Pub Date : 2022-06-30DOI: 10.23937/2378-3419/1410180
Karim Hersh Ham, Negm Ola, Ahmad Narmeen, Ilyas Mohammad
Introduction: Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between primary colorectal cancer (pCRC) and their respective metastases. Methods: A total of 22 pairs of pCRC and metastases were tested. Mutation profiling of 26 cancer-associated genes was undertaken in 22/22primary-metastasis tumour pairs using next-generation sequencing, whilst the expression of a panel of six microRNAs (miRNAs) was investigated using qPCR in 21/22 pairs and 22 protein biomarkers was tested using Reverse Phase Protein Array (RPPA) in 20/22 patients’ tumour pairs. Results: Among the primary and metastatic tumours, the mutation rates for the individual genes are as follows: TP53 (86%), APC (44%), KRAS (36%), PIK3CA (9%), SMAD4 (9%), NRAS (9%) and 4% for FBXW7 , BRAF , GNAS and CDH1 . The primary-metastasis tumour mutation status was identical in 54/60 (90%) loci. However, there was discordance in heterogeneity status in 40/58 genetic loci (z-score = 6.246, difference = 0.3793, P < 0.0001). Furthermore, there was loss of concordance in miRNA
{"title":"Comparative Analysis of Primary Tumour and Matched Metastases in Colorectal Cancer Patients: An Investigation of the Genomic, Proteomic and Post-Transcriptional Regulation Profiles","authors":"Karim Hersh Ham, Negm Ola, Ahmad Narmeen, Ilyas Mohammad","doi":"10.23937/2378-3419/1410180","DOIUrl":"https://doi.org/10.23937/2378-3419/1410180","url":null,"abstract":"Introduction: Approximately 50% of patients with primary colorectal carcinoma develop liver metastases. This study investigates the possible molecular discrepancies between primary colorectal cancer (pCRC) and their respective metastases. Methods: A total of 22 pairs of pCRC and metastases were tested. Mutation profiling of 26 cancer-associated genes was undertaken in 22/22primary-metastasis tumour pairs using next-generation sequencing, whilst the expression of a panel of six microRNAs (miRNAs) was investigated using qPCR in 21/22 pairs and 22 protein biomarkers was tested using Reverse Phase Protein Array (RPPA) in 20/22 patients’ tumour pairs. Results: Among the primary and metastatic tumours, the mutation rates for the individual genes are as follows: TP53 (86%), APC (44%), KRAS (36%), PIK3CA (9%), SMAD4 (9%), NRAS (9%) and 4% for FBXW7 , BRAF , GNAS and CDH1 . The primary-metastasis tumour mutation status was identical in 54/60 (90%) loci. However, there was discordance in heterogeneity status in 40/58 genetic loci (z-score = 6.246, difference = 0.3793, P < 0.0001). Furthermore, there was loss of concordance in miRNA","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77591355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.23937/2378-3419/1410170
Rungoutok Muangloei, Suprasert Prapaporn
Background: Malignant Ovarian Germ Cell Tumors (MOGCT) are rare and frequently occur in the young reproductive age and the oncologic and reproductive outcome after Fertility-Sparing Surgery (FSS) this disease is still limited. Objective: To evaluate the oncology and reproductive outcome of MOGCT who underwent FSS. Method: All MOGCT who underwent FSS defined as the operation with a preserved uterus and at least one side of the ovary at our institute between January 2005 and December 2020 were retrospective reviews. Results: Sixty-two patients were recruited in this study. The median age was 22-year-old and over 77% were nulliparity. The three most common histology findings were immature teratoma (32.2%), dysgerminoma (24.2%), and yolk sac tumor (24.2%). The distribution of stage was as follows; stage I = 74.8%, stage II = 9.7%, stage III = 11.3% and stage IV = 4.8%. Forty-three (67.7%) patients received adjuvant chemotherapy. With a median follow-up time of 96.3 months, the ten-year progression-free survival and overall survival were 82.4% and 91%, respectively. For reproductive outcomes, 43 patients who received adjuvant chemotherapy, 18 (41.9%) had normal menstruation, and 17 cases (39.5%) resumed menstruation with a median time of four months. About 14 patients who desired to conceive, four cases were pregnant and delivered good outcomes. Only one case was aborted. Therefore, the successful pregnancy rate was 28.6%. Conclusion: The oncology and reproductive outcome of MOGCT treated with FSS were excellent. Many patients showed a long survival time with normal menstruation. However, the obstetric outcome was not quite high.
