立了,成员们积极邀请和鼓励人们在发布泌尿相关内容时使用#UroSoMe标签。在推特上的#UroSoMe (@so_uro)平台发展到300多名用户后,发起了第一个在线案例讨论的现场活动,即#LiveCaseDiscussions。对#UroSoMe标签在2018年12月14日至2019年1月13日使用的第一个月内的Twitter活动进行了前瞻性观察研究。结果指标包括用户数量、推文数量、用户位置、最热门的推特用户、使用的最热门标签和互动。分析采用NodeXL (Social Media Research Foundation;美国加州;https://www.smrfoundation.org/nodexl/)、Symplur (https:// www.symplur.com)和Twitonomy (https://www.twitonomy.com)。结果#UroSoMe活动的第一个月记录了1008名推特者的1373条推文/转发,17698次提及和1003次回复。#LiveCaseDiscussions能够达到2,033,352个Twitter用户的潜在覆盖范围。排名靠前的推文主要包括#UroSoMe工作组成员在# livecasediscussion中提出的案例。twitonomy地图显示了来自214个地理位置的参与。使用#UroSoMe标签的主要参与者群体是“研究员/学者”和“医生”。#UroSoMe (@so_uro)的推特账号现在已经有1000多名粉丝。结论社交媒体是泌尿外科交流的良好平台。结果表明,#UroSoMe能够获得来自世界各地的广泛参与。
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引用次数: 16
Review of IPSS Questionnaire in Postoperative Transurethral Resection of Prostate (TURP) for Streamlining Follow-up Protocols 经尿道前列腺切除术(TURP)术后IPSS问卷的回顾,以简化随访方案
Pub Date : 2019-05-07 DOI: 10.22374/JELEU.V2I2.36
G. Broadley, G. Delves, S. Khwaja
ObjectiveClarify the role of IPSS questionnaire for post TURP operation patients, to assess and streamline best follow-up protocols Materials and MethodsWe identified 87 consecutive patients over 6 months undergoing standardized bipolar TURP. We retro-spectively reviewed patients at 3 months in follow-up clinic, where we performed tests including Qmax, Post-void residual (PVR) and IPSS (International Prostate Symptom Score). We identified patients who were discharged or underwent a change in standard management at this point, and used ROC (Receiver Operating Curve) curve analysis to identify the tools which showed the best ability to predict this decision. ResultsROC curve analysis suggested Qmax (AUC: 0.7751) and IPSS (AUC 0.8571) were the best tools to predict a change in management. Given the IPSS tool is a questionnaire, thus holding most promise to streamline protocols, we applied Youden-J test to show IPSS=8 cut-off was best to identify management changes. ConclusionThe IPSS tool is able to predict a need for change in management in post TURP patients at 3 months. This will allow a simple triage system to provide an efficient and effective decision-making process for discharge without the need for clinic attendance.
目的明确IPSS问卷在TURP术后患者中的作用,以评估和简化最佳随访方案。材料和方法我们确定了87例连续6个月以上接受标准化双极TURP的患者。我们在随访3个月的临床中对患者进行回顾性研究,在那里我们进行了Qmax,后虚空残留(PVR)和IPSS(国际前列腺症状评分)的测试。我们确定了此时出院或接受标准管理改变的患者,并使用ROC(接受者工作曲线)曲线分析来确定最能预测该决定的工具。结果roc曲线分析显示,Qmax (AUC: 0.7751)和IPSS (AUC: 0.8571)是预测管理变化的最佳工具。鉴于IPSS工具是一份问卷,因此最有希望简化协议,我们应用Youden-J测试来显示IPSS=8截止值是识别管理变化的最佳方法。结论IPSS工具能够预测TURP术后患者在3个月时是否需要改变治疗方法。这将允许一个简单的分诊系统,为出院提供一个高效和有效的决策过程,而不需要诊所出席。
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引用次数: 1
A Systematic Review and Single-Centre Experience of Ureterorenoscopy Under Local Anesthetic: A Safer Option for Anesthetically High-Risk Patients? 局部麻醉输尿管镜检查的系统评价和单中心经验:麻醉高危患者的安全选择?
