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Autism spectrum disorder in relation to associated factors of children in salah-addin province: Iraq 伊拉克萨拉赫丁省儿童自闭症谱系障碍与相关因素的关系
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.33545/27074447.2022.v4.i2a.50
A. M. Jumaa, Mohammed Rajab Ahmed, Ahmed Raad Hamed, Eman Rasheed Abdulhameed, Alkhansa Kefah Abbas
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引用次数: 0
Suicidal Pattern of Decapitation Injury and Associated Limb Injury in Railway Track Traumas: A Case Series 铁路轨道创伤中断头及肢体损伤的自杀模式:一个病例系列
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-07-01 DOI: 10.32598/ijmtfm.v12i3.38166
Sahajad Khilji, Ashish Jain, Priyamvada Kurveti Verma, Rajendra Baraw
Suicide by high-speed railway track trauma with complete decapitation is a rare event; however, it is well known and reported in the scientific literature. The authors analyzed 5 cases of suicide with complete decapitation along with upper limb amputation or severe injury by high-speed mainline train subjected to medico-legal autopsies at the Department of Forensic Medicine and Toxicology, Gandhi Medical College, Bhopal between 2019 and 2021. Upper limb injury is considered because of scientific reasons that they have been amputated along with decapitation. Personal, circumstantial, autopsy, and toxicological data and thevictim’s psychical profile were analyzed, and factors like the type of injury, the vital reaction of wound edges, absence of any signs of defense, alcohol, and drug consumption were also considered.
高铁轨道创伤自杀并完全斩首是罕见事件;然而,它是众所周知的,并在科学文献中有报道。作者分析了2019年至2021年间,在博帕尔甘地医学院法医和毒理学系接受法医尸检的5例高速干线列车自杀,其中包括完全斩首、上肢截肢或严重受伤。上肢损伤被认为是因为科学原因,他们被截肢和斩首。分析了个人、环境、尸检和毒理学数据以及受害者的心理状况,还考虑了损伤类型、伤口边缘的生命反应、没有任何防御迹象、酒精和药物消耗等因素。
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引用次数: 0
Spirulina Ameliorates Oxidative Damage and Inflammation in Rotenone-Induced Neurotoxicity in Male Mice 螺旋藻改善雄性小鼠鱼藤酮神经毒性的氧化损伤和炎症
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-13 DOI: 10.32598/ijmtfm.v12i1.35583
Marwa E.A. EL- Shamarka, M. Mwaheb, A. Hussein, Ola N. Sayed, Eman S Said
Background: Rotenone, a chemical compound produced naturally by leguminous plants, has conventionally been used as a pesticide by blocking the uptake of oxygen by body cells. Our study aimed to investigate the effect of spirulina on oxidative damage, inflammation, and neurotoxicity in male mice treated by rotenone. Methods: The experimental animals were divided into 5 groups. Group (I) served as control that received Dimethyl Sulfoxide (DMSO); Group (II) mice treated with rotenone (1.5 mg/kg, s.c.3 times per week); Group (III) mice received rotenone/L-dopa (25 mg/kg, P.O. daily); Group (IV) and Group (V) mice were treated with rotenone/spirulina (200 and 400 mg/kg, P.O. daily) respectively for two weeks. Results: Rotenone-treated mice indicated impaired motor coordination and activity in wire hanging, wood walking, open field, and stair tests. Furthermore, rotenone treatment caused elevation in striatal levels of Malondialdehyde (MDA), Nitric Oxide (NO), Tumor Necrosis Factor (TNF-α), Interleukin -1 beta (IL-1β), and caspase 3 and decrement in Bcl-2; dopamine and Glutathione (GSH) levels. Moreover, severe neuronal degeneration, striatal DNA fragmentation, and increased striatal 8-OHdG levels and MTH1 expression in the rotenone group. Additionally, spirulina treatment prevented rotenone-induced motor deficits striatal DNA fragmentation and demonstrated good restoration of the substantial neurons with reservation of the typical dark appearance. Besides, rotenone-induced biochemical changes were ameliorated by spirulina treatment as dopamine, Bcl-2, and GSH levels were increased, and striatal MDA, TNF-α, IL-1β, and caspase 3 levels were decreased. Conclusion: Natural products like spirulina could reverse rotenone-induced neurotoxicity in male mice due to their anti-inflammatory and antioxidant properties.
