Pub Date : 2022-05-29DOI: 10.18535/ijmsci/v9i05.06
T. Yasuda
The purpose of this study was to compare the fitness levels of healthy young Japanese adults based on the “old” and “new” sarcopenia versions of the European Working Group on Sarcopenia in the Older People (EWGSOP1 and EWGSOP2) and the Asian Working Group for Sarcopenia (AWGS 2014 and AWGS 2019) criteria. Sixty-nine Japanese young adults were evaluated using the diagnostic criteria and classification of sarcopenia (muscle strength, physical ability, and muscle mass). For both sexes, the percentage classified as “robust” on the sarcopenia diagnostic criteria was lower in “old” than in “new” classification. The “sarcopenia” category comprised 2% of females only, but none of them had “severe sarcopenia”. The proportion of participants with “presarcopenia” (old classification) was 19-38%, and that with “possible sarcopenia” (new classification) was 2% for females only. A higher proportion of healthy young adults were classified as “robust” in “new” compared to “old” because "presarcopenia" was eliminated in “new”. Moreover, since the proportion of low muscle mass exists in one-fifth of males and one-third of females, it would be difficult to use the new criteria to promote muscle mass gains and prevent from a young age to care for the future.
{"title":"Physical Fitness of Young Japanese Adults Evaluated by Old and New Diagnostic Criteria for Sarcopenia","authors":"T. Yasuda","doi":"10.18535/ijmsci/v9i05.06","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.06","url":null,"abstract":"The purpose of this study was to compare the fitness levels of healthy young Japanese adults based on the “old” and “new” sarcopenia versions of the European Working Group on Sarcopenia in the Older People (EWGSOP1 and EWGSOP2) and the Asian Working Group for Sarcopenia (AWGS 2014 and AWGS 2019) criteria. Sixty-nine Japanese young adults were evaluated using the diagnostic criteria and classification of sarcopenia (muscle strength, physical ability, and muscle mass). For both sexes, the percentage classified as “robust” on the sarcopenia diagnostic criteria was lower in “old” than in “new” classification. The “sarcopenia” category comprised 2% of females only, but none of them had “severe sarcopenia”. The proportion of participants with “presarcopenia” (old classification) was 19-38%, and that with “possible sarcopenia” (new classification) was 2% for females only. A higher proportion of healthy young adults were classified as “robust” in “new” compared to “old” because \"presarcopenia\" was eliminated in “new”. Moreover, since the proportion of low muscle mass exists in one-fifth of males and one-third of females, it would be difficult to use the new criteria to promote muscle mass gains and prevent from a young age to care for the future.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79510646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-27DOI: 10.18535/ijmsci/v9i05.05
Arshan Khan, Mohammad K. Balaw, H. Sattar, Yash Garg, Freny Sebastian, C. Agyingi, Hardik A. Fichadiya, Muhammad Haseeb
Coronavirus disease 2019 (Covid-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Initially, COVID-19 was considered a respiratory illness, but later on, it was found out that this disease can affect many organ systems. Cardiovascular manifestations of this disease include myocarditis, heart failure, myocardial infarction, and thromboembolism. Myocarditis related to COVID-19 is thought to be due to the direct viral injury and host immune response. The cases of myocarditis after the COVID-19 mRNA vaccine have been reported in the literature as well. COVID-19 myocarditis can present as chest pain, shortness of breath, acute heart failure, arrhythmia, and possibly death. The initial workup should include an electrocardiogram (ECG) and troponins if myocarditis is suspected. Further screening should be done if troponins are elevated, or the patient has ECG changes concerning myocardial damage. Noninvasive imaging that helps to diagnose COVID-19 myocarditis includes echocardiograms, computerized tomographic (CT) with contrast, and cardiac magnetic resonance imaging (CMR). An endomyocardial biopsy (EMB) can be performed if the diagnosis remains unclear. Initial treatment of COVID-19 myocarditis is mainly supportive, and intravenous immunoglobulin (IVIG) and corticosteroid may be effective, particularly in fulminant myocarditis. If the patient develops life-threatening arrhythmias or shock, advanced mechanical support is required. Early intervention is a critical factor in decreasing morbidity and mortality. Further research is needed to determine the efficacy of different treatment modalities, including IVIG and corticosteroids, in patients with COVID-19 myocarditis.
