{"title":"Early improvement of HbA1c, weight and low-density lipoprotein (LDL) for Type 2 diabetes (T2D) patient by Rybelsus (oral semaglutide)","authors":"","doi":"10.36266/ijed/138","DOIUrl":"https://doi.org/10.36266/ijed/138","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"10 21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85716148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safer Treatment of Novel Imeglimin (Twymeeg) For Elderly Female with Type 2 Diabetes (T2D)","authors":"","doi":"10.36266/ijed/137","DOIUrl":"https://doi.org/10.36266/ijed/137","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73727594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bayode Samuel Ibitoye, O. A. Abel, John Kareem Abiodun, Olakunle Salau Qasim, Opeoluwa Jegede Tolulope, Olabisi Fasoranti Ifedayo, Olumide Oluwatuyi Korede, Olasunkanmi Babalola Emmanuel, Ejiyooye Toluwalope
Obesity is associated with diverse morbidities, and elevated blood pressure has been suggested to be associated with increased body weight. This study therefore aimed to determine the relationship between obesity and elevated blood pressure among adolescent. This is a cross-sectional study. Consenting adolescents aged 10 to 18 years completed a pretested semi-structured questionnaire. Anthropometric parameters and blood pressure were measured using standard methods. Data were analysed using descriptive and inferential statistics. A total of 1000 adolescents were recruited with male to female ratio of 1:1. The mean age was 14.05±1.98 years. Early adolescence was predominant (43.3%). The prevalence of obesity was 1.3% while overweight was 4.1%. There was female preponderance for both overweight (53.7%) and obesity (53.8%). Sixty–nine (6.9%) had systolic hypertension while 50 (5.0%) had diastolic hypertension. Three (23.1%) obese and four (9.8%) overweight adolescents had statistically significant elevated systolic blood pressure in the hypertensive range (χ 2 = 11.306, p = 0.015). One (7.7%) obese and four (9.8%) overweight subjects had statistically significant elevated diastolic blood pressure (χ 2 = 9.803, p = 0.029). Routine screening for elevated blood pressure in schools is highly recommended among school-aged adolescents especially the obese and overweight. Inferential statistics was done using Chi-square and Student’s t-test for categorical and continuous variables respectively. Correlation of blood pressure with overweight and obesity was also done to know the strength of association. Logistic regression was used to examine the association between overweight and obesity and the blood pressure that were significantly associated with it. Analyses with probability value p less than 0.05 were taken as statistically significant.
肥胖与多种疾病有关，血压升高被认为与体重增加有关。因此，这项研究旨在确定青少年肥胖和血压升高之间的关系。这是一项横断面研究。10至18岁的青少年自愿完成了一份预先测试的半结构化问卷。采用标准方法测量人体测量参数和血压。数据分析采用描述性和推断性统计。共招募1000名青少年，男女比例为1:1。平均年龄14.05±1.98岁。青少年早期居多(43.3%)。肥胖患病率为1.3%，超重患病率为4.1%。超重(53.7%)和肥胖(53.8%)均为女性优势。收缩期高血压69例(6.9%)，舒张期高血压50例(5.0%)。3名肥胖青少年(23.1%)和4名超重青少年(9.8%)在高血压范围内的收缩压升高有统计学意义(χ 2 = 11.306, p = 0.015)。1名肥胖患者(7.7%)和4名超重患者(9.8%)的舒张压升高具有统计学意义(χ 2 = 9.803, p = 0.029)。强烈建议学龄青少年，特别是肥胖和超重的学生，在学校进行血压升高的常规筛查。对分类变量和连续变量分别采用卡方检验和学生t检验进行推理统计。研究人员还研究了血压与超重和肥胖之间的相关性，以了解这种相关性的强度。使用逻辑回归来检验超重和肥胖之间的关系以及与之显著相关的血压。以概率值p < 0.05为有统计学意义。
{"title":"Obesity and elevated blood pressure among school-aged adolescents in Nigeria","authors":"Bayode Samuel Ibitoye, O. A. Abel, John Kareem Abiodun, Olakunle Salau Qasim, Opeoluwa Jegede Tolulope, Olabisi Fasoranti Ifedayo, Olumide Oluwatuyi Korede, Olasunkanmi Babalola Emmanuel, Ejiyooye Toluwalope","doi":"10.5897/jde2022.0149","DOIUrl":"https://doi.org/10.5897/jde2022.0149","url":null,"abstract":"Obesity is associated with diverse morbidities, and elevated blood pressure has been suggested to be associated with increased body weight. This study therefore aimed to determine the relationship between obesity and elevated blood pressure among adolescent. This is a cross-sectional study. Consenting adolescents aged 10 to 18 years completed a pretested semi-structured questionnaire. Anthropometric parameters and blood pressure were measured using standard methods. Data were analysed using descriptive and inferential statistics. A total of 1000 adolescents were recruited with male to female ratio of 1:1. The mean age was 14.05±1.98 years. Early adolescence was predominant (43.3%). The prevalence of obesity was 1.3% while overweight was 4.1%. There was female preponderance for both overweight (53.7%) and obesity (53.8%). Sixty–nine (6.9%) had systolic hypertension while 50 (5.0%) had diastolic hypertension. Three (23.1%) obese and four (9.8%) overweight adolescents had statistically significant elevated systolic blood pressure in the hypertensive range (χ 2 = 11.306, p = 0.015). One (7.7%) obese and four (9.8%) overweight subjects had statistically significant elevated diastolic blood pressure (χ 2 = 9.803, p = 0.029). Routine screening for elevated blood pressure in schools is highly recommended among school-aged adolescents especially the obese and overweight. Inferential statistics was done using Chi-square and Student’s t-test for categorical and continuous variables respectively. Correlation of blood pressure with overweight and obesity was also done to know the strength of association. Logistic regression was used to examine the association between overweight and obesity and the blood pressure that were significantly associated with it. Analyses with probability value p less than 0.05 were taken as statistically significant.