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The role of infection in signalling root resorption: A narrative review 感染在牙根吸收信号中的作用：叙述性综述
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-18 DOI: 10.1111/iej.14132
S. Lin, D. Moreinos, A. M. Marvidou, R. Novak, I. Rotstein, P. V. Abbott
Root resorption consists of complex, multistep processes that involve cell signalling caused by inflammation and stromal cells, which promotes the secretion of receptor activator of nuclear factor κB ligand/ macrophage-colony stimulating factor (RANKL/M-CSF) resulting in a resorptive process.
牙根吸收是一个复杂的多步骤过程，涉及由炎症和基质细胞引起的细胞信号传递，从而促进核因子κB配体受体激活剂/巨噬细胞集落刺激因子（RANKL/M-CSF）的分泌，导致吸收过程。
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引用次数: 0
Efficacy of laser adjuvant therapy in the management of post-operative endodontic pain: A systematic review and meta-analysis 激光辅助疗法在治疗牙髓术后疼痛方面的疗效：系统回顾和荟萃分析
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-17 DOI: 10.1111/iej.14140
Zhiqiang Luo, Yiquan He, Hongkun Wu, Yuxuan Li, Leyao Shen, Lei Cheng, Xuedong Zhou, Libang He, Jing Chen
Postoperative endodontic pain (PEP) is crucial in clinical practice. Recently, the effects of various laser adjuvant therapies in endodontic treatments have been widely evaluated. However, as a virtually side-effect-free treatment, its effect on postoperative pain management during endodontic treatment remains controversial.
牙髓术后疼痛（PEP）在临床实践中至关重要。最近，各种激光辅助疗法在牙髓治疗中的效果得到了广泛评估。然而，作为一种几乎无副作用的治疗方法，激光对牙髓治疗术后疼痛控制的效果仍存在争议。
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引用次数: 0
Rationale to apply specific temperatures for testing NiTi instruments in endodontics—Letter to the authors 在牙髓治疗中使用特定温度测试镍钛器械的理由-致作者的信
IF 5.4 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-16 DOI: 10.1111/iej.14115
Emmanuel J. N. L. Silva, Jorge N. R. Martins, Marco A. Versiani
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引用次数: 0
The effectiveness of partial pulpotomy compared with full pulpotomy in managing deep caries in vital permanent teeth with a diagnosis of non-traumatic pulpitis 在治疗诊断为非创伤性牙髓炎的重要恒牙深龋方面，部分牙髓切除术与全牙髓切除术的效果比较
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-12 DOI: 10.1111/iej.14149
Lidiane M. Louzada, Hauke Hildebrand, Klaus W. Neuhaus, Henry F. Duncan
Pulpitis may be pain free or alternatively characterized by mild to severe pain and associated symptoms. Evidence has recently emerged that patients presenting with carious pulp exposure range of symptoms can be treated effectively with pulpotomy.
牙髓炎可能没有疼痛，也可能伴有轻微至严重的疼痛和相关症状。最近有证据表明，出现龋坏牙髓症状的患者可以通过牙髓切除术得到有效治疗。
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引用次数: 0
XP-Endo Finisher behaviour and irrigant temperature in intracanal environment: Clinical measurements XP-Endo Finisher 在龋内环境中的表现和灌洗液温度：临床测量
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-12 DOI: 10.1111/iej.14146
Fernanda de Melo Silva, Isabella Figueiredo Assis Macedo, Pedro Damas Resende, Warley Luciano Fonseca Tavares, Vicente Tadeu Lopes Buono, Leandro de Arruda Santos, Isabella Faria da Cunha Peixoto, Ana Cecília Diniz Viana
To evaluate the behaviour of the XP-Endo Finisher and the variation in the intracanal temperature of the irrigant at rest and when activated over time.
评估 XP-Endo Finisher 的性能，以及灌洗剂在静止时和激活后随着时间的推移在龋洞内温度的变化。
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引用次数: 0
Reporting quality of scoping reviews in endodontics: A meta-research study 牙髓病学范围综述的报告质量：荟萃研究
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-10 DOI: 10.1111/iej.14141
Giorgos N. Tzanetakis, Xenos Petridis, Aleksandar Jakovljevic, Despina Koletsi, Venkateshbabu Nagendrababu, Henry F. Duncan, Paul M. H. Dummer
To evaluate the reporting quality of Scoping Reviews (ScRs) in endodontics according to the PRISMA Extension Checklist for Scoping Reviews (PRISMA-ScR) and to analyse their association with a range of publication and methodological/reporting characteristics.
根据范围界定综述的 PRISMA 扩展核对表 (PRISMA-ScR) 评估牙髓病学范围界定综述 (ScR) 的报告质量，并分析其与一系列出版物和方法学/报告特征之间的关联。
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引用次数: 0
Multiple cell death modalities and immune response in pulpitis 牙髓炎的多种细胞死亡模式和免疫反应
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-10 DOI: 10.1111/iej.14145
Ben Wang, Wenwen Li, Weiying Huang, Xuemeng Li, Jiaqi Li, Songtao Shi, Xueli Mao, Xi Wei
To investigate the level and distribution of apoptosis, pyroptosis, necroptosis, and NETosis in pulpitis with or without necrosis on a basis of histological classification. Additionally, to examine the effect of pulpitis with necrosis (PWN) on the number and activation of peripheral and bone marrow (BM) neutrophils, as well as spleen lymphocytes, in a mouse model of pulpitis.