背景:鱼藤酮是一种由豆科植物天然产生的化合物,通常被用作杀虫剂,通过阻断人体细胞对氧气的吸收。我们的研究旨在研究螺旋藻对鱼藤酮治疗雄性小鼠的氧化损伤、炎症和神经毒性的影响。方法:实验动物分为5组。组(I)用作接受二甲基亚砜(DMSO)的对照;组(II)用鱼藤酮处理的小鼠(1.5mg/kg,每周皮下注射.3次);组(III)小鼠接受鱼藤酮/L-多巴(25mg/kg,P.O.每日);第(IV)组和第(V)组小鼠分别用鱼藤酮/螺旋藻(200和400mg/kg,P.O.每日)处理两周。结果:鱼藤酮治疗的小鼠在挂线、走木、开阔场地和楼梯测试中表现出运动协调和活动受损。此外,鱼藤酮治疗导致纹状体丙二醛(MDA)、一氧化氮(NO)、肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)和胱天蛋白酶3水平升高,Bcl-2水平降低;多巴胺和谷胱甘肽(GSH)水平。此外,鱼藤酮组出现严重的神经元变性、纹状体DNA断裂、纹状体8-OHdG水平和MTH1表达增加。此外,螺旋藻处理防止了鱼藤酮诱导的运动缺陷纹状体DNA断裂,并证明了大量神经元的良好恢复,保留了典型的深色外观。此外,螺旋藻处理改善了鱼藤酮诱导的生化变化,多巴胺、Bcl-2和GSH水平升高,纹状体MDA、TNF-α、IL-1β和胱天蛋白酶3水平降低。结论:螺旋藻等天然产物具有抗炎和抗氧化作用,可逆转鱼藤酮对雄性小鼠的神经毒性。
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引用次数: 2
Quality of Life and Mental Health in Iranian Transgender Womefx qn per Socio-Demographic Differences 伊朗跨性别妇女的生活质量和心理健康:按社会人口差异计算
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-13 DOI: 10.32598/ijmtfm.v12i1.35133
A. Nematollahi, F. Farnam, M. Damghanian, S. Gharibzadeh, Saeid Gholamzadeh
Background: Mental health issues and quality of life are among the critical items of general health in individuals, especially transgender subjects. The present study aimed to assess the quality of life, depression, anxiety, and stress in transgender women and determine the factors contributing to them. Methods: A cross-sectional study was performed on 127 Iranian transgender women using a convenience sampling method from August 2019 to April 2020. The Quality of Life (QOL) was determined using the World Health Organization (WHO) Questionnaire (WHOQOL-BREF). The DASS-21 questionnaire was employed to evaluate the subjects’ anxiety, depression, and stress. Results: In total, 48% of the individuals had a moderate QOL. The highest score was achieved in the physical health dimension and the lowest in social relationships. Depression, anxiety, and stress were severe and extremely severe in 22%, 20.4%, and 17.3% of the subjects, respectively. A significant relationship was observed between the overall perception of QOL and depression, anxiety, and stress (P<0.001). A significant positive association was observed between the subscales of QOL and education and favorable economic status among transgender women. Furthermore, a significant negative correlation existed between the subscales of QOL with age and sexual violence. Regarding mental health, education had a significant relationship with reduced stress and anxiety, and good economic status had a significant relationship with reduced depression. Still, sexual violence was associated with increased stress in individuals. Conclusion: The present study results emphasize that transgender women are at risk of mental health disorders, including depression, anxiety, and stress. These conditions are in close association with the quality of life in this population. Moreover, considering the high sexual violence in transgender women of the present study and its considerable effects on mental health disorders, there is a strong need to develop violence prevention services in the community and legal protections in this area. The culture of preventing violence against women in society should be emphasized, and education to families should be considered the first line of prevention.
