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Screening for Nephropathy in Diabetes Mellitus: Is Micral-Test Valid among All Diabetics? 糖尿病肾病筛查:微量试验对所有糖尿病患者有效吗?
Pub Date : 2016-01-01 Epub Date: 2016-05-18 DOI: 10.1155/2016/2910627
Koubaa Afifa, Sriha Belguith Asma, Harzallah Nabil, Bellaleh Ahlem, Sahtout Mounira, Younes Kawthar, Triki Sonia, Hellara Ilhem, Neffati Fadoua, Najjar Fadhel, Soltani Mohamed

Background. Using Micral-test (MT) for screening microalbuminuria (MA) among type 2 diabetics (T2D) is helpful. We aimed at determining prevalence of MA and at describing the MT validity. Methods. We studied 182 T2D followed up in family medicine. Two 24-hour urinary quantitative assays of MA had been used as a gold standard. Results. Prevalence of MA was 23%, CI 95%: 16.9-29.1. MT validity was 77% for sensitivity, 88% for negative predictive value, and 0.2 for Kappa coefficient (p = 0.001). Among subjects having a blood pressure ≥130/80 mmHg, having a CHT/HDL ratio ≥ 3, being a T2D for more than 5 years, and being women, negative predictive values were, respectively, 91%, 89%, 95%, and 91%. The area under the ROC curve was 0.81 in men (p = 0.008) and 0.80 when diabetes duration exceeds 5 years (p = 0.001). The MA value at 100% Sp for MT was 35 mg/L. Conclusion. The use of MT in primary healthcare for yearly screening for MA in T2D must be accentuated especially when diabetes duration exceeds 5 years or when associated with other cardiovascular risks.

背景。微量白蛋白试验(MT)对2型糖尿病(T2D)患者微量白蛋白尿(MA)的筛查有一定的帮助。我们的目的是确定MA的患病率和描述MT效度。方法。我们对182例家庭医学T2D随访患者进行了研究。两次24小时尿液MA定量检测作为金标准。结果。MA患病率为23%,CI 95%: 16.9-29.1。MT效度敏感性为77%,阴性预测值为88%,Kappa系数为0.2 (p = 0.001)。在血压≥130/80 mmHg、CHT/HDL比值≥3、T2D≥5年以及女性受试者中,阴性预测值分别为91%、89%、95%和91%。男性的ROC曲线下面积为0.81 (p = 0.008),糖尿病病程超过5年的ROC曲线下面积为0.80 (p = 0.001)。MT在100% Sp下的MA值为35 mg/L。结论。在初级卫生保健中,必须加强对T2D中MA的年度筛查,特别是当糖尿病病程超过5年或与其他心血管风险相关时。
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引用次数: 7
Corrigendum to "A Systematic Review of Peripheral and Central Nervous System Involvement of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, and Associated Immunological Profiles". “类风湿关节炎、系统性红斑狼疮、原发性Sjögren综合征和相关免疫学概况的外周和中枢神经系统受累的系统综述”的勘误表。
Pub Date : 2016-01-01 Epub Date: 2016-04-07 DOI: 10.1155/2016/9854813
Anastasia Bougea, Evangelos Anagnostou, Konstantinos Giatas, George Paraskevas, Nikolaos Triantafyllou, Evangelia Kararizou

[This corrects the article DOI: 10.1155/2015/910352.].