{"title":"Oncology and Reproductive Outcomes Over Sixteen Years of Malignant Ovarian Germ Cell Tumors Treated with Fertility Sparing Surgery","authors":"Rungoutok Muangloei, Suprasert Prapaporn","doi":"10.23937/2378-3419/1410170","DOIUrl":"https://doi.org/10.23937/2378-3419/1410170","url":null,"abstract":"Background: Malignant Ovarian Germ Cell Tumors (MOGCT) are rare and frequently occur in the young reproductive age and the oncologic and reproductive outcome after Fertility-Sparing Surgery (FSS) this disease is still limited. Objective: To evaluate the oncology and reproductive outcome of MOGCT who underwent FSS. Method: All MOGCT who underwent FSS defined as the operation with a preserved uterus and at least one side of the ovary at our institute between January 2005 and December 2020 were retrospective reviews. Results: Sixty-two patients were recruited in this study. The median age was 22-year-old and over 77% were nulliparity. The three most common histology findings were immature teratoma (32.2%), dysgerminoma (24.2%), and yolk sac tumor (24.2%). The distribution of stage was as follows; stage I = 74.8%, stage II = 9.7%, stage III = 11.3% and stage IV = 4.8%. Forty-three (67.7%) patients received adjuvant chemotherapy. With a median follow-up time of 96.3 months, the ten-year progression-free survival and overall survival were 82.4% and 91%, respectively. For reproductive outcomes, 43 patients who received adjuvant chemotherapy, 18 (41.9%) had normal menstruation, and 17 cases (39.5%) resumed menstruation with a median time of four months. About 14 patients who desired to conceive, four cases were pregnant and delivered good outcomes. Only one case was aborted. Therefore, the successful pregnancy rate was 28.6%. Conclusion: The oncology and reproductive outcome of MOGCT treated with FSS were excellent. Many patients showed a long survival time with normal menstruation. However, the obstetric outcome was not quite high.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86041249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.23937/2378-3419/1410166
Mohamed Saeed Mahmoud Saeed, Amin Afaf Mosaad, Skander Suzanne William, Hewala Taha Ismail Mahmoud, Saleh Eithar Omer Mohamed, Salih Aisha Mohammed Osman, Al-Qadasi Sabah Ali Mugahed, Badawi Marwan Mustafa, Hamed Mahmoud Assem
Colorectal Cancer (CRC) is among the most common types of cancer in the world. Globally a steadily increasing proportion of elderly people in the world result in approximately 16 million new cases of cancer by the year 2021. Regarding treatment; Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect, capacity for cell cycle arrest, and pro-apoptotic effects, also acted as free radical scavenger, in particular superoxide anion oxidation scavenge. The aim of the current study was to clarify much important information on histopathology, histochemistry and immunoassay of CEA tumor marker characteristics of 1,2 DMH-induced colon tumor in albino rat and its relationship with the aberrant crypt mucosa as precursor in colon cancer progression. The study was carried out on 60 male albino rats, animals were divided into 5 groups; A: control group, B: animals received S.C. injections of 20 mg 1,2 DMH/Kg b.w, C: animals received 1,2 DMH with ad libitum access to water and high fat diet, D: animals fed high fat diet and water ad libitum. E: animals received S.C. injections of 1,2 DMH and oral 15 mg/Kg/day meloxicam/0.1 ml saline. Colon tissues from all studied groups were stained applying the following techniques: Hematoxylin & eosin, Alcian blue pH 2.5-acid mucopolysaccharide, Feulgen nuclear staining of DNA, Whole mount staining of colon and Immunoassay of serum CEA. The results confirmed the efficacy of meloxicam inhibiting or delaying growth of aberrant crypt foci in colon. Further research is needed to support presented findings.
