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Diabetes Mellitus as Hub for Tuberculosis Infection: A Snapshot 糖尿病是结核病感染的中心:概况
Pub Date : 2016-10-12 DOI: 10.1155/2016/5981574
R. Pal, M. Ansari, S. Hameed, Z. Fatima
Tuberculosis (TB) still remains the thorn in the flesh of efficient therapeutics affecting one-third of global population annually. There are several factors that enhance the susceptibility to TB infections including malnutrition, smoking, and immunocompromised conditions such as AIDS. In the recent years, growing body of evidence has gained considerable prominence which suggests that Diabetes Mellitus (DM) is individual risk factor leading to complicated TB infections. In this article the authors have attempted to summarize the link of type 2 DM with TB, the mechanistic action of how DM sensitizes for developing the active TB infection from the latent infection, and problems faced during treatment followed by possible preventive measures. We have tried to give account of the alterations that occurred in DM making a person more prone to develop TB.
结核病(TB)仍然是有效治疗的眼中钉,每年影响全球三分之一的人口。有几个因素会增加对结核感染的易感性,包括营养不良、吸烟和艾滋病等免疫功能低下的情况。近年来,越来越多的证据表明,糖尿病(DM)是导致并发结核感染的个体危险因素。在本文中,作者试图总结2型糖尿病与结核的联系,糖尿病敏化如何从潜伏感染发展为活动性结核感染的机制作用,以及在治疗过程中面临的问题以及可能的预防措施。我们试图解释DM中发生的改变,使一个人更容易患结核病。
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引用次数: 31
Prevalence of Osteoporosis and Its Risk Factors in Men with COPD in Qazvin 卡兹温地区男性COPD患者骨质疏松症患病率及其危险因素
Pub Date : 2016-09-27 DOI: 10.1155/2016/4038530
M. Abbasi, M. Zohal, Banafsheh Atapour, Z. Yazdi
Introduction. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Proper diagnosis of osteoporosis as a systemic adverse effect of COPD is of significant importance. The present study aimed at evaluating the prevalence of osteoporosis and its risk factors in men suffering from COPD in Qazvin (2014). Methods. This descriptive-analytical study was conducted on 90 patients with COPD using random sampling. Anthropometric data and results from physical examination were collected. Pulmonary function test and bone mineral densitometry were done for all participants as well. Results. The prevalence of osteopenia and osteoporosis in COPD patients was 31.5 and 52.8 percent, respectively. Bone mineral density (BMD) at the femoral neck was associated significantly with body mass index (BMI), increased severity of COPD, and use of oral corticosteroid (P < 0.05). Conclusion. The results showed that patients' BMI and severity of COPD are two valuable risk factors for osteoporosis screening in COPD patients.
介绍。慢性阻塞性肺疾病(COPD)是全世界发病率和死亡率的主要原因。正确诊断骨质疏松作为慢性阻塞性肺病的系统性不良反应是非常重要的。本研究旨在评估Qazvin(2014)男性COPD患者骨质疏松症的患病率及其危险因素。方法。本描述性分析研究采用随机抽样方法对90例COPD患者进行研究。收集了人体测量数据和体格检查结果。同时对所有参与者进行肺功能检查和骨密度测定。结果。COPD患者骨质减少和骨质疏松的患病率分别为31.5%和52.8%。股骨颈骨矿物质密度(BMD)与身体质量指数(BMI)、COPD严重程度增加和口服皮质类固醇使用显著相关(P < 0.05)。结论。结果表明,患者的BMI和COPD的严重程度是COPD患者骨质疏松筛查的两个有价值的危险因素。
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引用次数: 11
Behavioral Problems in Juvenile Idiopathic Arthritis: A Controlled Study to Examine the Risk of Psychopathology in a Chronic Pediatric Disorder 青少年特发性关节炎的行为问题:一项检查慢性儿科疾病精神病理风险的对照研究
Pub Date : 2016-08-30 DOI: 10.1155/2016/5726236
A. Memari, Elham Chamanara, V. Ziaee, R. Kordi, S. Raeeskarami
