Pub Date : 2022-01-01DOI: 10.33545/26646501.2022.v4.i1a.27
N. Aljamali, Aryaf Mahmood Sabea, Zainab H. Al-zubaidy
{"title":"Nano-electrocrystals in pharmaceutical drug delivery","authors":"N. Aljamali, Aryaf Mahmood Sabea, Zainab H. Al-zubaidy","doi":"10.33545/26646501.2022.v4.i1a.27","DOIUrl":"https://doi.org/10.33545/26646501.2022.v4.i1a.27","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88857820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33545/26646501.2022.v4.i2a.31
F. Ghory
{"title":"Models of reproduction, development, and growth in invertebrates","authors":"F. Ghory","doi":"10.33545/26646501.2022.v4.i2a.31","DOIUrl":"https://doi.org/10.33545/26646501.2022.v4.i2a.31","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84482768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rotaviruses are the most common cause of acute gastroenteritis in neonates and young children worldwide. Human rotaviruses are the leading cause of acute gastroenteritis in neonates and young children worldwide. The immunochromatography test is frequently used in clinical practice to detect rotavirus infection. When the immunochromatography test is incorrectly positive, there may be a discrepancy between the two tests, the immunochromatography test and the nucleic acid test. As a result, when interpreting the findings of basic rotavirus monitoring in a system based on immunochromatography tests, we must made adjustments to address the issue of accuracy.
Methods: The findings on the expected pattern of rotavirus epidemiology in a tropical setting was presented. The modified rotavirus pattern was created to address the issue of false positives. To solve the false positive issue, the modified rotavirus pattern derived from mathematical model-based correction by extracting false positivity was predicted.
Results: We demonstrated an altered rotavirus epidemiology pattern in the setting studied in this study. Rotavirus has been detected in up to 19.3% of patients with rotavirus-like symptoms, with G4P[8] accounting for 6% of those infected.
Conclusion: As a result, the rotavirus remains an important problem that must be addressed in the framework of this study.
{"title":"Rotavirus epidemiology adjusted pattern in a tropical setting: mathematical correction for false positive problem relating to primary immunochromatography test surveillance.","authors":"Rujittika Mungmunpuntipantip, Viroj Wiwanitkit","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Rotaviruses are the most common cause of acute gastroenteritis in neonates and young children worldwide. Human rotaviruses are the leading cause of acute gastroenteritis in neonates and young children worldwide. The immunochromatography test is frequently used in clinical practice to detect rotavirus infection. When the immunochromatography test is incorrectly positive, there may be a discrepancy between the two tests, the immunochromatography test and the nucleic acid test. As a result, when interpreting the findings of basic rotavirus monitoring in a system based on immunochromatography tests, we must made adjustments to address the issue of accuracy.</p><p><strong>Methods: </strong>The findings on the expected pattern of rotavirus epidemiology in a tropical setting was presented. The modified rotavirus pattern was created to address the issue of false positives. To solve the false positive issue, the modified rotavirus pattern derived from mathematical model-based correction by extracting false positivity was predicted.</p><p><strong>Results: </strong>We demonstrated an altered rotavirus epidemiology pattern in the setting studied in this study. Rotavirus has been detected in up to 19.3% of patients with rotavirus-like symptoms, with G4P[8] accounting for 6% of those infected.</p><p><strong>Conclusion: </strong>As a result, the rotavirus remains an important problem that must be addressed in the framework of this study.</p>","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"13 6","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884340/pdf/ijbmb0013-0054.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10599949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33545/26646501.2022.v4.i1a.30
O. ., Bestman ., O. A. Aghoghovwia
{"title":"Carcass composition and product quality of Clarias gariepinus fingerlings fed varying dietary inclusion levels of blood meal","authors":"O. ., Bestman ., O. A. Aghoghovwia","doi":"10.33545/26646501.2022.v4.i1a.30","DOIUrl":"https://doi.org/10.33545/26646501.2022.v4.i1a.30","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76647972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33545/26646501.2022.v4.i1a.25
Ghazwan T Khudair, A. Mekhlif
{"title":"Antibacterial activity body extracts of developmental stages the blowfly, Calliphora vomitoria (Diptera: Calliphoridae)","authors":"Ghazwan T Khudair, A. Mekhlif","doi":"10.33545/26646501.2022.v4.i1a.25","DOIUrl":"https://doi.org/10.33545/26646501.2022.v4.i1a.25","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86336631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33545/26646501.2022.v4.i1a.23
A. Noman, Honufa Akter, Md Maruf Parves
{"title":"Mucormycosis (The black fungus): A quick look","authors":"A. Noman, Honufa Akter, Md Maruf Parves","doi":"10.33545/26646501.2022.v4.i1a.23","DOIUrl":"https://doi.org/10.33545/26646501.2022.v4.i1a.23","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74034002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33545/26646501.2022.v4.i1a.26
N. Aljamali, Wijdan Kamal Noor Al-Qraawy, T. Helal
{"title":"Review on carcinogens materials in chemical laboratories","authors":"N. Aljamali, Wijdan Kamal Noor Al-Qraawy, T. Helal","doi":"10.33545/26646501.2022.v4.i1a.26","DOIUrl":"https://doi.org/10.33545/26646501.2022.v4.i1a.26","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85174157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Sickle cell anemia (SCA) can cause substantial kidney dysfunction resulting in sickle cell nephropathy, which may be affected by the presence of modifier genes. This study evaluates the effects of some modifier genes on sickle cell nephropathy.