[这更正了文章DOI: 10.1155/2015/910352.]
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引用次数: 4
Burden of Self-Reported Noncommunicable Diseases in 26 Villages of Anand District of Gujarat, India 印度古吉拉特邦阿南德区26个村庄自我报告的非传染性疾病负担
Pub Date : 2015-11-30 DOI: 10.1155/2015/260143
Dinesh Kumar, S. Raithatha, S. Gupta, Ravi Raj, N. Kharod
Introduction. Noncommunicable diseases (NCDs) account for 53% of deaths and 44% of disability adjusted life years lost in India. A survey was undertaken to measure the prevalence of tobacco and alcohol use and self-reported NCDs in a rural community in western part of India. Methodology. Trained Village Health Workers did the survey in the years 2012-13 under supervision. The data was collected for five NCDs, namely, hypertension, diabetes mellitus, cancer, heart disease, and mental illnesses. Results. 18,269 households with a population of 89755 were covered. Prevalence of any form of tobacco use in the age group of >20 years was 34.5 and 52.7% and 15.2% in males and females, respectively. Prevalence of any NCD was 5.3% with a slightly higher prevalence in females (5.4%) than males (5.2%) in the age group of 20–69 years. Prevalence of NCD multimorbidity (≥2 NCDs) was 0.7% in the age group of 20–69 years. 80.7% of hypertensives and 94.9% of diabetics were taking treatment. More females than males were taking antihypertensive treatment. Conclusion. Tobacco use was high. Prevalence of NCDs was less than that reported in other studies. Data generated from this study can be useful in planning a community based NCD programme.
介绍。在印度,非传染性疾病占死亡人数的53%,占残疾调整生命年损失的44%。在印度西部的一个农村社区进行了一项调查,以衡量烟草和酒精使用的流行程度以及自我报告的非传染性疾病。方法。训练有素的村卫生工作者在监督下于2012-13年进行了调查。收集了五种非传染性疾病的数据,即高血压、糖尿病、癌症、心脏病和精神疾病。结果:共覆盖18269户,人口89755人。在>20岁年龄组中,任何形式的烟草使用流行率在男性和女性中分别为34.5%、52.7%和15.2%。任何非传染性疾病的患病率为5.3%,在20-69岁年龄组中,女性患病率(5.4%)略高于男性(5.2%)。20-69岁年龄组非传染性疾病多病(≥2种非传染性疾病)患病率为0.7%。80.7%的高血压患者和94.9%的糖尿病患者正在接受治疗。接受降压治疗的女性多于男性。结论。烟草使用率很高。非传染性疾病的流行率低于其他研究报告。这项研究产生的数据可用于规划以社区为基础的非传染性疾病规划。
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引用次数: 10
A Systematic Review of Peripheral and Central Nervous System Involvement of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, and Associated Immunological Profiles 类风湿关节炎、系统性红斑狼疮、原发性Sjögren综合征和相关免疫概况的外周和中枢神经系统受累的系统综述
Pub Date : 2015-11-25 DOI: 10.1155/2015/910352
A. Bougea, E. Anagnostou, G. Konstantinos, Paraskevas George, N. Triantafyllou, E. Kararizou
Both central (CNS) and peripheral nervous system (PNS) complications are frequent and varied in connective tissue diseases. A systematic review was conducted between 1989 and 2014 in the databases Medline, Scopus, and Cochrane Library using the search terms, peripheral and central nervous complications and immunological profiles, to identify studies in specific connective tissue disorders such as rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren's syndrome. A total of 675 references were identified, of which 118 were selected for detailed analysis and 22 were included in the final review with a total of 