Children with juvenile idiopathic arthritis (JIA) are prone to the problems that can delay their psychosocial development; however, the existing literature has not reached a consensus on the psychological problems related to JIA. A total of 51 children and adolescents with JIA and 75 healthy controls aged 6 to 18 years were examined using the Child Behavioral Checklist (CBCL). Our results represented that 70 percent of JIA group reached “borderline clinical” range or “clinical” range in internalizing problems, while this percentage in the control group was 18 percent. In addition, our results indicated that JIA group has gotten significantly higher scores (more than twofold) in externalizing behaviors compared to control group. Furthermore, children with JIA showed higher rate of anxiety/depression, withdrawal/depression, somatic complaints, rule breaking behaviors, and aggressive behaviors as well as thought and social problems compared to control group (p < 0.001). As a conclusion, children and adolescents with JIA compared to healthy controls may show higher rate of both internalizing and externalizing problems. Furthermore, our novel findings on externalizing, social, and thought problems in JIA warrant further investigation on affected children who may be at greater risk of future psychopathologies.
患有幼年特发性关节炎(JIA)的儿童容易出现延迟其心理社会发育的问题;然而,现有文献对JIA相关的心理问题尚未达成共识。采用儿童行为检查表(Child Behavioral Checklist, CBCL)对51名JIA儿童和青少年以及75名6 - 18岁的健康对照者进行检查。我们的结果表明,70%的JIA组在内化问题上达到了“临床边缘”范围或“临床”范围,而对照组的这一比例为18%。此外,我们的研究结果表明,JIA组在外化行为方面的得分明显高于对照组(两倍以上)。此外,JIA患儿的焦虑/抑郁、退缩/抑郁、躯体抱怨、违规行为、攻击行为以及思想和社会问题发生率高于对照组(p < 0.001)。综上所述,与健康对照相比,JIA患儿和青少年的内化和外化问题发生率均较高。此外,我们在JIA的外化、社会和思想问题上的新发现,值得对未来可能有更大精神病理风险的受影响儿童进行进一步调查。
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引用次数: 29
An Innovative Approach to Evaluate the Morphological Patterns of Soft Palate in Oral Submucous Fibrosis Patients: A Digital Cephalometric Study 一种评估口腔粘膜下纤维化患者软腭形态模式的创新方法:数字头测量研究
Pub Date : 2016-03-13 DOI: 10.1155/2016/5428581
Chintamaneni Raja Lakshmi, Dharmavaram Ayesha Thabusum, S. Bhavana
Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting mucosa and submucosa of oral cavity and soft palate. The present study aimed to evaluate the morphology of soft palate in normal individuals and OSMF patients using lateral cephalometry and to compare and correlate these variants of soft palate with different stages of OSMF. 100 subjects were included in the study, who were divided into two groups. Group I included 50 subjects with clinical diagnosis of OSMF and Group II included 50 normal subjects (control group). Using digital lateral cephalometry, velar length and width were measured and soft palatal patterns were categorized based on You et al.'s classification. Leaf and rat-tail patterns of soft palate were predominant in control group, whereas butt and crook shaped variants were more in study group. Anteroposterior (A-P) length of soft palate was significantly greater in stage I OSMF, while superoinferior (S-I) width was greater in stage III OSMF. Interestingly, a negative correlation was observed in staging of OSMF and A-P dimensions. As the staging of OSMF advances, the A-P length of soft palate decreases, but S-I width increases.
口腔粘膜下纤维化(OSMF)是一种影响口腔和软腭粘膜和粘膜下的慢性隐匿性疾病。本研究旨在利用侧位测量法评估正常人和OSMF患者的软腭形态,并比较这些软腭变异与OSMF不同阶段的相关性。该研究包括100名受试者,他们被分为两组。第一组50例临床诊断为OSMF的受试者,第二组50例正常受试者(对照组)。采用数字侧位测量术,测量腭长和腭宽,并根据You等人的分类对软腭模式进行分类。对照组软腭以叶型和鼠尾型为主,研究组以臀型和弯型为主。I期OSMF软腭正位长度(A-P)明显大于III期OSMF软腭上位宽度(S-I)。有趣的是,OSMF分期与a - p维度呈负相关。随着OSMF分期的推进,软腭上腭长度减小,上腭宽度增大。
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引用次数: 8
Revealing Maximal Diameter of Upper Limb Superficial Vein with an Elevated Environmental Temperature. 用升高的环境温度揭示上肢浅静脉的最大直径
Pub Date : 2016-01-01 Epub Date: 2016-08-15 DOI: 10.1155/2016/8096473
Hira Irfan, Guo Shen Ooi, May M Kyin, Pei Ho