{"title":"Chemoprevention of 1,2 Dimethyl Hydrazine-Induced Colon Tumor in Albino Rat by Meloxicam and its Correlation with Immunoassay of Serum CEA","authors":"Mohamed Saeed Mahmoud Saeed, Amin Afaf Mosaad, Skander Suzanne William, Hewala Taha Ismail Mahmoud, Saleh Eithar Omer Mohamed, Salih Aisha Mohammed Osman, Al-Qadasi Sabah Ali Mugahed, Badawi Marwan Mustafa, Hamed Mahmoud Assem","doi":"10.23937/2378-3419/1410166","DOIUrl":"https://doi.org/10.23937/2378-3419/1410166","url":null,"abstract":"Colorectal Cancer (CRC) is among the most common types of cancer in the world. Globally a steadily increasing proportion of elderly people in the world result in approximately 16 million new cases of cancer by the year 2021. Regarding treatment; Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect, capacity for cell cycle arrest, and pro-apoptotic effects, also acted as free radical scavenger, in particular superoxide anion oxidation scavenge. The aim of the current study was to clarify much important information on histopathology, histochemistry and immunoassay of CEA tumor marker characteristics of 1,2 DMH-induced colon tumor in albino rat and its relationship with the aberrant crypt mucosa as precursor in colon cancer progression. The study was carried out on 60 male albino rats, animals were divided into 5 groups; A: control group, B: animals received S.C. injections of 20 mg 1,2 DMH/Kg b.w, C: animals received 1,2 DMH with ad libitum access to water and high fat diet, D: animals fed high fat diet and water ad libitum. E: animals received S.C. injections of 1,2 DMH and oral 15 mg/Kg/day meloxicam/0.1 ml saline. Colon tissues from all studied groups were stained applying the following techniques: Hematoxylin & eosin, Alcian blue pH 2.5-acid mucopolysaccharide, Feulgen nuclear staining of DNA, Whole mount staining of colon and Immunoassay of serum CEA. The results confirmed the efficacy of meloxicam inhibiting or delaying growth of aberrant crypt foci in colon. Further research is needed to support presented findings.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86381631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-28DOI: 10.23937/2378-3419/1410168
Ruggeri Carlos Santiago, Aguirre Claudina, E. Claudia, Aragon Guillermo Sebastian
Introduction: Inverted papilloma (IP) may be associated with synchronously or metachronously rhinosinusal squamous cell carcinoma. Objectives: To determine the incidence of squamous cell carcinoma in patients with IP of the paranasal sinuses andlocal control in patients treated for cancer associated with IP. Methods: A descriptive and retrospective study was carried out. All patients who were treated in the rhinosinusology section of the otorhinolaryngology department of the Hospital Italiano de Buenos Aires with histopathology diagnosis of inverted papilloma between January 2005 and December 2021 were included. Those with associated malignant tumors were selected. Results: Sixty three patients with a histopathological diagnosis of inverted papiloma were treated. Five had a synchronous malignant tumors, 4 epidermoid carcinomas and one a verrucous carcinoma and two a metachronous cancer (11.11%). The treatment included surgery, radiotherapy and chemotherapy combined in different schemes according to the indication of the tumor committee. Conclusions: The incidence of malignant tumors associated with inverted papilloma found in our study was 11.11% (7 of 63 patients). Two patients had metachronous and 5 synchronous malignant tumors. In three patients local control of the disease was obtained. The prognosis of epidermoid and verrucous carcinoma associated with inverted papilloma is similar to rhinosinusal squamous carcinomas not associated with inverted papilloma.
