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A case of frontotemporal dementia in the shadow of schizophrenia diagnosis 精神分裂症阴影下额颞叶痴呆1例
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300312
S. Arslan, B. Yucens, Cengiz Çelebi
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引用次数: 0
Update on research into the genetics and pharmacogenetics of bipolar disorder 双相情感障碍的遗传学和药物遗传学研究进展
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN20173003001
T. Schulze, Selen Ozkan
Bipolar disorder (BD) is a severe mental disorder that is characterized by recurrent episodes of mania, and depression. The phenotypic expression can be complemented by suicidal behavior, psychosis, comorbid anxiety, substance abuse, and rapid cycling (1). With a prevalence of ~1% and high risk of morbidity, it is a major health problem (2). BD has been shown to be a highly heritable disease, with concordance rates being ~85% within twin studies (3). As in other psychiatric disorders, polygenic components have a role in the liability of the disorder. The combination of both genetic and environmental effects influence the risk of developing the disorder. Up to date, there have been several studies of BD including linkage analysis, candidate gene studies, and genomewide association studies (GWAS). Moreover, it has been established that there is a genetic correlation between BD and schizophrenia conferred by common genetic variation, so called single nucleotide polymorphisms (SNPs), suggesting a shared genetic etiology between these diagnostic entities (4). Yet, our knowledge of the role of genetic factors in susceptibility of BD is still limited. Given the fact that BD is a highly heterogeneous disorder, studies with more homogenized groups that gather samples with more specific properties, such as subphenotypes of BD or patients positively responsive to specific drug treatments, may help improve the efficiency of studies. Main challenges in the treatment of BD, as in other disorders, are the differences of response to treatment within patients. Furthermore, adverse events and metabolic conditions caused by mood stabilizers and/ or antipsychotic drugs can affect the treatment procedure of a patient (5).
双相情感障碍(BD)是一种严重的精神障碍,其特征是反复发作的躁狂和抑郁。表型表达可以由自杀行为、精神病、共病焦虑、药物滥用和快速循环补充(1)。患病率约为1%,发病率高,是一个主要的健康问题(2)。双相障碍已被证明是一种高度遗传性疾病,在双胞胎研究中,一致性率约为85%(3)。与其他精神疾病一样,多基因成分在该疾病的倾向性中起作用。遗传和环境影响的结合影响了患这种疾病的风险。迄今为止,对双相障碍的研究包括连锁分析、候选基因研究和全基因组关联研究(GWAS)。此外,已经确定双相障碍和精神分裂症之间存在遗传相关性,这是由共同的遗传变异所赋予的,即所谓的单核苷酸多态性(SNPs),这表明这些诊断实体之间具有共同的遗传病因学(4)。然而,我们对遗传因素在双相障碍易感性中的作用的了解仍然有限。鉴于双相障碍是一种高度异质性的疾病,采用更均匀的组进行研究,收集具有更具体性质的样本,如双相障碍的亚表型或对特定药物治疗有积极反应的患者,可能有助于提高研究效率。与其他疾病一样,治疗双相障碍的主要挑战是患者对治疗的反应差异。此外,由情绪稳定剂和/或抗精神病药物引起的不良事件和代谢状况会影响患者的治疗过程(5)。
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引用次数: 0
Retrospective analysis of sociodemographic characteristics of inpatients at Kayseri Research and Training Hospital AMATEM Clinic 开塞利研究与培训医院AMATEM诊所住院患者社会人口学特征回顾性分析
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300309
H. Karaagac, Z. Usta, A. Usta, Merve Gumus Yarmali, A. Godekmerdan
Objective: The purpose of this study is to retrospectively determine the sociodemographic characteristics of inpatients with the diagnoses of alcohol and substance use disorder in AMATEM (Research, Treatment and Training Center for Alcohol and Substance Dependence) clinic of Kayseri Training and Research Hospital. Methods: Medical records of 1222 patients who were hospitalized at AMATEM clinic of Kayseri Training and Research Hospital between the years 2007-2015 were analyzed retrospectively and the obtained data were recorded on data sheets prepared by us. Statistical evaluation of the data was recorded in a database prepared by SPSS 23 software. Chi-square test was used for descriptive analyzes. The confidence level was taken as 95% and the statistical significance limit was accepted as p
目的:回顾性分析开塞利培训和研究医院酒精和物质依赖研究、治疗和培训中心诊断为酒精和物质使用障碍的住院患者的社会人口学特征。方法:回顾性分析2007-2015年在开塞利培训与研究医院AMATEM门诊就诊的1222例患者的病历,并将所得资料记录在自行制作的资料表上。数据的统计评价记录在SPSS 23软件编制的数据库中。描述性分析采用卡方检验。置信水平取95%,统计学显著性极限取p
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引用次数: 13
The relationship between harming behavior and substance use profile, and attention deficit hyperactivity disorder symptoms in antisocial personality disorder 反社会型人格障碍中伤害行为与物质使用及注意缺陷多动障碍症状的关系