Ultrasonography is the primary tool for preoperative analysis of vein morphology for fistula creation in patients with end-stage renal disease. This study examines the effect of environmental temperature on the superficial vein size. Superficial veins of thirteen healthy volunteers were marked at three sites: cephalic vein in left lateral arm near cubital fossa, cephalic vein in left forearm at wrist, and basilic vein in left medial arm near cubital fossa. Mean diameters were recorded using ultrasound probe at 26°C and 43°C. Body temperature was increased using a Bair Hugger blanket. Mean values from the two temperatures were analyzed using paired sample t-test. All three superficial vein sites displayed statistically significant increase in diameter when the temperature was increased from 26°C to 43°C. Paired t-test showed p values of 0.001 for cephalic vein at wrist, 0.01 for cephalic vein near cubital fossa, and 0.01 for basilic vein near cubital fossa. This study proved that environmental temperature exerts a statistically significant effect on vein size measured by ultrasound during preoperative assessment for vascular access. Not to the extent of 43°C, the authors would recommend setting the room temperature higher during ultrasound vascular assessment to avoid underestimating the superficial vein size.

超声波检查是终末期肾病患者术前分析静脉形态以建立瘘管的主要工具。本研究探讨了环境温度对浅静脉大小的影响。13 名健康志愿者的浅静脉在三个部位做了标记:左臂外侧靠近肘窝的头静脉、左前臂手腕处的头静脉和左臂内侧靠近肘窝的基底静脉。在 26°C 和 43°C 温度下使用超声波探头记录平均直径。使用 Bair Hugger 毯子提高体温。采用配对样本 t 检验分析两种温度下的平均值。当温度从 26°C 升至 43°C 时,所有三个浅静脉部位的直径都有明显的统计学增长。配对 t 检验显示,腕部头静脉的 p 值为 0.001,肘窝附近头静脉的 p 值为 0.01,肘窝附近基底静脉的 p 值为 0.01。这项研究证明,在术前评估血管通路时,环境温度对超声波测量的静脉大小有显著的统计学影响。作者建议在超声血管评估时将室温调高至 43°C,以避免低估浅静脉的大小。
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引用次数: 0
The Negligible Influence of Chronic Obesity on Hospitalization, Clinical Status, and Complications in Elective Posterior Lumbar Interbody Fusion. 慢性肥胖对择期后路腰椎椎体间融合术住院、临床状况和并发症的影响可忽略不计。
Pub Date : 2016-01-01 Epub Date: 2016-07-10 DOI: 10.1155/2016/2964625
Olaf Suess, Theodoros Kombos, Frank Bode