{"title":"Myocarditis Associated With COVID-19 Infection and Mrna Vaccination: A Review Article","authors":"Arshan Khan, Mohammad K. Balaw, H. Sattar, Yash Garg, Freny Sebastian, C. Agyingi, Hardik A. Fichadiya, Muhammad Haseeb","doi":"10.18535/ijmsci/v9i05.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.05","url":null,"abstract":"Coronavirus disease 2019 (Covid-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Initially, COVID-19 was considered a respiratory illness, but later on, it was found out that this disease can affect many organ systems. Cardiovascular manifestations of this disease include myocarditis, heart failure, myocardial infarction, and thromboembolism. Myocarditis related to COVID-19 is thought to be due to the direct viral injury and host immune response. The cases of myocarditis after the COVID-19 mRNA vaccine have been reported in the literature as well. COVID-19 myocarditis can present as chest pain, shortness of breath, acute heart failure, arrhythmia, and possibly death. The initial workup should include an electrocardiogram (ECG) and troponins if myocarditis is suspected.\u0000Further screening should be done if troponins are elevated, or the patient has ECG changes concerning myocardial damage. Noninvasive imaging that helps to diagnose COVID-19 myocarditis includes echocardiograms, computerized tomographic (CT) with contrast, and cardiac magnetic resonance imaging (CMR). An endomyocardial biopsy (EMB) can be performed if the diagnosis remains unclear. Initial treatment of COVID-19 myocarditis is mainly supportive, and intravenous immunoglobulin (IVIG) and corticosteroid may be effective, particularly in fulminant myocarditis. If the patient develops life-threatening arrhythmias or shock, advanced mechanical support is required. Early intervention is a critical factor in decreasing morbidity and mortality. Further research is needed to determine the efficacy of different treatment modalities, including IVIG and corticosteroids, in patients with COVID-19 myocarditis.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85272187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-25DOI: 10.18535/ijmsci/v9i05.04
Kothwala Deveshkumar Mahendralal, Minocha Dr. Pramod Kumar, Dave Arpit Pradipkumar
A balloon expandable tracheal stent is used to broaden the respiratory system, primarily to avoid tracheal rings from collapsing or causing central airway obstruction (CAO). The research relates to a stent that improves air flow in the "windpipe" or "trachea tract" by limiting the amount of surface area covered by the stent, allowing cilia to function normally. Furthermore, the stent decreases mucus collection and tissue granulation within the stent, which has improved anti-migration properties due to flare ends, is suited for custom size, and reduces the risk of airway perforation and erosion. A therapeutic substance is coated on the stent to avoid infection at the treatment site.
{"title":"Development of Bronchial Stent for High Ciliary Function in Respiratory Tract","authors":"Kothwala Deveshkumar Mahendralal, Minocha Dr. Pramod Kumar, Dave Arpit Pradipkumar","doi":"10.18535/ijmsci/v9i05.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.04","url":null,"abstract":"A balloon expandable tracheal stent is used to broaden the respiratory system, primarily to avoid tracheal rings from collapsing or causing central airway obstruction (CAO). The research relates to a stent that improves air flow in the \"windpipe\" or \"trachea tract\" by limiting the amount of surface area covered by the stent, allowing cilia to function normally. Furthermore, the stent decreases mucus collection and tissue granulation within the stent, which has improved anti-migration properties due to flare ends, is suited for custom size, and reduces the risk of airway perforation and erosion. A therapeutic substance is coated on the stent to avoid infection at the treatment site.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84368215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-22DOI: 10.18535/ijmsci/v9i05.03
M. Z. Mohamed Jiffry, Jonathan Vargas, M. Ahmed-khan, Teena Thomas, Jeltsina Sosa
Introduction: Although Acute Myeloid Leukemia (AML) has been associated with several environmental factors, in some patients the evolution to AML is preceded by myelodysplastic syndrome (MDS). We report a case of 63-year-old male who was diagnosed with sporadic monosomy 7 MDS/AML who achieved good response to treatment with CPX-351 (Vyxeos) induction chemotherapy. Case information: A 63-year-old male initially presented to the ED for further evaluation of pancytopenia that was discovered incidentally during a routine office visit. Further evaluation revealed his blast count was elevated with presence of Auer rods, myelocytes and basophilia. He was admitted for further work-up of pancytopenia with suspicion being for MDS/AML and bone marrow biopsy for flow cytometric evaluation of the bone marrow was strongly suggestive of acute myeloid leukemia, with morphology suggesting a predisposing MDS. Subsequent molecular cytogenetic [FISH] report confirmed -7/7q abnormality in 80% of nuclei with loss of 1 copy of chromosome 7. The following week, patient was initiated on CPX–351 [Vyxeos; daunorubicin and cytarabine liposome for injection]. Bone marrow biopsy following induction chemotherapy showed 11 to 12% of CD34 positive myeloid blasts with abnormal myeloid maturation, representing notable improvement with greater than 50% reduction in his blast count. Conclusion: Sporadic monosomy 7 MDS/AML that arises without evidence of germline genetic predisposition and in the absence of other predisposing medical conditions or treatments is an uncommon subset of AML. Vyxeos induction chemotherapy may be an excellent option in the management of sporadic monosomy 7 MDS/AML.