根据组织学分类，研究有无坏死的牙髓炎中细胞凋亡、脓毒血症、坏死和NETosis的水平和分布。此外，研究牙髓炎伴坏死（PWN）对小鼠牙髓炎模型中外周和骨髓（BM）中性粒细胞以及脾脏淋巴细胞的数量和活化的影响。
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引用次数: 0
Comparative analysis of methods for measuring root canal curvature based on periapical radiography: A laboratory study 基于根尖周放射摄影的根管曲率测量方法比较分析：实验室研究
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-10 DOI: 10.1111/iej.14142
Rafael Chies Hartmann, Eduardo Silva Ferraz, Theodoro Weissheimer, Jose Antônio Poli de Figueiredo, Giampiero Rossi-Fedele, Maximiliano Schünke Gomes
To evaluate the agreement between six currently available periapical radiography-based methods for measuring the root canal curvatures in mesial roots of mandibular first molars, assessed by two examiners with different proficiency levels.
目的：评估目前六种基于根尖周放射摄影的下颌第一磨牙中牙根管弯曲度测量方法之间的一致性，由两名不同熟练程度的检查人员进行评估。
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引用次数: 0
27-Hydroxycholesterol contributes to hypercholesterolemia-associated aggravation of apical periodontitis in ovariectomized rats and raloxifene counteracts its action 27-羟基胆固醇导致卵巢切除大鼠与高胆固醇血症相关的根尖牙周炎恶化，而雷洛昔芬可抵消其作用
IF 5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-09-10 DOI: 10.1111/iej.14143
H.-W. Wang, C.-N. Yang, S.-H. Kok, C.-Y. Hong, C.-T. Shun, E. H.-H. Lai, S.-J. Cheng, H.-Y. Lin, F.-Y. Wu, S.-K. Lin
The influence of hypercholesterolemia on the development of apical periodontitis (AP) is inconclusive. Recent studies revealed that cholesterol metabolite 27-hydoxycholesterol (27HC) can affect cellular responses to bacterial infections and oestrogen status and raloxifene may influence its action. Herein, we aimed to examine the impact of 27HC on production of inflammatory mediators by macrophages and the regulatory function of raloxifene. The contribution of 27HC to AP development and the therapeutic effect of raloxifene were evaluated in a rat model.
高胆固醇血症对根尖牙周炎（AP）发病的影响尚无定论。最近的研究发现，胆固醇代谢产物 27-羟基胆固醇（27HC）可影响细胞对细菌感染的反应，而雌激素状态和雷洛昔芬可能会影响其作用。在此，我们旨在研究 27HC 对巨噬细胞产生炎症介质的影响以及雷洛昔芬的调节功能。我们在大鼠模型中评估了 27HC 对 AP 发展的贡献以及雷洛昔芬的治疗效果。
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引用次数: 0
The immune landscape in apical periodontitis: From mechanism to therapy 根尖牙周炎的免疫环境：从机制到治疗
IF 5.4 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
International endodontic journal
Pub Date : 2024-08-01 DOI: 10.1111/iej.14125
Yuan-Hao Wen, Yu-Xiu Lin, Lu Zhou, Chen Lin, Lu Zhang

Apical periodontitis (AP) is featured by a persistent inflammatory response and alveolar bone resorption initiated by microorganisms, posing risks to both dental and systemic health. Nonsurgical endodontic treatment is the recommended treatment plan for AP with a high success rate, but in some cases, periapical lesions may persist despite standard endodontic treatment. Better comprehension of the AP inflammatory microenvironment can help develop adjunct therapies to improve the outcome of endodontic treatment. This review presents an overview of the immune landscape in AP, elucidating how microbial invasion triggers host immune activation and shapes the inflammatory microenvironment, ultimately impacting bone homeostasis. The destructive effect of excessive immune activation on periapical tissues is emphasized. This review aimed to systematically discuss the immunological basis of AP, the inflammatory bone resorption and the immune cell network in AP, thereby providing insights into potential immunotherapeutic strategies such as targeted therapy, antioxidant therapy, adoptive cell therapy and cytokine therapy to mitigate AP-associated tissue destruction.

根尖周炎（Apical periodontitis，AP）的特征是由微生物引发的持续性炎症反应和牙槽骨吸收，对牙齿和全身健康都构成威胁。非手术牙髓治疗是牙髓炎的推荐治疗方案，成功率很高，但在某些情况下，尽管进行了标准的牙髓治疗，根尖周病变仍可能持续存在。更好地了解 AP 炎症微环境有助于开发辅助疗法，改善牙髓治疗的效果。本综述概述了 AP 的免疫状况，阐明了微生物入侵如何引发宿主免疫激活并塑造炎症微环境，最终影响骨稳态。文章强调了过度免疫激活对根尖周组织的破坏性影响。本综述旨在系统地讨论 AP 的免疫学基础、炎性骨吸收和 AP 中的免疫细胞网络，从而为潜在的免疫治疗策略（如靶向治疗、抗氧化治疗、收养细胞治疗和细胞因子治疗）提供见解，以减轻 AP 相关的组织破坏。
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引用次数: 0
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