{"title":"Squamous Cell Carcinoma Arising from Inverted Papilloma","authors":"Ruggeri Carlos Santiago, Aguirre Claudina, E. Claudia, Aragon Guillermo Sebastian","doi":"10.23937/2378-3419/1410168","DOIUrl":"https://doi.org/10.23937/2378-3419/1410168","url":null,"abstract":"Introduction: Inverted papilloma (IP) may be associated with synchronously or metachronously rhinosinusal squamous cell carcinoma. Objectives: To determine the incidence of squamous cell carcinoma in patients with IP of the paranasal sinuses andlocal control in patients treated for cancer associated with IP. Methods: A descriptive and retrospective study was carried out. All patients who were treated in the rhinosinusology section of the otorhinolaryngology department of the Hospital Italiano de Buenos Aires with histopathology diagnosis of inverted papilloma between January 2005 and December 2021 were included. Those with associated malignant tumors were selected. Results: Sixty three patients with a histopathological diagnosis of inverted papiloma were treated. Five had a synchronous malignant tumors, 4 epidermoid carcinomas and one a verrucous carcinoma and two a metachronous cancer (11.11%). The treatment included surgery, radiotherapy and chemotherapy combined in different schemes according to the indication of the tumor committee. Conclusions: The incidence of malignant tumors associated with inverted papilloma found in our study was 11.11% (7 of 63 patients). Two patients had metachronous and 5 synchronous malignant tumors. In three patients local control of the disease was obtained. The prognosis of epidermoid and verrucous carcinoma associated with inverted papilloma is similar to rhinosinusal squamous carcinomas not associated with inverted papilloma.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79703652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.23937/2378-3419/1410167
Niakan Behzad
It is suggested that the spontaneous remission of acute myeloid leukemia, particularly hypoplastic acute myeloid leukemia seen after G-CSF treatment is possibly due to G-CSF augmenting an acute inflammatory response. This acute inflammatory response is one occurring during a low count of activated platelets and a low hemoglobulin. It appears that hypoplastic acute myeloid leukemia treated with G-CSF would be more likely to result in a remission if accompanied by an acute inflammatory response. The timing between subcutaneous G-CSF administration and an acute inflammatory response seems to be crucial to obtain an optimum acute inflammatory response and the optimum activation of innate immunity. Spontaneous remission of leukemia may be preceded with a low platelet count and anemia. A low count of activated platelets may diminish the immunosuppressive effects of activated platelets on innate and adoptive immunity. Anemia or low hemoglobulin may result in anerobic tissue respiration followed by lactic acidosis. Lactic acidosis in activating the enzyme lactate dehydrogenase and thereby dysfunctional cancer cells.
{"title":"Proposed Immunology of the Spontaneous Remission of Acute Myleiod","authors":"Niakan Behzad","doi":"10.23937/2378-3419/1410167","DOIUrl":"https://doi.org/10.23937/2378-3419/1410167","url":null,"abstract":"It is suggested that the spontaneous remission of acute myeloid leukemia, particularly hypoplastic acute myeloid leukemia seen after G-CSF treatment is possibly due to G-CSF augmenting an acute inflammatory response. This acute inflammatory response is one occurring during a low count of activated platelets and a low hemoglobulin. It appears that hypoplastic acute myeloid leukemia treated with G-CSF would be more likely to result in a remission if accompanied by an acute inflammatory response. The timing between subcutaneous G-CSF administration and an acute inflammatory response seems to be crucial to obtain an optimum acute inflammatory response and the optimum activation of innate immunity. Spontaneous remission of leukemia may be preceded with a low platelet count and anemia. A low count of activated platelets may diminish the immunosuppressive effects of activated platelets on innate and adoptive immunity. Anemia or low hemoglobulin may result in anerobic tissue respiration followed by lactic acidosis. Lactic acidosis in activating the enzyme lactate dehydrogenase and thereby dysfunctional cancer cells.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78965780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-18DOI: 10.23937/2378-3419/1410165
Budi Tulaka, H. Haroen, Linda Rotty, P. Lasut, C. Hendratta
Coronavirus Disease 2019 (COVID-19) is an outbreak of respiratory disease caused by novel coronavirus and has reached pandemic state. Cancer patients have increase susceptibility to infection caused by the malignancy itself and anticancer systemic therapy. Based on individual patient assessment, the oncologist's decision regarding the need for immediate oncological intervention classifies patients into 'urgent' and 'non-urgent' conditions. Consideration of risk and benefit for active intervention in the cancer population during an infectious disease pandemic must be individualized. Consideration for postponing elective surgery or chemotherapy for cancer patients with low risk of progression should be considered on a case-by-case basis. Options for treating or delaying treatment are best discussed with the patient in the context of multidisciplinary care.