Methods: Patients living with SCA were recruited. Alpha-thalassemia (3.7kb HBA1/HBA2 deletion) was genotyped using gap PCR multiplex. Senegal haplotype (Xmn1-rs7412844), BCL11A-rs4671393 and NPRL3-rs11248850 were genotyped using Mass Array. The effects of variants on kidney dysfunction were then evaluated using multivariate analysis.
Results: The number of patients living with SCA included in this study was 162 with a median age of 20 years [minimum-maximum: 4-57] and a female frequency of 53.21%. Senegal haplotype, BCL11A-rs4671393 variant were protective factors against albuminuria stage A2 with an odds ratio (OR) of 0.22 (95% CI 0.05-0.90) and 0.27 (95% CI 0.08-0.96) respectively. The combination NPRL3-rs11248850 variant - 3.7kb HBA1/HBA2 deletion was a protective factor against albuminuria stage A2 (OR = 0.087, 95% Cl 0.01-0.78) but it was a risk factor for glomerular hyperfiltration (OR = 17.69, 95% CI 1.85-169.31).
Conclusions: All four variants displayed a protective effect against albuminuria stage A2. The combination alpha-thalassemia - NPRL3-rs11248850 variant is a risk factor for glomerular hyperfiltration.
目的:镰状细胞性贫血(SCA)可引起严重的肾功能障碍，导致镰状细胞肾病，这可能受到修饰基因存在的影响。本研究评估了一些修饰基因对镰状细胞肾病的影响。方法:招募SCA患者。α -地中海贫血(3.7kb HBA1/HBA2缺失)采用gap PCR多重分型。采用Mass Array对塞内加尔单倍型(Xmn1-rs7412844)、BCL11A-rs4671393和NPRL3-rs11248850进行基因分型。然后使用多变量分析评估变异对肾功能障碍的影响。结果:本研究纳入SCA患者162例，中位年龄20岁[最小-最大:4-57岁]，女性占53.21%。塞内加尔单倍型、BCL11A-rs4671393变异是A2期蛋白尿的保护因素，比值比(OR)分别为0.22 (95% CI 0.05-0.90)和0.27 (95% CI 0.08-0.96)。NPRL3-rs11248850变异- 3.7kb HBA1/HBA2缺失是A2期蛋白尿的保护因素(OR = 0.087, 95% Cl 0.01-0.78)，但它是肾小球高滤过的危险因素(OR = 17.69, 95% CI 1.85-169.31)。结论:所有四种变异对A2期蛋白尿都有保护作用。联合α -地中海贫血- NPRL3-rs11248850变异是肾小球高滤过的危险因素。
{"title":"Effects of Senegal haplotype (<i>Xmn1</i>-rs7412844), alpha-thalassemia (3.7kb <i>HBA1/HBA2</i> deletion), <i>NPRL3</i>-rs11248850 and <i>BCL11A</i>-rs4671393 variants on sickle cell nephropathy.","authors":"El Hadji Malick Ndour, Khuthala Mnika, Fatou Guèye Tall, Moussa Seck, Indou Dème Ly, Victoria Nembaware, Hélène Ange Thérèse Sagna-Bassène, Rokhaya Dione, Aliou Abdoulaye Ndongo, Jean Pascal Demba Diop, Nènè Oumou Kesso Barry, Moustapha Djité, Rokhaya Ndiaye Diallo, Papa Madièye Guèye, Saliou Diop, Ibrahima Diagne, Aynina Cissé, Ambroise Wonkam, Philomène Lopez Sall","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Sickle cell anemia (SCA) can cause substantial kidney dysfunction resulting in sickle cell nephropathy, which may be affected by the presence of modifier genes. This study evaluates the effects of some modifier genes on sickle cell nephropathy.</p><p><strong>Methods: </strong>Patients living with SCA were recruited. Alpha-thalassemia (3.7kb <i>HBA1/HBA2</i> deletion) was genotyped using gap PCR multiplex. Senegal haplotype (Xmn1-rs7412844), <i>BCL11A</i>-rs4671393 and <i>NPRL3</i>-rs11248850 were genotyped using Mass Array. The effects of variants on kidney dysfunction were then evaluated using multivariate analysis.</p><p><strong>Results: </strong>The number of patients living with SCA included in this study was 162 with a median age of 20 years [minimum-maximum: 4-57] and a female frequency of 53.21%. Senegal haplotype, <i>BCL11A</i>-rs4671393 variant were protective factors against albuminuria stage A2 with an <i>odds ratio (OR)</i> of 0.22 (95% CI 0.05-0.90) and 0.27 (95% CI 0.08-0.96) respectively. The combination <i>NPRL3</i>-rs11248850 variant - 3.7kb <i>HBA1/HBA2</i> deletion was a protective factor against albuminuria stage A2 (<i>OR</i> = 0.087, 95% Cl 0.01-0.78) but it was a risk factor for glomerular hyperfiltration (<i>OR</i> = 17.69, 95% CI 1.85-169.31).</p><p><strong>Conclusions: </strong>All four variants displayed a protective effect against albuminuria stage A2. The combination alpha-thalassemia - <i>NPRL3</i>-rs11248850 variant is a risk factor for glomerular hyperfiltration.</p>","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"13 2","pages":"5-16"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123508/pdf/ijbmb0013-0005.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Syndromes of autoantibodies to the insulin receptor.","authors":"Ishwarlal Jialal, Hiba Basheer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"13 6","pages":"87-91"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884337/pdf/ijbmb0013-0087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10593443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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