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Nephrotoxic evaluation of ethanol stem bark extract of Dialium guineense in normal wistar rats 豚鼠乙醇茎皮提取物对正常wistar大鼠肾毒性评价
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.33545/27074447.2022.v4.i2a.51
Abu Od, Onoagbe Io, O. F
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引用次数: 4
The effectiveness of logistic regression equations for solving problems of determining the sex of a person by odontometric parameters 逻辑回归方程的有效性,以解决问题,确定一个人的性别,通过牙齿测量参数
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.33545/27074447.2022.v4.i1a.48
Shakir M. Musayev, Z. M. Kerimov, Anar Sh. Ibragimov, Namik N Orudjov
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引用次数: 0
Prevalence of Delayed Neuropathy and Intermediate Syndrome in Acute Organophosphorus Poisoning: A Cross-sectional Toxicological/Clinical Study 急性有机磷中毒中迟发性神经病变和中间综合征的患病率:一项横断面毒理学/临床研究
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.v12i3.37091
Mitra Rahimi, Rezvan Kefayati, S. Shadnia, PeymanErfan Talab Evini
Background: Organophosphates are among the most common causes of poisoning worldwide—responsible for 3 million poisoning and 200000 deaths every year. Nearly 15% of people who are poisoned die. This cross-sectional toxicological/clinical study aimed to investigate the prevalence and influential factors in the incidence of delayed peripheral neuropathy and intermediate syndrome in acute poisoning with organophosphorus toxins. The study was conducted in Loghman Hakim Hospital, Tehran City, Iran, from 2017 to 2020. Methods: The study data were obtained from the patients’ records during follow-up. Data included demographic information (age, sex, etc.), vital signs, muscarinic, nicotinic, and neurological symptoms at admission, atropine therapy status, and pralidoxime intake status. Post-discharge complications were obtained, and patients’ Electromyography (EMG) and Nerve Conduction Velocity (NCV) results were recorded and evaluated during hospitalization and follow-up. Statistical analysis was performed using SPSS software, version 22. Results: Of 63 studied patients, 61.9% were female. The Mean±SD age of the patients was 31.90±13.128 years. Male patients were significantly (P<0.010) older than female ones. The most common muscarinic symptoms were nausea and vomiting (73.2%), diarrhea (34.92%), and abdominal pain (33.33%). Regarding the nicotinic symptoms, sweating (30.16%) and fasciculation (19.05%) were the commonest. Neurological complications were less common; seizures were observed in 3 cases (4.76%) and coma in 2 cases (3.17%). Most patients (79.4%) received pralidoxime with atropine. The Mean±SD days of treatment with atropine and pralidoxime were 5.51±3.52 and 4.06±4.62 days, respectively. Only one death was recorded. The results of the initial EMG-NCV test on the second day of hospitalization showed abnormalities in 4 patients (6.3%), indicating the presence of the intermediate syndrome. Conclusion: The results of the EMG-NCV tests at our patients’ follow-up (30 days) showed no abnormalities. Hence no cases of delayed neuropathy were seen. During hospitalization, one patient had flaccid paralysis and showed significant impairment on the EMG-NCV test (P<0.01).