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300303
O. Durmaz
The relationship between harming behavior and substance use profile, and attention deficit hyperactivity disorder symptoms in antisocial personality disorder Objective: The aim of this study was to investigate the relationship between substance use and harming behavior profile, and attention deficit hyperactivity disorder (ADHD) symptoms in young adult male population diagnosed with antisocial personality disorder (ASPD). Method: The study enrolled 119 ASPD subjects who reported substance use history. All participants were administered sociodemographic data and clinical information form, Addiction Profile Index (API), and Adult ADD/ADHD DSM IVBased Diagnostic Screening and Rating Scale (Adult ADHD Scale). Results: The diagnosis subscale of API and hyperactivity/impulsivity subscale of Adult ADHD Scale scores were significantly higher in subjects with a history of suicide attempt. All subscales of Adult ADHD scale and all API subscales other than motivation subscale scores were significantly higher in forensic cases. In pairwise comparison, attention deficit, hyperactivity/impulsivity and total scores of Adult ADHD scale were significantly higher in moderate and high level addiction groups than low level addiction group. There was a significant correlation between all subscales of Adult ADHD scale and API except motivation subscale. Conclusion: Our study suggests a considerable relationship between substance use profile and harming behavior, and ADHD symptoms in people with ASPD.
反社会人格障碍中伤害行为与物质使用特征、注意缺陷多动障碍症状的关系目的:探讨反社会人格障碍年轻成年男性人群中物质使用与伤害行为特征、注意缺陷多动障碍(ADHD)症状的关系。方法:研究招募了119名有药物使用史的反社会人格障碍患者。所有参与者都接受了社会人口学数据和临床信息表、成瘾概况指数(API)和基于成人ADHD /ADHD DSM iv的诊断筛查和评定量表(成人ADHD量表)。结果:有自杀企图史的被试在API诊断分量表和ADHD多动/冲动分量表得分均显著高于有自杀企图史的被试。成人ADHD量表和API量表除动机量表得分外,其他各量表得分均显著高于法医病例。两两比较,中度和高度成瘾组的注意缺陷、多动/冲动和成人ADHD量表总分显著高于低水平成瘾组。成人ADHD量表除动机量表外,其余各分量表与API均有显著相关。结论:我们的研究表明,在反社会障碍患者中,物质使用状况和伤害行为以及ADHD症状之间存在相当大的关系。
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引用次数: 1
Turkish adaptation of adult parental acceptance and rejection questionnaire short form (adult parq - short form) 土耳其语改编成人父母接受和拒绝问卷(adult parq - short form)
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300302
Meryem Dedeler, Ebru Akün, A. Batigun
Turkish adaptation of Adult Parental Acceptance Rejection Questionnaire Short Form Objective: The aim of the current study was to examine the reliability and validity of Adult Parental Acceptance Rejection Questionnaire Short Form (Adult PARQ Short Form) which can be used to assess adults’ remembrance of parental acceptance-rejection in their childhood, in a normal population in Turkey. Method: The study was conducted with two samples and in two phases. The first study, investigating the factor structure, composed of 424 women (62%) and 261 men (38%), in total 685 subjects between the ages of 18 and 63. A total of 201 university students including 163 women (81%) and 38 men (19%), between the ages of 18 and 25 took part in the second study, evaluating the criterion-related validity, discriminant validity and reliability. In this phase, in addition to Adult PARQShort Form, the Parental Bonding Instrument was used. Results: In exploratory factor analysis, Mother Form of the scale revealed two factor structure (acceptance and rejection) and Father Form revealed three factor structure (acceptance, rejection and neglect). However confirmatory factor analysis showed that revised version of the scale which was obtained by displacing one item in the theoretically proposed 4-factor structure (item 13 was included in Warmth/ Affection instead of Indifference/Neglect), represented better goodness of fit values. The scale represented good internal consistency, test-retest and split half reliabilities. Similarly, the criterion related and discriminant validity features of the scale were supported. Conclusion: Adult PARQShort Form is a reliable and valid instrument evaluating adults’ remembrance of parental acceptance and rejection in their childhood, to use in both clinical applications and scientific researches in Turkey.
