Pub Date : 2021-01-01DOI: 10.23937/2378-3419/1410156
Ramon Eduardo Garcia-Cahuich, Felipe Rodríguez-Solis, N. García-Carrillo, Alondra Yereldi Naranjo-Cruz, Lorena Berenice Hernández-Hoil, María Valeria Jiménez-Báez
Pub Date : 2021-01-01DOI: 10.23937/2378-3419/1410159
Agustina Lorea, E. Figueroa, J. Larrañaga, C. Ruggeri
We describe the clinical cases of two pediatric patients who were treated with a total maxillectomy and chemo/ radiotherapy for suffering from malignant tumors of the maxilla. The reconstruction of the floor of the orbit was done with titanium micromesh and the defect in the maxilla and hard palate was reconstructed with free flaps. This allowed a quick swallowing rehabilitation and an excellent cosmetic result.
{"title":"Total Maxillectomy in Children: A Report Two Cases","authors":"Agustina Lorea, E. Figueroa, J. Larrañaga, C. Ruggeri","doi":"10.23937/2378-3419/1410159","DOIUrl":"https://doi.org/10.23937/2378-3419/1410159","url":null,"abstract":"We describe the clinical cases of two pediatric patients who were treated with a total maxillectomy and chemo/ radiotherapy for suffering from malignant tumors of the maxilla. The reconstruction of the floor of the orbit was done with titanium micromesh and the defect in the maxilla and hard palate was reconstructed with free flaps. This allowed a quick swallowing rehabilitation and an excellent cosmetic result.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80155501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.23937/2378-3419/1410143
S RuggeriCarlos, Acosta Lautaro, P. Valentina, Serrano Candelaria
Introduction: Metastasis in the nasal cavity and paranasal sinuses are rare. The most common tumor that produces them is clear cell renal carcinoma. The objective of the study is to determine the incidence of metastases in the nasal cavity and paranasal sinuses among malignant rhinosinusal tumors in our patient poblation and survival after rhinosinusal metastasis treatment. Methods: The medical records of all patients who had malignant rhinosinusal tumors diagnosed and treated in the hospital Italiano of Buenos Aires from 1989 to 2019 were retrospectively reviewed. Patients who had metastases of primary neoplasms located outside the head were selected. Results: 67 patients with malignant tumors located in the nasal cavity and paranasal sinuses were diagnosed and treated. Eight patients had metastases in the nasal cavity and paranasal sinuses. All the patients at the time the metastasis was diagnosed had a controlled primary neoplasm. The treatments indicated were: Endonasal surgery with endoscopes with complete resection of the metastasis (3/8), radiotherapy (4/8), and chemo/radiotherapy (1/8). Only two patients who died from systemic metastases had persistent tumor in the paranasal sinuses (25%). Survival at one and two years was 75% and 25% respectively. Conclusions: The incidence of metastasis in the nasal cavity and paranasal sinuses among malignant neoplasms of the rhinosinusal region was 11.94%. Survival was poor, but the performed treatments had a high rate of local control and improved the quality of life of the patients.
{"title":"Nasal Cavity and Paranasal Sinuses Metastasis","authors":"S RuggeriCarlos, Acosta Lautaro, P. Valentina, Serrano Candelaria","doi":"10.23937/2378-3419/1410143","DOIUrl":"https://doi.org/10.23937/2378-3419/1410143","url":null,"abstract":"Introduction: Metastasis in the nasal cavity and paranasal sinuses are rare. The most common tumor that produces them is clear cell renal carcinoma. The objective of the study is to determine the incidence of metastases in the nasal cavity and paranasal sinuses among malignant rhinosinusal tumors in our patient poblation and survival after rhinosinusal metastasis treatment. Methods: The medical records of all patients who had malignant rhinosinusal tumors diagnosed and treated in the hospital Italiano of Buenos Aires from 1989 to 2019 were retrospectively reviewed. Patients who had metastases of primary neoplasms located outside the head were selected. Results: 67 patients with malignant tumors located in the nasal cavity and paranasal sinuses were diagnosed and treated. Eight patients had metastases in the nasal cavity and paranasal sinuses. All the patients at the time the metastasis was diagnosed had a controlled primary neoplasm. The treatments indicated were: Endonasal surgery with endoscopes with complete resection of the metastasis (3/8), radiotherapy (4/8), and chemo/radiotherapy (1/8). Only two patients who died from systemic metastases had persistent tumor in the paranasal sinuses (25%). Survival at one and two years was 75% and 25% respectively. Conclusions: The incidence of metastasis in the nasal cavity and paranasal sinuses among malignant neoplasms of the rhinosinusal region was 11.94%. Survival was poor, but the performed treatments had a high rate of local control and improved the quality of life of the patients.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88022282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-28DOI: 10.23937/2378-3419/1410142
M. Luisetto, Almukthar Naseer, HamidHabibah Abdul, G. Ibrahim, A. Nili, R. Yesvi, Mashori Ghulam Rasool, Gadama Tuweh Prince, Latyshev Oleg Yurievich
A better understanding of the forces controlling cell growth will be essential for considering wound healing as a fundamental evolutionary with possibility of scar formation and reparative regeneration and the developing effective therapies in regenerative medicine and also in cancer. Historically, the literature has linked to cancer and tissue regeneration—proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. Aim of this work is to verify similarity and difference between this process un a evolutionary approach. The same verify the evolution of some factors involved in cancer development . In all this process ,genetically conserved or not , there are determinate kind of program ( finalistic or afinalistic ) whit a start messages but also a stop when the scope is achieved ( regeneration).It is clear that regeneration abilities in adult form is reduced in some superior vertebrates like humans and the same it seem related to an introduction of adaptative immunity .This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate, in light of cancer regulation.
