Pub Date : 2022-11-15DOI: 10.18535/ijmsci/v9i11.05
Sonia Martilova, Nadiah Ushbah, Andhika Ardi Perdana
Background: Postpartum hemorrhage defined as the condition blood loss more than 500 mL from the female genital tract after vaginal delivery of the fetus (or >1000 mL after cesarean section). Case Presentation: Mrs. FA 31 year’s old G2P1A0 40 weeks age gestation preeclampsia with main complaints dyspnea and swollen legs. Physical examination showed decreased saturation, increase blood pressure, rhonci, and pitting edema of the pedal. Cardiomegaly with pulmonary edema on x-ray, elevated liver enzymes, LEA value +3, perfectly compensated respiratory alkalosis and electrolyte imbalance on laboratory test. Four-hour post C-section she got postpartum hemorrhagic and given oxytocin due to maximizing use of uterotonic agent, MgSO4 stopped and patient reported with postpartum eclampsia. Conclusion: Many studies discus other drugs to replace oxytocin, considering side effects to prevent postpartum hemorrhage. Carbetocin could be one potent agent of uterotonic agents with lower side effect.
{"title":"Carbetocin: The New Preferred Treatment For Partum Hemorrhage","authors":"Sonia Martilova, Nadiah Ushbah, Andhika Ardi Perdana","doi":"10.18535/ijmsci/v9i11.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i11.05","url":null,"abstract":"Background: Postpartum hemorrhage defined as the condition blood loss more than 500 mL from the female genital tract after vaginal delivery of the fetus (or >1000 mL after cesarean section).\u0000Case Presentation: Mrs. FA 31 year’s old G2P1A0 40 weeks age gestation preeclampsia with main complaints dyspnea and swollen legs. Physical examination showed decreased saturation, increase blood pressure, rhonci, and pitting edema of the pedal. Cardiomegaly with pulmonary edema on x-ray, elevated liver enzymes, LEA value +3, perfectly compensated respiratory alkalosis and electrolyte imbalance on laboratory test. Four-hour post C-section she got postpartum hemorrhagic and given oxytocin due to maximizing use of uterotonic agent, MgSO4 stopped and patient reported with postpartum eclampsia.\u0000Conclusion: Many studies discus other drugs to replace oxytocin, considering side effects to prevent postpartum hemorrhage. Carbetocin could be one potent agent of uterotonic agents with lower side effect.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83154254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-09DOI: 10.18535/ijmsci/v9i11.03
Manasik siddig Hasssan, Abubker Alsiddig Abd Algader, Esraa Kamal Almahy Abdallah, W. Ibrahim, Sawsan A. Hamed, Alsadig Gassoum, Maye M. Merghani, T. Alabid, Asim Eltyeb Ibrahim, Nihad alsadig Babiker
Background Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, also known as cerebral bleed, intraparenchymal bleed and hemorrhagic stroke. This study was designed to detect the possible present of factor II polymorphism (G20210A) among Sudanese patients with Intercereberal hemorrhage. Material and method This study was cross sectional hospital-based study,conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage, demographic data ( age , gender, associated disease ). DNA extraction was done from blood of all patients and control.PCR for factor prothrombin gene was done and thus Sanger sequencing. Results: The PCR results showed; 100% positive forfactor II gene. And sequencing result showed base bare exchange in factor II gene G to A (G20210A)polymorphism . Conclusion Factor II gene polymorphism (G20210A) was detected and might be association with Intercereberal hemorrhage among Sudanese patients
颅内出血是脑血管疾病的第三大常见病因，又称脑出血、脑实质出血和出血性中风。本研究旨在检测苏丹脑出血患者中可能存在的因子II多态性(G20210A)。材料与方法本研究为横断面医院研究，于2022年6月至2022年8月在苏丹喀土穆国家神经科学中心(NCNS)研究实验室进行。它包括所有脑出血患者、人口统计数据(年龄、性别、相关疾病)。对所有患者和对照组的血液进行DNA提取。对凝血酶原基因进行PCR检测，并进行Sanger测序。结果:PCR结果显示;因子II基因100%阳性。测序结果显示因子II基因G - A (G20210A)多态性为碱基裸交换。结论在苏丹脑出血患者中检测到因子II基因多态性(G20210A)，可能与脑出血有关
{"title":"Prothrombin Gene Polymorphism (G20210A) among Sudanese Patients with Intracerebral Hemorrhage, Khartoum State, 2022","authors":"Manasik siddig Hasssan, Abubker Alsiddig Abd Algader, Esraa Kamal Almahy Abdallah, W. Ibrahim, Sawsan A. Hamed, Alsadig Gassoum, Maye M. Merghani, T. Alabid, Asim Eltyeb Ibrahim, Nihad alsadig Babiker","doi":"10.18535/ijmsci/v9i11.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i11.03","url":null,"abstract":"Background \u0000Intracranial hemorrhage is the third most frequent cause of cerebrovascular disease, also known as cerebral bleed, intraparenchymal bleed and hemorrhagic stroke. This study was designed to detect the possible present of factor II polymorphism (G20210A) among Sudanese patients with Intercereberal hemorrhage. \u0000Material and method \u0000This study was cross sectional hospital-based study,conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage, demographic data ( age , gender, associated disease ). DNA extraction was done from blood of all patients and control.PCR for factor prothrombin gene was done and thus Sanger sequencing. \u0000Results: \u0000The PCR results showed; 100% positive forfactor II gene. And sequencing result showed base bare exchange in factor II gene G to A (G20210A)polymorphism . \u0000Conclusion \u0000Factor II gene polymorphism (G20210A) was detected and might be association with Intercereberal hemorrhage among Sudanese patients","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86610288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-05DOI: 10.18535/ijmsci/v9i11.02