{"title":"A Favorable Outcome With CPX-351 Liposome (Vyxeos) in the Management of A Sporadic Monosomy 7 Myelodysplastic Syndrome Related Acute Myeloid Leukemia","authors":"M. Z. Mohamed Jiffry, Jonathan Vargas, M. Ahmed-khan, Teena Thomas, Jeltsina Sosa","doi":"10.18535/ijmsci/v9i05.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.03","url":null,"abstract":"Introduction: Although Acute Myeloid Leukemia (AML) has been associated with several environmental factors, in some patients the evolution to AML is preceded by myelodysplastic syndrome (MDS). We report a case of 63-year-old male who was diagnosed with sporadic monosomy 7 MDS/AML who achieved good response to treatment with CPX-351 (Vyxeos) induction chemotherapy.\u0000Case information: A 63-year-old male initially presented to the ED for further evaluation of pancytopenia that was discovered incidentally during a routine office visit. Further evaluation revealed his blast count was elevated with presence of Auer rods, myelocytes and basophilia. He was admitted for further work-up of pancytopenia with suspicion being for MDS/AML and bone marrow biopsy for flow cytometric evaluation of the bone marrow was strongly suggestive of acute myeloid leukemia, with morphology suggesting a predisposing MDS. Subsequent molecular cytogenetic [FISH] report confirmed -7/7q abnormality in 80% of nuclei with loss of 1 copy of chromosome 7. The following week, patient was initiated on CPX–351 [Vyxeos; daunorubicin and cytarabine liposome for injection]. Bone marrow biopsy following induction chemotherapy showed 11 to 12% of CD34 positive myeloid blasts with abnormal myeloid maturation, representing notable improvement with greater than 50% reduction in his blast count.\u0000Conclusion: Sporadic monosomy 7 MDS/AML that arises without evidence of germline genetic predisposition and in the absence of other predisposing medical conditions or treatments is an uncommon subset of AML. Vyxeos induction chemotherapy may be an excellent option in the management of sporadic monosomy 7 MDS/AML.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91542468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-15DOI: 10.18535/ijmsci/v9i04.05
Sakharam Sirvi, D. Joshi, Raghvendra Singh Bhadauria
The objective of current study is to design, synthesize the benzimidazoles derivative and evaluate it for anti-malarialactivity by the recently developed Computer Aided Drug Designing techniques with development of new pharmacological active compounds However, a promising approach is needed to use these agents as templates for designing new derivatives with improved properties. The Aim of this project was thus to investigate the potential of the lead compound for future antimalrial drugs. . In order to accomplish this aim a range of synthetic derivatives of Benzimidazoles were prepared and biologically evaluated for Antimalarial activity. 2D Structure of all the designed compounds were draw with the help of chem Draw ultra-version 8.0.3 and exported to window of Chem 3D ultra version 8.0.3 Energy of all the 3D structures were minimized through MOPAC up to RMS gradient 0.001 and saved in MDL Mol file (.Mol) format. )]. In order to examine the predictive power of the QSAR models, the dataset was divided into training set consisting of 32 molecules and test set consisting of 8 compounds in such a way that the utilizing the diversity method in such a way that the structural diversity and a wide range of biological activity in the data set were added. The IC50 values were transformed to pIC50 in order to give numerically larger data values.