{"title":"Regeneration Abilities of Vertebrates and Invertebrates and Relationship with Pharmacological Research: Hypothesis of Genetic Evolution Work and Microenvironment Inhibition Role","authors":"M. Luisetto, Almukthar Naseer, HamidHabibah Abdul, G. Ibrahim, A. Nili, R. Yesvi, Mashori Ghulam Rasool, Gadama Tuweh Prince, Latyshev Oleg Yurievich","doi":"10.23937/2378-3419/1410142","DOIUrl":"https://doi.org/10.23937/2378-3419/1410142","url":null,"abstract":"A better understanding of the forces controlling cell growth will be essential for considering wound healing as a fundamental evolutionary with possibility of scar formation and reparative regeneration and the developing effective therapies in regenerative medicine and also in cancer. Historically, the literature has linked to cancer and tissue regeneration—proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. Aim of this work is to verify similarity and difference between this process un a evolutionary approach. The same verify the evolution of some factors involved in cancer development . In all this process ,genetically conserved or not , there are determinate kind of program ( finalistic or afinalistic ) whit a start messages but also a stop when the scope is achieved ( regeneration).It is clear that regeneration abilities in adult form is reduced in some superior vertebrates like humans and the same it seem related to an introduction of adaptative immunity .This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate, in light of cancer regulation.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79141392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Solitary Brain Metastasis in Low-Risk Prostate Cancer - A Case Report","authors":"Nguyen Sonha, Shaharyar Sameer, Dudheker Neil, Ranpura Vishal","doi":"10.23937/2378-3419/1410138","DOIUrl":"https://doi.org/10.23937/2378-3419/1410138","url":null,"abstract":"","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86925477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-23DOI: 10.23937/2378-3419/1410127
A. Albert, Badeti Saiaditya, Liu Chen, Dongfang Liu, Donghong Cai
Objective/Background: Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. Methods: A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/cytogenetics studies. He started HCV and HIV medication but refused lymphoma chemotherapy. Results: Radiological follow up during a four-year period showed a spontaneous regression of his liver mass to a non-detectable size. Review of the English literature revealed 18 cases of DLBCL spontaneous regression, none of which were found in the liver. Here, two mechanisms are proposed to explain this phenomenon; the immunologic and the genetic. Conclusion: Chemoimmunotherapy is recommended for all DLBCL patients. However, this case of DLBCL spontaneous regression in an HIV and HCV positive patient offers a rare platform to understand the immune and genetic mechanisms for cancer and lymphoma in particular.