2338 participants. Our search focused only on studies upon connective tissue disorders such as rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren's syndrome associated with seroimmunological data. The reported prevalence of CNS involvement ranges from 9 to 92% across the reported studies. However, the association between CNS and PNS manifestations and seroimmunological profiles remains controversial. Τo date, no laboratory test has been shown as pathognomonic neither for CNS nor for PNS involvement.
中枢(CNS)和周围神经系统(PNS)并发症在结缔组织疾病中是常见和多样的。1989年至2014年间,在Medline、Scopus和Cochrane Library数据库中使用搜索词、外周和中枢神经并发症和免疫学概况进行了一项系统综述,以确定特定结缔组织疾病(如类风湿关节炎、系统性红斑狼疮和原发性Sjögren综合征)的研究。共识别675篇参考文献,其中118篇被选中进行详细分析,22篇被纳入最终评审,共计2338名参与者。我们的研究只关注结缔组织疾病的研究,如类风湿关节炎、系统性红斑狼疮和原发性Sjögren综合征与血清免疫数据相关。在报告的研究中,报道的中枢神经系统受累的患病率从9%到92%不等。然而,CNS和PNS表现与血清免疫学特征之间的关系仍然存在争议。Τo到目前为止,没有实验室检查显示中枢神经系统和PNS受累的病理特征。
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引用次数: 26
Genetic Evaluation of E. coli Strains Isolated from Asymptomatic Children with Neurogenic Bladders 无症状儿童神经源性膀胱分离大肠杆菌的遗传评价
Pub Date : 2015-11-01 DOI: 10.1155/2015/206570
J. Kryger, A. Burleigh, M. Christensen, W. Hopkins
This study was conducted to describe the genetic profiles of E. coli that colonize asymptomatic pediatric neurogenic bladders. E. coli was isolated from 25 of 80 urine samples. Patients were excluded if they presented with symptomatic urinary tract infection or received treatment with antibiotics in the preceding three months. Multiplex PCR was performed to determine E. coli phylotype (A, B1, B2, and D) and the presence of seven pathogenicity islands (PAIs) and 10 virulence factors (VFs). E. coli strains were predominantly of the B1 and B2 phylotype, with few strains in the A or D phylotype. The PAIs IV536, ICFT073, and IICFT073 had the highest prevalence: 76%, 64%, and 48%, respectively. The PAIs II536, IJ96, and IIJ96 were less prevalent: 28%, 20%, and 24%, respectively. The most prevalent VF was vat (40%), while the least prevalent VFs were sfa (8%) and iha (12%). None of the strains carried the VF fyuA, which is very common in uropathogenic E. coli (UPEC). The genetic profiles of E. coli in this cohort seem to be more similar to UPEC than to commensal E. coli. However, they appear to have reduced virulence potential that allows them to colonize asymptomatically.
本研究旨在描述大肠杆菌在无症状儿童神经源性膀胱中定植的遗传谱。80份尿样中有25份分离出大肠杆菌。如果患者在前三个月内出现症状性尿路感染或接受过抗生素治疗,则排除在外。采用多重PCR检测大肠杆菌A、B1、B2和D型,并检测7个致病性岛(PAIs)和10个毒力因子(VFs)的存在。大肠杆菌以B1和B2型菌株为主,A和D型菌株较少。PAIs IV536、ICFT073和IICFT073的患病率最高,分别为76%、64%和48%。PAIs II536、IJ96和IIJ96患病率较低,分别为28%、20%和24%。最常见的VF是vat(40%),而最不常见的VF是sfa(8%)和iha(12%)。这些菌株都没有携带尿路致病性大肠杆菌(UPEC)中非常常见的VF fyuA。该队列中大肠杆菌的遗传谱似乎更类似于upc而不是共生大肠杆菌。然而,它们似乎具有降低的毒力潜力,使它们能够无症状地定植。
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引用次数: 6
Reduced Risk of Parkinson's Disease in Users of Calcium Channel Blockers: A Meta-Analysis. 钙通道阻滞剂使用者帕金森病风险降低:一项荟萃分析
Pub Date : 2015-01-01 Epub Date: 2015-02-03 DOI: 10.1155/2015/697404
Kapil Gudala, Raju Kanukula, Dipika Bansal