{"title":"Treatment of Cancer Patients in the Era of the Covid-19 Pandemic","authors":"Budi Tulaka, H. Haroen, Linda Rotty, P. Lasut, C. Hendratta","doi":"10.23937/2378-3419/1410165","DOIUrl":"https://doi.org/10.23937/2378-3419/1410165","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) is an outbreak of respiratory disease caused by novel coronavirus and has reached pandemic state. Cancer patients have increase susceptibility to infection caused by the malignancy itself and anticancer systemic therapy. Based on individual patient assessment, the oncologist's decision regarding the need for immediate oncological intervention classifies patients into 'urgent' and 'non-urgent' conditions. Consideration of risk and benefit for active intervention in the cancer population during an infectious disease pandemic must be individualized. Consideration for postponing elective surgery or chemotherapy for cancer patients with low risk of progression should be considered on a case-by-case basis. Options for treating or delaying treatment are best discussed with the patient in the context of multidisciplinary care.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87165220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23937/2378-3419/1410172
Niakan Behzad
{"title":"Proposed Biology of the Spontaneous Remission of Merkel Cell Carcinoma after Biopsy","authors":"Niakan Behzad","doi":"10.23937/2378-3419/1410172","DOIUrl":"https://doi.org/10.23937/2378-3419/1410172","url":null,"abstract":"","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86784613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23937/2378-3419/1410175
PW Alabrah, A. Eguvbe, J. Agbo, D. Allagoa
Background: Breast cancer is the leading cause of cancer deaths presently, representing about 23% of all cancer cases and approximately 18% percent of deaths are attributed to it in Nigeria. It is presently the most prevalent kind of cancer worldwide, with 2.26 million cases reported in 2020. Breast Self-Examination (BSE) is a way to watch for signs of breast cancer. It is a step-by-step process women can use to examine their breasts. By looking at, and feeling their breasts regularly, they can observe abnormal changes. Aim: To assess the awareness of breast cancer and practice of breast self-examination amongst female students in a tertiary institution in South-South Nigeria. Methods: This was a cross-sectional descriptive study done amongst female students of the Federal University Otuoke from January to March 2018. Simple random sampling technique by simple balloting was used in the selection of the respondents until sample size was achieved. Data was collected using a semi-structured questionnaire and were analyzed using SPSS version 23. Results: Most, 406 (95.8%) of the respondents have heard about breast cancer. Just 52.1% of the respondents practice Breast Self-Examination (BSE) and 203 (47.9%) do not. Amongst those that practice BSE, majority 113 (54.1%) do it at least once a month. Amongst those that do not practice BSE, 48 (27.6%) do not consider it important. Age, ethnic group/tribe and the religion of respondents have a statistically significant association with been aware of breast cancer and also with practice of BSE (p > 0.05). Conclusion: Awareness about breast cancer was very high but practice of breast self-examination was on the average. There is need for more education on the risks of the disease in the general population and the need for early detection by practicing BSE and other screening measures.