F. Fazli
Ventriculoperitoneal shunt treats hydrocephalus by altering CSF flow within the brain. In most of the cases, shunts consist of three parts, which are serially connected to each other: the proximal catheter, one-way valve and distal catheter. Ventriculoperitoneal shunt is one of the most commonly performed neurosurgical procedure, both on the elective and emergency basis. Consequently, in this paper, the indications for shunt, the types used, cure, and complications of ventriculoperitoneal shunts were studied. During this “Quantitative “, with amalgamating with case series study out of 109 VP-stunted patients, 38 were show up with complication. The shunt complication diagnosis is initially suspected according to the history and physical examination and high intracranial pressure. The purpose of this study is to determine VP-shunt complication, incidence of VP shunt complication in different age of childhood life and geographic findings of complication. 20 patients which is 52.6% of study is male patient, from 2 months to 2 years were 30 patients which (78.3%) of study, 26 complicated patients which is (68.4%) from Nangarhar province. During this study we found 8 patients (21.1%) with abdominal pseudo cyst, 3 patients (7.9%) with skin irritation, 2 patients with (5.3%) fever, 8 patients (21.1%) with shunt upper end and reserve infection, 6 patients (15.8%) with shunt lower end infection, 2 patients (5.3%) with disconnected shunt, 8 patients (21.1%) shunt tube lower end obstruction and 1 patient (2.6) with VP Shunt extrusion from month (real complication).
{"title":"A Descriptive Study on Complications of Ventriculoperitoneal Shunt Surgery in Nangarhar Regional Hospital 25/Mar/2018 – 16/Mar/2019","authors":"F. Fazli","doi":"10.18535/ijmsci/v9i11.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i11.02","url":null,"abstract":"Ventriculoperitoneal shunt treats hydrocephalus by altering CSF flow within the brain. In most of the cases, shunts consist of three parts, which are serially connected to each other: the proximal catheter, one-way valve and distal catheter. Ventriculoperitoneal shunt is one of the most commonly performed neurosurgical procedure, both on the elective and emergency basis. Consequently, in this paper, the indications for shunt, the types used, cure, and complications of ventriculoperitoneal shunts were studied. During this “Quantitative “, with amalgamating with case series study out of 109 VP-stunted patients, 38 were show up with complication. The shunt complication diagnosis is initially suspected according to the history and physical examination and high intracranial pressure. The purpose of this study is to determine VP-shunt complication, incidence of VP shunt complication in different age of childhood life and geographic findings of complication. \u000020 patients which is 52.6% of study is male patient, from 2 months to 2 years were 30 patients which (78.3%) of study, 26 complicated patients which is (68.4%) from Nangarhar province. During this study we found 8 patients (21.1%) with abdominal pseudo cyst, 3 patients (7.9%) with skin irritation, 2 patients with (5.3%) fever, 8 patients (21.1%) with shunt upper end and reserve infection, 6 patients (15.8%) with shunt lower end infection, 2 patients (5.3%) with disconnected shunt, 8 patients (21.1%) shunt tube lower end obstruction and 1 patient (2.6) with VP Shunt extrusion from month (real complication).","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73805208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-05DOI: 10.18535/ijmsci/v9i11.01
Hani Maalouf, S. Ghattas, Toufic Saber, A. Malek
Lebanon is a relatively low Tuberculosis burden country but has a high proportion of extrapulmonary tuberculosis. Tuberculosis involving the chest wall is found in around 1% of all skeletal tuberculosis cases. We present the case of an 81-year-old immunocompetent patient who presented with 3 months history of a painful lump in the anterior chest wall. PCR for MTB (mycobacterium tuberculosis) was positive and a diagnosis of the tubercular abscess of the chest wall was made mimicking a pyogenic abscess.