本研究的目的是利用计算机辅助药物设计技术来设计、合成苯并咪唑衍生物，并对其抗疟疾活性进行评价，同时开发新的药理活性化合物。然而，利用这些药物作为模板来设计具有更好性能的新衍生物还需要一种有前途的方法。因此，该项目的目的是研究这种先导化合物在未来抗疟药物中的潜力。为了实现这一目标，制备了一系列苯并咪唑的合成衍生物，并对其抗疟活性进行了生物学评价。利用chem draw ultra version 8.0.3绘制所有设计化合物的二维结构，并导出到chem 3D ultra version 8.0.3窗口，通过MOPAC将所有三维结构的能量最小化至RMS梯度为0.001，并保存在MDL Mol文件(.Mol)格式中。］. 为了检验QSAR模型的预测能力，我们将数据集分为由32个分子组成的训练集和由8个化合物组成的测试集，利用多样性方法，增加了数据集中的结构多样性和广泛的生物活性。将IC50值转换为pIC50，以便给出数值较大的数据值。
{"title":"Design and Qsar Studies of Benzimidazole Nucleus As Anti-Infective Agents","authors":"Sakharam Sirvi, D. Joshi, Raghvendra Singh Bhadauria","doi":"10.18535/ijmsci/v9i04.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i04.05","url":null,"abstract":" \u0000The objective of current study is to design, synthesize the benzimidazoles derivative and evaluate it for anti-malarialactivity by the recently developed Computer Aided Drug Designing techniques with development of new pharmacological active compounds However, a promising approach is needed to use these agents as templates for designing new derivatives with improved properties. The Aim of this project was thus to investigate the potential of the lead compound for future antimalrial drugs. . In order to accomplish this aim a range of synthetic derivatives of Benzimidazoles were prepared and biologically evaluated for Antimalarial activity. 2D Structure of all the designed compounds were draw with the help of chem Draw ultra-version 8.0.3 and exported to window of Chem 3D ultra version 8.0.3 Energy of all the 3D structures were minimized through MOPAC up to RMS gradient 0.001 and saved in MDL Mol file (.Mol) format. )]. In order to examine the predictive power of the QSAR models, the dataset was divided into training set consisting of 32 molecules and test set consisting of 8 compounds in such a way that the utilizing the diversity method in such a way that the structural diversity and a wide range of biological activity in the data set were added. The IC50 values were transformed to pIC50 in order to give numerically larger data values.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83307283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-14DOI: 10.18535/ijmsci/v9i04.06
Aditya Thakur, D. Joshi, R. Bhadauria
All the three batches resulted in granules with desired flow and compaction which is evident from the data of compressed tablets. At compression stage Weight parameters and Speed parameters evaluated and found within Specified limit as well as, The Statistical analysis process performance is high capable, Data is normal and Z bench value also give assurance that process remains in state of control (Process validation state) during manufacturing of Sevelamer Hydrochloride film coated tablets, 800 mg. Coating process proven as validated from the weight build up data of tablets as validation data provided for after 50% coating, 75% coating and 100% coating and found in accordance with process validation protocol. Finished product result was evidence of Weight gain while the inspection activity as this material is in very high hygroscopic in nature. However results found within specified limit.
{"title":"Process Validation of Sevelamer Hydrochloride Film Coated Tablet","authors":"Aditya Thakur, D. Joshi, R. Bhadauria","doi":"10.18535/ijmsci/v9i04.06","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i04.06","url":null,"abstract":"All the three batches resulted in granules with desired flow and compaction which is evident from the data of compressed tablets. At compression stage Weight parameters and Speed parameters evaluated and found within Specified limit as well as, The Statistical analysis process performance is high capable, Data is normal and Z bench value also give assurance that process remains in state of control (Process validation state) during manufacturing of Sevelamer Hydrochloride film coated tablets, 800 mg. Coating process proven as validated from the weight build up data of tablets as validation data provided for after 50% coating, 75% coating and 100% coating and found in accordance with process validation protocol. Finished product result was evidence of Weight gain while the inspection activity as this material is in very high hygroscopic in nature. However results found within specified limit.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75991832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-13DOI: 10.18535/ijmsci/v9i05.02
Estik Ikka Indah Purwati, Ristya Widi Endah Yani
One effort made by the government for implementing the strategy to reduce maternal mortality was by pushing society to have a willingness to live healthy through the alert village. This study aimed to analyze the establishment village in lowering the number of maternal mortalities in Jember Regency. The research was qualitative research, with study studies case design. The research was viewed from the stages of approach and preparation for the alert village in Jember Regency. At approach stage, alert village budget at Jember Regency Health Department as well as in Glagahwero village still was not yet realized well. However, at this stage, the preparation for each activity ran well. Attempts made by the alert village in lowering number of maternal deaths in Glagahwero village, including Tabulin (pregnant mother savings) program and blood donors, until this time still runs well.