背景:乳腺癌是目前癌症死亡的主要原因，约占所有癌症病例的23%，尼日利亚约18%的死亡归因于乳腺癌。它是目前世界上最常见的癌症，2020年报告的病例为226万例。乳房自检(BSE)是一种观察乳腺癌迹象的方法。这是一个循序渐进的过程，女性可以用它来检查自己的乳房。通过定期观察和触摸乳房，她们可以观察到不正常的变化。目的:评估尼日利亚南南一所高等教育机构的女学生对乳腺癌的认识和乳房自我检查的做法。方法:这是一项横断面描述性研究，于2018年1月至3月在奥图奥克联邦大学的女学生中进行。在调查对象的选择中，采用简单随机抽样的方法进行简单投票，直到达到样本量为止。使用半结构化问卷收集数据，并使用SPSS version 23进行分析。结果:406人(95.8%)的受访者听说过乳腺癌。只有52.1%的受访者进行乳房自我检查(BSE)， 203人(47.9%)没有。在患有疯牛病的人中，大多数113人(54.1%)每月至少做一次。在没有患疯牛病的人中，48人(27.6%)认为不重要。调查对象的年龄、民族/部落和宗教信仰与乳腺癌意识和疯牛病实践有统计学意义的相关性(p < 0.05)。结论:乳腺癌的知晓率很高，但乳房自检的实现率一般。有必要就该疾病在普通人群中的风险进行更多的教育，并通过实施疯牛病和其他筛查措施进行早期发现。
{"title":"Awareness of Breast Cancer and Practice of Breast Self-Examination Amongst Female Students of a Tertiary Institution in South-South Nigeria","authors":"PW Alabrah, A. Eguvbe, J. Agbo, D. Allagoa","doi":"10.23937/2378-3419/1410175","DOIUrl":"https://doi.org/10.23937/2378-3419/1410175","url":null,"abstract":"Background: Breast cancer is the leading cause of cancer deaths presently, representing about 23% of all cancer cases and approximately 18% percent of deaths are attributed to it in Nigeria. It is presently the most prevalent kind of cancer worldwide, with 2.26 million cases reported in 2020. Breast Self-Examination (BSE) is a way to watch for signs of breast cancer. It is a step-by-step process women can use to examine their breasts. By looking at, and feeling their breasts regularly, they can observe abnormal changes. Aim: To assess the awareness of breast cancer and practice of breast self-examination amongst female students in a tertiary institution in South-South Nigeria. Methods: This was a cross-sectional descriptive study done amongst female students of the Federal University Otuoke from January to March 2018. Simple random sampling technique by simple balloting was used in the selection of the respondents until sample size was achieved. Data was collected using a semi-structured questionnaire and were analyzed using SPSS version 23. Results: Most, 406 (95.8%) of the respondents have heard about breast cancer. Just 52.1% of the respondents practice Breast Self-Examination (BSE) and 203 (47.9%) do not. Amongst those that practice BSE, majority 113 (54.1%) do it at least once a month. Amongst those that do not practice BSE, 48 (27.6%) do not consider it important. Age, ethnic group/tribe and the religion of respondents have a statistically significant association with been aware of breast cancer and also with practice of BSE (p > 0.05). Conclusion: Awareness about breast cancer was very high but practice of breast self-examination was on the average. There is need for more education on the risks of the disease in the general population and the need for early detection by practicing BSE and other screening measures.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76676934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.23937/2378-3419/1410174
Ruggeri Carlos Santiago, Gonzalez Gabriel Rondón, Ragoni Ana Clara, Fagalde Inés
Introduction: Malignant neural sheath tumors located in the head and neck region are very rare. Surgical treatment if possible is the best option, trying to obtain wide resection margins free of tumor. Objects: To determine the incidence of malignant tumors of neural histology, in relation to nerve tumors originating in the head and neck and description of two clinical cases. Methods: A retrospective and descriptive study was carried out by reviewing the electronic medical records of all patients who were diagnosed and treated for neural histology tumors originating in the head and neck, between March 1998 and December 2021. Results: Eighteen patients were treated for nerve tumors originating in the head and neck. The benign tumors of neural origin were located in the nasal cavity and paranasal sinuses (6/18) and in the neck (10/18). Four originated from the facial nerve in the parotid, three from the cervical sympathetic nerve in the retro styloid carotid space, one in the submaxillary region, and two in the supraclavicular fossa. The incidence of malignant nerve tumors was 11.11% (2/18). Conclusions: The incidence of malignant neural sheath tumors in our study was 11.11%. Most neural sheath tumors are benign and can cause functional alterations due to compression of the nerve of origin or adjacent structures, but when the neoplasm grows rapidly malignancy should be suspected. The main treatment is surgery trying to obtain wide tumor-free margins.