Aim. To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson's disease (PD). Methods. Literature search in PubMed, EBSCO, and Cochrane library was undertaken through March 2014, looking for observational studies evaluating the association between CCBs use and PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup analyses, sensitivity Analysis, and cumulative meta-analysis were also performed. Results. Six studies were included in our meta-analysis according to the selection criteria, including three cohort studies and three case-control studies involving 27,67,990 subjects including 11,941 PD cases. We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%). Both the classes of CCB, that is, dihydropyridine calcium channel blockers (DiCCB) (0.80 (95% CI, 0.65-0.98) P = 0.032) and non-DiCCB (0.70 (95% CI, 0.53-0.92) P = 0.013), were found to be reducing the risk of PD. Conclusion. In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.

的目标。汇总目前可用的数据,以确定钙通道阻滞剂(CCBs)与帕金森病(PD)风险之间的关系。方法。2014年3月,在PubMed、EBSCO和Cochrane图书馆进行文献检索,寻找评估CCBs使用与PD之间关系的观察性研究。采用随机效应模型计算合并相对危险度(RR)估计值和95%置信区间(ci)。还进行了亚组分析、敏感性分析和累积荟萃分析。结果。根据选择标准,我们将6项研究纳入meta分析,包括3项队列研究和3项病例对照研究,涉及27,67,990名受试者,其中11,941例PD病例。我们发现,与不使用CCBs相比,使用CCBs与PD风险显著降低相关(随机效应模型合并RR, 0.81 (95% CI, 0.69-0.95));研究间存在显著异质性(P = 0.031;I(2) 54.6%。两类CCB,即二氢吡啶钙通道阻滞剂(DiCCB) (0.80 (95% CI, 0.65-0.98) P = 0.032)和非DiCCB (0.70 (95% CI, 0.53-0.92) P = 0.013)均可降低PD的风险。结论。在我们的分析中,我们发现与非ccb使用相比,ccb使用与PD风险显著降低相关。
{"title":"Reduced Risk of Parkinson's Disease in Users of Calcium Channel Blockers: A Meta-Analysis.","authors":"Kapil Gudala,&nbsp;Raju Kanukula,&nbsp;Dipika Bansal","doi":"10.1155/2015/697404","DOIUrl":"https://doi.org/10.1155/2015/697404","url":null,"abstract":"<p><p>Aim. To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson's disease (PD). Methods. Literature search in PubMed, EBSCO, and Cochrane library was undertaken through March 2014, looking for observational studies evaluating the association between CCBs use and PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup analyses, sensitivity Analysis, and cumulative meta-analysis were also performed. Results. Six studies were included in our meta-analysis according to the selection criteria, including three cohort studies and three case-control studies involving 27,67,990 subjects including 11,941 PD cases. We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69-0.95)); a significant heterogeneity was found between studies (P = 0.031; I (2) 54.6%). Both the classes of CCB, that is, dihydropyridine calcium channel blockers (DiCCB) (0.80 (95% CI, 0.65-0.98) P = 0.032) and non-DiCCB (0.70 (95% CI, 0.53-0.92) P = 0.013), were found to be reducing the risk of PD. Conclusion. In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use. </p>","PeriodicalId":13831,"journal":{"name":"International Journal of Chronic Diseases","volume":"2015 ","pages":"697404"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/697404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34255032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Untreated Isolated Sytolic Hypertension among Middle-Aged and Old Adults in the United States: Trends in the Prevalence by Demographic Factors During 1999-2010. 美国中老年人群中未经治疗的孤立性收缩期高血压:1999-2010年人口统计学因素的流行趋势
Pub Date : 2015-01-01 Epub Date: 2015-02-23 DOI: 10.1155/2015/508584
Xuefeng Liu, Van Minh Hoang, Yali Liu, Rachel L W Brown

Isolated systolic hypertension (ISH) predominates hemodynamic hypertension subtypes and becomes a significant factor for cardiovascular and renal outcomes in middle-aged and old adults. The prevalence and changes of untreated ISH have not been fully investigated in this population. A total of 12,097 participants aged ≥40 years were selected from the National Health and Nutrition Examination Survey 1999-2010. The overall prevalence of untreated ISH was 15.2%. The prevalence decreased significantly from 16.8% in 1999-2004 to 13.5% in 2005-2010. Females, non-Hispanic blacks, and adults with low education had higher prevalence of untreated ISH than males, non-Hispanic whites, and adults with high education, respectively. Compared with 1999-2004, the prevalence of untreated ISH in 2005-2010 reduced in old adults (28.0% versus 37.7%), females (14.3% versus 19.5%), and non-Hispanic whites (12.7% versus 16.2%). The stratified prevalence of untreated ISH decreased in 2005-2010 in non-Hispanic white females (12.8% versus 18.6%) and females who did not attend college (16.9% versus 21.8%). Untreated ISH is more prevalent in old and female subjects, and significant improvements in these groups suggest that public health measures or changes are in the right direction.