{"title":"Analysis the Alert Village to Reduce Maternal Mortality Rate in Jember Regency","authors":"Estik Ikka Indah Purwati, Ristya Widi Endah Yani","doi":"10.18535/ijmsci/v9i05.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.02","url":null,"abstract":"One effort made by the government for implementing the strategy to reduce maternal mortality was by pushing society to have a willingness to live healthy through the alert village. This study aimed to analyze the establishment village in lowering the number of maternal mortalities in Jember Regency. The research was qualitative research, with study studies case design. The research was viewed from the stages of approach and preparation for the alert village in Jember Regency. At approach stage, alert village budget at Jember Regency Health Department as well as in Glagahwero village still was not yet realized well. However, at this stage, the preparation for each activity ran well. Attempts made by the alert village in lowering number of maternal deaths in Glagahwero village, including Tabulin (pregnant mother savings) program and blood donors, until this time still runs well.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87147902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.18535/ijmsci/v9i04.04
Rakesh P. Singh, D. Joshi, R. Bhadauria
Hydrotropic agents are stated as ionic organic salts which help to increase or decrease the solubility of solute in a given solvent via ‘salt in’ or ‘salt out’ effects, respectively. Salts which show ‘salt in’ of non-electrolytes are called “hydrotropic salts” and the phenomenon is known as “hydrotropism. There are about 45,000 plant species in India, with concentrated hotspots in the region of Eastern Himalayas. Entire plants of Barleriaprionitis L. collected from Shrinathji Institute of pharmacy, Nathdwara and the plant was authenticated by Dr. R.L. Bhardwaj. The leaves of Barleria Prionitis L plant was characterized by its morphological features like colour, shape, size and surface characteristics has been studies. The plant materials (1 kg) were initially defatted with petroleum ether and then extracted with blends RP-1 to RP-6 using a Soxhlet apparatus. The yield of the plant extracts measured about 20 g each after evaporating the solvent using water bath. As per result of HPTLC, we found that the hydrotropic blends solution aur ecoferindly and cost effective method for the extraction purpose. All the phytoconstitutents which was earlier reported in previous literature by the use of organic solvents which were also present for the use of hydrotropic solvents.
{"title":"Phytochemical Screening of Barleria Prionitis L Leaves Using Hydrotropic Solvents","authors":"Rakesh P. Singh, D. Joshi, R. Bhadauria","doi":"10.18535/ijmsci/v9i04.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i04.04","url":null,"abstract":"Hydrotropic agents are stated as ionic organic salts which help to increase or decrease the solubility of solute in a given solvent via ‘salt in’ or ‘salt out’ effects, respectively. Salts which show ‘salt in’ of non-electrolytes are called “hydrotropic salts” and the phenomenon is known as “hydrotropism. There are about 45,000 plant species in India, with concentrated hotspots in the region of Eastern Himalayas. Entire plants of Barleriaprionitis L. collected from Shrinathji Institute of pharmacy, Nathdwara and the plant was authenticated by Dr. R.L. Bhardwaj. The leaves of Barleria Prionitis L plant was characterized by its morphological features like colour, shape, size and surface characteristics has been studies. The plant materials (1 kg) were initially defatted with petroleum ether and then extracted with blends RP-1 to RP-6 using a Soxhlet apparatus. The yield of the plant extracts measured about 20 g each after evaporating the solvent using water bath. As per result of HPTLC, we found that the hydrotropic blends solution aur ecoferindly and cost effective method for the extraction purpose. All the phytoconstitutents which was earlier reported in previous literature by the use of organic solvents which were also present for the use of hydrotropic solvents.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79142913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-10DOI: 10.18535/ijmsci/v9i04.03
Jitendra Malviya, D. Joshi, R. Bhadauria
A rapid and sensitive LC–MS/MS method for the bioanalytical method development and validation for estimation of olanzapine in k3EDTA human plasma using Olanzapine D3 as internal standard has been developed and validated. The analytes and IS were extracted from plasma by solid phase extraction using Oasis HLB 1cc (30mg) Extraction Cartridge and separated on a Cosmosil, 5µm, C18 150*4. 6 mmcolumn using a 10 mM ammonium formate in Water: Acetonitrile (10: 90) at a flow rate of 1.0 mL/min. Detection involved an API-4000 LC–MS/MS with electrospray ionization in the positive ion mode and multiple-reaction monitoring for analysis. The method was validated according to FDA guidelines and shown to provide intra- and inter-day precision and accuracy within acceptable limits in a run time of only 4.0 min. The method was successfully applied to a pharmacokinetic study involving a single oral administration of a combination tablet to human male volunteers
