Pub Date : 2023-01-01DOI: 10.22271/flora.2023.v11.i5b.897
Sowmya M, Kavya S, Kaveri KR, Shashank AS
The present work was planned to evaluate minimum dose level and pathomorphological alterations in Wistar albino rats after administration of polyherbal formulation (Rosmarinus officinalis) and Ashwagandha (Withania somnifera) in 3:1 at 2 g/kg body weight accordance with the OECD guidelines 423. All the animals that were orally exposed to polyherbal formulation extracts were sacrificed after the Fourteen days trial. On gross examination, no specific lesions were observed in any of the organs, whereas microscopic examination revealed no changes. As there was zero mortality even after 14 days of exposure, it was concluded that the LD50 value was more than 2 g/kg body weight, and the above polyherbal formulation was considered non-toxic. The present study analyzed the minimum dose level of polyherbal formulation extract Rosmarinus officinalis and Withania somnifera and observed slight weight gain in all the experimental rats. Still, this study could not monitor any mortality or pathomorphological changes, so it can be concluded that the extracts of Rosmarinus officinalis and Withania somnifera are non-toxic or safe at 2 g/kg body weight. However, further studies with more experimental animals are warranted to ascertain polyherbal formulation's toxicity and safety level and use this to prepare new therapeutic agents in Ayurvedic medicine in the coming days.
{"title":"A critical study on the acute oral toxicity of polyherbal formulation of Rosmarinus officinalis L. AND Withania somnifera L. in wistar Albino Rats","authors":"Sowmya M, Kavya S, Kaveri KR, Shashank AS","doi":"10.22271/flora.2023.v11.i5b.897","DOIUrl":"https://doi.org/10.22271/flora.2023.v11.i5b.897","url":null,"abstract":"The present work was planned to evaluate minimum dose level and pathomorphological alterations in Wistar albino rats after administration of polyherbal formulation (Rosmarinus officinalis) and Ashwagandha (Withania somnifera) in 3:1 at 2 g/kg body weight accordance with the OECD guidelines 423. All the animals that were orally exposed to polyherbal formulation extracts were sacrificed after the Fourteen days trial. On gross examination, no specific lesions were observed in any of the organs, whereas microscopic examination revealed no changes. As there was zero mortality even after 14 days of exposure, it was concluded that the LD50 value was more than 2 g/kg body weight, and the above polyherbal formulation was considered non-toxic. The present study analyzed the minimum dose level of polyherbal formulation extract Rosmarinus officinalis and Withania somnifera and observed slight weight gain in all the experimental rats. Still, this study could not monitor any mortality or pathomorphological changes, so it can be concluded that the extracts of Rosmarinus officinalis and Withania somnifera are non-toxic or safe at 2 g/kg body weight. However, further studies with more experimental animals are warranted to ascertain polyherbal formulation's toxicity and safety level and use this to prepare new therapeutic agents in Ayurvedic medicine in the coming days.","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current world survey states that it has become a major issue of huge wastage of fruits and vegetables in our ecology and economy. The by-products of these vegetables can be a major source of nutrients with having potential phytochemical, antioxidant, and antimicrobial potential. Hence, the significance of our study is to do the comparative analysis of phytonutrients and in-vitro medicinal activity by using the discarded onion and garlic peels as sustainable resources. The results of the current study depict onion peel extracts contain highest concentration of polyphenols (174.95 ±20.42 mg GAE/g DW), flavonoids (49.97±1.77 mg QE/g DW), tannins (31.72±0.02 mg TAE/g DW), carbohydrates (30.39±1.30 mg GE/g DW), proteins (38.07±0.86 mg BSAE/g FW), whereas, garlic peel extracts contain highest concentration of antioxidants (37.54±1.05 mg AAE/g DW). Both the onion and garlic peel extract show the maximum zone of inhibition against E. coli . The outcome of the study comes up as a very innovative and beneficial way to cope up with the current life-style disorder and to reduce the risk of diseases.