{"title":"Spontaneous Regression of Hepatic Diffuse Large B-cell Lymphoma in HIV and HCV Positive Patient: A Novel Case Study","authors":"A. Albert, Badeti Saiaditya, Liu Chen, Dongfang Liu, Donghong Cai","doi":"10.23937/2378-3419/1410127","DOIUrl":"https://doi.org/10.23937/2378-3419/1410127","url":null,"abstract":"Objective/Background: Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. Methods: A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/cytogenetics studies. He started HCV and HIV medication but refused lymphoma chemotherapy. Results: Radiological follow up during a four-year period showed a spontaneous regression of his liver mass to a non-detectable size. Review of the English literature revealed 18 cases of DLBCL spontaneous regression, none of which were found in the liver. Here, two mechanisms are proposed to explain this phenomenon; the immunologic and the genetic. Conclusion: Chemoimmunotherapy is recommended for all DLBCL patients. However, this case of DLBCL spontaneous regression in an HIV and HCV positive patient offers a rare platform to understand the immune and genetic mechanisms for cancer and lymphoma in particular.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84191017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-14DOI: 10.23937/2378-3419/1410126
C. Sharmila, H. LevinePaul, Senapati Surendra Nath, Samanta Dipti Rani, Panigrahi Pinaki
Background: Odisha, a populous state and a major mining belt in India has high levels of environmental carcinogens. There is no population-based cancer registry in Odisha, thus giving no opportunity to develop systematic studies on important regional carcinogens. This paper highlights current patterns of cancer as seen at Acharya Harihar Regional Cancer Centre (AHRCC), and provides the first opportunity to determine the most important research questions that could drive cancer control programs in Odisha. Methods: The analysis included all patients diagnosed and admitted with cancer at AHRCC, Cuttack, Odisha between January, 1st and December, 31st, 2012. Patient data were extracted from inpatient records, investigation reports and from in-patient registers and admission registers maintained by the Medical Records Department. Relevant information on diagnosis, primary site and demographic data were retrieved. Results: There were a total of 4811 patients, with a mean age of 47.5 ± 15.5 years, 44% males. The most common cancers among males were oral (14%), gastric (13%) and lung (10%) cancers. For females, among the most common cancers were breast (26%), cervix (21%), ovary (11%) gastric (5%) and gall bladder (3.7%). Seven percent of our cancer patients were aged ≤ 20 years. Acute lymphoblastic leukemia, Non-Hodgkin’s lymphoma, Hodgkin’s lymphoma and brain tumors were most common in this age group. Conclusion: Findings from this study suggest that particular attention be given to high prevalence cancers as import ant areas of research for risk factors and cancer control in Odisha.
{"title":"Cancer Patterns in Odisha - An Important Mining State in India","authors":"C. Sharmila, H. LevinePaul, Senapati Surendra Nath, Samanta Dipti Rani, Panigrahi Pinaki","doi":"10.23937/2378-3419/1410126","DOIUrl":"https://doi.org/10.23937/2378-3419/1410126","url":null,"abstract":"Background: Odisha, a populous state and a major mining belt in India has high levels of environmental carcinogens. There is no population-based cancer registry in Odisha, thus giving no opportunity to develop systematic studies on important regional carcinogens. This paper highlights current patterns of cancer as seen at Acharya Harihar Regional Cancer Centre (AHRCC), and provides the first opportunity to determine the most important research questions that could drive cancer control programs in Odisha. Methods: The analysis included all patients diagnosed and admitted with cancer at AHRCC, Cuttack, Odisha between January, 1st and December, 31st, 2012. Patient data were extracted from inpatient records, investigation reports and from in-patient registers and admission registers maintained by the Medical Records Department. Relevant information on diagnosis, primary site and demographic data were retrieved. Results: There were a total of 4811 patients, with a mean age of 47.5 ± 15.5 years, 44% males. The most common cancers among males were oral (14%), gastric (13%) and lung (10%) cancers. For females, among the most common cancers were breast (26%), cervix (21%), ovary (11%) gastric (5%) and gall bladder (3.7%). Seven percent of our cancer patients were aged ≤ 20 years. Acute lymphoblastic leukemia, Non-Hodgkin’s lymphoma, Hodgkin’s lymphoma and brain tumors were most common in this age group. Conclusion: Findings from this study suggest that particular attention be given to high prevalence cancers as import ant areas of research for risk factors and cancer control in Odisha.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"CE-23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84563393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-28DOI: 10.23937/2378-3419/1410125
Smolarz Beata, Samulak Dariusz, M. Marianna, Romanowicz Hanna, Kojs Zbigniew, W. Luiza, M. MichalskaMagdalena
Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This article contains the latest reports on the structure, function and role of HPV in the development of cervical cancer. It was also underlined the importance of performing molecular tests for the presence of HPV DNA as a more sensitive and the most accurate method of detecting the threat posed by infection with this oncovirus. The review also highlights the most beneficial prophylactic algorithm, which should be guided by gynecologists during the diagnosis, individual clinical cases.
