Pub Date : 2023-04-20DOI: 10.11648/j.ijde.20230801.15
S. Abebe, Wondimagegn Paulos, R. Tschopp
: The burden of disease caused by NCDs is quickly growing in emerging nations, with substantial social, economic, and health repercussions. However, data on the prevalence of diabetes and related variables among adults aged 25–64 years in Ethiopia, particularly in drought-stricken areas, is limited. The goal of this study is to find out how common diabetes is and what variables contribute to it in the middle-aged population. From January to February 2020, a community-based cross-sectional survey was undertaken among adults aged 25–64 years in Humbo district, southern Ethiopia. 587 people were chosen using a multi-stage sampling process. Weight, height, and fasting blood glucose levels were all measured. To enter data into a computer, Epi Data version 3.1 was utilized, which was subsequently exported to SPSS version 20 for analysis. Descriptive statistics and bivariate and multivariate logistic regression analyses were performed, and statistical significance was determined at a p-value of less than 0.05. Diabetes was found in 5.9% of the research participants (95 percent CI: 3.8–7.8). Age 45–54 (AOR = 4.80, 1.25, 18.32), physical inactivity (AOR = 5.33, 1.37, 20.72), family history of diabetes mellitus (AOR = 6.34, 95 percent CI: 2.43, 16.55), and obesity (AOR = 3.26, 95 percent CI: 1.43, 7.42) were all significantly associated with diabetes, according to multivariable logistic regression. The findings demonstrated the need for implementing educational public policies to encourage population behavior changes in order to prevent and control diabetes.
{"title":"Diabetes Prevalence and Associated Factors in the Adult Population Aged 25–64 in the Humbo Districts of Woliata Zone","authors":"S. Abebe, Wondimagegn Paulos, R. Tschopp","doi":"10.11648/j.ijde.20230801.15","DOIUrl":"https://doi.org/10.11648/j.ijde.20230801.15","url":null,"abstract":": The burden of disease caused by NCDs is quickly growing in emerging nations, with substantial social, economic, and health repercussions. However, data on the prevalence of diabetes and related variables among adults aged 25–64 years in Ethiopia, particularly in drought-stricken areas, is limited. The goal of this study is to find out how common diabetes is and what variables contribute to it in the middle-aged population. From January to February 2020, a community-based cross-sectional survey was undertaken among adults aged 25–64 years in Humbo district, southern Ethiopia. 587 people were chosen using a multi-stage sampling process. Weight, height, and fasting blood glucose levels were all measured. To enter data into a computer, Epi Data version 3.1 was utilized, which was subsequently exported to SPSS version 20 for analysis. Descriptive statistics and bivariate and multivariate logistic regression analyses were performed, and statistical significance was determined at a p-value of less than 0.05. Diabetes was found in 5.9% of the research participants (95 percent CI: 3.8–7.8). Age 45–54 (AOR = 4.80, 1.25, 18.32), physical inactivity (AOR = 5.33, 1.37, 20.72), family history of diabetes mellitus (AOR = 6.34, 95 percent CI: 2.43, 16.55), and obesity (AOR = 3.26, 95 percent CI: 1.43, 7.42) were all significantly associated with diabetes, according to multivariable logistic regression. The findings demonstrated the need for implementing educational public policies to encourage population behavior changes in order to prevent and control diabetes.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73571342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Association between Insulin Signaling, Type2 Diabetes, And Cognitive Dysfunction","authors":"","doi":"10.36266/ijed/148","DOIUrl":"https://doi.org/10.36266/ijed/148","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90272444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-24DOI: 10.11648/j.ijde.20230801.14
R. Sane, R. Mandole, G. Amin, P. Ghadigaonkar, Harshita Gupta
: Chronic fatigue in diabetic patients can be the outcome of protein deficiency. Plant based protein is closer to nature and bodily acceptable, hence we chose to assess plant-based protein “Balya Protex Powder” over whey protein. A prospective, multicentre, post-market study was conducted in India. Patients with a diagnosis of diabetes mellitus aged 18 years and above were included in this study. All patients adhered to the Comprehensive Diabetic Care (CDC) Program. Comparative data of change in fatigue score was collected retrospectively from type 2 diabetes mellitus patients assigned a low carbohydrate low calorie diet for 90 days. A total of 101 patients were included in this study, 50 patients consumed the Balya Protex Powder whilst 51 did not consume the Balya Protex powder whilst adhering to the CDC program. Weight of the patients decreased by 7.92% and 5.52% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. Body mass index decreased by 5.93% and 5.18% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. Abdomen girth decreased by 8.39% and 4.67% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. Weakness grade decreased by 83.69% and 47.61% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. All patients showed significant reduction in glycated hemoglobin (HbA1c) levels, however patients in the subgroup who were taking 30 gm of Balya Protex Powder daily showed 50% greater reduction in chronic fatigue score. It can be concluded that Balya Protex Powder consumption leads to good glycemic control with reduced fatigue in diabetic patients whilst adhering to the CDC program.