背景:心理健康问题和生活质量是个人,尤其是跨性别者总体健康的关键项目。本研究旨在评估跨性别女性的生活质量、抑郁、焦虑和压力,并确定导致这些问题的因素。方法:从2019年8月到2020年4月,采用方便抽样方法对127名伊朗变性女性进行了横断面研究。使用世界卫生组织(世界卫生组织)问卷(WHOQOL-BREF)测定生活质量(QOL)。DAS-21问卷用于评估受试者的焦虑、抑郁和压力。结果:总的来说,48%的个体具有中等的生活质量。在身体健康方面得分最高,在社会关系方面得分最低。22%、20.4%和17.3%的受试者的抑郁、焦虑和压力分别为严重和极严重。跨性别女性的总体生活质量感知与抑郁、焦虑和压力之间存在显著关系(P<0.001)。生活质量分量表与教育程度和良好的经济状况之间存在显著的正相关。此外,生活质量各分量表与年龄和性暴力呈显著负相关。在心理健康方面,教育与压力和焦虑的减轻有显著关系,良好的经济状况与抑郁的减轻有明显关系。尽管如此,性暴力与个人压力增加有关。结论:目前的研究结果强调,跨性别女性有患心理健康障碍的风险,包括抑郁、焦虑和压力。这些情况与这一人群的生活质量密切相关。此外,考虑到本研究中跨性别女性的性暴力率很高,对心理健康障碍的影响很大,因此迫切需要在社区中发展暴力预防服务,并在这一领域提供法律保护。应强调预防社会中暴力侵害妇女行为的文化,并应将对家庭的教育视为预防的第一道防线。
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引用次数: 2
Medical Malpractices in Tehran Public Hospitals Referred to the Forensic Medicine Commission of Tehran Province in 2018: An Analytical Review 2018年德黑兰公立医院的医疗不端行为被移交给德黑兰省法医委员会:分析综述
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-13 DOI: 10.32598/IJMTFM.VI.34586
F. Najari, J. Khoshnevis, Zahra Javaheri, Dorsa Najari
Background: The current status of medical malpractice in Tehran medical centers is unclear, while understanding the situation may help the authorities carefully plan, continuously monitor and, consequently, be sensitive to eliminate the weaknesses. Hence, the present study aimed at investigating the existing problems. Methods: In the present Descriptive and cross-sectional study, all patients complaining of the medical staff of public hospitals affiliated to three medical sciences universities (i e, Tehran, Iran, Shahid Beheshti, and Baqiyatallah) were evaluated in terms of demographic characteristics, physicians gender, the type of hospital, the type of specialty, the type of staff, and reason for complaint (disability, death) using a data collection form, and the results were analyzed in SPSS version 18 using the Chi-square and Fisher tests. P-value <0.01 was considered the level of significance. Results: Most of the filed complaints were against hospitals affiliated to Tehran and Shahid Beheshti universities of medical sciences, and 66% against private centers. Most cases won in the court were against general practitioners, dentists, general surgeons, and hospital technicians. The number of malpractices proven for teaching hospitals was significantly lower than that of non-teaching ones. Given the prevalence of plastic surgery in Iranian society, the number of complaints filed from female patients was two-thirds of male ones; almost 50% aged 21-40 years. For some reason, more than three-fourths of wrongful death complaints were for female patients. Conclusion: Complaints of medical malpractice in hospitals are an integral part of physicians and nursing staff work, as the saying goes: an unwritten dictation has no errors.