孤立性收缩期高血压(ISH)在血流动力学高血压亚型中占主导地位,并成为中老年人心血管和肾脏预后的重要因素。在这一人群中,未经治疗的ISH患病率和变化尚未得到充分调查。从1999-2010年全国健康与营养调查中选取年龄≥40岁的12,097名参与者。未经治疗的ISH总患病率为15.2%。流行率从1999-2004年的16.8%显著下降到2005-2010年的13.5%。女性、非西班牙裔黑人和受教育程度低的成年人未经治疗的ISH患病率分别高于男性、非西班牙裔白人和受教育程度高的成年人。与1999-2004年相比,2005-2010年未经治疗的ISH患病率在老年人(28.0%对37.7%)、女性(14.3%对19.5%)和非西班牙裔白人(12.7%对16.2%)中有所下降。2005-2010年,非西班牙裔白人女性(12.8%对18.6%)和未上过大学的女性(16.9%对21.8%)未经治疗的ISH分层患病率下降。未经治疗的ISH在老年人和女性受试者中更为普遍,这些群体的显著改善表明,公共卫生措施或变化正朝着正确的方向发展。
{"title":"Untreated Isolated Sytolic Hypertension among Middle-Aged and Old Adults in the United States: Trends in the Prevalence by Demographic Factors During 1999-2010.","authors":"Xuefeng Liu,&nbsp;Van Minh Hoang,&nbsp;Yali Liu,&nbsp;Rachel L W Brown","doi":"10.1155/2015/508584","DOIUrl":"https://doi.org/10.1155/2015/508584","url":null,"abstract":"<p><p>Isolated systolic hypertension (ISH) predominates hemodynamic hypertension subtypes and becomes a significant factor for cardiovascular and renal outcomes in middle-aged and old adults. The prevalence and changes of untreated ISH have not been fully investigated in this population. A total of 12,097 participants aged ≥40 years were selected from the National Health and Nutrition Examination Survey 1999-2010. The overall prevalence of untreated ISH was 15.2%. The prevalence decreased significantly from 16.8% in 1999-2004 to 13.5% in 2005-2010. Females, non-Hispanic blacks, and adults with low education had higher prevalence of untreated ISH than males, non-Hispanic whites, and adults with high education, respectively. Compared with 1999-2004, the prevalence of untreated ISH in 2005-2010 reduced in old adults (28.0% versus 37.7%), females (14.3% versus 19.5%), and non-Hispanic whites (12.7% versus 16.2%). The stratified prevalence of untreated ISH decreased in 2005-2010 in non-Hispanic white females (12.8% versus 18.6%) and females who did not attend college (16.9% versus 21.8%). Untreated ISH is more prevalent in old and female subjects, and significant improvements in these groups suggest that public health measures or changes are in the right direction. </p>","PeriodicalId":13831,"journal":{"name":"International Journal of Chronic Diseases","volume":"2015 ","pages":"508584"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/508584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34255030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study. 平均血小板体积和脾肿大是埃及儿童家族性地中海热亚临床活性的有用标志物:一项横断面研究。
Pub Date : 2015-01-01 Epub Date: 2015-07-13 DOI: 10.1155/2015/152616
Huda Marzouk, Hala M Lotfy, Yomna Farag, L A Rashed, Kamal El-Garf

Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P = 0.045). Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