背景:有机磷是世界上最常见的中毒原因之一,每年造成300万人中毒和20万人死亡。近15%的中毒患者死亡。本横断面毒理学/临床研究旨在探讨急性有机磷毒素中毒中迟发性周围神经病变和中间综合征的发生率及其影响因素。该研究于2017年至2020年在伊朗德黑兰市的Loghman Hakim医院进行。方法:研究资料来源于随访期间的患者病历。数据包括人口统计信息(年龄、性别等)、生命体征、入院时毒蕈碱、烟碱和神经系统症状、阿托品治疗情况和哌拉西肟摄入情况。观察出院后并发症,记录患者住院及随访期间的肌电图(EMG)和神经传导速度(NCV)。统计分析采用SPSS软件,版本22。结果:63例患者中,女性占61.9%。患者平均±SD年龄为31.90±13.128岁。男性患者年龄明显大于女性患者(P<0.010)。最常见的毒蕈病症状为恶心呕吐(73.2%)、腹泻(34.92%)和腹痛(33.33%)。在烟碱症状中,出汗(30.16%)和抽搐(19.05%)最为常见。神经系统并发症较少见;癫痫发作3例(4.76%),昏迷2例(3.17%)。大多数患者(79.4%)同时使用普拉多肟和阿托品。阿托品和普拉多嗪治疗的平均±SD天分别为5.51±3.52天和4.06±4.62天。只有一人死亡。入院第2天的初始肌电- ncv检查结果显示4例(6.3%)患者异常,提示存在中间综合征。结论:患者随访30天,肌电- ncv检查未见异常。因此,未见迟发性神经病变病例。住院期间1例出现弛缓性麻痹,EMG-NCV检查出现明显损伤(P<0.01)。
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引用次数: 0
α-Globin Messenger Ribonucleic Acid as a Molecular Marker for Determining the Age of Human Blood Spots in Different Temperatures α-球蛋白信使核糖核酸作为测定不同温度下人类血斑年龄的分子标记
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.vi.37096
Heba Abdullah Mostafa Eid, Usama Mohammed Ibrahim Elbarrany, S. Ghaleb, M. Mohamed, Dina Sabry Abdelfattah, H. Aboubakr
Background: Analyzing recovered evidence, such as blood which is one of the most encountered types of biological evidence, can provide information to establish the definite time when a crime was committed. This study aims to investigate the timeand temperature-related effects on human bloodstain’s α-globin messenger RNA expression and to estimate the bloodstain’s age using α-globin mRNA. Methods: A total of 22 blood samples were collected from healthy middle-aged volunteers (12 women and 10 men). After preparation, the samples were exposed to temperatures of 4°C, 24°C, and 40°C. Next, the mRNA expression of the α-globin gene was quantified by real-time RT-PCR at different time intervals of 0, 30, 90, and 150 days. Results: The α-globin gene expression showed the highest mean values by 0 day and at 4°C and the lowest mean values by 150 days and at 40°C. Samples from male participants showed higher mean values of α-globin gene expression compared to their female counterparts. A significant negative correlation was detected between α-globin gene expression and time interval. Meanwhile, a regression equation was formulated to estimate the time interval using the α-globin gene concentration. Conclusion: α-Globin mRNA could be a useful marker to estimate the age of human blood spots.
背景:分析回收的证据,如血液,这是最常见的生物证据类型之一,可以提供信息来确定犯罪的确切时间。本研究旨在研究时间和温度对人类血迹α-珠蛋白信使核糖核酸表达的影响,并利用α-珠蛋白质信使核糖核酸估计血迹的年龄。方法:从健康的中年志愿者(12名女性和10名男性)中采集22份血液样本。制备后,将样品暴露在4°C、24°C和40°C的温度下。接下来,通过实时RT-PCR在0、30、90和150天的不同时间间隔定量α-珠蛋白基因的mRNA表达。结果:α-珠蛋白基因表达在0天和4°C时平均值最高,在150天和40°C时最低。来自男性参与者的样本显示,与女性参与者相比,α-珠蛋白基因表达的平均值更高。α-珠蛋白基因表达与时间间隔呈显著负相关。同时,利用α-珠蛋白基因浓度建立了一个回归方程来估计时间间隔。结论:α-球蛋白mRNA可作为判断人体血斑年龄的有用标志物。
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引用次数: 0
Survey of the Presence of Nivalenol and Deoxynivalenol in Wheat Flour Factories of Khuzestan Province, Iran 伊朗胡齐斯坦省小麦粉工厂中雪腐镰刀醇和脱氧雪腐镰刀醇的调查
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.vi.35842
Zahra Nazari Khorasgani, M. Mahdavi, H. Kalantari, M. Goudarzi
Background: Wheat is frequently contaminated by Deoxynivalenol (DON) and Nivalenol (NIV), which are type B trichothecenes produced by Fusarium fungi. Most problems related to these contaminants involve prolonged feed intake at low levels of contamination. This study investigated the occurrence of NIV and Deoxynivalenol (DON) in wheat flour in flour factories in Khuzestan Providence, Iran. Methods: In total, 104 samples were collected in this study. An acetonitrile/water mixture (84:16, v/v) was used to extract the samples. The extracts were filtered and purified using a Whatman No. 4 paper and MycoSepTM 227 column. Then, they were evaporated