{"title":"Isolated Chest Wall Tuberculosis Presenting As an Abscess","authors":"Hani Maalouf, S. Ghattas, Toufic Saber, A. Malek","doi":"10.18535/ijmsci/v9i11.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i11.01","url":null,"abstract":"Lebanon is a relatively low Tuberculosis burden country but has a high proportion of extrapulmonary tuberculosis. Tuberculosis involving the chest wall is found in around 1% of all skeletal tuberculosis cases. We present the case of an 81-year-old immunocompetent patient who presented with 3 months history of a painful lump in the anterior chest wall. PCR for MTB (mycobacterium tuberculosis) was positive and a diagnosis of the tubercular abscess of the chest wall was made mimicking a pyogenic abscess.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87554704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-30DOI: 10.18535/ijmsci/v9i10.06
Dr. Rameshwar Mahaseth, Dr. Sidhi Datri Jha, Dr. Digbijay Kumar Thakur
Aim: Clinical use of Recombinant Human Erythropoietin (rHuEPO) effectively increases the level of Hemoglobin in blood and improve quality of life of patients. Methods: Blood cancer patients is divided into two groups namely Treatment group and Control group. There is altogether 24 patients in treatment gp to whom both chemotherapy and rHuEPO is given for 4 weeks. rHuEPO is given as 150u/kg，subcutaneously, three times a week. Blood routine check up is done in every week and iron is prescribed after 2 weeks. Result: After 4 weeks of treatment, patients were evaluated for drugs effectiveness in both groups; total effectiveness were 58.34% and 20% respectively, P >0.05; after 4 weeks of treatment, there was distinct statistical significance. Comparing with pretreatment level, Treatment group has remarkable rise in Hb after 4 weeks (81.29±9.85)对（65.75±12.37），（P<0.01, whereas control group has not distinct change in Hb level(86.95±11.61)对（84.30±16.25），（P>0.05. Conclusion: Hb is significantly increased after the use of rHuEPO and side effects were less with well tolerances.
{"title":"Application of Rhuepo to Post-Chemotherapy Blood Cancer Patients and Clinical Observation","authors":"Dr. Rameshwar Mahaseth, Dr. Sidhi Datri Jha, Dr. Digbijay Kumar Thakur","doi":"10.18535/ijmsci/v9i10.06","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i10.06","url":null,"abstract":"Aim: Clinical use of Recombinant Human Erythropoietin (rHuEPO) effectively increases the level of Hemoglobin in blood and improve quality of life of patients.\u0000Methods: Blood cancer patients is divided into two groups namely Treatment group and Control group. There is altogether 24 patients in treatment gp to whom both chemotherapy and rHuEPO is given for 4 weeks. rHuEPO is given as 150u/kg，subcutaneously, three times a week. Blood routine check up is done in every week and iron is prescribed after 2 weeks.\u0000Result: After 4 weeks of treatment, patients were evaluated for drugs effectiveness in both groups; total effectiveness were 58.34% and 20% respectively, P >0.05; after 4 weeks of treatment, there was distinct statistical significance. Comparing with pretreatment level, Treatment group has remarkable rise in Hb after 4 weeks (81.29±9.85)对（65.75±12.37），（P<0.01, whereas control group has not distinct change in Hb level(86.95±11.61)对（84.30±16.25），（P>0.05.\u0000Conclusion: Hb is significantly increased after the use of rHuEPO and side effects were less with well tolerances.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76456197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Papillome inversé est une tumeur bénigne naso-sinusienne rare marquée par une forte agressivité locale, un taux élevé de récidive après chirurgie et un risque imprévisible d’association à un carcinome épidermoïde. Nous rapportons le cas d’un patient congolais de 40 ans, qui a présenté une obstruction nasale gauche isolée. La lésion a évolué depuis plus de 4 mois, le diagnostic a été posé à l’examen d’anatomopathologie après une exérèse biopsique. Le traitement a consisté en une exérèse tumorale et à la surveillance clinique.