Pub Date : 2019-04-29 DOI: 10.22374/JELEU.V2I2.39
A. Tasleem, S. Yallappa, M. Mikhail, T. Amer, Peter Pietrzak, P. Acher, A. Young
Patients are living longer with an increasing number of co-morbidities. Minimally invasive ureterorenoscopy (URS) to manage upper tract calculi or transitional cell carcinoma (TCC) can be performed under general or spinal anaesthesia, however certain co-morbid patients are not suitable for this and may benefit from a different approach. We report on URS under local anaesthesia (LA) using intra-ureteric marcaine as the primary form of anaesthesia. We also aimed to perform a robust systematic review of this topic.   A retrospective analysis over 6 years was undertaken on all patients who underwent URS for calculi or TCC under LA, with the use of intra-urethral lidocaine gel (2%) and intra-ureteric marcaine (0.5%, 20ml) with sedoanalgesia as an adjunct. A systematic review and all English Language articles on ureteroscopic procedures with the use of LA with or without intravenous sedoanalgesia were selected and data extracted.   In our case series, twelve patients had a total of 42 procedures. Stone size varied from 4-35mm. Twenty-two percent of procedures (9/41) did not require any sedation or intravenous analgesia as an adjunct to the bupivacaine with a further 49% (20/41) requiring midazolam. (The anaesthetic chart was not available for one procedure). No procedures were abandoned and there were no conversions to general/spinal anaesthesia. There were no complications secondary to the use of LA. Eighty-one percent of cases (34/42) were performed as day-case or overnight stays. The complication rate was similar to that for conventional anaesthesia. The systematic review yielded 1121 procedures from 11 papers and 7 countries. In 32 cases the procedure was converted to general anaesthesia.  Stone clearance rates were between 78-100%. The procedures were well tolerated in 80-90% of cases.   This study highlights that URS can be safely performed under LA. It is well tolerated and represents an option for carefully selected patients who have been adequately counselled, and who would be at high risk from anaesthesia. Such patients may otherwise be considered “unfit” for endourological intervention.    
患者的寿命越来越长,同时出现的合并症也越来越多。微创输尿管镜(URS)治疗上尿路结石或移行细胞癌(TCC)可以在全身麻醉或脊髓麻醉下进行,但某些合并症患者不适合这样做,可能从不同的方法中获益。我们报道了局部麻醉(LA)下URS使用输尿管内麻醉药作为主要麻醉形式。我们还旨在对这一主题进行强有力的系统回顾。我们对所有在LA下因结石或TCC而行尿路治疗的患者进行了为期6年的回顾性分析,同时使用了尿道内利多卡因凝胶(2%)和输尿管内卡因(0.5%,20ml),并辅以sedo镇痛。对输尿管镜手术中使用LA伴或不伴静脉sedo镇痛的所有英文文献进行系统回顾并提取数据。在我们的病例系列中,12名患者总共进行了42次手术。石料大小从4-35毫米不等。22%的手术(9/41)不需要任何镇静或静脉镇痛作为布比卡因的辅助,另外49%(20/41)需要咪达唑仑。(没有一个手术的麻醉图表)。没有手术被放弃,也没有转到全身/脊髓麻醉。使用LA后无继发并发症。81%的病例(34/42)作为日间病例或过夜住院。并发症发生率与常规麻醉相似。系统评价产生了来自7个国家11篇论文的1121个程序。32例手术转为全身麻醉。结石清除率在78-100%之间。在80-90%的病例中,手术耐受良好。本研究强调在LA下URS可以安全进行。它具有良好的耐受性,是经过精心挑选的患者的一种选择,这些患者接受了充分的咨询,并且处于麻醉的高风险中。否则,这些患者可能被认为“不适合”进行泌尿系统介入治疗。
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引用次数: 2
Holmium Laser Treatment of an Obstructive Ureterocele in an Adult Patient: A Case Report and Video 钬激光治疗梗阻性输尿管囊肿1例报告及视频
Pub Date : 2019-02-21 DOI: 10.22374/JELEU.V2I1.27
O. Abdalla, Y. C. Phan, S. Sriprasad
Adult Ureteroceles are uncommon, majority of which are asymptomatic and commonly found incidentally. Surgical deroofing is indicated in patients with bothersome symptoms or complications secondary to ureteroceles. Several deroofing techniques has been described in the literature including nephroscopic scissors, collin's knife, and use of lasers in the last two decades became popular.  Herein we report a case and demonstare our technique of using Holmium laser to treat an adult with symptomatic obstructive unilateral ureterocele. 
成人输尿管囊肿并不常见,大多数是无症状的,通常是偶然发现的。输尿管囊肿继发有麻烦症状或并发症的患者需要手术切除。文献中描述了几种清除技术,包括肾镜剪刀、科林刀和激光的使用,在过去的二十年中变得流行起来。在此,我们报告一个病例,并展示我们的技术,使用钬激光治疗成人有症状的单侧输尿管梗阻性囊肿。
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引用次数: 0
Thulium Laser Vaporization versus Vapoenucleation (without morcellation) Technique for BPH: Do We Have a Winner? 铥激光汽化与汽化(无粉碎)技术治疗BPH:我们有赢家吗?