to dryness at 40˚C under a nitrogen stream. After dissolving the dry residue in the mobile phase, containing a mixture of methanol, acetonitrile, and water (5:5:90, v/v/v), the contents of NIV and DON in the samples were measured in High-Performance Liquid Chromatography (HPLC) system with a column C18 (150 mm×4.6 mm ID, 5 μm) and a UV detector (220 nm). Results: The results showed that among 104 wheat flour samples, 28 (26.8%) and 54 (51.9%) samples were contaminated with NIV and DON, respectively. The mean and maximum concentrations were 118.75 and 2278 ng/g for NIV, and 593 and 67.88 ng/g for DON, respectively. Conclusion: Based on the findings, DON and NIV had significantly lower concentrations than the maximum tolerated level (1 μg/g), established by the Institute of Standards and Industrial Research of Iran. Therefore, there were no health risks for consumers at the studied contamination levels.
背景:小麦经常受到镰刀菌产生的B型天花粉烯脱氧雪腐镰刀菌烯醇(DON)和尼瓦烯醇(NIV)的污染。与这些污染物有关的大多数问题都涉及在低污染水平下延长进料时间。本研究调查了伊朗胡齐斯坦普罗维登斯面粉厂小麦面粉中NIV和脱氧雪腐镰刀菌烯醇(DON)的发生情况。方法:本研究共采集标本104份。使用乙腈/水混合物(84:16,v/v)提取样品。使用Whatman No.4纸和MycoSepTM 227柱过滤和纯化提取物。然后,在40˚C的氮气流下将其蒸发至干。将干残留物溶解在含有甲醇、乙腈和水的混合物(5:5:90,v/v/v)的流动相中后,在高效液相色谱(HPLC)系统中用C18柱(150mm×4.6mm ID,5μm)和紫外检测器(220nm)测定样品中NIV和DON的含量。结果:104份小麦粉样品中,NIV和DON分别污染28份(26.8%)和54份(51.9%)。NIV的平均和最大浓度分别为118.75和2278ng/g,DON的平均和最高浓度分别为593和67.88ng/g。结论:根据研究结果,DON和NIV的浓度明显低于伊朗标准与工业研究所制定的最大耐受水平(1μg/g)。因此,在所研究的污染水平下,消费者没有健康风险。
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引用次数: 0
Evaluating Post-discharge Thromboembolic Events in Patients With COVID-19 评估COVID-19患者出院后血栓栓塞事件
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.vi.36851
Maryam Taherkhani, Houra Yeganegi, Adineh Taherkhani, Reza Hamneshin Behbahani, Pegah Soltani Samani, Kimia Taheri Karimi
Background: COVID-19 is associated with a high rate of thromboembolic events in hospitalized patients, but it is unclear whether this risk remains high after discharge. This study aimed to evaluate the association of underlying factors with post-discharge thrombolytic events in COVID-19 patients and the association of thrombolytic events with subsequent mortality and ischemic heart disease. Methods: In this study, eligible patients with COVID-19 who were admitted to the respiratory ward of Loghman Hakim Hospital, Tehran, Iran, followed up for about 3 months after discharge to record any thromboembolic events. Patients who reported postdischarge thromboembolic events were confirmed based on their diagnostic tests. The Chi-square test was used to evaluate the association between thromboembolic events and qualitative parameters, and an independent t-test was used to evaluate their association with quantitative parameters. Logistic regression analysis was performed to assess the association between independent variables and the composite outcome. Results: Thromboembolic events were diagnosed in 35 patients (5.04%), including Myocardial Infarction (MI) in 17 patients (2.44%), venous thromboembolism in 10 patients (1.44%), and ischemic stroke in 8 patients (1.15%). None of the 26 patients who received thromboprophylaxis had thromboembolic events. During follow-up, 22 patients (3.17%) died, of whom, 10 patients (43.47%) had thromboembolic events. Thromboembolic events were not associated with sedentary life and oxygen (O2) dependency after discharge (P value of 0.40 and 0.098, respectively). Regression analyses showed that thromboembolic events were significantly associated with ischemic heart disease and mortality (P=0.007 and P<0.001, respectively). Conclusion: Our findings support a high rate of post-hospitalization thromboembolic events in COVID-19 patients; however, it needs more large-scale trials.