Background. Posterior lumbar interbody fusion (PLIF) is a common surgical treatment for degenerative spinal instability, but many surgeons consider obesity a contraindication for elective spinal fusion. The aim of this study was to analyze whether obesity has any influence on hospitalization parameters, change in clinical status, or complications. Methods. In this prospective study, regression analysis was used to analyze the influence of the body mass index (BMI) on operating time, postoperative care, hospitalization time, type of postdischarge care, change in paresis or sensory deficits, pain level, wound complications, cerebrospinal fluid leakage, and implant complications. Results. Operating time increased only 2.5 minutes for each increase of BMI by 1. The probability of having a wound complication increased statistically with rising BMI. Nonetheless, BMI accounted for very little of the variation in the data, meaning that other factors or random chances play a much larger role. Conclusions. Obesity has to be considered a risk factor for wound complications in patients undergoing elective PLIF for degenerative instability. However, BMI showed no significant influence on other kinds of peri- or postoperative complications, nor clinical outcomes. So obesity cannot be considered a contraindication for elective PLIF.

背景。后路腰椎椎体间融合术(PLIF)是退行性脊柱不稳定的常见手术治疗,但许多外科医生认为肥胖是择期脊柱融合术的禁忌症。本研究的目的是分析肥胖是否对住院参数、临床状态的改变或并发症有任何影响。方法。本前瞻性研究采用回归分析方法,分析体重指数(BMI)对手术时间、术后护理、住院时间、出院后护理类型、轻瘫或感觉缺陷的改变、疼痛程度、伤口并发症、脑脊液漏、植入物并发症的影响。结果。BMI每增加1,手术时间仅增加2.5分钟。出现伤口并发症的概率随着BMI的升高而增加。尽管如此,BMI在数据变化中所占的比例很小,这意味着其他因素或随机机会发挥了更大的作用。结论。肥胖被认为是选择性PLIF治疗退行性不稳定患者伤口并发症的危险因素。然而,BMI对其他类型的围手术期或术后并发症以及临床结果没有显著影响。因此,肥胖不能被认为是选择性PLIF的禁忌症。
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引用次数: 2
Effect of Aerobic Exercise Training on Blood Pressure in Indians: Systematic Review. 有氧运动训练对印度人血压的影响:系统综述。
Pub Date : 2016-01-01 Epub Date: 2016-07-17 DOI: 10.1155/2016/1370148
Sonu Punia, Sivachidambaram Kulandaivelan, Varun Singh, Vandana Punia

Introduction. High blood pressure (BP) is one of the most important modifiable risk factors for cardiovascular diseases, which accounts for one in every eight deaths worldwide. It has been predicted that, by 2020, there would be 111% increase in cardiovascular deaths in India. Aerobic exercise in the form of brisk walking, jogging, running, and cycling would result in reduction in BP. Many meta-analytical studies from western world confirm this. However, there is no such review from Indian subcontinent. Objective. Our objective is to systematically review and report the articles from India in aerobic exercise on blood pressure. Methodology. Study was done in March 2016 in Google Scholar using search terms "Aerobic exercise" AND "Training" AND "Blood pressure" AND "India." This search produced 3210 titles. Results. 24 articles were identified for this review based on inclusion and exclusion criteria. Total of 1107 subjects participated with median of 25 subjects. Studies vary in duration from +3 weeks to 12 months with each session lasting 15-60 minutes and frequency varies from 3 to 8 times/week. The results suggest that there was mean reduction of -05.00 mmHg in SBP and -03.09 mmHg in DBP after aerobic training. Conclusion. Aerobic training reduces the blood pressure in Indians.

介绍。高血压(BP)是心血管疾病最重要的可改变危险因素之一,全世界每8例死亡中就有1例与高血压有关。据预测,到2020年,印度心血管疾病死亡人数将增加111%。快走、慢跑、跑步和骑自行车等有氧运动可以降低血压。西方许多元分析研究证实了这一点。然而,印度次大陆没有这样的审查。目标。我们的目标是系统地回顾和报道来自印度的关于有氧运动对血压的影响的文章。方法。这项研究于2016年3月在谷歌学术搜索中完成,搜索词是“有氧运动”、“训练”、“血压”和“印度”。这个搜索产生了3210个标题。结果:根据纳入和排除标准,本综述确定了24篇文章。共1107名受试者参与,中位数为25名。研究时间从3周到12个月不等,每次持续15-60分钟,频率从3到8次/周不等。结果表明,有氧训练后收缩压平均降低-05.00 mmHg,舒张压平均降低-03.09 mmHg。结论。有氧训练可以降低印度人的血压。
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引用次数: 20
Musculoskeletal Disorders and Perceived Work Demands among Female Nurses at a Tertiary Care Hospital in India. 印度某三级医院女护士的肌肉骨骼疾病和工作需求感知
Pub Date : 2016-01-01 Epub Date: 2016-07-14 DOI: 10.1155/2016/5038381
Apexa S Raithatha, Daxa G Mishra