{"title":"Impact of Balya Protex Powder on Fatigue Levels in Patients with Diabetes Mellitus Adhering to the Ayurveda-Based Comprehensive Diabetic Care Program","authors":"R. Sane, R. Mandole, G. Amin, P. Ghadigaonkar, Harshita Gupta","doi":"10.11648/j.ijde.20230801.14","DOIUrl":"https://doi.org/10.11648/j.ijde.20230801.14","url":null,"abstract":": Chronic fatigue in diabetic patients can be the outcome of protein deficiency. Plant based protein is closer to nature and bodily acceptable, hence we chose to assess plant-based protein “Balya Protex Powder” over whey protein. A prospective, multicentre, post-market study was conducted in India. Patients with a diagnosis of diabetes mellitus aged 18 years and above were included in this study. All patients adhered to the Comprehensive Diabetic Care (CDC) Program. Comparative data of change in fatigue score was collected retrospectively from type 2 diabetes mellitus patients assigned a low carbohydrate low calorie diet for 90 days. A total of 101 patients were included in this study, 50 patients consumed the Balya Protex Powder whilst 51 did not consume the Balya Protex powder whilst adhering to the CDC program. Weight of the patients decreased by 7.92% and 5.52% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. Body mass index decreased by 5.93% and 5.18% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. Abdomen girth decreased by 8.39% and 4.67% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. Weakness grade decreased by 83.69% and 47.61% in the Balya Protex Powder consumption and Balya Protex Powder non-consumption group, respectively. All patients showed significant reduction in glycated hemoglobin (HbA1c) levels, however patients in the subgroup who were taking 30 gm of Balya Protex Powder daily showed 50% greater reduction in chronic fatigue score. It can be concluded that Balya Protex Powder consumption leads to good glycemic control with reduced fatigue in diabetic patients whilst adhering to the CDC program.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83441096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of imeglimin (Twymeeg) on pre-prandial glucose in patient with persisting post-prandial hyperglycemia","authors":"","doi":"10.36266/ijed/147","DOIUrl":"https://doi.org/10.36266/ijed/147","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77141349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-03DOI: 10.11648/j.ijde.20230801.13
R. Sane, R. Mandole, G. Amin, Harshita Gupta
{"title":"Impact of Myo B <i>Basti</i> on Type 2 Diabetes Mellitus Patients with Low Body Mass Index","authors":"R. Sane, R. Mandole, G. Amin, Harshita Gupta","doi":"10.11648/j.ijde.20230801.13","DOIUrl":"https://doi.org/10.11648/j.ijde.20230801.13","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74379799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Background : The burden of foot ulceration and amputation among persons living with diabetes mellitus is quite huge and peripheral neuropathy is a well known risk factor for this. The prevalence of peripheral neuropathy and associated factors among persons living with diabetes, using an objective assessment (biothesiometer), is unknown in our study environment. Method : This was a cross-sectional study involving 108 age matched diabetes mellitus patients and controls. The study was conducted in the Diabetes Clinic of the University of Uyo Teaching Hospital, in Southern Nigeria. Basic demographics and other parameters such as duration of diabetes and glycated haemoglobin were recorded. All participants were recruited consecutively and screened for vibration perception threshold (VPT) using a biothesiometer. Participants with VPT ≥ 25 were considered to have significant neuropathy. Results : Significant neuropathy was recorded in 18 (33.3%) of the 54 diabetes patients. Only 3 (5.5%) of the 54 controls had significant neuropathy (p<0.01). The diabetes patients with significant neuropathy had a mean HbA1c of 8.9% compared to 7.3% for diabetes patients without significant neuropathy (p=0.02). The mean age of the diabetes patients with peripheral neuropathy was 54.0±2.3 years compared to 48.3±1.9 years for the diabetes patients without peripheral neuropathy (p<0.01). The mean duration of diabetes among diabetes patients with significant neuropathy was 10.3 years compared to 6.7 years for diabetes patients without significant neuropathy (p=0.01). Conclusion: There is a high prevalence of significant peripheral neuropathy among diabetes patients as determined using a biothesiometer. Early detection and achieving a good glycaemic control may help in reducing this burden which exposes the patients to the risk of possible amputation, depression and even death.