背景:新冠肺炎与住院患者的高血栓栓塞事件发生率有关,但目前尚不清楚出院后这种风险是否仍然很高。本研究旨在评估潜在因素与新冠肺炎患者出院后溶栓事件的相关性,以及溶栓事件与随后死亡率和缺血性心脏病的相关性。方法:在本研究中,伊朗德黑兰Loghman Hakim医院呼吸科收治的符合条件的新冠肺炎患者出院后随访约3个月,记录任何血栓栓塞事件。报告出院后血栓栓塞事件的患者根据其诊断测试进行确认。卡方检验用于评估血栓栓塞事件与定性参数之间的相关性,独立t检验用于评估它们与定量参数的相关性。进行Logistic回归分析以评估自变量与综合结果之间的相关性。结果:35例患者(5.04%)被诊断为血栓栓塞事件,其中心肌梗死17例(2.44%),静脉血栓栓塞10例(1.44%),缺血性卒中8例(1.15%)。26例接受血栓预防的患者中没有一例发生血栓栓塞事件。随访期间,22名患者(3.17%)死亡,其中10名患者(43.47%)发生血栓栓塞事件。血栓栓塞事件与久坐生活和出院后氧(O2)依赖性无关(P值分别为0.40和0.098)。回归分析显示,血栓栓塞事件与缺血性心脏病和死亡率显著相关(分别为P=0.007和P<0.001)。结论:我们的研究结果支持新冠肺炎患者住院后血栓栓塞事件的高发生率;然而,它需要更大规模的试验。
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引用次数: 0
Violence Against Medical Assistants by Colleagues at Educational Hospitals and Its Effects on the Quality of Education 教育医院同事对医务助理的暴力行为及其对教育质量的影响
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.vi.37001
Mahdi Chinichian, A. Aghabiklooei, R. Mehrdad, G. Pouryaghoub, Milad Orouji
Background: Violence against medical assistants (residents) by colleagues is a serious problem at educational hospitals that has not been sufficiently examined. The present study was conducted to determine the prevalence, risk factors, and types of violence perpetrated by colleagues against medical assistants. Methods: In a cross-sectional study conducted at two large tertiary referral educational hospitals, the study questionnaires were distributed among 480 healthcare professionals to investigate their experiences of violence. Results: Of 280 responders, 162 residents (57.9%) reported a history of violence or aggression. Of these, nearly 50% had experienced pure psychological violence, and 16.7% had been physically abused. The prevalence of victimization was high among the residents of the neurosurgery, orthopedic, and obstetric departments (90%, 88%, and 85%, respectively). Conclusion: Harassment experience was more common among the surgical residents than the internal medicine residents because of the former’s high level of work stress. Senior residents or fellowship residents were the main abusers. Losing professional selfesteem, decreasing job satisfaction, and dropping out of school were the main adverse outcomes of violence experienced by the victims.