背景:德黑兰医疗中心医疗事故的现状尚不清楚,而了解情况可能有助于当局仔细规划、持续监测,从而敏感地消除弱点。因此,本研究旨在调查存在的问题。方法:在本描述性和横断面研究中,从人口统计学特征、医生性别、医院类型、专业类型、工作人员类型、,以及投诉原因(残疾、死亡),并在SPSS 18版中使用卡方检验和Fisher检验对结果进行分析。P值<0.01为显著性水平。结果:大多数提交的投诉是针对德黑兰和沙希德·贝赫什蒂医科大学附属医院的,66%是针对私人中心的。在法庭上胜诉的大多数案件都是针对全科医生、牙医、全科外科医生和医院技术人员的。教学医院被证实的不当行为数量明显低于非教学医院。考虑到整形手术在伊朗社会的普遍性,女性患者提出的投诉数量是男性患者的三分之二;年龄在21-40岁的占50%。出于某种原因,超过四分之三的不当死亡投诉是针对女性患者的。结论:医院医疗事故投诉是医生和护理人员工作的组成部分,俗话说:不成文的听写没有错误。
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引用次数: 0
The Relationship Between Post-Traumatic Stress Disorder After Childbirth and Social Support and Marital Satisfaction 产后创伤后应激障碍与社会支持及婚姻满意度的关系
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-13 DOI: 10.32598/IJMTFM.VI.35741
M. Tajik, M. Emamhadi, S. A. Akbari, M. Doulabi, Parisa Reza NejadAsl
Background: Childbirth is among the most significant and pleasant events in a woman’s life. This event can be a traumatic event and a threat to the mother’s mental health. This study recognizes the relationship between Post-Traumatic Stress Disorder (PTSD) after childbirth and social support and marital satisfaction. Methods: This Cross-sectional analytical study was performed on a sample of 400 mothers who had delivered at Shohadaye-15-Khordad Hospital in Varamin (in two groups with & without PTSD). The research instruments include the Demographic, Midwifery, Neonatal Factors checklist, Enrich Marital Satisfaction, Weinfeld and Tigman Social Support, and the PTSD Symptoms Scale. We used SPSS to analyze the descriptive and Pearson correlation and logistic regression data. A P<0.05 was considered significant. Results: The prevalence of PTDS in this study was equal to 16.8%. There was no significant correlation between the mean of the total score of PTSD in all dimensions with social support (P>0.05). Marital satisfaction significantly affected the probability of PTSD after childbirth (P=0.001). There was a significant correlation between PTSD total score and dimension of avoidance symptoms and infant gender (P=0.038). There was also a significant correlation between gestational age and avoidance symptoms (P=0.001) and type of nutrition feeding and motivational symptoms (P=0.041) of PTSD dimensions. Conclusion: According to the relationship between marital satisfaction and PTSD, it is recommended to design suitable interventions to improve the marital status and promptly diagnose the susceptible mothers to prevent the spread of this complication.
背景:分娩是女性一生中最重要、最愉快的事情之一。这一事件可能是创伤性事件,对母亲的心理健康构成威胁。本研究探讨了产后创伤后应激障碍(PTSD)与社会支持和婚姻满意度之间的关系。方法:本横断面分析研究对在瓦拉明的Shohadaye-15-Khordad医院分娩的400名母亲进行了样本分析(分为两组,有和没有PTSD)。研究工具包括人口学量表、助产学量表、新生儿因素量表、充实婚姻满意度量表、Weinfeld和Tigman社会支持量表和PTSD症状量表。我们使用SPSS分析描述性和Pearson相关以及逻辑回归数据。P0.05)。婚姻满意度显著影响分娩后PTSD的发生概率(P=0.001)。PTSD总分、回避症状维度与婴儿性别有显著相关(P=0.038)。胎龄与PTSD维度的回避症状(P=0.001)、营养喂养类型和动机症状(P=0.041)也有显著相关。结论:根据婚姻满意度与创伤后应激障碍的关系,建议设计合适的干预措施,改善婚姻状况,及时诊断易感母亲,防止该并发症的蔓延。
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引用次数: 0
Tramadol-Induced Organ Toxicity via Oxidative Stress : A Review Study 曲马多通过氧化应激诱导器官毒性的研究综述
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-13 DOI: 10.32598/ijmtfm.v12i1.35430
L. Mohammadnejad, K. Soltaninejad