{"title":"Biothesiometric Assessment of Persons Living with Diabetes Mellitus in a Tertiary Hospital in Uyo, Southern Nigeria","authors":"Onung Samuel, Akhimienho Kingsley, Amadi Collins, A. Ekanem, Umoren Ubong, Ekuma Ikwo, Asukpong Eso","doi":"10.11648/j.ijde.20230801.12","DOIUrl":"https://doi.org/10.11648/j.ijde.20230801.12","url":null,"abstract":": Background : The burden of foot ulceration and amputation among persons living with diabetes mellitus is quite huge and peripheral neuropathy is a well known risk factor for this. The prevalence of peripheral neuropathy and associated factors among persons living with diabetes, using an objective assessment (biothesiometer), is unknown in our study environment. Method : This was a cross-sectional study involving 108 age matched diabetes mellitus patients and controls. The study was conducted in the Diabetes Clinic of the University of Uyo Teaching Hospital, in Southern Nigeria. Basic demographics and other parameters such as duration of diabetes and glycated haemoglobin were recorded. All participants were recruited consecutively and screened for vibration perception threshold (VPT) using a biothesiometer. Participants with VPT ≥ 25 were considered to have significant neuropathy. Results : Significant neuropathy was recorded in 18 (33.3%) of the 54 diabetes patients. Only 3 (5.5%) of the 54 controls had significant neuropathy (p<0.01). The diabetes patients with significant neuropathy had a mean HbA1c of 8.9% compared to 7.3% for diabetes patients without significant neuropathy (p=0.02). The mean age of the diabetes patients with peripheral neuropathy was 54.0±2.3 years compared to 48.3±1.9 years for the diabetes patients without peripheral neuropathy (p<0.01). The mean duration of diabetes among diabetes patients with significant neuropathy was 10.3 years compared to 6.7 years for diabetes patients without significant neuropathy (p=0.01). Conclusion: There is a high prevalence of significant peripheral neuropathy among diabetes patients as determined using a biothesiometer. Early detection and achieving a good glycaemic control may help in reducing this burden which exposes the patients to the risk of possible amputation, depression and even death.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81647686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early elderly male with type 2 diabetes (T2D) changed from metformin to imeglimin (Twymeeg)","authors":"","doi":"10.36266/ijed/145","DOIUrl":"https://doi.org/10.36266/ijed/145","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72675834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-09DOI: 10.11648/j.ijde.20230801.11
Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, A. Dafalla, Khalid Abdelsamea
{"title":"The Effect of Aspirin on HbA1c Assay Among Diabetic Hypertensive Patients Attending Abu Aqulah Centre in Wad Madani, Gezira State, Sudan","authors":"Abdalwahab Ahmed Abdalla, Salman Taha Ahmed Elmukashfi, Ahmed Yasin Hassan, A. Dafalla, Khalid Abdelsamea","doi":"10.11648/j.ijde.20230801.11","DOIUrl":"https://doi.org/10.11648/j.ijde.20230801.11","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88921191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mergani, A. Mansour, O. M. Saleh, R. N. Zahran, A. M. Mustafa, M. A. Mohammed, T. Askar
Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia and associated with an increased production of reactive oxygen species (ROS) affecting beta cells in pancreas. Glutathione S-transferases (GSTs) are a family of antioxidant enzymes that include several classes of GSTs. These enzymes have important roles in decreasing ROS species and act as a kind of antioxidant defense. In a case-control study, the role of GSTMI and TI polymorphisms in predisposition for T2DM using multiplex polymerase chain reaction in 103 T2DM patients and 170 healthy controls from Turabah Province, Saudi Arabia was investigated. GSTM1 null variant was associated with higher genetic risk predisposing to T2DM in the study population. Our study revealed that individuals who are GSTM1 null genotype are associated with 1.863 times risk for predisposition to T2DM (Odds ratio = 1.863; 95% CI = 1.265 - 2.742; P-value=0.00001). While GSTT1 polymorphism has no role in genetic predisposing to T2DM in the study population ( Odds ratio = 1.053; 95% CI = 0.921 - 1.203 ) and its contribution in susceptibility for T2DM was only detected with combined double deletions with GSTM1 null variant in the population ( P-value = 0.041, Odds Ratio = 1.104; 95% CI = 0.991 - 1.230 ) . These results indicated that individuals who have GSTM1 null variant or GSTM1 and GSTT1 double deletion are at higher risk for developing T2DM than those who are positive genotyped for GSTT1 gene.