目的:本研究的目的是检验成人父母接受拒绝问卷短格式(成人PARQ短格式)的信度和效度,该问卷可用于评估土耳其正常人群中成年人童年对父母接受-拒绝的记忆。方法:采用两种样品分两期进行研究。第一项研究,调查因素结构,由424名女性(62%)和261名男性(38%)组成,共685名年龄在18至63岁之间的受试者。第二项研究共选取201名年龄在18 - 25岁的大学生,其中女性163人(81%),男性38人(19%),对量表进行标准相关效度、判别效度和信度评估。在这个阶段,除了使用成人PARQShort Form外,还使用了亲代亲缘结合仪。结果:在探索性因子分析中,量表的母亲表呈现两因子结构(接受和拒绝),父亲表呈现三因子结构(接受、拒绝和忽视)。然而,验证性因子分析表明,通过在理论上提出的四因素结构中替换一个项目(项目13被纳入温暖/情感而不是冷漠/忽视)而获得的修订版量表具有更好的拟合优度值。量表具有良好的内部一致性、重测信度和分半信度。同样,量表的标准相关和判别效度特征也得到了支持。结论:成人PARQShort Form是一种可靠有效的评估成人童年时期父母接受和拒绝记忆的工具,可用于土耳其的临床应用和科学研究。
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引用次数: 1
Negativism associated urinary bladder overdistension: a case report - 消极相关膀胱过度膨胀1例报告
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300311
Ebru Şahan, M. Eroğlu
Negativism is known as resistance to instructions, contrary comportment to what asked. Negativism is mostly associated with catatonia. Genitourinary complications like urinary retention or urinary incontinence or infections can be seen in catatonia. Here we describe a case of negativism associated urinary bladder overdistension without catatonia. We aim to call attention that urinary bladder overdistension may be associated with negativism without catatonia. A 37 years old female patient had a history of psychotic depression for seven years. She had been on olanzapine treatment during last year until she learnt that she was pregnant six weeks ago. In the past ten days, the patient has not talked, eaten, drunk or slept so she was hospitalized in psychiatry inpatient clinic. Abdominal ultrasound revealed that her bladder volume was nearly 1500 cc and compressing on uterus. A urinary catheter was placed and urinary bladder overdistension resolved. After seven sessions of Electroconvulsive therapy (ECT), she recovered completely. Pulmonary complications like pulmonary embolism, pneumonia and aspiration; gastrointestinal complications like constipation due to decreased food intake and dehydration; dental complications due to decreased oral hygiene; genitourinary complications like urinary retention or urinary incontinence or infections; flexion contractures, postural nerve palsies and rhabdomyolysis due to immobilization can be seen in catatonia. Urinary bladder overdistension was associated with catatonia in literature but in our case urinary bladder overdistension was associated with negativism without full criteria of catatonia. Caution should be given to negativist pregnant woman because urinary bladder overdistension could be concealed by pregnancy.