Background: Tramadol (TR) is a synthetic opioid-like centrally acting analgesic used for moderate to severe pain management in various diseases. Numerous investigations have supported the association between tramadol use and increased levels of oxygen-free radicals. Mass production of reactive oxygen species produces secondary toxic compounds. This could damage the internal components of the cell and ultimately causes organ damage. There exists a growing trend of tramadol abuse and the increasing reports of poisoning, abuse, and mortality due to this drug. Thus, the present study aimed to review the animals and human studies on the effects of acute and chronic exposure of tramadol in inducing organ toxicities through oxidative stress. Methods: Pubmed, Google Scholar, and Scopus bibliographic databases were searched for studies that investigated oxidative stress as a mechanism of toxicity by tramadol. A manual search of reference lists of the retrieved articles was conducted. Data were collected from 2000 to 2021 (up to June 2021). Results: From 28 articles concerning experimental and human studies of TR-induced oxidative stress organ damage, which included in this review, the occurrence of lipid peroxidation, alteration in the levels of total antioxidant capacity, and other oxidative stress biomarkers in many organs such as the brain, liver, kidney, adrenal and lung in the experimental studies of tramadol exposure have been observed. Conclusion: Oxidative stress could be considered the most critical toxic mechanism in TR-induced tissue damage.
背景:曲马多(TR)是一种合成的阿片类中枢镇痛药,用于各种疾病的中重度疼痛管理。大量研究支持曲马多的使用与氧自由基水平升高之间的联系。大量生产活性氧会产生二次毒性化合物。这可能会破坏细胞的内部成分,最终导致器官损伤。曲马多滥用的趋势越来越大,因该药物而中毒、滥用和死亡的报告也越来越多。因此,本研究旨在回顾急性和慢性接触曲马多通过氧化应激诱导器官毒性的动物和人类研究。方法:检索Pubmed、Google Scholar和Scopus文献数据库中研究氧化应激作为曲马多毒性机制的研究。对检索到的文章的参考文献列表进行了手动搜索。数据收集于2000年至2021年(截至2021年6月)。结果:从28篇关于TR诱导的氧化应激器官损伤的实验和人类研究的文章中,包括本综述中脂质过氧化的发生、总抗氧化能力水平的改变以及许多器官(如脑、肝、肾、,肾上腺和肺在曲马多暴露的实验研究中都有观察。结论:氧化应激可能是TR诱导组织损伤的最关键的毒性机制。
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引用次数: 2
Estimating Stature and Gender by the Length of the Third, Fourth, and Fifth Fingers of Dominant Hand in Iranian Adults 伊朗成年人优势手第三、四、五指长度估算身高和性别
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-13 DOI: 10.32598/ijmtfm.v12i1.34718
Seyed Reza Saadat Mostafavi, A. Memarian, S. Soltani, Abdolkarimi Leyla, F. Taftachi
Background: Stature and gender are essential parameters of forensic anthropology. Moreover, their estimation is critical for medico-legal investigations to identify unknown remains. The present study aimed to estimate stature and gender by the anthropometric dimensions of the Iranian population’s third, fourth, and fifth fingers. Methods: In this cross-sectional study, 199 individuals (99 men & 100 women) were included. Individuals’ demographic information was recorded. A caliper measured the length of the fingers. An anthropometer was used for the measurement of stature. The obtained data were analyzed using SPSS. A multivariate linear regression test was used to predict the stature of individuals based on finger length. Results: In males and females, a solid and positive direct relationship was observed between the length of the third, fourth, and fifth fingers of the hand with the stature of individuals and between the length of the fingers with each other. In the coefficient table of the regression model of this study, in males, the length of the fingers was not predictive of stature, and only the length of the third finger in females had a predictive effect on stature (P=0.007). Conclusion: According to the obtained results, stature is predictable in women through the third finger length using the derived regression equation.