Pub Date : 2019-02-15 DOI: 10.22374/jeleu.v2i1.26
D. Sarma, Y. Singh, S. J. Baruah, T. P. Rajeev, S. Barua, P. K. Bagchi, Mandeep Phukan, M. Kashyap
Background and ObjectiveThe thulium laser surgery is a relatively new approach in which a wavelength of approximately 2 μm is emitted in continuous-wave mode, thus enabling the precise incision of tissue by using a wavelength that matches the water absorption peak of 1.92 μm in tissue. However, no published multinational study or other evidence definitively declares the superiority of thulium vaporization (ThuVAP) over thulium vapoenucle-ation (ThuVEP) without morcellator for better management of bothersome benign prostatic hyperplasia. The present study aims to evaluate the efficacy of vaporization and vapoenucleation (without a morcellator) in thulium laser prostatectomy for the treatment of benign prostatic hyperplasia.MethodsA retrospective analysis of 82 patients who underwent thulium laser prostatectomy between February 2017 and January 2018 with ThuVAP and ThuVEP techniques was done and outcome measures analyzed were International Prostate Symptom Score (IPSS), quality-of-life score (QoL), maximum flow rate (Q max), post-void residual (PVRU), total operating time, laser time and resected tissue weight.ResultsNo significant differences were noted between ThuVAP and ThuVEP in terms of post-operative prostate volume (22.4 vs. 21.7 mL) and post-operative prostate specific antigen (PSA) (2.54 vs. 1.85 ng/mL). Nonetheless, there were differences between the groups in total lasing time (56.5 vs. 44.8 min, p = 0.001) and total operative time (88.5 vs. 71.5 min, p= 0.001). There was also a significant difference in IPSS, QoL score, Q max, and PVRU at 6 weeks, 3 months, 6 months and 9 months after surgery.
背景与目的铥激光手术是一种相对较新的手术方式,其波长约为2 μm,以连续波模式发射,从而利用与组织中1.92 μm的吸水峰相匹配的波长来精确切割组织。然而,没有发表的多国研究或其他证据明确表明,在治疗恼人的良性前列腺增生方面,铥汽化(ThuVAP)优于无粉碎剂的铥汽化核(ThuVEP)。本研究旨在评估汽化和汽化核(无粉碎器)在铥激光前列腺切除术中治疗良性前列腺增生的疗效。方法回顾性分析2017年2月至2018年1月期间采用ThuVAP和ThuVEP技术行铥激光前列腺切除术的82例患者,分析结局指标为国际前列腺症状评分(IPSS)、生活质量评分(QoL)、最大血流率(Q max)、空后残留(PVRU)、总手术时间、激光时间和切除组织重量。结果两组患者术后前列腺体积(22.4 vs. 21.7 mL)和前列腺特异性抗原(PSA) (2.54 vs. 1.85 ng/mL)差异无统计学意义。然而,两组在总激光照射时间(56.5 vs. 44.8 min, p= 0.001)和总手术时间(88.5 vs. 71.5 min, p= 0.001)上存在差异。术后6周、3个月、6个月、9个月IPSS、QoL评分、qmax、PVRU差异均有统计学意义。
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引用次数: 1
Novel Surgical Treatments for Benign Prostatic Hyperplasia 良性前列腺增生的新手术治疗方法
Pub Date : 2019-01-31 DOI: 10.22374/JELEU.V2I1.29
Blessing Dhliwayo, S. Mukhtar
Transurethral resection of the prostate (TURP) has been the gold standard for the treatment of elderly men with lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). However, over the last few years, advances in surgical treatment have led to the development of other treatment modalities. These innovations include convective WAter Vapor Energy (WAVE; Rezum System), prostatic urethral lift (PUL; UroLift System), Prostate Artery Embolisation (PAE) and Aquablation (AQUABEAM System). This review provides an update on these current minimal invasive surgical treatments. The evidence of their safety, tolerability and efficacy in clinical practice is reviewed.
经尿道前列腺切除术(TURP)一直是治疗老年男性由良性前列腺增生(BPH)引起的下尿路症状(LUTS)的金标准。然而,在过去的几年里,外科治疗的进步导致了其他治疗方式的发展。这些创新包括对流水蒸汽能(WAVE);Rezum系统),前列腺尿道提升(PUL;前列腺动脉栓塞(PAE)和水消融(AQUABEAM系统)。本文综述了目前微创手术治疗的最新进展。在临床实践中对其安全性、耐受性和有效性的证据进行了综述。
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引用次数: 1
期刊
Journal of Endoluminal Endourology
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