消极主义被认为是对指令的抗拒,与要求相反的行为。消极主义通常与紧张症有关。泌尿生殖系统并发症,如尿潴留或尿失禁或感染可以在紧张症中看到。我们在此报告一例无紧张症的负性膀胱过度膨胀。我们的目的是引起人们的注意,膀胱过度膨胀可能与无紧张症的消极情绪有关。女,37岁,有精神病性抑郁病史7年。她去年一直在接受奥氮平治疗,直到六周前得知自己怀孕。在过去的十天里,病人不说话,不吃饭,不喝酒,也不睡觉,所以她住进了精神科住院诊所。腹部超声显示膀胱体积近1500cc,压迫子宫。放置导尿管,膀胱过度膨胀得到解决。经过7次电休克治疗,她完全康复了。肺栓塞、肺炎和误吸等肺部并发症;由于食物摄入减少和脱水导致的便秘等胃肠道并发症;口腔卫生不良引起的口腔并发症;泌尿生殖系统并发症,如尿潴留或尿失禁或感染;在紧张症中可以看到屈曲挛缩、体位神经麻痹和由于固定引起的横纹肌溶解。在文献中,膀胱过度膨胀与紧张症有关,但在我们的病例中,膀胱过度膨胀与没有完全紧张症标准的消极情绪有关。阴性孕妇应谨慎,因为膀胱过度膨胀可能被妊娠所掩盖。
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引用次数: 0
Validity and reliability of the Turkish version of the DSM-5 “Severity Measure for Agoraphobia—Child Age 11–17” 土耳其版DSM-5《广场恐惧症严重程度量表- 11-17岁儿童》的效度和信度
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300305
Ş. Y. Sapmaz, Handan Özek Erkuran, Dilek Ergin, Masum Öztürk, Nesrin Şen Celasin, Duygu Karaarslan, Ertuğrul Köroğlu, Ö. Aydemir
Objective: This study aimed to assess the validity and reliability of the Turkish version of the DSM-5 “Severity Measure for Agoraphobia—Child Age 11–17”. Method: Study group consisted of 36 patients, who have been treated in a child psychiatry unit and diagnosed with agoraphobia, and 100 healthy volunteers who have been secondary and highschool students. For the assessment, the Screen for Childhood Anxiety and Related Emotional Disorders (SCARED) was used along with the DSM-5 “Severity Measure for Agoraphobia—Child Age 11–17”. Results: Regarding reliability analyses, Cronbach’s alpha internal consistency coefficient was calculated as 0.929. Test-retest correlation coefficient was 0.566. For concurrent validity, the measure showed a high correlation with the SCARED. In ROC analysis, area under ROC curve was calculated as 0.934. Conclusion: It was concluded that Turkish version of the DSM-5 “Severity Measure for Agoraphobia—Child Age 11–17” could be used as a valid and reliable tool both in clinical practice and for research purposes.
目的:本研究旨在评估土耳其语版DSM-5 €œSeverity广场恐惧症量表 -“11 - 17 岁儿童”的效度和信度。方法:研究组由36例在儿童精神科接受治疗的广场恐怖症患者和100名健康的初高中学生志愿者组成。对于评估,儿童焦虑和相关情绪障碍筛查(SCARED)与DSM-5 €œSeverity广场恐惧症测量 -“儿童年龄11 - 17 -”一起使用。结果:信度分析计算出cronbach α内部一致性系数为0.929。重测相关系数为0.566。对于并发效度,该测量显示出与害怕高度相关。在ROC分析中,计算ROC曲线下面积为0.934。结论:结论是土耳其版DSM-5 €œSeverity广场恐惧症测量方法 -“儿童年龄11 - 17 -”可作为临床实践和研究目的的有效和可靠的工具。
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引用次数: 0
Relationship between body image, psychological symptom level and interpersonal style: alternative models 身体意象、心理症状水平与人际交往方式的关系:可选模型
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300301
Ahmet Altınok, A. Kara
Relationship between body image, psychological symptom level and interpersonal style: alternative models Objective: The purpose of this study was to evaluate the relationship between body image, psychological symptom levels and interpersonal styles in college students. Two models have been tested for this purpose. In one of the models, the mediating effect of interpersonal style on the relationship between body image and psychological symptom levels; in the other model, the mediating effect of psychological symptom levels on the relationship between body image and interpersonal style was tested. Method: The study group consists of 250 undergraduate students at several schools of a public university in Eskisehir who have been on the first term of the academic year 2015-2016. Subjects’ ages ranged 18–26 years. Body-Cathexis Scale, Personality Style Scale, and Brief Symptom Inventory were used as data collection tools in the study. The data were analyzed using structural equation modeling. The bootstrapping method was also used to test the significance of the indirect effects. Results: Findings revealed that the relationship between body image and interpersonal style was fully mediated by psychological symptom level, whereas the relationship between body image and psychological symptom level was partially mediated by interpersonal style. Conclusion: This study revealed that body image is an important factor in college youth mental health.