背景:身高和性别是法医人类学的基本参数。此外,它们的估计对于鉴定未知遗骸的法医调查至关重要。本研究旨在通过伊朗人口的第三、第四和第五个手指的人体测量尺寸来估计身高和性别。方法:在这项横断面研究中,包括199名个体(99名男性和100名女性)。记录了个人的人口统计信息。用卡尺测量手指的长度。身高计被用来测量身高。所得数据采用SPSS统计软件进行分析。采用多元线性回归检验,根据手指长度预测个体的身高。结果:在男性和女性中,手部的第三、第四和第五指的长度与个体的身高以及手指的长度之间存在着坚实的正相关关系。在本研究回归模型的系数表中,男性手指长度对身高没有预测作用,女性只有无名指长度对身高有预测作用(P=0.007)。结论:根据所得结果,利用推导出的回归方程,可以通过无名指长度预测女性的身材。
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引用次数: 1
Demographic Characteristics and Personality Disorders in People With Gender Dysphoria in East Azerbaijan Province, Iran 伊朗东阿塞拜疆省性别焦虑症患者的人口学特征和人格障碍
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-01 DOI: 10.32598/ijmtfm.v12i2.36056
Ali Reza Shafiei Kandjani, Sona Sadeghpour, B. Samadirad, Arezoo Mehrara, Parisa Hosseinnejad, B. Shalchi
Background: Gender identity is an important part of human identity. It is a personal conception of oneself as male or female. One of the major goals of treatment for individuals with Gender Dysphoria (GD) is to treat comorbid psychological and psychiatric disorders such as personality disorders. The present study aims to investigate demographic characteristics and personality disorders in people with GD seeking gender reassignment therapy in East Azerbaijan Province, Iran. Methods: In this descriptive cross-sectional study, study population consists of all patients with GD referred to the forensic medicine centers in East Azerbaijan province during 2016-2020, of whom 61 (21 males and 40 females) were selected using a convenience sampling method. Their age, gender, educational level, and marital status were recorded and their personality profile was assessed by the Millon Clinical Multiaxial Inventory–III. Results: The frequency (percentage) of Cluster A, B and C personality disorders in males were 0(0%), 9(50%) and 2(11.10%), while in females they were 1(5.56%), 4(22.40%), and 2(11.10%), respectively. The frequency (percentage) of antisocial, obsessive, borderline, avoidant, narcissistic, histrionic, and paranoid personality disorders in males were 4(22.2%), 2(11.10%), 3(16.67%), 0(0%), 0(0%), 2(11.10%), and 0(0%), while in females they were 4(22.20%), 1(5.56%), 3(16.67%), 1(5.56%), 1(5.56%), 2(11.10%), and 1(5.56%), respectively. The prevalence of different clusters (P=0.34) and types (P=0.18) of personality disorders was not significantly different between males and females. Conclusion: Personality disorders are comorbid with GD. They exist in one-third of patients with GD in East Azerbaijan Province. Personality disorders are significantly more prevalent in male patients with GD than in females.
背景:性别认同是人类认同的重要组成部分。它是个人对自己是男性还是女性的观念。治疗性别焦虑症(GD)患者的主要目标之一是治疗共病的心理和精神障碍,如人格障碍。本研究旨在调查伊朗东阿塞拜疆省寻求性别重置治疗的GD患者的人口学特征和人格障碍。方法:在这项描述性横断面研究中,研究人群由2016-2020年东阿塞拜疆省法医学中心转诊的所有GD患者组成,其中61例(男性21例,女性40例)采用方便抽样方法。记录他们的年龄、性别、教育水平和婚姻状况,并通过百万临床多轴量表- iii评估他们的性格特征。结果:男性A类、B类和C类人格障碍发生率分别为0(0%)、9(50%)和2(11.10%),女性分别为1(5.56%)、4(22.40%)和2(11.10%)。男性反社会型、强迫型、边缘型、回避型、自恋型、表演型、偏执型人格障碍的出现频率(百分比)分别为4(22.2%)、2(11.10%)、3(16.67%)、0(0%)、0(0%)、2(11.10%)、0(0%),女性分别为4(22.20%)、1(5.56%)、3(16.67%)、1(5.56%)、1(5.56%)、2(11.10%)、1(5.56%)。不同类型人格障碍的患病率(P=0.34)和不同类型人格障碍的患病率(P=0.18)在男女之间无显著差异。结论:人格障碍与GD共病。在东阿塞拜疆省,三分之一的GD患者存在这种疾病。人格障碍在男性GD患者中明显比在女性患者中更为普遍。