{"title":"Papilloma Inverse Nasosinusien: À Propos D’un CAS Aux Cliniques Universitaires De Lubumbashi /RDC","authors":"Mundeke Sangol Héritier, Musoka Kyungu Agnès, Madi Fatuma, Nyembo Luty, Kizonde Kalungwe, Yowa Muya Sandra, Kapita Izana Marie Jeanne, C. Borasisi","doi":"10.18535/ijmsci/v9i10.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i10.05","url":null,"abstract":"Le Papillome inversé est une tumeur bénigne naso-sinusienne rare marquée par une forte agressivité locale, un taux élevé de récidive après chirurgie et un risque imprévisible d’association à un carcinome épidermoïde. Nous rapportons le cas d’un patient congolais de 40 ans, qui a présenté une obstruction nasale gauche isolée. La lésion a évolué depuis plus de 4 mois, le diagnostic a été posé à l’examen d’anatomopathologie après une exérèse biopsique. Le traitement a consisté en une exérèse tumorale et à la surveillance clinique.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80382241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-26DOI: 10.18535/ijmsci/v9i10.04
J. Inklebarger, M. A., Mehrez O, Rimbault T, Joshi T, A. A., Galanis N, M. J, Gyer G, Whitehouse K
Lumbar fluoroscopic or CT-guided intra-discal ozone injections with or without corticosteroid, have reportedly been a successful back pain-sciatica treatment. Ozone may also enhance the longevity of corticosteroid anti-inflammatory effects. However, growing evidence that the mere act of needle puncturing the intervertebral disc may inadvertently set off an annular degenerative cascade taking several years to manifest, has prompted a search for less invasive yet effective alternatives. Ultrasound Guided (USG) Erector spinae plane (ESPB) blocks may offer a relatively safer, less technically challenging alternative to intra-discal ozone injection by means of diffusing ozone through tissues into the gas-permeable annulus, rather than injecting ozone into the disc itself. ESPB is a relatively new procedure and its use with ozone in DLBP management has not yet been described in the literature. This paper details the management of a 40-year-old male chef suffering from disabling low back pain and unilateral lower limb radiculopathy using an ESBP with Ozone-corticosteroid, with rapid-sustained pain relief, and restoration of sustained work-ADL function on 6 months follow up.
{"title":"Ultrasound Guided Erector Spinae Plane Block with Ozone & Corticosteroid for the Management of Discogenic Back Pain: A Case Report","authors":"J. Inklebarger, M. A., Mehrez O, Rimbault T, Joshi T, A. A., Galanis N, M. J, Gyer G, Whitehouse K","doi":"10.18535/ijmsci/v9i10.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i10.04","url":null,"abstract":"Lumbar fluoroscopic or CT-guided intra-discal ozone injections with or without corticosteroid, have reportedly been a successful back pain-sciatica treatment. Ozone may also enhance the longevity of corticosteroid anti-inflammatory effects. However, growing evidence that the mere act of needle puncturing the intervertebral disc may inadvertently set off an annular degenerative cascade taking several years to manifest, has prompted a search for less invasive yet effective alternatives. Ultrasound Guided (USG) Erector spinae plane (ESPB) blocks may offer a relatively safer, less technically challenging alternative to intra-discal ozone injection by means of diffusing ozone through tissues into the gas-permeable annulus, rather than injecting ozone into the disc itself. ESPB is a relatively new procedure and its use with ozone in DLBP management has not yet been described in the literature. This paper details the management of a 40-year-old male chef suffering from disabling low back pain and unilateral lower limb radiculopathy using an ESBP with Ozone-corticosteroid, with rapid-sustained pain relief, and restoration of sustained work-ADL function on 6 months follow up.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88958955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-23DOI: 10.18535/ijmsci/v9i10.03
Patrick Opoku Maison, Douglas Arthur, Alvin Asante-Asamani, Patrick Kafui Akakpo
Introduction: Prostate cancer is the commonly diagnosed male cancer worldwide. The best technique for the diagnosis of prostate cancer is prostate biopsy. Transrectal ultrasound (TRUS)-guided biopsy of the prostate enhances early diagnosis of prostate cancers. Objective: The aim of the study is to describe the clinical and pathological characteristics of Prostate cancers as seen at the Cape Coast Teaching Hospital Materials and Methods: A total of 62 patients who underwent TRUS-guided prostatic biopsy over a period of 3 years (January 2019- December 2021) participated in the study. Their data were analyzed retrospectively using the archives of the pathology department of the Cape Coast Teaching Hospital. Results: Of the 62 patients who underwent TRUS-guided prostrate biopsy from January 2019 to December 2021, their mean age was 68.3 with an age range of 34-89 years. 67.7% had adenocarcinoma of the prostate, 1.6% had spindle cell cancer, 24.2% had benign prostate hyperplasia and 6.5% had chronic prostatitis. Conclusion: The indications for prostate biopsy in our center detect more patients with prostate cancer than other prostate pathologies. The serum PSA significantly correlated with the Gleason grade.