Introduction. Musculoskeletal disorders (MSD) are common among nurses and can affect patient outcomes. There is a dearth of literature on MSD among Indian nurses. The study objective was to measure prevalence of MSD and their association with perceived work demands and sociodemographic variables among female nurses at a tertiary care hospital in rural India. Methods. A cross-sectional study was undertaken in 2013 through interviewer administered questionnaires which comprised three parts: sociodemographic data, modified Nordic questionnaire, and perceived physical and psychological work demands. Results. 296 nurses with a mean age of 30.4 years participated. Prevalence of any MSD in the last seven days was 60.5% with low back pain being the most common and elbow pain the least common. Occurrence of any MSD was associated with age, number of children, working hours at home, BMI, and total work experience. High perceived physical demands score was associated with lower back (OR: 3.06) and knee pain (OR: 7.73). Conclusion. Prevalence of MSD was high and occurrence of lower back and knee MSD was associated with perceived physical demands. This information should be used as a benchmark and guiding tool for designing work place interventions to improve working conditions and health of nurses.

介绍。肌肉骨骼疾病(MSD)在护士中很常见,并能影响患者的预后。在印度护士中缺乏关于默沙东的文献。本研究的目的是测量印度农村一家三级医院女护士的MSD患病率及其与感知工作需求和社会人口变量的关系。方法。横断面研究于2013年进行,通过采访者管理的问卷调查,包括三部分:社会人口统计数据,修改北欧问卷,感知生理和心理工作需求。结果:护士296名,平均年龄30.4岁。过去7天内的MSD患病率为60.5%,最常见的是腰痛,最不常见的是肘部疼痛。任何MSD的发生都与年龄、子女数量、在家工作时间、BMI和总工作经验有关。高感知体力需求得分与腰背部疼痛(OR: 3.06)和膝盖疼痛(OR: 7.73)相关。结论。MSD的患病率很高,下背部和膝盖MSD的发生与感知到的身体需求有关。这些信息应作为设计工作场所干预措施的基准和指导工具,以改善护士的工作条件和健康。
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引用次数: 24
Effectiveness of a Pharmacist-Led Cardiovascular Risk Reduction Clinic in Rural Perry County, Alabama. 阿拉巴马州佩里县农村药剂师主导的心血管风险降低诊所的有效性
Pub Date : 2016-01-01 Epub Date: 2016-07-25 DOI: 10.1155/2016/4304761
Pilar Z Murphy, Charles Sands, Frances Ford

Background. The Cardiovascular Risk Reduction Clinic (CRRC) in Perry County, Alabama, provides free pharmacist-led services. Clinic goals include improving health outcomes and reducing cardiovascular risk factors. Objective. To investigate the effectiveness of the CRRC in rural Perry County, Alabama. The reduction of the modifiable cardiovascular risk factors, blood pressure and body mass index, was evaluated to measure a decrease from baseline to last clinic date. Methods. This retrospective chart review identified 130 patients with at least two blood pressure and BMI measurements from baseline to June 30, 2010. The patients' paper files were used to collect baseline data and most recent measurements, which were recorded on a data collection sheet. Results. There was a statistically significant reduction in systolic blood pressure of 4.08 mmHg, 3.25 mmHg reduction in diastolic blood pressure, and 0.42 kg/m(2) reduction in mean BMI. At their last visit prior to June 30, 2010, 59% of hypertensive patients and 35% of diabetic patients were meeting their blood pressure goals. Conclusion. Pharmacist-led management of patients with cardiovascular risk factors significantly reduced blood pressure and allowed more patients to meet their hypertension treatment goals. Despite being modest, reductions in blood pressure and BMI help reduce overall cardiovascular risks.