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引用次数: 0
Prevalence of Helicobacter felis and Helicobacter heilmannii and Co-infection With Helicobacter pylori in Gastric Biopsy Specimens in Endoscopy Ward of Shahid Beheshti Hospital, Hamadan City, Iran 伊朗哈马丹市Shahid Beheshti医院内镜病房胃活检标本中猫幽门螺杆菌、海氏幽门螺杆菌及幽门螺杆菌合并感染的患病率
IF 0.3 Q4 MEDICINE, LEGAL Pub Date : 2022-03-01 DOI: 10.32598/ijmtfm.v12i2.33088
A. Khalilian, Pezhman Karami, Somaye Bakhtyari, Razieh Ezati, Sara Khosravi, R. Amini, S. Talebi, Fatemeh Torkaman Asadi, M. Fazeli, Somayeh Soleimani, Shahab Mahmoudvand, H. Ghasemi, Shadi Baniardalan, F. Azizi Jalilian
Background: Helicobacter pylori (H. pylori) has various strains associated with human infections. H. pylori, H. heilmannii, and H. felis are the most common strains in humans. H. pylori is associated with several human diseases such as chronic gastritis, peptic ulcer, mucous membrane lymphoma, and gastric adenocarcinoma. This study aimed to determine the prevalence rates of H. felis and H. heilmannii and the effect of co-infection with H. pylori in gastric biopsy specimens of patients. Methods: Totally, 80 gastric biopsy specimens were taken by a physician from the patients referred to Shahid Beheshti Hospital, Hamadan City, Iran. PCR test was used to confirm the presence of H. pylori in samples that had positive rapid urease tests. Moreover, the ureB gene and ureA and ureB genes were used for H. heilmannii and H. felis, respectively. Results: Of the study patients, 61.5% were females, and 38.5% were males with a mean age of 37.8 years. Of 80 biopsies, 50% were H. pylori-positive, 53.8% were H. heilmannii-positive, but no H. felis was identified in any sample. Results indicate that smoking, having a history of gastrointestinal diseases, and taking certain medications can be risk factors for H. pylori. Conclusion: Any agent contributing to gastric mucosal damage can enhance the susceptibility to bacterial contamination. Overall, the results indicate a low probability of interactions between H. pylori, H. heilmannii, and H. felis.
背景:幽门螺杆菌(H.pylori)有多种菌株与人类感染有关。幽门螺杆菌、海尔曼氏菌和猫科动物是人类最常见的菌株。幽门螺杆菌与多种人类疾病有关,如慢性胃炎、消化性溃疡、粘膜淋巴瘤和胃腺癌。本研究旨在确定患者胃活检标本中H.felis和H.heilmannii的患病率以及幽门螺杆菌共同感染的影响。方法:医生从伊朗哈马丹市Shahid Beheshti医院转诊的患者身上采集80份胃活检标本。PCR检测用于确认快速尿素酶检测呈阳性的样本中是否存在幽门螺杆菌。此外,ureB基因以及ureA和ureB基因分别用于H.海尔曼尼和H.猫科动物。结果:研究患者中,61.5%为女性,38.5%为男性,平均年龄37.8岁。在80例活组织检查中,50%为幽门螺杆菌阳性,53.8%为海尔曼氏菌阳性,但在任何样本中都没有发现H.猫科动物。结果表明,吸烟、有胃肠道疾病史和服用某些药物可能是幽门螺杆菌的危险因素。结论:任何有助于胃黏膜损伤的药物都可以增加对细菌污染的易感性。总体而言,研究结果表明幽门螺杆菌、海尔曼氏菌和猫科动物之间相互作用的可能性很低。
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International Journal of Medical Toxicology and Forensic Medicine
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