背景:同事对医疗助理(住院医师)的暴力行为是教育医院的一个严重问题,但尚未得到充分调查。本研究旨在确定同事对医务助理实施暴力的流行程度、风险因素和类型。方法:在两家大型三级转诊教育医院进行横断面研究,向480名医护人员发放研究问卷,调查他们的暴力经历。结果:在280名应答者中,162名居民(57.9%)报告有暴力或攻击史。其中,近50%的人经历过纯粹的心理暴力,16.7%的人遭受过身体虐待。受害率在神经外科、骨科和产科的住院医师中较高(分别为90%、88%和85%)。结论:外科住院医师比内科住院医师更容易遭受骚扰,因为外科住院医师的工作压力较大。老年住院医师或住院医师是主要的施虐者。失去职业自尊、工作满意度下降和辍学是受害者遭受暴力的主要不良后果。
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引用次数: 0
Effect of extracts of dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats 豚鼠干皮提取物对正常大鼠肾脏脂质过氧化指数及组织学变化的影响
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.33545/27074447.2022.v4.i2a.52
Abu Od, Ngedaa Os, Osarhenomase Eg
{"title":"Effect of extracts of dialium guineense stem bark on lipid peroxidation index and histological changes in kidneys of normal rats","authors":"Abu Od, Ngedaa Os, Osarhenomase Eg","doi":"10.33545/27074447.2022.v4.i2a.52","DOIUrl":"https://doi.org/10.33545/27074447.2022.v4.i2a.52","url":null,"abstract":"","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73454373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical design of boron-nitride nanotubes, nanotubes by Gaussian 5.0 version 化学设计氮化硼纳米管,纳米管采用高斯5.0版
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.33545/27074447.2022.v4.i2a.49
Dr. Antesar Rheem Obead, Doaa Nassr Wahhab, Sharara Fadhial Abbood
{"title":"Chemical design of boron-nitride nanotubes, nanotubes by Gaussian 5.0 version","authors":"Dr. Antesar Rheem Obead, Doaa Nassr Wahhab, Sharara Fadhial Abbood","doi":"10.33545/27074447.2022.v4.i2a.49","DOIUrl":"https://doi.org/10.33545/27074447.2022.v4.i2a.49","url":null,"abstract":"","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":"34 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79387957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Postmortem Examination in Exhumed Cases Done in and Around Bangalore, India for 10 Years: A Retrospective Study 印度班加罗尔及其周边地区10年来尸检结果分析:回顾性研究
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.v12i3.37680
S. V., Jyothi S, Agnes J Cyriac
Background: Exhumation is the process of removing the dead body from the grave. The reasons and time limit for exhumation may vary from country to country. After receiving a request from the Magistrate, exhumation followed by postmortem is done to gain essential evidence. To comprehensively analyze the exhumation cases done in Victoria Hospital, Bangalore, and how exhumation followed by postmortem examination aids in finding the cause of death. Methods: All cases of exhumations performed for 10 years (from January 1, 2012, to December 31, 2021) in the Department of Forensic Medicine and Toxicology, Victoria Hospital, Bangalore, were studied retrospectively. The essential data were collected from requisition forms, exhumation, and postmortem reports. The results were obtained after tabulating, and data were analyzed with an observational method. Results: A total of 37 exhumation cases were done during the study period. Young males in the age group of 21 to 30 years were the major population. Out of 37 cases, the cause of death was established in 25 cases (68%). Conclusion: Analysis of postmortem examination in exhumed cases gives much information from a medicolegal point of view to determine the cause and reveal the mysteries behind the manner of death. Hence it is not a vain procedure.
背景:发掘是将尸体从坟墓中取出的过程。挖掘遗骸的原因和时限可能因国家而异。在收到治安法官的请求后,进行挖掘,然后进行尸检,以获得必要的证据。全面分析班加罗尔维多利亚医院的挖掘病例,以及挖掘后的尸检如何有助于找到死因。方法:对班加罗尔维多利亚医院法医和毒理学系10年(2012年1月1日至2021年12月31日)进行的所有挖掘病例进行回顾性研究。基本数据是从请购单、挖掘和尸检报告中收集的。结果是在制表后获得的,并用观测方法对数据进行分析。结果:在研究期间,共进行了37例挖掘病例。21至30岁年龄组的年轻男性是主要人群。在37例病例中,有25例(68%)确定了死亡原因。结论:从法医学的角度对挖掘出的尸体进行尸检分析,为确定死因和揭示死亡方式背后的奥秘提供了大量信息。因此,这不是一个徒劳的程序。
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引用次数: 0
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International Journal of Medical Toxicology and Forensic Medicine
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