目标。探讨平均血小板体积(MPV)和脾肿大是否可作为家族性地中海热(FMF)患儿无发作期的亚临床炎症指标。患者和方法。该研究包括97名患有FMF的儿童。MPV在4小时内按照标准实验室操作进行血样采集。腹腔超声(USG)检查脾肿大。结果。在我们研究的患者中,84.45%的患者检测到高MPV, FMF伴脾肿大患者的MPV明显高于无脾肿大患者。MPV与脾跨度有统计学意义(P = 0.045)。结论。FMF患儿无发作期MPV升高及其与脾跨度的显著相关性支持MPV和脾肿大作为FMF患者无发作期亚临床炎症的有用标志物。
{"title":"Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study.","authors":"Huda Marzouk,&nbsp;Hala M Lotfy,&nbsp;Yomna Farag,&nbsp;L A Rashed,&nbsp;Kamal El-Garf","doi":"10.1155/2015/152616","DOIUrl":"https://doi.org/10.1155/2015/152616","url":null,"abstract":"<p><p>Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P = 0.045). Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period. </p>","PeriodicalId":13831,"journal":{"name":"International Journal of Chronic Diseases","volume":"2015 ","pages":"152616"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/152616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34085880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Relationship between Helicobacter pylori Infections in Diabetic Patients and Inflammations, Metabolic Syndrome, and Complications. 糖尿病患者幽门螺杆菌感染与炎症、代谢综合征及并发症的关系
Pub Date : 2015-01-01 Epub Date: 2015-01-22 DOI: 10.1155/2015/290128
Yusuf Kayar, Özgül Pamukçu, Hatice Eroğlu, Kübra Kalkan Erol, Aysegul Ilhan, Orhan Kocaman

Helicobacter pylori infection and diabetes mellitus are two independent common diseases. It is showed that the worsening glycemic and metabolic control increases the rates of Helicobacter pylori infections and Helicobacter pylori is shown as one of the common problems in diabetic patients with complaints of gastrointestinal diseases. In this study, we aimed to investigate the prevalence and eradication rates of Helicobacter pylori in diabetic patients and the relationship of Helicobacter pylori with the risk factors and diabetic complications. In our study, in which we have included 133 patients, we have shown a significant relationship between Helicobacter pylori infections and metabolic syndrome, insulin resistance, inflammations, and diabetic complications.

幽门螺杆菌感染与糖尿病是两种独立的常见病。结果表明,血糖和代谢控制的恶化增加了幽门螺杆菌的感染率,幽门螺杆菌是糖尿病患者主诉胃肠道疾病的常见问题之一。本研究旨在探讨幽门螺杆菌在糖尿病患者中的患病率和根除率,以及幽门螺杆菌与糖尿病危险因素和糖尿病并发症的关系。在我们纳入133例患者的研究中,我们发现幽门螺杆菌感染与代谢综合征、胰岛素抵抗、炎症和糖尿病并发症之间存在显著关系。
{"title":"Relationship between Helicobacter pylori Infections in Diabetic Patients and Inflammations, Metabolic Syndrome, and Complications.","authors":"Yusuf Kayar,&nbsp;Özgül Pamukçu,&nbsp;Hatice Eroğlu,&nbsp;Kübra Kalkan Erol,&nbsp;Aysegul Ilhan,&nbsp;Orhan Kocaman","doi":"10.1155/2015/290128","DOIUrl":"https://doi.org/10.1155/2015/290128","url":null,"abstract":"<p><p>Helicobacter pylori infection and diabetes mellitus are two independent common diseases. It is showed that the worsening glycemic and metabolic control increases the rates of Helicobacter pylori infections and Helicobacter pylori is shown as one of the common problems in diabetic patients with complaints of gastrointestinal diseases. In this study, we aimed to investigate the prevalence and eradication rates of Helicobacter pylori in diabetic patients and the relationship of Helicobacter pylori with the risk factors and diabetic complications. In our study, in which we have included 133 patients, we have shown a significant relationship between Helicobacter pylori infections and metabolic syndrome, insulin resistance, inflammations, and diabetic complications. </p>","PeriodicalId":13831,"journal":{"name":"International Journal of Chronic Diseases","volume":"2015 ","pages":"290128"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/290128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34255028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection. 绝经前和绝经后慢性丙型肝炎病毒(基因型4)感染患者女性性激素模式及其与疾病严重程度和治疗的关系
Pub Date : 2015-01-01 Epub Date: 2015-08-17 DOI: 10.1155/2015/927974
Nora H Ahmed, Taghrid B El-Abaseri, Hesham F El-Sayed, Taher I El-Serafi