背景。阿拉巴马州佩里县的心血管风险降低诊所(CRRC)提供由药剂师主导的免费服务。临床目标包括改善健康结果和减少心血管危险因素。目标。调查CRRC在阿拉巴马州佩里县农村地区的有效性。降低可改变的心血管危险因素,血压和体重指数,评估从基线到最后一次门诊日期的降低。方法。本回顾性图表回顾确定了130例患者,从基线到2010年6月30日至少有两次血压和BMI测量。患者的纸质档案用于收集基线数据和最近的测量数据,这些数据记录在数据收集表上。结果。收缩压降低4.08 mmHg,舒张压降低3.25 mmHg,平均BMI降低0.42 kg/m(2)。在2010年6月30日前的最后一次访问中,59%的高血压患者和35%的糖尿病患者达到了他们的血压目标。结论。药师主导的心血管危险因素患者管理显著降低血压,使更多患者达到高血压治疗目标。尽管幅度不大,但血压和身体质量指数的降低有助于降低整体心血管风险。
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引用次数: 3
Evolution of Experience of Care of Patients with and without Chronic Diseases following a Québec Primary Healthcare Reform. 瞿氏初级医疗改革后慢性病患者和非慢性病患者护理经验的演变。
Pub Date : 2016-01-01 Epub Date: 2016-04-07 DOI: 10.1155/2016/2497637
Raynald Pineault, Roxane Borgès Da Silva, Sylvie Provost, Mylaine Breton, Pierre Tousignant, Michel Fournier, Alexandre Prud'homme, Jean-Frédéric Levesque

Objectives. To assess the extent to which new primary healthcare (PHC) models implemented in two regions of Quebec have improved patient experience of care, unmet needs, and use of services for individuals with and without chronic diseases, compared with other forms of PHC practices. Methods. In 2005 and 2010, we carried out population and organization surveys. We divided PHC organizations into new model practices and other practices and followed the evolution over time of patient experience of care. Results. Patients with chronic diseases had better accessibility but worse continuity of care in the new model practices than in the other practices at both time periods. Through the reform, accessibility decreased evenly in both groups, but continuity and perceived outcomes improved more in the other practices. Use of primary care services decreased more in the new model practices. Among patients without chronic disease, accessibility decreased much less in the new models and responsiveness increased more. There was no significant change in ER attendance and hospitalization. Conclusion. The evolution of patient experience of care has been more favorable for patients without chronic diseases. These findings raise concerns about equity since the aim of the PHC reform was targeting in priority individuals with the greatest needs.

目标。评估在魁北克省两个地区实施的新的初级卫生保健(PHC)模式与其他形式的初级卫生保健做法相比,在多大程度上改善了患者的护理体验、未满足的需求以及患有和不患有慢性病的个人的服务使用情况。方法。在2005年和2010年,我们进行了人口和组织调查。我们将初级保健组织分为新模式实践和其他实践,并跟踪患者护理经验的演变。结果。在这两个时期,慢性病患者在新模式实践中有更好的可及性,但护理的连续性较差。通过改革,两组的可及性平均下降,但其他实践的连续性和感知结果改善更多。在新的模式实践中,初级保健服务的使用减少得更多。在没有慢性疾病的患者中,新模型的可及性降低得更少,反应性增加得更多。急诊室的出勤率和住院率没有显著变化。结论。患者护理经验的演变对无慢性疾病的患者更有利。这些发现引起了对公平的关注,因为初级保健改革的目标是优先针对最需要的个人。
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引用次数: 3
期刊
International Journal of Chronic Diseases
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