{"title":"An Analysis of Prostate Biopsy Results at the Cape Coast Teaching Hospital, Ghana","authors":"Patrick Opoku Maison, Douglas Arthur, Alvin Asante-Asamani, Patrick Kafui Akakpo","doi":"10.18535/ijmsci/v9i10.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i10.03","url":null,"abstract":"Introduction: Prostate cancer is the commonly diagnosed male cancer worldwide. The best technique for the diagnosis of prostate cancer is prostate biopsy. Transrectal ultrasound (TRUS)-guided biopsy of the prostate enhances early diagnosis of prostate cancers.\u0000Objective: The aim of the study is to describe the clinical and pathological characteristics of Prostate cancers as seen at the Cape Coast Teaching Hospital\u0000Materials and Methods: A total of 62 patients who underwent TRUS-guided prostatic biopsy over a period of 3 years (January 2019- December 2021) participated in the study. Their data were analyzed retrospectively using the archives of the pathology department of the Cape Coast Teaching Hospital.\u0000Results: Of the 62 patients who underwent TRUS-guided prostrate biopsy from January 2019 to December 2021, their mean age was 68.3 with an age range of 34-89 years. 67.7% had adenocarcinoma of the prostate, 1.6% had spindle cell cancer, 24.2% had benign prostate hyperplasia and 6.5% had chronic prostatitis.\u0000Conclusion: The indications for prostate biopsy in our center detect more patients with prostate cancer than other prostate pathologies. The serum PSA significantly correlated with the Gleason grade.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83576060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-12DOI: 10.18535/ijmsci/v9i10.02
A. Razdan, R. Arora, Gauri G Agarwal, Vandana Sharma, J. Kandpal, N. Singh, Malobi Nandi
Background Screening for fetal anomalies is one of the most critical parts of prenatal testing to reduce the burden of chromosomal aberrations and improve clinical outcomes in pregnancy. The available literature suggests that India carries a strong economic, emotional, and health care burden of new-born genetic diseases. Material and Methods: We present a single-center retrospective study of 200 singletons and 6 dichorionic diamniotic twin gestations screened for chromosomal abnormalities and trisomies using NIPT. The patients were presented with a gestation period of 10-12 (plus a few days) weeks, clinically confirmed with singleton or diamniotic dizygotic twins, who underwent NIPT between the years 2021-2022 (mid) at our center. All the patients underwent sonographic examination and biochemical investigations with regular follow-up and genetic counseling. The clinical history and family history of the presence of any genetic disease or any other disease were previously taken by the clinician in all cases. The main clinical indications were increased risk of trisomies found in markers test, advanced maternal age, or presented with some mild complications in pregnancy. Results; Out of the total (206) pregnancies, only 2 singleton cases were found at high risk in NIPT screen, prospectively followed up, and showed normal twins in six cases of twin pregnancy growing successfully. The high-risk cases were genetically counselled and further tests using amniotic or chorionic villi samples were recommended by the clinician with regular clinical follow-up. Conclusion: This retrospective study clearly indicates that non-invasive prenatal testing in pregnancy is a safe and effective screening test to rule out certain chromosomal abnormalities and to omit the need of further invasive tests among low-risk cases.