Chronic hepatitis C (CHC) course revealed differences between men and women. Male gender and postmenopausal women are thought to be of the critical factors affecting HCV infection progression. The study aimed to assess female sex hormones and their relation to disease severity and treatment in HCV infected females. Subjects were divided to 2 groups: 44 CHC female patients and 44 controls. Both groups were classified to premenopausal and postmenopausal females. Serum estradiol (E2), progesterone (PRG), and total testosterone (TT) were assessed using chemiluminescent immunoassay. Our results showed that menopausal patients had significantly higher levels of estradiol, total testosterone, and progesterone compared to controls (P < 0.001). Reproductive aged patients had lower level of total testosterone compared to menopausal patients (P < 0.001). HCV infected females of reproductive age had higher level of progesterone compared to menopausal HCV infected females (P = 0.0014). Indicators of disease severity and treatment response were significantly worse in menopausal women compared to reproductive aged women (fibrosis: P < 0.001, activity: P = 0.045, and treatment: P < 0.001). We observed that lower estradiol level may be related to fibrosis severity in CHC females. Higher total testosterone and progesterone levels may be related to fibrosis severity and poor response to treatment in CHC menopausal females only.

慢性丙型肝炎(CHC)病程在男性和女性之间存在差异。男性和绝经后妇女被认为是影响HCV感染进展的关键因素。本研究旨在评估女性性激素及其与HCV感染女性疾病严重程度和治疗的关系。研究对象分为2组:女性CHC患者44例,对照组44例。两组均分为绝经前和绝经后两组。采用化学发光免疫法测定血清雌二醇(E2)、孕酮(PRG)和总睾酮(TT)。我们的研究结果显示,绝经期患者的雌二醇、总睾酮和孕酮水平明显高于对照组(P < 0.001)。育龄期患者总睾酮水平低于绝经期患者(P < 0.001)。育龄期感染HCV的女性孕酮水平高于绝经期感染HCV的女性(P = 0.0014)。与育龄妇女相比,绝经妇女的疾病严重程度和治疗反应指标明显更差(纤维化:P < 0.001,活动:P = 0.045,治疗:P < 0.001)。我们观察到较低的雌二醇水平可能与CHC女性纤维化严重程度有关。仅在CHC绝经期女性中,较高的总睾酮和孕酮水平可能与纤维化严重程度和治疗反应差有关。
{"title":"Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection.","authors":"Nora H Ahmed,&nbsp;Taghrid B El-Abaseri,&nbsp;Hesham F El-Sayed,&nbsp;Taher I El-Serafi","doi":"10.1155/2015/927974","DOIUrl":"https://doi.org/10.1155/2015/927974","url":null,"abstract":"<p><p>Chronic hepatitis C (CHC) course revealed differences between men and women. Male gender and postmenopausal women are thought to be of the critical factors affecting HCV infection progression. The study aimed to assess female sex hormones and their relation to disease severity and treatment in HCV infected females. Subjects were divided to 2 groups: 44 CHC female patients and 44 controls. Both groups were classified to premenopausal and postmenopausal females. Serum estradiol (E2), progesterone (PRG), and total testosterone (TT) were assessed using chemiluminescent immunoassay. Our results showed that menopausal patients had significantly higher levels of estradiol, total testosterone, and progesterone compared to controls (P < 0.001). Reproductive aged patients had lower level of total testosterone compared to menopausal patients (P < 0.001). HCV infected females of reproductive age had higher level of progesterone compared to menopausal HCV infected females (P = 0.0014). Indicators of disease severity and treatment response were significantly worse in menopausal women compared to reproductive aged women (fibrosis: P < 0.001, activity: P = 0.045, and treatment: P < 0.001). We observed that lower estradiol level may be related to fibrosis severity in CHC females. Higher total testosterone and progesterone levels may be related to fibrosis severity and poor response to treatment in CHC menopausal females only. </p>","PeriodicalId":13831,"journal":{"name":"International Journal of Chronic Diseases","volume":"2015 ","pages":"927974"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/927974","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34255034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
期刊
International Journal of Chronic Diseases
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