2型糖尿病(T2DM)的特征是慢性高血糖，并与影响胰腺β细胞的活性氧(ROS)的产生增加有关。谷胱甘肽s -转移酶(GSTs)是一个抗氧化酶家族，包括几种类型的GSTs。这些酶在减少活性氧方面具有重要作用，是一种抗氧化防御。在一项病例对照研究中，使用多重聚合酶链反应研究了来自沙特阿拉伯Turabah省的103名T2DM患者和170名健康对照者的GSTMI和TI多态性在T2DM易感性中的作用。在研究人群中，GSTM1零变异与易患T2DM的较高遗传风险相关。我们的研究显示，GSTM1零基因型个体与1.863倍的2型糖尿病易感性相关(优势比= 1.863;95% ci = 1.265 - 2.742;假定值= 0.00001)。而GSTT1多态性在研究人群中与2型糖尿病的遗传易感性无关(优势比= 1.053;95% CI = 0.921 - 1.203)，其对T2DM易感性的贡献仅在人群中与GSTM1零变异合并双缺失时检测到(p值= 0.041，优势比= 1.104;95% ci = 0.991 - 1.230)。这些结果表明，GSTM1零变异或GSTM1和GSTT1双缺失的个体发生T2DM的风险高于GSTT1基因型阳性的个体。
{"title":"GSTM1 and T1 null variants effects on the predisposition to type 2 diabetes mellitus in Turabah population, Saudi Arabia","authors":"A. Mergani, A. Mansour, O. M. Saleh, R. N. Zahran, A. M. Mustafa, M. A. Mohammed, T. Askar","doi":"10.5897/jde2017.0116","DOIUrl":"https://doi.org/10.5897/jde2017.0116","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is characterized by chronic hyperglycemia and associated with an increased production of reactive oxygen species (ROS) affecting beta cells in pancreas. Glutathione S-transferases (GSTs) are a family of antioxidant enzymes that include several classes of GSTs. These enzymes have important roles in decreasing ROS species and act as a kind of antioxidant defense. In a case-control study, the role of GSTMI and TI polymorphisms in predisposition for T2DM using multiplex polymerase chain reaction in 103 T2DM patients and 170 healthy controls from Turabah Province, Saudi Arabia was investigated. GSTM1 null variant was associated with higher genetic risk predisposing to T2DM in the study population. Our study revealed that individuals who are GSTM1 null genotype are associated with 1.863 times risk for predisposition to T2DM (Odds ratio = 1.863; 95% CI = 1.265 - 2.742; P-value=0.00001). While GSTT1 polymorphism has no role in genetic predisposing to T2DM in the study population ( Odds ratio = 1.053; 95% CI = 0.921 - 1.203 ) and its contribution in susceptibility for T2DM was only detected with combined double deletions with GSTM1 null variant in the population ( P-value = 0.041, Odds Ratio = 1.104; 95% CI = 0.991 - 1.230 ) . These results indicated that individuals who have GSTM1 null variant or GSTM1 and GSTT1 double deletion are at higher risk for developing T2DM than those who are positive genotyped for GSTT1 gene.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90489614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Future individualization medicine in diabetes with different responsive subtypes","authors":"","doi":"10.36266/ijed/139","DOIUrl":"https://doi.org/10.36266/ijed/139","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89161103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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