目的:探讨大学生身体形象、心理症状水平与人际交往方式的关系。为此已经测试了两个模型。在其中一个模型中,人际交往方式在身体形象与心理症状水平之间的中介作用;在另一个模型中,检验心理症状水平对身体形象与人际风格关系的中介作用。方法:研究小组由Eskisehir一所公立大学几个学院的250名2015-2016学年第一学期的本科生组成。受试者年龄在18-26岁之间。采用身体-导管量表、人格风格量表和简短症状量表作为数据收集工具。采用结构方程模型对数据进行分析。采用自举法检验间接效应的显著性。结果:身体形象与人际风格之间的关系完全受心理症状水平的调节,而身体形象与心理症状水平之间的关系部分受人际风格的调节。结论:身体意象是影响大学生青少年心理健康的重要因素。
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引用次数: 3
Cigarette consumption and related factors in schizophrenia, schizoaffective disorder and delusional disorder 精神分裂症、分裂情感性障碍和妄想障碍的吸烟及其相关因素
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300307
Sukriye Bosgelmez, M. Yıldız
Cigarette consumption and related factors in schizophrenia, schizoaffective disorder and delusional disorder Objective: The present study is designed to assess the rate of smoking and related factors in outpatients with schizophrenia, schizoaffective disorder and delusional disorder. Methods: Medical records of 541 patients, diagnosed with schizophrenia, schizoaffective disorder and delusional disorder according to DSM-IV were examined retrospectively. Daily cigarette consumption, sociodemographic characteristics and medical data of the patients were evaluated. Logistic regression analysis was conducted to determine the factors associated with smoking. Correlation analysis was performed to assess factors related with daily cigarette consumption. Results: Of the 541 patients, 242 (44.7%) were current smokers. Smoking rate was significantly higher in males. Although there were differences in sociodemographic characteristics and disorder related variables, there was no difference in smoking rates of patients with schizophrenia, schizoaffective disorder, and delusional disorder. In logistic regression analysis it was shown that smoking was associated with male gender and violent behavior after illness onset in psychotic disorders. Correlation analysis showed that mean number of daily consumed cigarettes correlated moderately with the duration of the illness. Conclusions: In the study, similar smoking rates were found between psychotic disorders. Smoking is strongly related with male gender and violent behavior after onset of illness. The relation between smoking and violent behavior emerges as a new field deserving further investigation.
目的:了解精神分裂症、分裂情感性障碍和妄想障碍门诊患者的吸烟率及其相关因素。方法:回顾性分析541例按照DSM-IV诊断为精神分裂症、分裂情感性障碍和妄想障碍的患者的病历。评估患者的日常卷烟消费量、社会人口学特征和医疗资料。通过Logistic回归分析确定与吸烟相关的因素。进行相关分析,评估与日常卷烟消费相关的因素。结果:541例患者中,242例(44.7%)为当前吸烟者。男性吸烟率明显较高。虽然社会人口学特征和障碍相关变量存在差异,但精神分裂症、分裂情感性障碍和妄想障碍患者的吸烟率没有差异。logistic回归分析显示,吸烟与男性性别、精神障碍患者发病后的暴力行为相关。相关分析显示,平均每日吸烟数量与疾病持续时间有中等相关性。结论:在研究中,精神障碍患者的吸烟率相似。吸烟与男性性别和发病后的暴力行为密切相关。吸烟与暴力行为的关系是一个值得进一步研究的新领域。
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引用次数: 4
Change starts with us: stigmatizing attitudes towards mental illnesses and the use of stigmatizing language among mental health professionals 改变从我们开始:污名化对待精神疾病的态度以及在精神卫生专业人员中使用污名化的语言
Pub Date : 2017-09-22 DOI: 10.5350/DAJPN2017300306
Ü. Özer, C. Varlık, V. Çeri, B. Ince, M. Delice
{"title":"Change starts with us: stigmatizing attitudes towards mental illnesses and the use of stigmatizing language among mental health professionals","authors":"Ü. Özer, C. Varlık, V. Çeri, B. Ince, M. Delice","doi":"10.5350/DAJPN2017300306","DOIUrl":"https://doi.org/10.5350/DAJPN2017300306","url":null,"abstract":"","PeriodicalId":136580,"journal":{"name":"Düşünen Adam: The Journal of Psychiatry and Neurological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134357097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
期刊
Düşünen Adam: The Journal of Psychiatry and Neurological Sciences
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