{"title":"Non-Invasive Prenatal Genetic Screening to Detect Trisomies In Singleton and Twin Pregnancies","authors":"A. Razdan, R. Arora, Gauri G Agarwal, Vandana Sharma, J. Kandpal, N. Singh, Malobi Nandi","doi":"10.18535/ijmsci/v9i10.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i10.02","url":null,"abstract":"Background\u0000Screening for fetal anomalies is one of the most critical parts of prenatal testing to reduce the burden of chromosomal aberrations and improve clinical outcomes in pregnancy. The available literature suggests that India carries a strong economic, emotional, and health care burden of new-born genetic diseases.\u0000Material and Methods:\u0000We present a single-center retrospective study of 200 singletons and 6 dichorionic diamniotic twin gestations screened for chromosomal abnormalities and trisomies using NIPT. The patients were presented with a gestation period of 10-12 (plus a few days) weeks, clinically confirmed with singleton or diamniotic dizygotic twins, who underwent NIPT between the years 2021-2022 (mid) at our center. All the patients underwent sonographic examination and biochemical investigations with regular follow-up and genetic counseling. The clinical history and family history of the presence of any genetic disease or any other disease were previously taken by the clinician in all cases. The main clinical indications were increased risk of trisomies found in markers test, advanced maternal age, or presented with some mild complications in pregnancy.\u0000Results;\u0000Out of the total (206) pregnancies, only 2 singleton cases were found at high risk in NIPT screen, prospectively followed up, and showed normal twins in six cases of twin pregnancy growing successfully. The high-risk cases were genetically counselled and further tests using amniotic or chorionic villi samples were recommended by the clinician with regular clinical follow-up.\u0000Conclusion:\u0000This retrospective study clearly indicates that non-invasive prenatal testing in pregnancy is a safe and effective screening test to rule out certain chromosomal abnormalities and to omit the need of further invasive tests among low-risk cases.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88787853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-04DOI: 10.18535/ijmsci/v9i10.01
L. Susanti
Background: Myasthenia gravis is a rare autoimmune disease due to neuromuscular junction (NMJ) disorders. The diagnosis of myasthenia gravis is based on cardinal clinical symptoms, including fluctuating weakness, worsening with activity, and improving with rest. In addition to clinical signs and antibody tests, other tests that are also crucial for diagnosis are electrodiagnostic examination (EDX) such as repetitive nerve stimulation (RNS) and single fibre electromyography (SFEMG). Recent studies have focused on assessing patients' severity and quality of life, essential for determining the prognosis and subsequent treatment plans. Objective: To evaluate the characteristic of RNS and its correlation with rigor and quality of life of myasthenia gravis patients. Methods: Inclusion criteria: patients diagnosed with myasthenia gravis, aged 18-65 years, willing to participate in the study. Exclusion criteria include a history of neuropathy, motor neuron disease, or myopathy and dropping out of the study. Patient demographic data were collected. The results of the RNS examination were divided into two categories, normal and abnormal. MG severity was assessed by the Myasthenia gravis foundation of America (MGFA) classification, and the patient's quality of life was assessed by Myasthenia Gravis Quality of Life 15 (MG-QOL 15). Results: Of the 24 samples, 69.1% of RNS were positive. The most sensitive muscle for assessing RNS is the anconeus muscle, followed by the trapezius and nasal. There was no significant relationship between RNS features and severity and the quality of life of myasthenic Gravis patients. Conclusion: Onconeus muscle is the best location for assessing RNS. Although the number of patients with normal RNS had lower severity and better quality of life, there was no statistically significant relationship. Further studies with larger samples and longer follow-ups are needed.
背景:重症肌无力是一种罕见的由神经肌肉连接处(NMJ)疾病引起的自身免疫性疾病。重症肌无力的诊断是基于主要的临床症状，包括波动性无力，活动时加重，休息时改善。除了临床体征和抗体测试外，其他对诊断也至关重要的测试是电诊断检查(EDX)，如重复神经刺激(RNS)和单纤维肌电图(SFEMG)。最近的研究集中在评估患者的严重程度和生活质量，这对确定预后和后续治疗计划至关重要。目的:探讨重症肌无力患者的RNS特征及其与严谨性和生活质量的关系。方法:纳入标准:诊断为重症肌无力的患者，年龄18-65岁，愿意参加研究。排除标准包括有神经病变、运动神经元疾病或肌病病史并退出研究。收集患者人口统计数据。RNS检查结果分为正常和异常两类。MG严重程度采用美国重症肌无力基金会(MGFA)分级，患者生活质量采用重症肌无力生活质量15 (MG- qol 15)评分。结果:24份标本中，RNS阳性率为69.1%。评估RNS最敏感的肌肉是anconus肌，其次是斜方肌和鼻肌。重症肌无力患者的RNS特征、严重程度及生活质量无显著相关性。结论:圆锥肌是评价RNS的最佳部位。虽然RNS正常的患者数量严重程度较低，生活质量较好，但没有统计学意义上的相关性。进一步的研究需要更大的样本和更长的随访时间。
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