{"title":"Malignant Neural Sheath Tumors of the Head and Neck","authors":"Ruggeri Carlos Santiago, Gonzalez Gabriel Rondón, Ragoni Ana Clara, Fagalde Inés","doi":"10.23937/2378-3419/1410174","DOIUrl":"https://doi.org/10.23937/2378-3419/1410174","url":null,"abstract":"Introduction: Malignant neural sheath tumors located in the head and neck region are very rare. Surgical treatment if possible is the best option, trying to obtain wide resection margins free of tumor. Objects: To determine the incidence of malignant tumors of neural histology, in relation to nerve tumors originating in the head and neck and description of two clinical cases. Methods: A retrospective and descriptive study was carried out by reviewing the electronic medical records of all patients who were diagnosed and treated for neural histology tumors originating in the head and neck, between March 1998 and December 2021. Results: Eighteen patients were treated for nerve tumors originating in the head and neck. The benign tumors of neural origin were located in the nasal cavity and paranasal sinuses (6/18) and in the neck (10/18). Four originated from the facial nerve in the parotid, three from the cervical sympathetic nerve in the retro styloid carotid space, one in the submaxillary region, and two in the supraclavicular fossa. The incidence of malignant nerve tumors was 11.11% (2/18). Conclusions: The incidence of malignant neural sheath tumors in our study was 11.11%. Most neural sheath tumors are benign and can cause functional alterations due to compression of the nerve of origin or adjacent structures, but when the neoplasm grows rapidly malignancy should be suspected. The main treatment is surgery trying to obtain wide tumor-free margins.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75054946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.23937/2378-3419/1410164
Zamar Claudia Esper, Pita Elián García, Cajelli Ana Laura, Ruggeri Carlos Santiago
Two patients who had squamous cell carcinomas of the nasal cavity with extension to the nasal septum and previous treatments with surgery and in another with surgery and radiotherapy were treated by rhinectomy. The reconstruction of the internal mucosal lining was done with mucoperiosteal flaps from the lateral nasal wall with anterior pedicle with the assistance of endoscopes. There are few descriptions in the literature of the use of this flap to reconstruct the inner lining after rhinectomy.
{"title":"Mucosal Reconstruction with Nasal Lateral Wall Flap after Rhinectomy: Two Case Reports","authors":"Zamar Claudia Esper, Pita Elián García, Cajelli Ana Laura, Ruggeri Carlos Santiago","doi":"10.23937/2378-3419/1410164","DOIUrl":"https://doi.org/10.23937/2378-3419/1410164","url":null,"abstract":"Two patients who had squamous cell carcinomas of the nasal cavity with extension to the nasal septum and previous treatments with surgery and in another with surgery and radiotherapy were treated by rhinectomy. The reconstruction of the internal mucosal lining was done with mucoperiosteal flaps from the lateral nasal wall with anterior pedicle with the assistance of endoscopes. There are few descriptions in the literature of the use of this flap to reconstruct the inner lining after rhinectomy.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82218284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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