{"title":"Phytonutrient screening and evaluation of in-vitro antibacterial activity of onion and garlic peels: A comparative study with the prospects of waste to wealth","authors":"Moumita Saha, Shirsha Mukherjee, Shouvik Das, M. Chowdhury, Madhurima Das, Souhardya Sarkar, Sirshendu Chatterjee","doi":"10.22271/flora.2022.v10.i6a.844","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i6a.844","url":null,"abstract":"The current world survey states that it has become a major issue of huge wastage of fruits and vegetables in our ecology and economy. The by-products of these vegetables can be a major source of nutrients with having potential phytochemical, antioxidant, and antimicrobial potential. Hence, the significance of our study is to do the comparative analysis of phytonutrients and in-vitro medicinal activity by using the discarded onion and garlic peels as sustainable resources. The results of the current study depict onion peel extracts contain highest concentration of polyphenols (174.95 ±20.42 mg GAE/g DW), flavonoids (49.97±1.77 mg QE/g DW), tannins (31.72±0.02 mg TAE/g DW), carbohydrates (30.39±1.30 mg GE/g DW), proteins (38.07±0.86 mg BSAE/g FW), whereas, garlic peel extracts contain highest concentration of antioxidants (37.54±1.05 mg AAE/g DW). Both the onion and garlic peel extract show the maximum zone of inhibition against E. coli . The outcome of the study comes up as a very innovative and beneficial way to cope up with the current life-style disorder and to reduce the risk of diseases.","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91414570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.22271/flora.2022.v10.i6a.845
AnjeIina Nor Sari, S. Hamidah, Gusti Abdul Rahmat Thamrin, Y. Arifin
Several research results it is stated that the size of the tea powder affects the quality of the tea produced, so in this research the size of the red bajakah tea powder is divided into three sizes categories, namely: A1 (<10 mesh), A2 (10-16 mesh), A3 (>16 mesh). Furthermore, the treatment was compared with SNI Biack tea bags No. 3753:2014. Parameters observed were moisture content, total ash content, and organoleptic tests. Organoleptic testing using description and hedonic tests. The treatment was compared with SNI black tea bags No 3753:2014. Parameters observed were moisture content, total ash content, and organoIeptic tests. Organoleptic testing using description and hedonic tests. The result showed that the size of the red bajakah powder had a significant and very significant effect on all parameters except taste. However, the size of the bajakah powder still cannot produce tea that can meet the standards except for powder size >16 mesh. Therefore, it is recommended to make bajakah tea using a powder size >16 mesh.
{"title":"The effect of the size of the red bajakah powder (Uncaria acida (Hunter) Roxb) on the quality of the tea produced","authors":"AnjeIina Nor Sari, S. Hamidah, Gusti Abdul Rahmat Thamrin, Y. Arifin","doi":"10.22271/flora.2022.v10.i6a.845","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i6a.845","url":null,"abstract":"Several research results it is stated that the size of the tea powder affects the quality of the tea produced, so in this research the size of the red bajakah tea powder is divided into three sizes categories, namely: A1 (<10 mesh), A2 (10-16 mesh), A3 (>16 mesh). Furthermore, the treatment was compared with SNI Biack tea bags No. 3753:2014. Parameters observed were moisture content, total ash content, and organoleptic tests. Organoleptic testing using description and hedonic tests. The treatment was compared with SNI black tea bags No 3753:2014. Parameters observed were moisture content, total ash content, and organoIeptic tests. Organoleptic testing using description and hedonic tests. The result showed that the size of the red bajakah powder had a significant and very significant effect on all parameters except taste. However, the size of the bajakah powder still cannot produce tea that can meet the standards except for powder size >16 mesh. Therefore, it is recommended to make bajakah tea using a powder size >16 mesh.","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78092714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.22271/flora.2022.v10.i6a.839
K. Soumya, A. Srivani, G. K. Mohan
{"title":"Insights into phyto pharmaceutical studies of the under-utilized mangrove species of Lumnitzera racemosa wild: A review","authors":"K. Soumya, A. Srivani, G. K. Mohan","doi":"10.22271/flora.2022.v10.i6a.839","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i6a.839","url":null,"abstract":"","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74586425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.22271/flora.2022.v10.i6a.841
A. Aksharadevi, P. Deepika, Dr. K. Chitra
{"title":"Phytochemical analysis and anticancer activity of Majidea zanguebarica Kirk Ex Oliv","authors":"A. Aksharadevi, P. Deepika, Dr. K. Chitra","doi":"10.22271/flora.2022.v10.i6a.841","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i6a.841","url":null,"abstract":"","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85692639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.22271/flora.2022.v10.i6a.838
A. Putri, S. Hamidah, Dan Lusyiani, Y. Arifin
{"title":"Organoleptic test for herbal honey made from kelulut honey (Heterotrigona itama) and Sungkai’s leaf extract (Peronema canescens Jack)","authors":"A. Putri, S. Hamidah, Dan Lusyiani, Y. Arifin","doi":"10.22271/flora.2022.v10.i6a.838","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i6a.838","url":null,"abstract":"","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80985834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-01DOI: 10.22271/flora.2022.v10.i6a.843
A. Srivani, G. Mohan
{"title":"Antioxidant activity of various extracts of Givotia moluccana (L.) Sreem","authors":"A. Srivani, G. Mohan","doi":"10.22271/flora.2022.v10.i6a.843","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i6a.843","url":null,"abstract":"","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83734663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.22271/flora.2022.v10.i3a.815
C. Deutch
{"title":"Synergistic inhibition of the urinary tract pathogen Staphylococcus saprophyticus by curcumin and berberine","authors":"C. Deutch","doi":"10.22271/flora.2022.v10.i3a.815","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i3a.815","url":null,"abstract":"","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81253600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.22271/flora.2022.v10.i1a.788
S. Zareisedehizadeh, Y. Siew, H. Wee, C. Tan, H. Koh
{"title":"Medicinal uses of a leafy cactus, Pereskia bleo, in Singapore: A survey on the users' knowledge and their perceptions","authors":"S. Zareisedehizadeh, Y. Siew, H. Wee, C. Tan, H. Koh","doi":"10.22271/flora.2022.v10.i1a.788","DOIUrl":"https://doi.org/10.22271/flora.2022.v10.i1a.788","url":null,"abstract":"","PeriodicalId":14070,"journal":{"name":"International Journal of Herbal Medicine","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80170223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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