{"title":"The Role of Human Papillomavirus in Cervical Cancer","authors":"Smolarz Beata, Samulak Dariusz, M. Marianna, Romanowicz Hanna, Kojs Zbigniew, W. Luiza, M. MichalskaMagdalena","doi":"10.23937/2378-3419/1410125","DOIUrl":"https://doi.org/10.23937/2378-3419/1410125","url":null,"abstract":"Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This article contains the latest reports on the structure, function and role of HPV in the development of cervical cancer. It was also underlined the importance of performing molecular tests for the presence of HPV DNA as a more sensitive and the most accurate method of detecting the threat posed by infection with this oncovirus. The review also highlights the most beneficial prophylactic algorithm, which should be guided by gynecologists during the diagnosis, individual clinical cases.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81323551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-21DOI: 10.23937/2378-3419/1410124
J. Staffan, Olsson Hans
{"title":"TCM Combined Chemoradiotherapy in the Treatment of Limited-Stage Small Cell Lung Cancer: Current Status and Perspectives","authors":"J. Staffan, Olsson Hans","doi":"10.23937/2378-3419/1410124","DOIUrl":"https://doi.org/10.23937/2378-3419/1410124","url":null,"abstract":"","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89822578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-18DOI: 10.23937/2378-3419/1410123
J. Staffan, Olsson Hans
Objective: To study the resected volume (RV) and the resected tumour volume (RTV) in the microscopic examination of the TUR specimen in relation to tumour size, clinical variables and outcome. Materials and methods: This prospectively performed population-based study included all patients in the Southeast Healthcare Region in Sweden with T1 UBC registered in the period 1992-2001, inclusive. RV, RTV and important clinic-pathological variables were studied. All patients had T1 tumours including detrusor muscle at the histopathological examination. Median values for RV and RTV were cut-off points for dichotomisation and 3 cm was the cut-off point for tumour size measured at TUR. Recurrence and progression were analysed using Kaplan-Meier curves with Log-rank test and Cox Proportional Hazards analysis. Results: Out of 211 patients we observed low RV in 112 (53%), low RTV in 113 (54%) and tumour size > 3 cm in 109 (52%). Patients with tumour size > 3 cm and low RV had shorter time to recurrence and progression compared to those with high RV (p = 0.006 and p = 0.087, respectively) and this was also the case when comparing patients with low RTV versus high RTV (p < 0.001 and p = 0.017, respectively). Conclusions: Patients with tumours > 3 cm and low RV or low RTV at TUR for T1 UBC are at higher risk for recurrence or progression, indicating an insufficient TUR. Extensive SLR is particularly important for these patients. RV and RTV might also be used as markers to monitor the quality of the TUR to improve treatment outcome.
{"title":"The Resected Tumour Volume of the Specimen as a Marker of the Quality of the Transurethral Resection in T1 Urinary Bladder Cancer","authors":"J. Staffan, Olsson Hans","doi":"10.23937/2378-3419/1410123","DOIUrl":"https://doi.org/10.23937/2378-3419/1410123","url":null,"abstract":"Objective: To study the resected volume (RV) and the resected tumour volume (RTV) in the microscopic examination of the TUR specimen in relation to tumour size, clinical variables and outcome. Materials and methods: This prospectively performed population-based study included all patients in the Southeast Healthcare Region in Sweden with T1 UBC registered in the period 1992-2001, inclusive. RV, RTV and important clinic-pathological variables were studied. All patients had T1 tumours including detrusor muscle at the histopathological examination. Median values for RV and RTV were cut-off points for dichotomisation and 3 cm was the cut-off point for tumour size measured at TUR. Recurrence and progression were analysed using Kaplan-Meier curves with Log-rank test and Cox Proportional Hazards analysis. Results: Out of 211 patients we observed low RV in 112 (53%), low RTV in 113 (54%) and tumour size > 3 cm in 109 (52%). Patients with tumour size > 3 cm and low RV had shorter time to recurrence and progression compared to those with high RV (p = 0.006 and p = 0.087, respectively) and this was also the case when comparing patients with low RTV versus high RTV (p < 0.001 and p = 0.017, respectively). Conclusions: Patients with tumours > 3 cm and low RV or low RTV at TUR for T1 UBC are at higher risk for recurrence or progression, indicating an insufficient TUR. Extensive SLR is particularly important for these patients. RV and RTV might also be used as markers to monitor the quality of the TUR to improve treatment outcome.","PeriodicalId":13873,"journal":{"name":"International journal of cancer and clinical research","volume":"21 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91461943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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