{"title":"Bioanalytical method Development and Validation for Estimation of Olanzapine in K3edta Human Plasma by Liquid Chromatography–Tandem Mass Spectrometry and Application to a Pharmacokinetic Study","authors":"Jitendra Malviya, D. Joshi, R. Bhadauria","doi":"10.18535/ijmsci/v9i04.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i04.03","url":null,"abstract":"A rapid and sensitive LC–MS/MS method for the bioanalytical method development and validation for estimation of olanzapine in k3EDTA human plasma using Olanzapine D3 as internal standard has been developed and validated. The analytes and IS were extracted from plasma by solid phase extraction using Oasis HLB 1cc (30mg) Extraction Cartridge and separated on a Cosmosil, 5µm, C18 150*4. 6 mmcolumn using a 10 mM ammonium formate in Water: Acetonitrile (10: 90) at a flow rate of 1.0 mL/min. Detection involved an API-4000 LC–MS/MS with electrospray ionization in the positive ion mode and multiple-reaction monitoring for analysis. The method was validated according to FDA guidelines and shown to provide intra- and inter-day precision and accuracy within acceptable limits in a run time of only 4.0 min. The method was successfully applied to a pharmacokinetic study involving a single oral administration of a combination tablet to human male volunteers","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85744857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: This is the first study to evaluate the family (30) members (98) practice combining specific lifestyle with the use of medicinal plants based on EOM and conventional medicines. Clinical observation procedures: A considered multi-centric, controlled and single-blind, phase two clinical trial was realized to patients consulted and received in the Antananarivo Naturoestheticotherapy e-Coaching cabinet of Gasy Products Services and those from Covid-19 Treatment Centers, respectively, during twenty-two months: from May 1st, 2020 to March 1st, 2022. Patients were recommended to follow a specific alimentation and behavior lifestyle. Food Cosmetic Remedy, based on medicinal plant and essential oil mixtures with patient’s optional conventional medicines were given to those presenting Covid-19 principal symptom, such as breath shortness accompanied other indicated symptoms or confirmed medical diagnoses/tests. Outcomes and conclusion: Inhalation of EOM were immediately stopped breath shortness, combining medicinal plants based on essential oil and conventional medicines was psychologically help and physically reinforce the organism to improve Covid-19 symptoms. Food Cosmetic Remedy (combination of medicinal plant and essential oil mixtures) was quickly recovered patients from principal symptoms and reduced time care and long-Covid-19 period. No patient death was registered during the studied observation period.
{"title":"Naturoestheticotherapy, Based on E-Coaching with Food Cosmetic Remedy Prepared from Medicinal Plants and Essential Oils Mixtures, Alone or in Combination of Conventional Medicines to Treat Covid-19 Patients and Symptoms.","authors":"Rafatro Herintsoa, Andrianomentsoa Bezanahary Hanitrinivony, Randriamavo Solo Hasiniaina Norovololona Angèle, Ramanampamaharana Rija Herindrainy","doi":"10.18535/ijmsci/v9i05.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i05.01","url":null,"abstract":"Introduction: This is the first study to evaluate the family (30) members (98) practice combining specific lifestyle with the use of medicinal plants based on EOM and conventional medicines.\u0000Clinical observation procedures: A considered multi-centric, controlled and single-blind, phase two clinical trial was realized to patients consulted and received in the Antananarivo Naturoestheticotherapy e-Coaching cabinet of Gasy Products Services and those from Covid-19 Treatment Centers, respectively, during twenty-two months: from May 1st, 2020 to March 1st, 2022. Patients were recommended to follow a specific alimentation and behavior lifestyle. Food Cosmetic Remedy, based on medicinal plant and essential oil mixtures with patient’s optional conventional medicines were given to those presenting Covid-19 principal symptom, such as breath shortness accompanied other indicated symptoms or confirmed medical diagnoses/tests.\u0000Outcomes and conclusion: Inhalation of EOM were immediately stopped breath shortness, combining medicinal plants based on essential oil and conventional medicines was psychologically help and physically reinforce the organism to improve Covid-19 symptoms. Food Cosmetic Remedy (combination of medicinal plant and essential oil mixtures) was quickly recovered patients from principal symptoms and reduced time care and long-Covid-19 period. No patient death was registered during the studied observation period.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82306374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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