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80040860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improved Glucose Variability of Continuous Glucose Monitoring (CGM) By Intake of Japanese Healthy Tofu as Low Carbohydrate Diet (LCD)","authors":"","doi":"10.36266/ijed/136","DOIUrl":"https://doi.org/10.36266/ijed/136","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"219 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79789661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glucocorticoid Sensitivity in vitrocan predict the Clinical Response to Steroid Therapy in Children with Idiopathic Nephrotic Syndrome","authors":"","doi":"10.36266/ijed/132","DOIUrl":"https://doi.org/10.36266/ijed/132","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83857375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: As a novel oral hypoglycemic agent (OHA), imeglimin has been recently applied for patients with type 2 diabetes mellitus (T2DM) as Twymeeg. It has beneficial twin mechanisms associated with increasing insulin secretion, and decreasing insulin resistance. It has a triazine ring and become the first OHA for tetrahydrotriazine-containing agent in the category of the glimins. Case presentation: The case is 84-year-old female with T2DM and mild cognitive impairment (MCI). Her HbA1c was 9.3% a year ago. Results: She was begun to receive Dulaglutide 0.75mg/week and showed 1.3% HbA1c reduction for 6 months. However, HbA1c was elevated again to 8.5%, and then she was provided Twymeeg 2000mg/day. HbA1c decreased from 8.5% to 7.5% in 3 months. [Discussion and conclusion] From combined treatments of imeglimin and other agents in the previous study, mean HbA1c reduction showed single imiglimin -0.46%, DPP-4i -0.92% and GLP-1RA -0.12%. Possible reason for the difference between the latter two suggests that multiple action mechanisms of imeglimin may be present including the enhancement of glucose-stimulated insulin secretion (GSIS). In contrast, she showed satisfactory HbA1c reduction by the combination of imeglimin and GLP-1RA. The pathophysiology is not clear, and future follow up the clinical progress will be required.
{"title":"Improved HbA1c value by combined treatment of Dulaglutide and Imeglimin for patient with type 2 diabetes mellitus (T2DM)","authors":"H. Bando, Iwatsuki, Sakamoto","doi":"10.36266/ijed/135","DOIUrl":"https://doi.org/10.36266/ijed/135","url":null,"abstract":"Background: As a novel oral hypoglycemic agent (OHA), imeglimin has been recently applied for patients with type 2 diabetes mellitus (T2DM) as Twymeeg. It has beneficial twin mechanisms associated with increasing insulin secretion, and decreasing insulin resistance. It has a triazine ring and become the first OHA for tetrahydrotriazine-containing agent in the category of the glimins. Case presentation: The case is 84-year-old female with T2DM and mild cognitive impairment (MCI). Her HbA1c was 9.3% a year ago. Results: She was begun to receive Dulaglutide 0.75mg/week and showed 1.3% HbA1c reduction for 6 months. However, HbA1c was elevated again to 8.5%, and then she was provided Twymeeg 2000mg/day. HbA1c decreased from 8.5% to 7.5% in 3 months. [Discussion and conclusion] From combined treatments of imeglimin and other agents in the previous study, mean HbA1c reduction showed single imiglimin -0.46%, DPP-4i -0.92% and GLP-1RA -0.12%. Possible reason for the difference between the latter two suggests that multiple action mechanisms of imeglimin may be present including the enhancement of glucose-stimulated insulin secretion (GSIS). In contrast, she showed satisfactory HbA1c reduction by the combination of imeglimin and GLP-1RA. The pathophysiology is not clear, and future follow up the clinical progress will be required.","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77994034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation for Daily Profile of Blood Glucose by the Administration of Canagliflozin and Xultophy (IdegLira)","authors":"","doi":"10.36266/ijed/129","DOIUrl":"https://doi.org/10.36266/ijed/129","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84820607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.11648/j.ijde.20220701.12
Mario Sebastian Campana, M. Riofrío, R. Jadav, Guido Macchiavello
{"title":"A Case of Secondary Hypogonadism with Increased Risk of Fractures in a 57-year-old Male Patient on Methadone Maintenance Therapy","authors":"Mario Sebastian Campana, M. Riofrío, R. Jadav, Guido Macchiavello","doi":"10.11648/j.ijde.20220701.12","DOIUrl":"https://doi.org/10.11648/j.ijde.20220701.12","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89289572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.11648/j.ijde.20220701.11
Reza Sabzevari Rad
{"title":"Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review","authors":"Reza Sabzevari Rad","doi":"10.11648/j.ijde.20220701.11","DOIUrl":"https://doi.org/10.11648/j.ijde.20220701.11","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77563095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.11648/j.ijde.20220701.13
J. Jyoti, Younus Majeed Dar, Shahnaz Ahmed Mir, I. Ali
{"title":"Diabetic-Mellitus as an Etiological Factor in Hearing Loss","authors":"J. Jyoti, Younus Majeed Dar, Shahnaz Ahmed Mir, I. Ali","doi":"10.11648/j.ijde.20220701.13","DOIUrl":"https://doi.org/10.11648/j.ijde.20220701.13","url":null,"abstract":"","PeriodicalId":13900,"journal":{"name":"International Journal of Diabetes and Endocrinology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81720956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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